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PGLTTRVRHDALRLGVFLTVCLVGVFGLFAVFGQMRFGEKTHSYKAAFSNVTGLENGDFVRIAGVEVGQV KKVAIQPDTTALVEFTADQSVVLTEGSRAVIRYDDLIGGRYLALQEGAGATTTLKPGETIPLARTAPALD LDALIGGFRPLFRALDPEQVNALSGQLISALQGQGGTINSFLAQTATLTSTLADRDQLIGEVITNLNVVL GSLGDQNDQFAKAIDSLADLVQTLRDRKEDVSNGLAYTNAAAASIADLLAQARPPLAKTIKETDRSAAIV VADHEYFDNFLNTLPDAYQALARQGIYGDFFSFYLCDIVLKLNGKGGQPVYVKVAGQSTGRCAPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4603 | - | - | 100% (346) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0364 | - | e-129 | 67.46% (335) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4398 | - | e-126 | 65.97% (335) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0176 | mce1B | 5e-78 | 45.66% (346) | MCE-family protein MCE1B |
| M. gilvum PYR-GCK | Mflv_2102 | - | 1e-163 | 82.51% (343) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-128 | 67.37% (334) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 1e-75 | 45.00% (340) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 7e-61 | 38.64% (339) | MCE-family protein |
| M. marinum M | MMAR_4052 | mce3B_1 | 1e-161 | 80.76% (343) | MCE-family protein Mce3B_1 |
| M. avium 104 | MAV_2533 | - | 1e-130 | 68.56% (334) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-123 | 64.97% (334) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-135 | 70.36% (334) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3919 | mce3B_1 | 1e-161 | 80.76% (343) | MCE-family protein Mce3B_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0176|M.bovis_AF2122/97 -----MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRT-NGYTAEFS
MLBr_02590|M.leprae_Br4923 -----MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRT-NGYTAEFT
MMAR_4052|M.marinum_M ---MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFS
MUL_3919|M.ulcerans_Agy99 ---MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFS
Mvan_4603|M.vanbaalenii_PYR-1 MPGLTTRVRHDALRLGVFLTVCLVGVFGLFAVFGQMRFGEKTHSYKAAFS
Mflv_2102|M.gilvum_PYR-GCK ---MSVSIRRDATRLGAFLAVCLLGVFGLFAVFGQMRFGEKTQQYRAEFV
MAV_2533|M.avium_104 ---MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSE-KTYKAQFA
TH_3222|M.thermoresistible__bu ---LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEE-DTYHAIFT
Rv1967|M.tuberculosis_H37Rv ---MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDG-KTYYAEFA
MSMEG_0347|M.smegmatis_MC2_155 ---MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGER-KQYTAQFS
MAB_4152c|M.abscessus_ATCC_199 ------MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSG-KRYHAMFS
:: * . :. *.:.** * * *
Mb0176|M.bovis_AF2122/97 NVSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTT
MLBr_02590|M.leprae_Br4923 NISGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTT
MMAR_4052|M.marinum_M NVTGLEQNDFVRIAGVEVGQVKKVAIQPD-TTALVEFTADSSVVLTQGSR
MUL_3919|M.ulcerans_Agy99 NVTGLEQNDFVRIAGVEVGQVKKVAIQPD-TTALVEFTADSSVVLTQGSR
Mvan_4603|M.vanbaalenii_PYR-1 NVTGLENGDFVRIAGVEVGQVKKVAIQPD-TTALVEFTADQSVVLTEGSR
Mflv_2102|M.gilvum_PYR-GCK NVTGLETNDFVRIAGVEVGKVENVEIQPD-TTAVVEFTADDSVVLTQGSR
MAV_2533|M.avium_104 NVSGLEGGNFVRIAGVEVGKVKNITVEPD-STVLVEFTAAEKVVLTEGTR
TH_3222|M.thermoresistible__bu SVTGLENGNFVRIAGVEVGKVKHVSVRDD-STVLVKFSADRSVVLTEGSR
Rv1967|M.tuberculosis_H37Rv NVSNLRTGKLVRIAGVEVGKVTRISINPD-ATVRVQFTADNSVTLTRGTR
MSMEG_0347|M.smegmatis_MC2_155 DISGLKEGDFVRIAGVEVGQVQKVSMDEN-ALVLVEFAMEDSVELTSTST
MAB_4152c|M.abscessus_ATCC_199 TASDLRSGQKVRIAGVPVGRVKNVSLNRD-NSVEVTFDVDSKYQLYSSSR
:.*. .. ** :** :*:* : : . . * * . * :
Mb0176|M.bovis_AF2122/97 AQIRYSDLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIG
MLBr_02590|M.leprae_Br4923 AQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIG
MMAR_4052|M.marinum_M AVIRYDDLIGGRYLALE--EGAGSPKQLKPGDTIPMTHTSPALDLDALIG
MUL_3919|M.ulcerans_Agy99 AVIRYDDLIGGRYLALE--EGAGSPKQLKPGDTIPMTHTSPALDLDALIG
Mvan_4603|M.vanbaalenii_PYR-1 AVIRYDDLIGGRYLALQ--EGAGATTTLKPGETIPLARTAPALDLDALIG
Mflv_2102|M.gilvum_PYR-GCK AVIRYDDLIGGRYLALE--EGAGGTQKLNPGGTIPLARTSPALDLDALIG
MAV_2533|M.avium_104 AAIRFADLTGGRYVALE--EGAGNIRRLSPGATIPLARTEPALDLDALIG
TH_3222|M.thermoresistible__bu AIIRYDNLIGGRYLALE--EGAGGTTKLAPGETIPLDRTAPALDLDALIG
Rv1967|M.tuberculosis_H37Rv AVIRYDNLFGDRYLALE--EGAGGLAVLRPGHTIPLARTQPALDLDALIG
MSMEG_0347|M.smegmatis_MC2_155 AVIRYDNLIGGRYLELK--QGEEPGAVLQAGATIPLARTRPALDLDELIG
MAB_4152c|M.abscessus_ATCC_199 AIIRYENLVGDRYLEIT--AGPGELHKLPDGGTLDKEHTQPALDLDALLG
* **: :* *.**: : * : * : :* ****** *:*
Mb0176|M.bovis_AF2122/97 GFKPVFRALDPAKVNNIANALITVFQGQGGTINDTLDQTAQLTSQIAERD
MLBr_02590|M.leprae_Br4923 GFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERD
MMAR_4052|M.marinum_M GFRPLLKALDPEQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRD
MUL_3919|M.ulcerans_Agy99 GFRPLLKALDPDQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRD
Mvan_4603|M.vanbaalenii_PYR-1 GFRPLFRALDPEQVNALSGQLISALQGQGGTINSFLAQTATLTSTLADRD
Mflv_2102|M.gilvum_PYR-GCK GFRPLFRALDPDQINALSGQLISALQGQGGTINSFLAQTAALTSTLADRD
MAV_2533|M.avium_104 GFRPLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRD
TH_3222|M.thermoresistible__bu GFRPLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRD
Rv1967|M.tuberculosis_H37Rv GFKPLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRD
MSMEG_0347|M.smegmatis_MC2_155 GFRPLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRD
MAB_4152c|M.abscessus_ATCC_199 GLRPVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERD
*::*:::.::. ::* :: :: : *:* *:.. * ::: .*. :.:**
Mb0176|M.bovis_AF2122/97 QAIGEVVKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLA
MLBr_02590|M.leprae_Br4923 QAIGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFA
MMAR_4052|M.marinum_M QLIGDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGVA
MUL_3919|M.ulcerans_Agy99 QLIGDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGMA
Mvan_4603|M.vanbaalenii_PYR-1 QLIGEVITNLNVVLGSLGDQNDQFAKAIDSLADLVQTLRDRKEDVSNGLA
Mflv_2102|M.gilvum_PYR-GCK QLIGEVIINLNTVLGSLGDQSDQFAKAVDSLSQLVEGLSDRRQEISDGLA
MAV_2533|M.avium_104 HLIGQVIVNLNTVLGSLGGQSGQFARAVDSLSELVAGLEARKQDISNGMA
TH_3222|M.thermoresistible__bu ELIGQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLA
Rv1967|M.tuberculosis_H37Rv RLIGQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVA
MSMEG_0347|M.smegmatis_MC2_155 QLIGEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIA
MAB_4152c|M.abscessus_ATCC_199 QLIGDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALP
. **:*: :*: :* : : .: :: * *: * : :: ...
Mb0176|M.bovis_AF2122/97 HISNGAGTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPT
MLBr_02590|M.leprae_Br4923 HISNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPT
MMAR_4052|M.marinum_M YTNAAASSIADLLSQARPPLTKTVQETDRASAIVLADHEYFDNLINTLPD
MUL_3919|M.ulcerans_Agy99 YTNAAASSIADLLSQARPPLAKTVQETDRASAIVLADHEYFDNLINTLPD
Mvan_4603|M.vanbaalenii_PYR-1 YTNAAAASIADLLAQARPPLAKTIKETDRSAAIVVADHEYFDNFLNTLPD
Mflv_2102|M.gilvum_PYR-GCK YTNAAAGSIADFLTEARPPLKKTIDETDRAAGIVVADHEYFDNLINTLPD
MAV_2533|M.avium_104 YANAAAGSITDLLAQARPPVKKVVHEADRTAGTMLADREWLEKYLDHWPD
TH_3222|M.thermoresistible__bu KAGEGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPD
Rv1967|M.tuberculosis_H37Rv YTNAAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPD
MSMEG_0347|M.smegmatis_MC2_155 NSDNAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPD
MAB_4152c|M.abscessus_ATCC_199 PLASTASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAE
* : ..* : : : : : .: :. .
Mb0176|M.bovis_AF2122/97 ALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQP---TG
MLBr_02590|M.leprae_Br4923 VLNQIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TG
MMAR_4052|M.marinum_M AYQALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TG
MUL_3919|M.ulcerans_Agy99 AYQALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TG
Mvan_4603|M.vanbaalenii_PYR-1 AYQALARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---TG
Mflv_2102|M.gilvum_PYR-GCK AYQVLARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---SG
MAV_2533|M.avium_104 AFKILNRQ-GLYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQA---SG
TH_3222|M.thermoresistible__bu AYRVLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TG
Rv1967|M.tuberculosis_H37Rv KYQALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SG
MSMEG_0347|M.smegmatis_MC2_155 KYRVLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TG
MAB_4152c|M.abscessus_ATCC_199 NYLRLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKG
: . *.: :* *.: :* ** * : . .*
Mb0176|M.bovis_AF2122/97 RCTPQ--
MLBr_02590|M.leprae_Br4923 RCTPQ--
MMAR_4052|M.marinum_M RCAPR--
MUL_3919|M.ulcerans_Agy99 RCAPR--
Mvan_4603|M.vanbaalenii_PYR-1 RCAPR--
Mflv_2102|M.gilvum_PYR-GCK RCAPR--
MAV_2533|M.avium_104 RCTPR--
TH_3222|M.thermoresistible__bu RCAPR--
Rv1967|M.tuberculosis_H37Rv RCAPK--
MSMEG_0347|M.smegmatis_MC2_155 RCAPK--
MAB_4152c|M.abscessus_ATCC_199 RCAFKNE
**: :