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MRRKLSSIAWRVAIFTAVCLLFTFTLIAVFGQLRFEDRTGYQAVFTNISGLKSGNFVRIAGVEVGKVGDL SLHRDGTVTVGFAVDKGVRLSEGTKAVVRYENLIGDRYLALEEGPGSPRRLPPGATIPLARTSPALDLDA LIGGFRPLFRALDPDQVNALSGQLLRIFQGQGGTLASVLSQTSMLTSTLAGRSQLIGELITNLNTVLRTF ATRDHEFSDGLDKLAQLVDGLAQRRDDISTGLAYINAAAGSITDLLSQSRQPLKDVVQHTDRMSGQVLSD RDYVDNLLKELPDIYQVLARQGLNGDYFGFYFCEVLLKLNGKGGNPIFVKLLGQPSGRCTPK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2062 | - | - | 100% (342) | virulence factor Mce family protein |
| M. avium 104 | MAV_2533 | - | e-115 | 58.48% (342) | virulence factor Mce family protein |
| M. avium 104 | MAV_4550 | - | 9e-87 | 46.65% (343) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 5e-86 | 48.10% (343) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_2102 | - | 1e-116 | 60.90% (335) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-112 | 58.19% (342) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 1e-80 | 45.80% (345) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 1e-69 | 40.90% (335) | MCE-family protein |
| M. marinum M | MMAR_2883 | mce3B | 1e-112 | 57.60% (342) | MCE-family protein Mce3B |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-100 | 52.63% (342) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-111 | 54.97% (342) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3919 | mce3B_1 | 1e-112 | 57.43% (343) | MCE-family protein Mce3B_1 |
| M. vanbaalenii PYR-1 | Mvan_0923 | - | 1e-118 | 60.82% (342) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 ---MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHT-TGYSAVFTHV
MLBr_02590|M.leprae_Br4923 ---MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRT-NGYTAEFTNI
MAV_2062|M.avium_104 -MRRKLSSIAWRVAIFTAVCLLFTFTLIAVFGQLRFEDR-TGYQAVFTNI
Mvan_0923|M.vanbaalenii_PYR-1 MMKDSLSATIWRLAIFVCVCLLGLSLLVAVFGQLRFEPR-RGFTAEFTNV
Mflv_2102|M.gilvum_PYR-GCK -MSVSIRRDATRLGAFLAVCLLGVFGLFAVFGQMRFGEKTQQYRAEFVNV
MUL_3919|M.ulcerans_Agy99 -MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFSNV
TH_3222|M.thermoresistible__bu -LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEE-DTYHAIFTSV
Rv1967|M.tuberculosis_H37Rv -MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDG-KTYYAEFANV
MMAR_2883|M.marinum_M -MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDG-NTYYAEFSNV
MSMEG_0347|M.smegmatis_MC2_155 -MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGER-KQYTAQFSDI
MAB_4152c|M.abscessus_ATCC_199 ----MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSG-KRYHAMFSTA
:: . * : :. *.:.** : * *
Mb0605|M.bovis_AF2122/97 SGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTAS
MLBr_02590|M.leprae_Br4923 SGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQ
MAV_2062|M.avium_104 SGLKSGNFVRIAGVEVGKVGDLSLHR-DGTVTVGFAVDKGVRLSEGTKAV
Mvan_0923|M.vanbaalenii_PYR-1 GGLKSGDFVRIAGVEVGKVGDLSLRP-DAAVNVSFTVDDSVQLLDNTRAV
Mflv_2102|M.gilvum_PYR-GCK TGLETNDFVRIAGVEVGKVENVEIQP-DTTAVVEFTADDSVVLTQGSRAV
MUL_3919|M.ulcerans_Agy99 TGLEQNDFVRIAGVEVGQVKKVAIQP-DTTALVEFTADSSVVLTQGSRAV
TH_3222|M.thermoresistible__bu TGLENGNFVRIAGVEVGKVKHVSVRD-DSTVLVKFSADRSVVLTEGSRAI
Rv1967|M.tuberculosis_H37Rv SNLRTGKLVRIAGVEVGKVTRISINP-DATVRVQFTADNSVTLTRGTRAV
MMAR_2883|M.marinum_M SNLREGKLVRIAGVEVGKVEKISINP-DSTVKVGFTADNSVTLTQGTQAV
MSMEG_0347|M.smegmatis_MC2_155 SGLKEGDFVRIAGVEVGQVQKVSMDE-NALVLVEFAMEDSVELTSTSTAV
MAB_4152c|M.abscessus_ATCC_199 SDLRSGQKVRIAGVPVGRVKNVSLNR-DNSVEVTFDVDSKYQLYSSSRAI
.*. .. ** :** **:* : : . . * * : * : *
Mb0605|M.bovis_AF2122/97 IRYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGF
MLBr_02590|M.leprae_Br4923 IRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGF
MAV_2062|M.avium_104 VRYENLIGDRYLALEEGP--GSPRRLPPGATIPLARTSPALDLDALIGGF
Mvan_0923|M.vanbaalenii_PYR-1 IRYDNLYGDRYLAIEQGE--GEGRPLAPGGIIPFTQTAPALDLDTLIGGF
Mflv_2102|M.gilvum_PYR-GCK IRYDDLIGGRYLALEEGA--GGTQKLNPGGTIPLARTSPALDLDALIGGF
MUL_3919|M.ulcerans_Agy99 IRYDDLIGGRYLALEEGA--GSPKQLKPGDTIPMTHTSPALDLDALIGGF
TH_3222|M.thermoresistible__bu IRYDNLIGGRYLALEEGA--GGTTKLAPGETIPLDRTAPALDLDALIGGF
Rv1967|M.tuberculosis_H37Rv IRYDNLFGDRYLALEEGA--GGLAVLRPGHTIPLARTQPALDLDALIGGF
MMAR_2883|M.marinum_M IRYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDLDALIGGF
MSMEG_0347|M.smegmatis_MC2_155 IRYDNLIGGRYLELKQGE--EPGAVLQAGATIPLARTRPALDLDELIGGF
MAB_4152c|M.abscessus_ATCC_199 IRYENLVGDRYLEITAGP--GELHKLPDGGTLDKEHTQPALDLDALLGGL
:** :* *.*** : * : * : .* ****** *:**:
Mb0605|M.bovis_AF2122/97 RPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHA
MLBr_02590|M.leprae_Br4923 KPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQA
MAV_2062|M.avium_104 RPLFRALDPDQVNALSGQLLRIFQGQGGTLASVLSQTSMLTSTLAGRSQL
Mvan_0923|M.vanbaalenii_PYR-1 RPLFRALDPDQVNALSSQLIQAFQGQGDTIGSVLTQTAALTNTLADHDAL
Mflv_2102|M.gilvum_PYR-GCK RPLFRALDPDQINALSGQLISALQGQGGTINSFLAQTAALTSTLADRDQL
MUL_3919|M.ulcerans_Agy99 RPLLKALDPDQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRDQL
TH_3222|M.thermoresistible__bu RPLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRDEL
Rv1967|M.tuberculosis_H37Rv KPLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRL
MMAR_2883|M.marinum_M RPLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQL
MSMEG_0347|M.smegmatis_MC2_155 RPLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQL
MAB_4152c|M.abscessus_ATCC_199 RPVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQL
:*::: ::. ::* :: :: : *:* *: .* ::: .* :. :.
Mb0605|M.bovis_AF2122/97 IGEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHI
MLBr_02590|M.leprae_Br4923 IGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHI
MAV_2062|M.avium_104 IGELITNLNTVLRTFATRDHEFSDGLDKLAQLVDGLAQRRDDISTGLAYI
Mvan_0923|M.vanbaalenii_PYR-1 IGDAITNLDTVFGTLADNNAELGQAIDTFASLTESLAERRTDISNSVAYT
Mflv_2102|M.gilvum_PYR-GCK IGEVIINLNTVLGSLGDQSDQFAKAVDSLSQLVEGLSDRRQEISDGLAYT
MUL_3919|M.ulcerans_Agy99 IGDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGMAYT
TH_3222|M.thermoresistible__bu IGQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLAKA
Rv1967|M.tuberculosis_H37Rv IGQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYT
MMAR_2883|M.marinum_M IGQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYT
MSMEG_0347|M.smegmatis_MC2_155 IGEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIANS
MAB_4152c|M.abscessus_ATCC_199 IGDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPL
**: : :*: :: : . .: : : * * : :: . .
Mb0605|M.bovis_AF2122/97 SSAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAY
MLBr_02590|M.leprae_Br4923 SNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVL
MAV_2062|M.avium_104 NAAAGSITDLLSQSRQPLKDVVQHTDRMSGQVLSDRDYVDNLLKELPDIY
Mvan_0923|M.vanbaalenii_PYR-1 NAAAGSLADLLERSRPALQKITHETDRTAGIVLDEDDYVDNLLETLPDAY
Mflv_2102|M.gilvum_PYR-GCK NAAAGSIADFLTEARPPLKKTIDETDRAAGIVVADHEYFDNLINTLPDAY
MUL_3919|M.ulcerans_Agy99 NAAASSIADLLSQARPPLAKTVQETDRASAIVLADHEYFDNLINTLPDAY
TH_3222|M.thermoresistible__bu GEGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPDAY
Rv1967|M.tuberculosis_H37Rv NAAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKY
MMAR_2883|M.marinum_M NAAAGSVADLLSQARAPLSKALHETDRVATIALADHDYLDNLLNTLPDRY
MSMEG_0347|M.smegmatis_MC2_155 DNAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPDKY
MAB_4152c|M.abscessus_ATCC_199 ASTASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENY
* : ..* : : .: : *.
Mb0605|M.bovis_AF2122/97 RIIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQP---TGRC
MLBr_02590|M.leprae_Br4923 NQIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TGRC
MAV_2062|M.avium_104 QVLARQ-GLNGDYFGFYFCEVLLKLNGK--GGNPIFVKLLGQP---SGRC
Mvan_0923|M.vanbaalenii_PYR-1 KKLGRQ-GLYGDWFAFYVCEVVFKVNGK--GGQPVYIKAAGQS---SGRC
Mflv_2102|M.gilvum_PYR-GCK QVLARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---SGRC
MUL_3919|M.ulcerans_Agy99 QALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TGRC
TH_3222|M.thermoresistible__bu RVLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TGRC
Rv1967|M.tuberculosis_H37Rv QALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SGRC
MMAR_2883|M.marinum_M QALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRC
MSMEG_0347|M.smegmatis_MC2_155 RVLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TGRC
MAB_4152c|M.abscessus_ATCC_199 LRLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRC
: . *.:. :* *.: :*:** * : .***
Mb0605|M.bovis_AF2122/97 TPQ--
MLBr_02590|M.leprae_Br4923 TPQ--
MAV_2062|M.avium_104 TPK--
Mvan_0923|M.vanbaalenii_PYR-1 TPR--
Mflv_2102|M.gilvum_PYR-GCK APR--
MUL_3919|M.ulcerans_Agy99 APR--
TH_3222|M.thermoresistible__bu APR--
Rv1967|M.tuberculosis_H37Rv APK--
MMAR_2883|M.marinum_M TPK--
MSMEG_0347|M.smegmatis_MC2_155 APK--
MAB_4152c|M.abscessus_ATCC_199 AFKNE
: :