For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_2039 ()

annotation: PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN
coordinates: 4005217 - 4006443
length: 409

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2039-100% (409)PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN
M. thermoresistible (build 8)TH_0390-2e-1025.54% (368) major facilitator superfamily protein permease
M. thermoresistible (build 8)TH_0644narK23e-1030.52% (154) POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3018-1e-12854.69% (426) integral membrane protein
M. gilvum PYR-GCKMflv_4231-1e-15769.44% (396) major facilitator transporter
M. tuberculosis H37RvRv2994-1e-12854.69% (426) integral membrane protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3302-1e-15066.07% (392) major facilitator transporter
M. marinum MMMAR_1717-1e-13358.17% (404) integral membrane transport protein
M. avium 104MAV_3846-1e-12655.94% (404) sugar transporter family protein
M. smegmatis MC2 155MSMEG_2380-1e-16873.72% (392) sugar transporter family protein
M. ulcerans Agy99MUL_3155-4e-0725.28% (439) hypothetical protein MUL_3155
M. vanbaalenii PYR-1Mvan_2131-1e-16070.96% (396) major facilitator superfamily transporter

CLUSTAL 2.0.9 multiple sequence alignment


Mb3018|M.bovis_AF2122/97            -----------------------------MSRDPTG-----VGARWAIMI
Rv2994|M.tuberculosis_H37Rv         -----------------------------MSRDPTG-----VGARWAIMI
MMAR_1717|M.marinum_M               -----------------------------MPDESSATQELSLSARWWIVI
MAV_3846|M.avium_104                MAGRRPQAPMTGNGTRPTPKYPGGMQAWGMQTDPVATPDVGAGTRWSIMV
Mflv_4231|M.gilvum_PYR-GCK          ----------------------------------MAPSSIGPTRRWLMLA
Mvan_2131|M.vanbaalenii_PYR-1       --------------MSHIMRIWFSIVRRLCNHGAMPATAISSMRRWSMLA
MSMEG_2380|M.smegmatis_MC2_155      ------------------MELRFDILRSRDSMERMAAPVIGTLRRWSMLV
TH_2039|M.thermoresistible__bu      ----------------------------------MPVSSISPARRWSMLV
MAB_3302|M.abscessus_ATCC_1997      ------------------------------MVTMVHVDEVGTARRWAMLA
MUL_3155|M.ulcerans_Agy99           ------------------------MTTNGRAIRGGLADAVGGPARMRVIV
                                                                                *  :: 

Mb3018|M.bovis_AF2122/97            VSLGVTASSFLFINGVAFLIPRLENARGTPLSHAGLLASMPSWGLVVTMF
Rv2994|M.tuberculosis_H37Rv         VSLGVTASSFLFINGVAFLIPRLENARGTPLSHAGLLASMPSWGLVVTMF
MMAR_1717|M.marinum_M               VSLIVTASSFLFINGVAFLIPRLENARDTPLAEAGLLASMPSWGMVVTLV
MAV_3846|M.avium_104                VSLLATASSFLFINGVAFLIPSLQGARGIRLDEAGLLASMPSWGMVVTLV
Mflv_4231|M.gilvum_PYR-GCK          IGLLTTLCANVFINGVAFLIPTLHDERGLDLAGAALMSSLPSLGMVVTLI
Mvan_2131|M.vanbaalenii_PYR-1       IGLLATLCANVFINGVAFLIPTLHDERGLDLAAAGLMSSLPSLGMVVTLI
MSMEG_2380|M.smegmatis_MC2_155      IALTSTMCANVFINGAAFLIPTLHAERGLDLARSGLLSSMPSFGMVTTLI
TH_2039|M.thermoresistible__bu      IALAATLFSVVFINGVAFVIPTLHREHGLSLAQAGLLSALPSFGMVATLI
MAB_3302|M.abscessus_ATCC_1997      IALGSTAGANVFINGVAFLIPALHAERGLDLANAGLLSAMPSFGMVLTLI
MUL_3155|M.ulcerans_Agy99           LLALVVGLEGASNGTIGALAVVLKQAFGITNLQVGLLVTASTAIGIVVML
                                    :    .       .  . :   *.   .      .*: : .:   : .:.

Mb3018|M.bovis_AF2122/97            AWGYLLDHVG-ERMVMAVGSALTAAAAYAAASVHSLLWIGVFLFLGGMAA
Rv2994|M.tuberculosis_H37Rv         AWGYLLDHVG-ERMVMAVGSALTAAAAYAAASVHSLLWIGVFLFLGGMAA
MMAR_1717|M.marinum_M               AWGYVLDHVG-EQIVMTVGSALTAIAAYAAASVDSLLLMGIYLFLGGMAA
MAV_3846|M.avium_104                AWGYVLDRVG-ERVVMTTGSALTALAAYAASSAHSMVLIAVYLFLGGMAA
Mflv_4231|M.gilvum_PYR-GCK          AWGYVVDRIG-ERAVLTAGSALTAAASFAAASMDTLLTTGIFLFLGGMAA
Mvan_2131|M.vanbaalenii_PYR-1       AWGYVVDRVG-ERVVLTLGSALTAAAAFAAAAADTLLTTGVFLFLGGMAA
MSMEG_2380|M.smegmatis_MC2_155      AWGYVVDRFG-ERLVLGLGSALTAAAALAAASVQSLFAVGLFLLLGGMAA
TH_2039|M.thermoresistible__bu      AWGYLVDRIG-ERIVLTVGSALTAASAFAAAAVDSLLLVGVFLLLGGMAA
MAB_3302|M.abscessus_ATCC_1997      AWGALIDKFG-ERIALVSGLALTAVAAFAAAESPSLTVTGAFLLLGGAAA
MUL_3155|M.ulcerans_Agy99           VSGTLADRVNRTRVLWITVLIWSVAMALGGISAGYGWLLASRVALGAVVA
                                    . * : *:..  :         :.  : ..         .  : **. .*

Mb3018|M.bovis_AF2122/97            GGCNSAGGRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPELAE-RG
Rv2994|M.tuberculosis_H37Rv         GGCNSAGGRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPELAE-RG
MMAR_1717|M.marinum_M               ASCNSAGGRLVSGWFPPHQRGLAMGIRQTAQPLGIALGALVIPELAE-HS
MAV_3846|M.avium_104                ASCNTAGGRLVSAWFPPHQRGLAMGIRQTAQPLGIALGAMVIPELAE-HG
Mflv_4231|M.gilvum_PYR-GCK          ASSNTASARLVVGWFDAERRGLVMGIRQTAQPLGVGVGALVIPRLAESHG
Mvan_2131|M.vanbaalenii_PYR-1       ASSNTASGRLVVGWFDAERRGLVMGIRQTAQPLGVGVGALVIPRLAQAEG
MSMEG_2380|M.smegmatis_MC2_155      ASSNSASGRLVVGWFPPEQRGLVMGIRQTATPLGVGLGALVIPRLAESHG
TH_2039|M.thermoresistible__bu      ASSNTASARVVVGWFPPHQRGLVMGIRQTAQPLGVALGALVIPRLAQSHG
MAB_3302|M.abscessus_ATCC_1997      AACNSASGRVVVGWFPPHQRGTVMGIRQMAQPLGVAAGALVIPRIAEGHG
MUL_3155|M.ulcerans_Agy99           VG-GPVVASLMGDFFAQHERGRIYGFVLAGEGICTALGVLVSGWLAA-IT
                                     . ... . ::  :*  ..**   *:   .  :  . *.:*   :*    

Mb3018|M.bovis_AF2122/97            VHAGLMFPAVVCTLAAVASVLGIVDPPRK-----SRTKASEQELASPYRG
Rv2994|M.tuberculosis_H37Rv         VHAGLMFPAVVCTLAAVASVLGIVDPPRK-----SRTKASEQELASPYRG
MMAR_1717|M.marinum_M               IHNALMFPAAFCTIAAVASLVGVVDPPRK-----SRKVASKEELASPYRG
MAV_3846|M.avium_104                PQAGLRFTALACVFGAVASVIGIVDPPRK-----PRASASDQELASPYRG
Mflv_4231|M.gilvum_PYR-GCK          LSAALLFPAVVCAVSAVLCLAAVIDPPRP-----ARADAARTDLANPYRN
Mvan_2131|M.vanbaalenii_PYR-1       VSAALLFPAIVCAAAAVLCAIAVVDPPRP-----ARAEADDTDLANPYRG
MSMEG_2380|M.smegmatis_MC2_155      VSAALLFPAVVCGIAAVVSAVFVLDPPRP-----PRAEAPAEHLANPYRG
TH_2039|M.thermoresistible__bu      ISAALLFPAAVCAVAAVICLIGVLDPPRP-----PRASADGRHPQNPYRG
MAB_3302|M.abscessus_ATCC_1997      VATALLFPAIVCAVSSAVCLVGIIDPPRP-----PRSEAPEEHLANPYRG
MUL_3155|M.ulcerans_Agy99           WRLSFLWLAVTGLLLTLALARTVPEPARGGDTFGASAGSDRRDCSNDTLA
                                       .: : *      :      : :*.*      .   :   .  .    

Mb3018|M.bovis_AF2122/97            SSILWR---IHAASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTIS
Rv2994|M.tuberculosis_H37Rv         SSILWR---IHAASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTIS
MMAR_1717|M.marinum_M               SAVLWR---IHASSALLMMPQTVTVTFMLVWLMNHHGWPVATAGILVTVS
MAV_3846|M.avium_104                SLTLWR---IHAVAGLMMMPQTVTVTFMLVWLIRNLHWSVAAAGALVTLS
Mflv_4231|M.gilvum_PYR-GCK          SAMLWR---IHLTSVLLVIPQVVVWTFTLVWMISEHGWSPESAGVLVMVA
Mvan_2131|M.vanbaalenii_PYR-1       SPMLWR---IHLTSVLLVVPQVMVWTFTLVWLISEHRWSPESAGLLVMTA
MSMEG_2380|M.smegmatis_MC2_155      SSVLWR---IHAVSVLLVVPQGVLWTFALVWLITDRGWSAASAGILVTVT
TH_2039|M.thermoresistible__bu      SGLLWR---IHAVSVLLVVPQGVIWTFTLVWLMTERSWSAGSAGTMVMIA
MAB_3302|M.abscessus_ATCC_1997      SRVLWL---IHGVSVLLVVPQVVVWTFTLVWLVTDRGWSIGAASVMVTVA
MUL_3155|M.ulcerans_Agy99           AAVIAQRVSAHPHLILQESPEGRSLRWAVGYVLKIR------TNVALMVA
                                    :  :      *    *   *:     : : :::         :.  :  :

Mb3018|M.bovis_AF2122/97            QLLGALGRVAVGRWS--------DHVGSRMRPVRLIAAAAAATLFLLAAV
Rv2994|M.tuberculosis_H37Rv         QLLGALGRVAVGRWS--------DHVGSRMRPVRLIAAAAAATLFLLAAV
MMAR_1717|M.marinum_M               QLLGALGRIAVGRWS--------DRVGSRMRPVRVIAIASAAALFLLALV
MAV_3846|M.avium_104                QLLGALGRVAVGRWS--------DRLGSRMRPVRYIAAAAVLVLLLLAWA
Mflv_4231|M.gilvum_PYR-GCK          QIMGAAGRIGAGRWSDHYVRRSGDLLASRLRPIRIIAAAAAASMALLALT
Mvan_2131|M.vanbaalenii_PYR-1       QILGAAGRIGAGRWSDTFVRRSGDVIASRLRPIRMIAAAAAAAMALLAVT
MSMEG_2380|M.smegmatis_MC2_155      QLLGAGGRIAAGKWS--------DVIGYRLRPIRTIALAAAVTMAALALT
TH_2039|M.thermoresistible__bu      QVLGAGGRVAAGRWS--------DLVGSRLRPIRTIALAAAAAMALLALT
MAB_3302|M.abscessus_ATCC_1997      QLVGALGRVAAGMWS--------DRWGSRMRPIRAIAAAASATMALLAVT
MUL_3155|M.ulcerans_Agy99           SSFGYFFYTGLGTFA-------VALLRSRFRISQTLAISLIAIIGVGAPI
                                    . .*     . * ::             *:*  : :* :    :   *  

Mb3018|M.bovis_AF2122/97            DNEGSRYDVLLMIAISVIAVLD--NGLEATAITEYAGPYWSGRALGIQNT
Rv2994|M.tuberculosis_H37Rv         DNEGSRYDVLLMIAISVIAVLD--NGLEATAITEYAGPYWSGRALGIQNT
MMAR_1717|M.marinum_M               DDEGSRYDVLLMITITVIAVLD--NGLQATAITEYAGPYWSGRALGVQNT
MAV_3846|M.avium_104                DYLNSRWQAGLMVAISVIAVLD--NGLEATAITEFAGPYWSGRALGIQNT
Mflv_4231|M.gilvum_PYR-GCK          DLVNSPLSIALMMVASVITVSD--NGLAFTLIAEYAGPFWSGRALGTQNT
Mvan_2131|M.vanbaalenii_PYR-1       DWLDSPVSIVVMIAASVITVSD--NGLAFTLIAEYAGPFWSGRALGTQNT
MSMEG_2380|M.smegmatis_MC2_155      DWLSSPVSIALMVAASVITVSD--NGLAFTGIAEIAGPFWSGRALGTQNT
TH_2039|M.thermoresistible__bu      DALDSPVSVAFMVIAAVVTVSD--NSLAFTAIAEIAGPYWTGRALGTQNT
MAB_3302|M.abscessus_ATCC_1997      NQLDWSVSVVVMLVASVITVSD--NGLAYTSIAEIAGPFWSGRALGAQNT
MUL_3155|M.ulcerans_Agy99           GTLCAGRLADWLIGRGYLGARLGVAGAAFLVAGGFFVPALLTDNVVIAVV
                                    .          ::    : .     .           *      :    .

Mb3018|M.bovis_AF2122/97            TQRLMAA----AGPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLP
Rv2994|M.tuberculosis_H37Rv         TQRLMAA----AGPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLP
MMAR_1717|M.marinum_M               TQRLMAA----AGPPIFGALITTAAYPLAWGLCGLFPLAAIPLVPTRLRP
MAV_3846|M.avium_104                TQRMMAA----AGPPLFGALISAAKYPPAWLLCALFPLAAMPLVPTRLLP
Mflv_4231|M.gilvum_PYR-GCK          SQLFAQG----VAPPLFGGLIAVAGYPVAFAVCALLPVLAIPAVPLKVTV
Mvan_2131|M.vanbaalenii_PYR-1       SQLFAQG----VAPPLFGGLIAIAGYPVAFAVCALFPLLAIPSVPLTVKP
MSMEG_2380|M.smegmatis_MC2_155      SQHLATA----VSSPVFGGLIGVAGYPVAFAVCALLPALAIPLVPVEPAR
TH_2039|M.thermoresistible__bu      SQLLTTA----ITPPLFGGLIGVAGYPVAFALCAVLPLAAVPLVPADPAT
MAB_3302|M.abscessus_ATCC_1997      GQLLAAA----VAPPIFGAIAAAAGFSAAFAVCALFPLAAVGLVPVKLER
MUL_3155|M.ulcerans_Agy99           AAFLAAIGLGGVNPPLDAARLDIMHSRLWGRAEAIRTTLRSGFTAAAPLV
                                       :         .*: ..              .: .      ..     

Mb3018|M.bovis_AF2122/97            PGLETRARRQSVRRHRWWQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAIT
Rv2994|M.tuberculosis_H37Rv         PGLETRARRQSVRRHRWWQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAIT
MMAR_1717|M.marinum_M               PGLEPRERPQSARRLRRWQAVRSRELPSNPRPPDPPG-------------
MAV_3846|M.avium_104                PGLETRARRQSVRRLRWWRAVRSHALPDIVRRPGQPG-------------
Mflv_4231|M.gilvum_PYR-GCK          DR------------------------------------------------
Mvan_2131|M.vanbaalenii_PYR-1       DR------------------------------------------------
MSMEG_2380|M.smegmatis_MC2_155      ES------------------------------------------------
TH_2039|M.thermoresistible__bu      PQIRPSSPESPRRVR-----------------------------------
MAB_3302|M.abscessus_ATCC_1997      PAP-----------------------------------------------
MUL_3155|M.ulcerans_Agy99           FAWYPCSWRRSGARPVGWQPHRPG--------------------------
                                                                                      

Mb3018|M.bovis_AF2122/97            PPT
Rv2994|M.tuberculosis_H37Rv         PPT
MMAR_1717|M.marinum_M               ---
MAV_3846|M.avium_104                ---
Mflv_4231|M.gilvum_PYR-GCK          ---
Mvan_2131|M.vanbaalenii_PYR-1       ---
MSMEG_2380|M.smegmatis_MC2_155      ---
TH_2039|M.thermoresistible__bu      ---
MAB_3302|M.abscessus_ATCC_1997      ---
MUL_3155|M.ulcerans_Agy99           ---