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RTERQEITTDPTLDPASRVPTVAGGALLAVAVVLTALNLRPAVTSIATVLGDIRAELSVSATWAGLLMTL PALCFAGAGFAAPWLAARVGLGRTISAAMVALTAGLALRGAAGPHVIIGATLVACAGIALVNVLIPVVIK GSFPARIGLMTGIYTAALQGGGALGSAVTPGLEEPLGGWRAAVAVWAVVSLLALMVWIPATGRHRGAWAA HSLPAGRRSLLRSPLAWTITVFFGSQAFMAYIVMGWLPQVLVDNGVDQVQAGLLVGLMSLIGVPISLLIA PMAARRPSQSGWIVAVGMFGFAGAIGLMVAPAAQPLLWSVLIGIGMSAFSMALAVLGLRARTAADTAQLS GMVQGFGYLIAGAGPFLFGLLHDVSHGWTVPWMMFLAVYAVQIVAGALAGRARYV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0951 | - | - | 100% (406) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | 3e-07 | 23.04% (382) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_2131 | - | 7e-07 | 25.00% (264) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3018 | - | 1e-06 | 24.86% (370) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0017 | - | 1e-180 | 76.17% (407) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2994 | - | 1e-06 | 24.86% (370) | integral membrane protein |
| M. leprae Br4923 | MLBr_01562 | - | 1e-07 | 25.76% (264) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2273 | - | 1e-55 | 34.63% (387) | MFS family transporter |
| M. marinum M | MMAR_0750 | - | 3e-57 | 31.39% (395) | MFS transporter |
| M. avium 104 | MAV_4987 | - | 7e-05 | 25.38% (390) | sugar transporter family protein |
| M. smegmatis MC2 155 | MSMEG_2795 | - | 1e-148 | 66.67% (390) | transmembrane transport protein |
| M. thermoresistible (build 8) | TH_2039 | - | 1e-08 | 25.90% (390) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_1382 | - | 2e-57 | 31.14% (395) | MFS transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0951|M.vanbaalenii_PYR-1 --------------------------MRTERQEITTDPTLDPASRVPTVA
Mflv_0017|M.gilvum_PYR-GCK --------------------------MRSERQPMIVDPRATPDS-VPPVA
MSMEG_2795|M.smegmatis_MC2_155 ---------------------MPRNSLDSYEHDLELEIDGAAEFRAPAMA
MMAR_0750|M.marinum_M -------------------------------MTAVAAPAIHDPTASRSLF
MUL_1382|M.ulcerans_Agy99 --------------------------------------MIHDPTASRSLF
MAB_2273|M.abscessus_ATCC_1997 -------------------------------MTATLRDETHMISAA-ALR
Mb3018|M.bovis_AF2122/97 ------------------------------------------MSRDPTGV
Rv2994|M.tuberculosis_H37Rv ------------------------------------------MSRDPTGV
TH_2039|M.thermoresistible__bu ------------------------------------------MPVSSISP
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MAV_4987|M.avium_104 ---------------------------------MTAETANAAARTWTPRI
Mvan_0951|M.vanbaalenii_PYR-1 GG-ALLAVAVVLTALNLRPAVTS--IATVLGDIRAELSVSATWAGLLMTL
Mflv_0017|M.gilvum_PYR-GCK GG-ALLAVAVVLAALNLRPAVTS--IATLLHDIRGDLAVSATWAGLVTTL
MSMEG_2795|M.smegmatis_MC2_155 AGGVLLAVAVVLTALNLRPAITS--VGPLLGDMRSDLGASGVWAGVLTTM
MMAR_0750|M.marinum_M ASRVTVLLAIALSAFTMRSAVTS--MAPLLARVADTMGFGGTVIGVFGML
MUL_1382|M.ulcerans_Agy99 ASRVTVLLAIALSAFTMRSAVTS--MAPLLARVADTMGFGGTVIGVFGML
MAB_2273|M.abscessus_ATCC_1997 RGRLMVLAAILLFALCLRSAVTS--LSPLLTQISHEIGFGSAVIGVFGML
Mb3018|M.bovis_AF2122/97 GARWAIMIVSLGVTASSFLFING--VAFLIPRLENARGTPLSHAGLLASM
Rv2994|M.tuberculosis_H37Rv GARWAIMIVSLGVTASSFLFING--VAFLIPRLENARGTPLSHAGLLASM
TH_2039|M.thermoresistible__bu ARRWSMLVIALAATLFSVVFING--VAFVIPTLHREHGLSLAQAGLLSAL
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MAV_4987|M.avium_104 AAQLAILAAAAFTYVTAEILPVG-----ALPAIARNLQVSLVLVGTLLSW
: . : : .
Mvan_0951|M.vanbaalenii_PYR-1 PALCFAGAGFAAPWLAARVGLGRTISAAMVALTAGLALR-GAAGPHVIIG
Mflv_0017|M.gilvum_PYR-GCK PALCFAGAGLAAPWVASRIGLSRAISVALLALTAGLALR-GVGGEYVVIG
MSMEG_2795|M.smegmatis_MC2_155 PGLCFAAAGLAAPWLARKLGLGWAISLAMGVLTVGLLVR-VLDGALVVLG
MMAR_0750|M.marinum_M PTAMFALAGFAAP-LSRRFGPERLALLSVLATAAGTAGRSMASDTSELMA
MUL_1382|M.ulcerans_Agy99 PTAMFALAGFAAP-LSRRFGPERLALLSVLATAAGTAGRSMASDTSELMA
MAB_2273|M.abscessus_ATCC_1997 PTAMFAIAGLVTPALTERFGLERTTLAAVVATVIGMAARTAMNSTGGLLV
Mb3018|M.bovis_AF2122/97 PSWGLVVTMFAWGYLLDHVGERMVMAVGSALTAAAAYAAASVHSLLWIGV
Rv2994|M.tuberculosis_H37Rv PSWGLVVTMFAWGYLLDHVGERMVMAVGSALTAAAAYAAASVHSLLWIGV
TH_2039|M.thermoresistible__bu PSFGMVATLIAWGYLVDRIGERIVLTVGSALTAASAFAAAAVDSLLLVGV
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
MAV_4987|M.avium_104 YALVAALTTIPLVRWTAHLPRRRVLVASLTCLTASQLISALAPNFAVLAA
: . . . . . :
Mvan_0951|M.vanbaalenii_PYR-1 ATLVACAGIALVNVLIPVVIKGSFP--ARIGLMTGIYTAALQGGGALGSA
Mflv_0017|M.gilvum_PYR-GCK ATLIACAGIALANVLIPVVIKTSFP--ARIGMMTGIYTAALQGGGALGSA
MSMEG_2795|M.smegmatis_MC2_155 GTLVATGGIALINVLIPVVIKGSFP--ARIGLMTGIYTAALQGGGALGSG
MMAR_0750|M.marinum_M FTTLALVGMGIANIVIPPLVKKYFN--DRVALMSAIYLACLQLGTIMPAV
MUL_1382|M.ulcerans_Agy99 FTTLALVGMGIANIVVPPLVKKYFN--DRVALMSAIYLACLQLGTIMPAV
MAB_2273|M.abscessus_ATCC_1997 LSCLALLGMGIGNVVIPPLVKRYFS--HRVALMSAAYLTVLQIGTTVPAL
Mb3018|M.bovis_AF2122/97 FLFLGGMAAGGCNSAGGRLVSGWFPP-QQRGLAMGIRQTAQPLGIASGAL
Rv2994|M.tuberculosis_H37Rv FLFLGGMAAGGCNSAGGRLVSGWFPP-QQRGLAMGIRQTAQPLGIASGAL
TH_2039|M.thermoresistible__bu FLLLGGMAAASSNTASARVVVGWFPP-HQRGLVMGIRQTAQPLGVALGAL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
MAV_4987|M.avium_104 GRVLCAITHGLLWSVIAPIATRLVPP-SHAGRATMSIYVGTSLALVVGSP
: . : . . .
Mvan_0951|M.vanbaalenii_PYR-1 VTPGLEEPLGGWRAAVAVWAVVSLLALMVWIPATGRHRGAWAAHSLP---
Mflv_0017|M.gilvum_PYR-GCK VTPGLADPLGGWRTALMVWAAVSLLALTLWIPATARHRSAWAVHTRPS--
MSMEG_2795|M.smegmatis_MC2_155 VTSPLQDVLGGWREALGSWTVLALAALVVWLLAARSIHGARTTPMTAS--
MMAR_0750|M.marinum_M AAVPLAESYG-WRASLAIWALIPAVAVLPWILVLVRRR-TNGTDHAAR--
MUL_1382|M.ulcerans_Agy99 AAVPLAESYG-WRASLAIWALIPAVAVLPWILVLVRRR-TNGTDHAAR--
MAB_2273|M.abscessus_ATCC_1997 TAVPLADAYG-WRFSLVAWVLVPVAALLPWIGVVIARRGHDVEDHSAEPH
Mb3018|M.bovis_AF2122/97 VIPELAER-GVHAGLMFPAVVCTLAAVASVLGIVDPPRKSRTKASEQE--
Rv2994|M.tuberculosis_H37Rv VIPELAER-GVHAGLMFPAVVCTLAAVASVLGIVDPPRKSRTKASEQE--
TH_2039|M.thermoresistible__bu VIPRLAQSHGISAALLFPAAVCAVAAVICLIGVLDPPRPPRASADGRH--
MLBr_01562|M.leprae_Br4923 VGGALTEV--SWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAG--
MAV_4987|M.avium_104 LTAALSLMWGWRLAVVCVTVAAAVVTVAARLMLPEMVLTEHQLAHVGP--
* . . :
Mvan_0951|M.vanbaalenii_PYR-1 ---AGRRSLLRSPLAWTITVFFGSQAFMAY--IVMGWLPQVLVDNG-VDQ
Mflv_0017|M.gilvum_PYR-GCK ---AARRSLLRSPLAWTVTVFFGSQAFLAY--IMMGWLPQVFIDNG-IDK
MSMEG_2795|M.smegmatis_MC2_155 ---GKSRSLLRNPLAWTVTLFFGCQAFLAY--IVMGWLPEVFIDSG-VGK
MMAR_0750|M.marinum_M -TGKKIGPIWRSPISWGLTFMFSMTSLITY--AMFAWLPVIVTSAG-GSE
MUL_1382|M.ulcerans_Agy99 -TGKKIGPIWRSPISWGLTFMFSMTSLITY--AMFAWLPVIVTSAG-GSE
MAB_2273|M.abscessus_ATCC_1997 ADSAAVGQVWRSPLAWGMAGMFGMTSLVTY--SMFTWIPAILASAG-GSA
Mb3018|M.bovis_AF2122/97 ----LASPYRGSSILWRIHAASALLMMPQT--VTVTFMLVWLINHHGWSV
Rv2994|M.tuberculosis_H37Rv ----LASPYRGSSILWRIHAASALLMMPQT--VTVTFMLVWLINHHGWSV
TH_2039|M.thermoresistible__bu ----PQNPYRGSGLLWRIHAVSVLLVVPQG--VIWTFTLVWLMTERSWSA
MLBr_01562|M.leprae_Br4923 -AILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTA
MAV_4987|M.avium_104 ---RSRHHRNGRLITVSLLAMVAVTGHFVS----YTFIVEIIRNVV---G
: :
Mvan_0951|M.vanbaalenii_PYR-1 VQAGLLVGLMSLIGVPISLLIAPMAARRPSQSGWIVAVGMFGFAGAIGLM
Mflv_0017|M.gilvum_PYR-GCK VQAGLLVAVASLVGVPLSLVITPLAARSASQSGWIVGVGSFGFLGTVGLM
MSMEG_2795|M.smegmatis_MC2_155 TQAGLLVGLVSLLAVPISLVVAPLAARQSGQTGWIVGLGVVGFAGMVGLL
MMAR_0750|M.marinum_M ALGGAMVATFSGVGFLATLVTPRLCARAANPFPIVAASALCFLVGFAGLL
MUL_1382|M.ulcerans_Agy99 ALGGAMVATFSGVGFLATLVTPRLCARAANPFPIVAASALCFLVGFAGLL
MAB_2273|M.abscessus_ATCC_1997 KLGGVMVALFSAVGFVGTLAIPPLAARMRNPFPLVVACLVCFLIGFAGLL
Mb3018|M.bovis_AF2122/97 AQAGVLVTISQLLGALGRVAVGRWSDHVGSRMRPVRLIAAAAAATLF-LL
Rv2994|M.tuberculosis_H37Rv AQAGVLVTISQLLGALGRVAVGRWSDHVGSRMRPVRLIAAAAAATLF-LL
TH_2039|M.thermoresistible__bu GSAGTMVMIAQVLGAGGRVAAGRWSDLVGSRLRPIRTIALAAAAAMA-LL
MLBr_01562|M.leprae_Br4923 ENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALR
MAV_4987|M.avium_104 VRGPTLAWVLAAYGLAGLLSVPLVARPLDHRPKSAVILCMTGLTAAFAVL
. . :
Mvan_0951|M.vanbaalenii_PYR-1 VAPAAQPLLWSVLIGIGMSAFSMA----------------LAVLGLRART
Mflv_0017|M.gilvum_PYR-GCK VAPTAQPLLWSVLLGTGLSGFSLA----------------LALLGLRART
MSMEG_2795|M.smegmatis_MC2_155 VDPGAAPLLWSVLVGLGMSVFSLA----------------LTVIALRART
MMAR_0750|M.marinum_M WAPLTAPIVWAIFLGLGPSTFPAA----------------ITLINLRSRT
MUL_1382|M.ulcerans_Agy99 WAPLTAPIVWAIFLGLGPSTFPAA----------------ITLINLRSRT
MAB_2273|M.abscessus_ATCC_1997 WLPMHGTAVWVVALGFGPSTFPLG----------------LTLVNLRTRT
Mb3018|M.bovis_AF2122/97 AAVDNEGSRYDVLLMIAISVIAVL----------------DNGLEATAIT
Rv2994|M.tuberculosis_H37Rv AAVDNEGSRYDVLLMIAISVIAVL----------------DNGLEATAIT
TH_2039|M.thermoresistible__bu ALTDALDSPVSVAFMVIAAVVTVS----------------DNSLAFTAIA
MLBr_01562|M.leprae_Br4923 AGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFM
MAV_4987|M.avium_104 TALAFGGPTGATTALIGTAAIVLWG----------------AMATAVSPM
: :
Mvan_0951|M.vanbaalenii_PYR-1 AADTAQLS-----------GMVQGFG----YLIAGAGPFLFGLLHDVSHG
Mflv_0017|M.gilvum_PYR-GCK PEDTAALS-----------GMAQGFG----YLLAGTGPFLFGLLHDVTHG
MSMEG_2795|M.smegmatis_MC2_155 ADDTAQLS-----------GMAQGFG----YLLAGFGPFLFGLLHDVTGG
MMAR_0750|M.marinum_M ESGSAALS-----------GFTQGMG----YLLASPGPLIFGILYNATGR
MUL_1382|M.ulcerans_Agy99 ESGSAALS-----------GFTQGMG----YLLASPGPLIFGILYNATGR
MAB_2273|M.abscessus_ATCC_1997 PAGSAALS-----------GFTQGVG----YAVACLGPLLFGVLHDVSGG
Mb3018|M.bovis_AF2122/97 EYAGPYWS-----------GRALGIQNTTQRLMAAAGPPLFGSLITTAAY
Rv2994|M.tuberculosis_H37Rv EYAGPYWS-----------GRALGIQNTTQRLMAAAGPPLFGSLITTAAY
TH_2039|M.thermoresistible__bu EIAGPYWT-----------GRALGTQNTSQLLTTAITPPLFGGLIGVAGY
MLBr_01562|M.leprae_Br4923 NRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALM
MAV_4987|M.avium_104 MQSAAMRN-----------GADDPDG----ASGLYVTAFQVGIMAGSLLG
. * .* :
Mvan_0951|M.vanbaalenii_PYR-1 ---WTVPWMMFLAVYAVQIVAGALAG-----------RARYV--------
Mflv_0017|M.gilvum_PYR-GCK ---WTAPWVLFLAVFCVQTVTGALAG-----------RNRYV--------
MSMEG_2795|M.smegmatis_MC2_155 ---WTAPWALVLAVYLVQMGAGALAG-----------RNRYV--------
MMAR_0750|M.marinum_M ---WELSFGFLLVPLIALLAGGYHAC-----------KPRYLEDTLTPSR
MUL_1382|M.ulcerans_Agy99 ---WELSFGFLLVPLIALLAGGYHAC-----------KPRYLEDTLTPSR
MAB_2273|M.abscessus_ATCC_1997 ---WYAPFGLLLVAITVLGVGAFQAC-----------KPRTLEDTWN---
Mb3018|M.bovis_AF2122/97 PTAWALCGVFPLAAVPLVPVRLLPPGLETRARRQSVRRHRWWQAVRCHAW
Rv2994|M.tuberculosis_H37Rv PTAWALCGVFPLAAVPLVPVRLLPPGLETRARRQSVRRHRWWQAVRCHAW
TH_2039|M.thermoresistible__bu PVAFALCAVLPLAAVPLVPADPATP-------------------------
MLBr_01562|M.leprae_Br4923 LQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGL
MAV_4987|M.avium_104 GLLYERSVILMLSASGVLMAVALVGIAAN---------RRMLDVAPTSSR
: :
Mvan_0951|M.vanbaalenii_PYR-1 ---------------------------------------
Mflv_0017|M.gilvum_PYR-GCK ---------------------------------------
MSMEG_2795|M.smegmatis_MC2_155 ---------------------------------------
MMAR_0750|M.marinum_M KSGSDAVEDVVEGERLQECSTSCA---------------
MUL_1382|M.ulcerans_Agy99 KSGSDAVEDVVEGERLQECSTSCA---------------
MAB_2273|M.abscessus_ATCC_1997 -RGSGAVVSS-----------------------------
Mb3018|M.bovis_AF2122/97 PNGPRRPGPPGQPRRVRQGGTAITPPT------------
Rv2994|M.tuberculosis_H37Rv PNGPRRPGPPGQPRRVRQGGTAITPPT------------
TH_2039|M.thermoresistible__bu ---QIRPSSPESPRRVR----------------------
MLBr_01562|M.leprae_Br4923 LWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL
MAV_4987|M.avium_104 DS-------------------------------------