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MMKDSLSATIWRLAIFVCVCLLGLSLLVAVFGQLRFEPRRGFTAEFTNVGGLKSGDFVRIAGVEVGKVGD LSLRPDAAVNVSFTVDDSVQLLDNTRAVIRYDNLYGDRYLAIEQGEGEGRPLAPGGIIPFTQTAPALDLD TLIGGFRPLFRALDPDQVNALSSQLIQAFQGQGDTIGSVLTQTAALTNTLADHDALIGDAITNLDTVFGT LADNNAELGQAIDTFASLTESLAERRTDISNSVAYTNAAAGSLADLLERSRPALQKITHETDRTAGIVLD EDDYVDNLLETLPDAYKKLGRQGLYGDWFAFYVCEVVFKVNGKGGQPVYIKAAGQSSGRCTPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0923 | - | - | 100% (343) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0364 | - | e-119 | 59.94% (342) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4603 | - | e-114 | 60.36% (333) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 1e-76 | 46.04% (341) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_0651 | - | 1e-120 | 63.53% (340) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-119 | 61.40% (342) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 3e-74 | 42.15% (344) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 3e-59 | 37.50% (336) | MCE-family protein |
| M. marinum M | MMAR_2883 | mce3B | 1e-118 | 61.99% (342) | MCE-family protein Mce3B |
| M. avium 104 | MAV_2062 | - | 1e-118 | 60.82% (342) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-104 | 53.27% (336) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-106 | 55.85% (342) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2869 | mce3B | 1e-117 | 61.40% (342) | MCE-family protein Mce3B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 ---MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVS
MLBr_02590|M.leprae_Br4923 ---MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNIS
Mvan_0923|M.vanbaalenii_PYR-1 MMKDSLSATIWRLAIFVCVCLLGLSLLVAVFGQLRFEPRRGFTAEFTNVG
MAV_2062|M.avium_104 -MRRKLSSIAWRVAIFTAVCLLFTFTLIAVFGQLRFEDRTGYQAVFTNIS
Mflv_0651|M.gilvum_PYR-GCK -MTNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQRYTAVFANVS
TH_3222|M.thermoresistible__bu -LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEEDTYHAIFTSVT
MMAR_2883|M.marinum_M -MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDGNTYYAEFSNVS
MUL_2869|M.ulcerans_Agy99 -MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDGNTYYAEFSNVS
Rv1967|M.tuberculosis_H37Rv -MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDGKTYYAEFANVS
MSMEG_0347|M.smegmatis_MC2_155 -MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGERKQYTAQFSDIS
MAB_4152c|M.abscessus_ATCC_199 ----MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGKRYHAMFSTAS
. :: . * : :. *.:.** : * *:
Mb0605|M.bovis_AF2122/97 GLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASI
MLBr_02590|M.leprae_Br4923 GLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQI
Mvan_0923|M.vanbaalenii_PYR-1 GLKSGDFVRIAGVEVGKVGDLSLRP-DAAVNVSFTVDDSVQLLDNTRAVI
MAV_2062|M.avium_104 GLKSGNFVRIAGVEVGKVGDLSLHR-DGTVTVGFAVDKGVRLSEGTKAVV
Mflv_0651|M.gilvum_PYR-GCK GLTSGDFVRIAGVEVGKVRTLTVRD-DSTVAVEFGADDSVVLTDGSRAVI
TH_3222|M.thermoresistible__bu GLENGNFVRIAGVEVGKVKHVSVRD-DSTVLVKFSADRSVVLTEGSRAII
MMAR_2883|M.marinum_M NLREGKLVRIAGVEVGKVEKISINP-DSTVKVGFTADNSVTLTQGTQAVI
MUL_2869|M.ulcerans_Agy99 NLREGKLVRIAGVEVGKVEKISINP-DATVKVEFTADNSVTLTQGTQAVI
Rv1967|M.tuberculosis_H37Rv NLRTGKLVRIAGVEVGKVTRISINP-DATVRVQFTADNSVTLTRGTRAVI
MSMEG_0347|M.smegmatis_MC2_155 GLKEGDFVRIAGVEVGQVQKVSMDE-NALVLVEFAMEDSVELTSTSTAVI
MAB_4152c|M.abscessus_ATCC_199 DLRSGQKVRIAGVPVGRVKNVSLNR-DNSVEVTFDVDSKYQLYSSSRAII
.* *. ** :** **:* ::: . * * * : * : * :
Mb0605|M.bovis_AF2122/97 RYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFR
MLBr_02590|M.leprae_Br4923 RYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFK
Mvan_0923|M.vanbaalenii_PYR-1 RYDNLYGDRYLAIEQGE--GEGRPLAPGGIIPFTQTAPALDLDTLIGGFR
MAV_2062|M.avium_104 RYENLIGDRYLALEEGP--GSPRRLPPGATIPLARTSPALDLDALIGGFR
Mflv_0651|M.gilvum_PYR-GCK KYDNLIGDRYLAIEEGA--GGTTKLRPGDAIPLDRTAPALDLDAVIGGFR
TH_3222|M.thermoresistible__bu RYDNLIGGRYLALEEGA--GGTTKLAPGETIPLDRTAPALDLDALIGGFR
MMAR_2883|M.marinum_M RYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDLDALIGGFR
MUL_2869|M.ulcerans_Agy99 RYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDFDDLIDGFR
Rv1967|M.tuberculosis_H37Rv RYDNLFGDRYLALEEGA--GGLAVLRPGHTIPLARTQPALDLDALIGGFK
MSMEG_0347|M.smegmatis_MC2_155 RYDNLIGGRYLELKQGE--EPGAVLQAGATIPLARTRPALDLDELIGGFR
MAB_4152c|M.abscessus_ATCC_199 RYENLVGDRYLEITAGP--GELHKLPDGGTLDKEHTQPALDLDALLGGLR
:* :* *.*** : * : * : .* ****:* ::.*::
Mb0605|M.bovis_AF2122/97 PLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAI
MLBr_02590|M.leprae_Br4923 PLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAI
Mvan_0923|M.vanbaalenii_PYR-1 PLFRALDPDQVNALSSQLIQAFQGQGDTIGSVLTQTAALTNTLADHDALI
MAV_2062|M.avium_104 PLFRALDPDQVNALSGQLLRIFQGQGGTLASVLSQTSMLTSTLAGRSQLI
Mflv_0651|M.gilvum_PYR-GCK PLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELI
TH_3222|M.thermoresistible__bu PLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRDELI
MMAR_2883|M.marinum_M PLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLI
MUL_2869|M.ulcerans_Agy99 PLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLI
Rv1967|M.tuberculosis_H37Rv PLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLI
MSMEG_0347|M.smegmatis_MC2_155 PLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQLI
MAB_4152c|M.abscessus_ATCC_199 PVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLI
*::. ::. ::* :: :: : *** *: .* ::: .* :. :. *
Mb0605|M.bovis_AF2122/97 GEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHIS
MLBr_02590|M.leprae_Br4923 GEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHIS
Mvan_0923|M.vanbaalenii_PYR-1 GDAITNLDTVFGTLADNNAELGQAIDTFASLTESLAERRTDISNSVAYTN
MAV_2062|M.avium_104 GELITNLNTVLRTFATRDHEFSDGLDKLAQLVDGLAQRRDDISTGLAYIN
Mflv_0651|M.gilvum_PYR-GCK GQTIVNLNVVLGSLAGHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYAN
TH_3222|M.thermoresistible__bu GQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLAKAG
MMAR_2883|M.marinum_M GQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYTN
MUL_2869|M.ulcerans_Agy99 GQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYTN
Rv1967|M.tuberculosis_H37Rv GQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTN
MSMEG_0347|M.smegmatis_MC2_155 GEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIANSD
MAB_4152c|M.abscessus_ATCC_199 GDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLA
*: : :*: :: : . .: : : * * : :: . .
Mb0605|M.bovis_AF2122/97 SAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYR
MLBr_02590|M.leprae_Br4923 NAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLN
Mvan_0923|M.vanbaalenii_PYR-1 AAAGSLADLLERSRPALQKITHETDRTAGIVLDEDDYVDNLLETLPDAYK
MAV_2062|M.avium_104 AAAGSITDLLSQSRQPLKDVVQHTDRMSGQVLSDRDYVDNLLKELPDIYQ
Mflv_0651|M.gilvum_PYR-GCK EAARSIADLLAQARPPLQKAVHETDRTATAVLADRDYFDNLLNTLPDTYR
TH_3222|M.thermoresistible__bu EGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPDAYR
MMAR_2883|M.marinum_M AAAGSVADLLSQARAPLSKALHETDRVATIALADHDYLDNLLNTLPDRYQ
MUL_2869|M.ulcerans_Agy99 AAAGSVADLLSKARAPFSKALHETDRVATIALADHDYLDNLLNTLPDRYQ
Rv1967|M.tuberculosis_H37Rv AAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQ
MSMEG_0347|M.smegmatis_MC2_155 NAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPDKYR
MAB_4152c|M.abscessus_ATCC_199 STASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYL
* : .:* : : .: : *.
Mb0605|M.bovis_AF2122/97 IIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQP---TGRCT
MLBr_02590|M.leprae_Br4923 QIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TGRCT
Mvan_0923|M.vanbaalenii_PYR-1 KLGRQ-GLYGDWFAFYVCEVVFKVNGK--GGQPVYIKAAGQS---SGRCT
MAV_2062|M.avium_104 VLARQ-GLNGDYFGFYFCEVLLKLNGK--GGNPIFVKLLGQP---SGRCT
Mflv_0651|M.gilvum_PYR-GCK VMLRQ-GLYGNYFTFYLCDLLLKVNGK--GGQPVYIKLVEQS---SGRCT
TH_3222|M.thermoresistible__bu VLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TGRCA
MMAR_2883|M.marinum_M ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRCT
MUL_2869|M.ulcerans_Agy99 ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRCT
Rv1967|M.tuberculosis_H37Rv ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SGRCA
MSMEG_0347|M.smegmatis_MC2_155 VLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TGRCA
MAB_4152c|M.abscessus_ATCC_199 RLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRCA
: . *.:. :* *.: :*:** * : .***:
Mb0605|M.bovis_AF2122/97 PQ--
MLBr_02590|M.leprae_Br4923 PQ--
Mvan_0923|M.vanbaalenii_PYR-1 PR--
MAV_2062|M.avium_104 PK--
Mflv_0651|M.gilvum_PYR-GCK PQ--
TH_3222|M.thermoresistible__bu PR--
MMAR_2883|M.marinum_M PK--
MUL_2869|M.ulcerans_Agy99 PK--
Rv1967|M.tuberculosis_H37Rv PK--
MSMEG_0347|M.smegmatis_MC2_155 PK--
MAB_4152c|M.abscessus_ATCC_199 FKNE
: