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TNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQRYTAVFANVSGLTSGDFVRIAGVEVGKVRTLT VRDDSTVAVEFGADDSVVLTDGSRAVIKYDNLIGDRYLAIEEGAGGTTKLRPGDAIPLDRTAPALDLDAV IGGFRPLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELIGQTIVNLNVVLGSLA GHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYANEAARSIADLLAQARPPLQKAVHETDRTATAVLADR DYFDNLLNTLPDTYRVMLRQGLYGNYFTFYLCDLLLKVNGKGGQPVYIKLVEQSSGRCTPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0651 | - | - | 100% (342) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2102 | - | e-130 | 67.87% (333) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_0710 | - | 7e-78 | 44.31% (343) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 8e-79 | 46.36% (343) | MCE-family protein MCE2B |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-124 | 65.09% (338) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 4e-74 | 43.19% (345) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 3e-60 | 37.39% (329) | MCE-family protein |
| M. marinum M | MMAR_2883 | mce3B | 1e-127 | 65.98% (338) | MCE-family protein Mce3B |
| M. avium 104 | MAV_2533 | - | 1e-130 | 67.16% (338) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-115 | 59.36% (342) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-137 | 70.41% (338) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3919 | mce3B_1 | 1e-125 | 65.17% (333) | MCE-family protein Mce3B_1 |
| M. vanbaalenii PYR-1 | Mvan_0501 | - | 1e-150 | 99.28% (278) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 --MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTT-GYSAVFTHVS
MLBr_02590|M.leprae_Br4923 --MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTN-GYTAEFTNIS
Mflv_0651|M.gilvum_PYR-GCK MTNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQ-RYTAVFANVS
Mvan_0501|M.vanbaalenii_PYR-1 MTNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQ-RYTAVFANVS
TH_3222|M.thermoresistible__bu LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEED-TYHAIFTSVT
MAV_2533|M.avium_104 MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSEK-TYKAQFANVS
Rv1967|M.tuberculosis_H37Rv MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDGK-TYYAEFANVS
MMAR_2883|M.marinum_M MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDGN-TYYAEFSNVS
MUL_3919|M.ulcerans_Agy99 MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFSNVT
MSMEG_0347|M.smegmatis_MC2_155 MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGERK-QYTAQFSDIS
MAB_4152c|M.abscessus_ATCC_199 ---MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGK-RYHAMFSTAS
:: * : :. *.:.** * * *: :
Mb0605|M.bovis_AF2122/97 GLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASI
MLBr_02590|M.leprae_Br4923 GLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQI
Mflv_0651|M.gilvum_PYR-GCK GLTSGDFVRIAGVEVGKVRTLTVRD-DSTVAVEFGADDSVVLTDGSRAVI
Mvan_0501|M.vanbaalenii_PYR-1 GLTSGDFVRIAGVEVGKVRTLTVRD-DSTVAVEFGADDSVVLTDGSRAVI
TH_3222|M.thermoresistible__bu GLENGNFVRIAGVEVGKVKHVSVRD-DSTVLVKFSADRSVVLTEGSRAII
MAV_2533|M.avium_104 GLEGGNFVRIAGVEVGKVKNITVEP-DSTVLVEFTAAEKVVLTEGTRAAI
Rv1967|M.tuberculosis_H37Rv NLRTGKLVRIAGVEVGKVTRISINP-DATVRVQFTADNSVTLTRGTRAVI
MMAR_2883|M.marinum_M NLREGKLVRIAGVEVGKVEKISINP-DSTVKVGFTADNSVTLTQGTQAVI
MUL_3919|M.ulcerans_Agy99 GLEQNDFVRIAGVEVGQVKKVAIQP-DTTALVEFTADSSVVLTQGSRAVI
MSMEG_0347|M.smegmatis_MC2_155 GLKEGDFVRIAGVEVGQVQKVSMDE-NALVLVEFAMEDSVELTSTSTAVI
MAB_4152c|M.abscessus_ATCC_199 DLRSGQKVRIAGVPVGRVKNVSLNR-DNSVEVTFDVDSKYQLYSSSRAII
.* .. ** :** **:* ::: . . * * . * : * *
Mb0605|M.bovis_AF2122/97 RYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFR
MLBr_02590|M.leprae_Br4923 RYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFK
Mflv_0651|M.gilvum_PYR-GCK KYDNLIGDRYLAIEEGA--GGTTKLRPGDAIPLDRTAPALDLDAVIGGFR
Mvan_0501|M.vanbaalenii_PYR-1 KYDNLIGDRYLAIEEGA--GGTTKLRPGDAIPLDRTAPALDLDAVIGGFR
TH_3222|M.thermoresistible__bu RYDNLIGGRYLALEEGA--GGTTKLAPGETIPLDRTAPALDLDALIGGFR
MAV_2533|M.avium_104 RFADLTGGRYVALEEGA--GNIRRLSPGATIPLARTEPALDLDALIGGFR
Rv1967|M.tuberculosis_H37Rv RYDNLFGDRYLALEEGA--GGLAVLRPGHTIPLARTQPALDLDALIGGFK
MMAR_2883|M.marinum_M RYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDLDALIGGFR
MUL_3919|M.ulcerans_Agy99 RYDDLIGGRYLALEEGA--GSPKQLKPGDTIPMTHTSPALDLDALIGGFR
MSMEG_0347|M.smegmatis_MC2_155 RYDNLIGGRYLELKQGE--EPGAVLQAGATIPLARTRPALDLDELIGGFR
MAB_4152c|M.abscessus_ATCC_199 RYENLVGDRYLEITAGP--GELHKLPDGGTLDKEHTQPALDLDALLGGLR
:: :* *.**: : * : * : .* ****** ::**::
Mb0605|M.bovis_AF2122/97 PLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAI
MLBr_02590|M.leprae_Br4923 PLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAI
Mflv_0651|M.gilvum_PYR-GCK PLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELI
Mvan_0501|M.vanbaalenii_PYR-1 PLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELI
TH_3222|M.thermoresistible__bu PLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRDELI
MAV_2533|M.avium_104 PLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRDHLI
Rv1967|M.tuberculosis_H37Rv PLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLI
MMAR_2883|M.marinum_M PLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLI
MUL_3919|M.ulcerans_Agy99 PLLKALDPDQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRDQLI
MSMEG_0347|M.smegmatis_MC2_155 PLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQLI
MAB_4152c|M.abscessus_ATCC_199 PVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLI
*::. ::. ::* :: :: : *:* *:. :* ::: .* :.:**. *
Mb0605|M.bovis_AF2122/97 GEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHIS
MLBr_02590|M.leprae_Br4923 GEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHIS
Mflv_0651|M.gilvum_PYR-GCK GQTIVNLNVVLGSLAGHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYAN
Mvan_0501|M.vanbaalenii_PYR-1 GQTIVNLNVVLGSLAGHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYAN
TH_3222|M.thermoresistible__bu GQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLAKAG
MAV_2533|M.avium_104 GQVIVNLNTVLGSLGGQSGQFARAVDSLSELVAGLEARKQDISNGMAYAN
Rv1967|M.tuberculosis_H37Rv GQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTN
MMAR_2883|M.marinum_M GQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYTN
MUL_3919|M.ulcerans_Agy99 GDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGMAYTN
MSMEG_0347|M.smegmatis_MC2_155 GEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIANSD
MAB_4152c|M.abscessus_ATCC_199 GDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLA
*:.: :*: :* : : .: :: * *: * : :: . .
Mb0605|M.bovis_AF2122/97 SAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYR
MLBr_02590|M.leprae_Br4923 NAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLN
Mflv_0651|M.gilvum_PYR-GCK EAARSIADLLAQARPPLQKAVHETDRTATAVLADRDYFDNLLNTLPDTYR
Mvan_0501|M.vanbaalenii_PYR-1 EAARSIADLLAQARPPLQKAVHETDRTAIAYL------------------
TH_3222|M.thermoresistible__bu EGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPDAYR
MAV_2533|M.avium_104 AAAGSITDLLAQARPPVKKVVHEADRTAGTMLADREWLEKYLDHWPDAFK
Rv1967|M.tuberculosis_H37Rv AAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQ
MMAR_2883|M.marinum_M AAAGSVADLLSQARAPLSKALHETDRVATIALADHDYLDNLLNTLPDRYQ
MUL_3919|M.ulcerans_Agy99 AAASSIADLLSQARPPLAKTVQETDRASAIVLADHEYFDNLINTLPDAYQ
MSMEG_0347|M.smegmatis_MC2_155 NAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPDKYR
MAB_4152c|M.abscessus_ATCC_199 STASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYL
* : .:* : : .
Mb0605|M.bovis_AF2122/97 IIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQP---TGRCT
MLBr_02590|M.leprae_Br4923 QIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TGRCT
Mflv_0651|M.gilvum_PYR-GCK VMLRQ-GLYGNYFTFYLCDLLLKVNGK--GGQPVYIKLVEQS---SGRCT
Mvan_0501|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3222|M.thermoresistible__bu VLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TGRCA
MAV_2533|M.avium_104 ILNRQ-GLYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQA---SGRCT
Rv1967|M.tuberculosis_H37Rv ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SGRCA
MMAR_2883|M.marinum_M ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRCT
MUL_3919|M.ulcerans_Agy99 ALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TGRCA
MSMEG_0347|M.smegmatis_MC2_155 VLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TGRCA
MAB_4152c|M.abscessus_ATCC_199 RLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRCA
Mb0605|M.bovis_AF2122/97 PQ--
MLBr_02590|M.leprae_Br4923 PQ--
Mflv_0651|M.gilvum_PYR-GCK PQ--
Mvan_0501|M.vanbaalenii_PYR-1 ----
TH_3222|M.thermoresistible__bu PR--
MAV_2533|M.avium_104 PR--
Rv1967|M.tuberculosis_H37Rv PK--
MMAR_2883|M.marinum_M PK--
MUL_3919|M.ulcerans_Agy99 PR--
MSMEG_0347|M.smegmatis_MC2_155 PK--
MAB_4152c|M.abscessus_ATCC_199 FKNE