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VNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGERKQYTAQFSDISGLKEGDFVRIAGVEVGQVQKV SMDENALVLVEFAMEDSVELTSTSTAVIRYDNLIGGRYLELKQGEEPGAVLQAGATIPLARTRPALDLDE LIGGFRPLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQLIGEVIGNLDVLLGSL GEQSHQFDKAVNSLSELVAGLSARRTDITNAIANSDNAATEIADLLAQARPPLQNVVTQADRAAAIAVAD HEYLDNILNTLPDKYRVLGRQAMYGDYFSFYLCDLILKLNGKGGQPVYVKLAEQVTGRCAPK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0347 | - | - | 100% (342) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0135 | - | 7e-77 | 43.57% (342) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_4793 | - | 5e-70 | 41.62% (334) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 1e-78 | 46.61% (339) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_2102 | - | 1e-121 | 64.26% (333) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-113 | 59.88% (334) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 1e-74 | 42.90% (345) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 1e-59 | 36.58% (339) | MCE-family protein |
| M. marinum M | MMAR_2883 | mce3B | 1e-120 | 61.11% (342) | MCE-family protein Mce3B |
| M. avium 104 | MAV_2533 | - | 1e-110 | 57.31% (342) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4123 | - | 1e-113 | 62.11% (322) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3919 | mce3B_1 | 1e-120 | 63.47% (334) | MCE-family protein Mce3B_1 |
| M. vanbaalenii PYR-1 | Mvan_0364 | - | 1e-123 | 64.46% (332) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 --MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHT-TGYSAVFTHVS
MLBr_02590|M.leprae_Br4923 --MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRT-NGYTAEFTNIS
MSMEG_0347|M.smegmatis_MC2_155 MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGER-KQYTAQFSDIS
TH_4123|M.thermoresistible__bu --------------------MGTFGLLMIFAELRFYGE-EVYRAEFGDVS
Mflv_2102|M.gilvum_PYR-GCK MSVSIRRDATRLGAFLAVCLLGVFGLFAVFGQMRFGEKTQQYRAEFVNVT
MUL_3919|M.ulcerans_Agy99 MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFSNVT
MAV_2533|M.avium_104 MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSE-KTYKAQFANVS
Rv1967|M.tuberculosis_H37Rv MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDG-KTYYAEFANVS
MMAR_2883|M.marinum_M MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDG-NTYYAEFSNVS
Mvan_0364|M.vanbaalenii_PYR-1 MRGNFAAAAWRLGIFLAVCALGTFVLLSVFAQFRFGDG-KTYQAEFSNVS
MAB_4152c|M.abscessus_ATCC_199 ---MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSG-KRYHAMFSTAS
: :. *.:.** * * * :
Mb0605|M.bovis_AF2122/97 GLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASI
MLBr_02590|M.leprae_Br4923 GLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQI
MSMEG_0347|M.smegmatis_MC2_155 GLKEGDFVRIAGVEVGQVQKVSMDE-NALVLVEFAMEDSVELTSTSTAVI
TH_4123|M.thermoresistible__bu GLETGDFVRIAGVEVGKVKAIDLDD-NGIVHVEFSANSAAVLTDKTRAAI
Mflv_2102|M.gilvum_PYR-GCK GLETNDFVRIAGVEVGKVENVEIQP-DTTAVVEFTADDSVVLTQGSRAVI
MUL_3919|M.ulcerans_Agy99 GLEQNDFVRIAGVEVGQVKKVAIQP-DTTALVEFTADSSVVLTQGSRAVI
MAV_2533|M.avium_104 GLEGGNFVRIAGVEVGKVKNITVEP-DSTVLVEFTAAEKVVLTEGTRAAI
Rv1967|M.tuberculosis_H37Rv NLRTGKLVRIAGVEVGKVTRISINP-DATVRVQFTADNSVTLTRGTRAVI
MMAR_2883|M.marinum_M NLREGKLVRIAGVEVGKVEKISINP-DSTVKVGFTADNSVTLTQGTQAVI
Mvan_0364|M.vanbaalenii_PYR-1 GLKDGDLVRIAGVEVGKVKSITVGS-DAVVTVSFDTDDTVVLTDGTRAAI
MAB_4152c|M.abscessus_ATCC_199 DLRSGQKVRIAGVPVGRVKNVSLNR-DNSVEVTFDVDSKYQLYSSSRAII
.*. .. ** :** **:* : : . . * * * : * *
Mb0605|M.bovis_AF2122/97 RYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFR
MLBr_02590|M.leprae_Br4923 RYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFK
MSMEG_0347|M.smegmatis_MC2_155 RYDNLIGGRYLELKQGE--EPGAVLQAGATIPLARTRPALDLDELIGGFR
TH_4123|M.thermoresistible__bu RWADMIGGRYLSLEEPE--RGSRPLQPGETIPRDRTAPALDLDALIGGFR
Mflv_2102|M.gilvum_PYR-GCK RYDDLIGGRYLALEEGA--GGTQKLNPGGTIPLARTSPALDLDALIGGFR
MUL_3919|M.ulcerans_Agy99 RYDDLIGGRYLALEEGA--GSPKQLKPGDTIPMTHTSPALDLDALIGGFR
MAV_2533|M.avium_104 RFADLTGGRYVALEEGA--GNIRRLSPGATIPLARTEPALDLDALIGGFR
Rv1967|M.tuberculosis_H37Rv RYDNLFGDRYLALEEGA--GGLAVLRPGHTIPLARTQPALDLDALIGGFK
MMAR_2883|M.marinum_M RYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDLDALIGGFR
Mvan_0364|M.vanbaalenii_PYR-1 RYDNLFGGRYLALEEGV--GGLHEMSPGHTIPLARTEPALDLDSLIGGFR
MAB_4152c|M.abscessus_ATCC_199 RYENLVGDRYLEITAGP--GELHKLPDGGTLDKEHTQPALDLDALLGGLR
*: :: *.**: : : * : .* ****** *:**::
Mb0605|M.bovis_AF2122/97 PLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAI
MLBr_02590|M.leprae_Br4923 PLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAI
MSMEG_0347|M.smegmatis_MC2_155 PLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQLI
TH_4123|M.thermoresistible__bu PLFRALDPDQVNALSHQLIEAFQGQGSTISFLLRNTAEVTRTLADRDQLI
Mflv_2102|M.gilvum_PYR-GCK PLFRALDPDQINALSGQLISALQGQGGTINSFLAQTAALTSTLADRDQLI
MUL_3919|M.ulcerans_Agy99 PLLKALDPDQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRDQLI
MAV_2533|M.avium_104 PLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRDHLI
Rv1967|M.tuberculosis_H37Rv PLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLI
MMAR_2883|M.marinum_M PLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLI
Mvan_0364|M.vanbaalenii_PYR-1 PLFRALDPEQVNELSAQLIGALQGQGPTIGSFLEQAAAVTNTLADRDQLI
MAB_4152c|M.abscessus_ATCC_199 PVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLI
*::: ::. ::* :: :: : *:* *:. :* ::: .* :.:**: *
Mb0605|M.bovis_AF2122/97 GEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHIS
MLBr_02590|M.leprae_Br4923 GEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHIS
MSMEG_0347|M.smegmatis_MC2_155 GEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIANSD
TH_4123|M.thermoresistible__bu GEVITNLNTVLGTFAEEHEKFDQSVDSLSQLIEGLHDRRTDISNAVAHID
Mflv_2102|M.gilvum_PYR-GCK GEVIINLNTVLGSLGDQSDQFAKAVDSLSQLVEGLSDRRQEISDGLAYTN
MUL_3919|M.ulcerans_Agy99 GDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGMAYTN
MAV_2533|M.avium_104 GQVIVNLNTVLGSLGGQSGQFARAVDSLSELVAGLEARKQDISNGMAYAN
Rv1967|M.tuberculosis_H37Rv GQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTN
MMAR_2883|M.marinum_M GQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYTN
Mvan_0364|M.vanbaalenii_PYR-1 GEVVVNLNTVLGSIGQQSDRFDTAVTSLSELVHGLAERRTDISDAVAHTN
MAB_4152c|M.abscessus_ATCC_199 GDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLA
*:*: :*: :* : . .: :* * *: * : :: . .
Mb0605|M.bovis_AF2122/97 SAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYR
MLBr_02590|M.leprae_Br4923 NAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLN
MSMEG_0347|M.smegmatis_MC2_155 NAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPDKYR
TH_4123|M.thermoresistible__bu GAAGTIGELLVQARPPLKKVVHETDRAAGIAVGDHEYLDNFLNTLPDTYR
Mflv_2102|M.gilvum_PYR-GCK AAAGSIADFLTEARPPLKKTIDETDRAAGIVVADHEYFDNLINTLPDAYQ
MUL_3919|M.ulcerans_Agy99 AAASSIADLLSQARPPLAKTVQETDRASAIVLADHEYFDNLINTLPDAYQ
MAV_2533|M.avium_104 AAAGSITDLLAQARPPVKKVVHEADRTAGTMLADREWLEKYLDHWPDAFK
Rv1967|M.tuberculosis_H37Rv AAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQ
MMAR_2883|M.marinum_M AAAGSVADLLSQARAPLSKALHETDRVATIALADHDYLDNLLNTLPDRYQ
Mvan_0364|M.vanbaalenii_PYR-1 SATASLADLLAATRPPLQRVVHETDRAAAIAVADHEYLDNLLNTLPDRYQ
MAB_4152c|M.abscessus_ATCC_199 STASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYL
:: : ..* :. : . .: : .
Mb0605|M.bovis_AF2122/97 IIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQP---TGRCT
MLBr_02590|M.leprae_Br4923 QIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TGRCT
MSMEG_0347|M.smegmatis_MC2_155 VLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TGRCA
TH_4123|M.thermoresistible__bu IIARQ-GIHGDFFSFYLCDLVLKLNGK--GGNPVYVKLAGQD---SGRCA
Mflv_2102|M.gilvum_PYR-GCK VLARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---SGRCA
MUL_3919|M.ulcerans_Agy99 ALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TGRCA
MAV_2533|M.avium_104 ILNRQ-GLYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQA---SGRCT
Rv1967|M.tuberculosis_H37Rv ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SGRCA
MMAR_2883|M.marinum_M ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRCT
Mvan_0364|M.vanbaalenii_PYR-1 ALGRQ-GMYGDFFSFYLCEIVLKLNGK--GGQPVYVKVAGQD---SGRCT
MAB_4152c|M.abscessus_ATCC_199 RLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRCA
: . :*.:. :* *.: :*:** * : . .***:
Mb0605|M.bovis_AF2122/97 PQ--
MLBr_02590|M.leprae_Br4923 PQ--
MSMEG_0347|M.smegmatis_MC2_155 PK--
TH_4123|M.thermoresistible__bu PQ--
Mflv_2102|M.gilvum_PYR-GCK PR--
MUL_3919|M.ulcerans_Agy99 PR--
MAV_2533|M.avium_104 PR--
Rv1967|M.tuberculosis_H37Rv PK--
MMAR_2883|M.marinum_M PK--
Mvan_0364|M.vanbaalenii_PYR-1 PR--
MAB_4152c|M.abscessus_ATCC_199 FKNE
: