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M. leprae Br4923 MLBr_02590 (mce1B)

annotation: putative secreted protein
coordinates: 3093636 - 3094676
length: 346

MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISGLRTGQFVRASGVEVGKVNSVAL
INGGTRVRVKFNVDRSVPLYQSTTAQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLD
ALIGGFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGEVVKNLNVVLDT
TVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNAAGTVANLLAEDHALLHKSINYLDGIQQPLID
QRLQLEDYLHKLPTVLNQIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQPTGRCTPQ

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. leprae Br4923 MLBr_02590 mce1B - 100% (346) putative secreted protein
M. leprae Br4923 MLBr_02591 mce1C 5e-14 23.99% (296) putative secreted protein
M. leprae Br4923 MLBr_02592 mce1D 6e-13 22.26% (301) putative secreted protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0176 mce1B 1e-154 74.86% (346) MCE-family protein MCE1B
M. gilvum PYR-GCK Mflv_0710 - 1e-129 64.74% (346) virulence factor Mce family protein
M. tuberculosis H37Rv Rv0170 mce1B 1e-154 75.14% (346) MCE-family protein MCE1B
M. abscessus ATCC 19977 MAB_4152c - 6e-57 36.16% (318) MCE-family protein
M. marinum M MMAR_0413 mce1B 1e-163 80.06% (346) MCE-family protein Mce1B
M. avium 104 MAV_5014 - 1e-169 82.95% (346) virulence factor Mce family protein
M. smegmatis MC2 155 MSMEG_0135 - 1e-128 64.16% (346) virulence factor Mce family protein
M. thermoresistible (build 8) TH_3551 - 1e-133 65.90% (346) PUTATIVE virulence factor Mce family protein
M. ulcerans Agy99 MUL_1063 mce1B 1e-163 79.77% (346) MCE-family protein Mce1B
M. vanbaalenii PYR-1 Mvan_0135 - 1e-129 65.61% (346) virulence factor Mce family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0710|M.gilvum_PYR-GCK          MKITGTAIKLGAFALVLLMFTAIIIVVFGQMRFDRTTGYSAIFSNASGLR
Mvan_0135|M.vanbaalenii_PYR-1       MKITGTAIKLGAFSLVLLMFTAIIIVVFGQMRFDRTTGYSAIFSSASGLR
TH_3551|M.thermoresistible__bu      MKITGTAIKLGAFSVVLLVFTALIVVVFGQVRFDRTTGYTAVFSSASGLR
MSMEG_0135|M.smegmatis_MC2_155      MSIKGTLFKLGIFSLVLLTFTALIFVVFGQIRFNRTTEYSAIFKNVSGLR
Mb0176|M.bovis_AF2122/97            MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGLR
Rv0170|M.tuberculosis_H37Rv         MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGLR
MLBr_02590|M.leprae_Br4923          MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISGLR
MAV_5014|M.avium_104                MKITGTLVRLSIFSVVLLIFTVMIIVVFGQMRFDRTNGYSAEFSNISGLR
MMAR_0413|M.marinum_M               MKITGTAIRLGIFSLVLMLFSVMIIIVFGQIRFDRTYAYSAEFSNASGLR
MUL_1063|M.ulcerans_Agy99           MKITGTAIRLGIFSLVLMLFSVMIIIVFGQIRFDRTYAYSAEFSNASGLR
MAB_4152c|M.abscessus_ATCC_199      MKR-ATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGKRYHAMFSTASDLR
                                    *.  .* .::  .::*:: .:. :.: **:.**.    * * *.. *.**

Mflv_0710|M.gilvum_PYR-GCK          SGQFVRASGVEVGKVKGVELIDNGSKVRVDFDVDRSLELFDETTASVRYL
Mvan_0135|M.vanbaalenii_PYR-1       PGQFVRASGVEVGKVKGVELIEGGSKVRVDFNVDRSLELFDESTASIRYL
TH_3551|M.thermoresistible__bu      AGQFVRAAGVEVGKVSKVELIDGGQRVRVDFNVDRSLPLFQDTTATIRYL
MSMEG_0135|M.smegmatis_MC2_155      DGQFVRAAGVEVGKVKSVDLINGGEQAEVKFTVERSLPLFQETTAAIRYQ
Mb0176|M.bovis_AF2122/97            QGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYS
Rv0170|M.tuberculosis_H37Rv         QGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYS
MLBr_02590|M.leprae_Br4923          TGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIRYL
MAV_5014|M.avium_104                AGQFVRASGVEVGKVSSVQLVDGGKRARVEFNVDRSVPLYQSTTAQIRYL
MMAR_0413|M.marinum_M               PGQFVRASGVEIGKVKSVSLIDGGKRVRVNFDVDRSVPLYQSTSAQIRYL
MUL_1063|M.ulcerans_Agy99           PGQFVRASGVEIGKVKSVSLIDGGKRVRVNFDVDRSVPLYQSTSAQIRYL
MAB_4152c|M.abscessus_ATCC_199      SGQKVRIAGVPVGRVKNVSLNRDNS-VEVTFDVDSKYQLYSSSRAIIRYE
                                     ** ** :** :*:*. : *  ..  ..* * :: .  *:..: * :** 

Mflv_0710|M.gilvum_PYR-GCK          NLIGDRYLELARGD---SNTRLAAGGTIPVERTQPALDLDALIGGFRPVF
Mvan_0135|M.vanbaalenii_PYR-1       NLIGDRYLELARGE---SNTRMAAGGTIPIERTQPALDLDALIGGFRPVF
TH_3551|M.thermoresistible__bu      NLIGDRYLELKRGN---SNERLPAGGEIPLERTQPALDLDALVGGFRPLF
MSMEG_0135|M.smegmatis_MC2_155      DLIGNRYLELKRGD---SDQILPPGSTIPVERTEPALDLDALVGGFRPLF
Mb0176|M.bovis_AF2122/97            DLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVF
Rv0170|M.tuberculosis_H37Rv         DLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVF
MLBr_02590|M.leprae_Br4923          DLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKPLF
MAV_5014|M.avium_104                DLIGNRYLELKRGQGEGADKVLPPGGFIPLSRTQPALDLDALIGGFKPLF
MMAR_0413|M.marinum_M               DLIGNRYLELKRGEGDGSDRIMPPGGFIPLSRTSPALDLDALIGGFKPVF
MUL_1063|M.ulcerans_Agy99           DLIGNRYLELKRGEGDGSDRIMPPGGFIPLSRTSPALDLDALIGGFKPVF
MAB_4152c|M.abscessus_ATCC_199      NLVGDRYLEITAGPG--ELHKLPDGGTLDKEHTQPALDLDALLGGLRPVL
                                    :*:*:**:*:  *        :. *. :  .:*.********:**::*::

Mflv_0710|M.gilvum_PYR-GCK          QSLDPEKVNTIAQSLITVFQGQGGTINDILDQTASLTSALADRDQAIGEV
Mvan_0135|M.vanbaalenii_PYR-1       QSLEPEKVNTIAQSIITVFQGQGGTINDILDQTASLTSALADRDQAIGEV
TH_3551|M.thermoresistible__bu      RALDAEKVNTIAQSIITVFQGQGGTINDILDQTAQLTATLADRDQAIGEV
MSMEG_0135|M.smegmatis_MC2_155      RSLEPEKVNTIATSLITIFQGQGGTINDILDQTAQLTASLADRDQAIGEV
Mb0176|M.bovis_AF2122/97            RALDPAKVNNIANALITVFQGQGGTINDTLDQTAQLTSQIAERDQAIGEV
Rv0170|M.tuberculosis_H37Rv         RALDPAKVNNIANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEV
MLBr_02590|M.leprae_Br4923          RALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGEV
MAV_5014|M.avium_104                RALDPQKVNTIATALVTVFQGQGGTINDILDQTAQLTSQLGERDQAIGEV
MMAR_0413|M.marinum_M               RALDPDKVNTIASALVTVFQGQGGTINDILDQTAQLTSQLAERDQAIGEV
MUL_1063|M.ulcerans_Agy99           RALDPDKVNTIASALVTVFQGQGGTINDILDQTAWLTSQLAERDQAIGEV
MAB_4152c|M.abscessus_ATCC_199      KGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLIGDV
                                    :.::. *:* *: :::  :******:.: *.:*: :*: :.:*** **:*

Mflv_0710|M.gilvum_PYR-GCK          VTNLNTVLDTTVRHQQEFDDTVKNFEVLITGLKNRADPLAESVADISDAA
Mvan_0135|M.vanbaalenii_PYR-1       ITNLNTVLDTTVRHQQEFDDTVKNFEVLITGLKNRADPIATSVADISDAA
TH_3551|M.thermoresistible__bu      IRNLNTVLETTVRHQKEFDETIHNFEVLITGLRNRADPIAESTANISNAA
MSMEG_0135|M.smegmatis_MC2_155      IKNLNTVLDTTVRHQKQFDETLVNFETLITGLKNRADPIATSVADISDAA
Mb0176|M.bovis_AF2122/97            VKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNGA
Rv0170|M.tuberculosis_H37Rv         VKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNGA
MLBr_02590|M.leprae_Br4923          VKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNAA
MAV_5014|M.avium_104                IKNLNTVLDTTVRHRQQFDQTINNLEVLITGLKDHGDQLAGGTAHISNAA
MMAR_0413|M.marinum_M               IKNLNTVLDATVRHRKDFDQTVNNLEVLITGLNEHRDDLSGGIAHVSNAA
MUL_1063|M.ulcerans_Agy99           IKNLNTVLDATVRHRKDFDQTVNNLEVLITGLNEHRDDLSGGIAHVSNAA
MAB_4152c|M.abscessus_ATCC_199      INHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLASTA
                                    : :** ** :.  :  :*..:: ::: **:** :: * :: . . ::. *

Mflv_0710|M.gilvum_PYR-GCK          GTIGDLLADNRPLLQSTISKLEILNQPLVDQKDQLNQLLEQIPDALAIIG
Mvan_0135|M.vanbaalenii_PYR-1       GTIGDLLADNRPLLKDTVSKLEILNQPLVDQRDQLNDLLVKLPDALAIIG
TH_3551|M.thermoresistible__bu      GTLADVLAQNRPLLDNSIDHLEAVQGPLVEQSAELNNILVQLPTALKTIG
MSMEG_0135|M.smegmatis_MC2_155      GSLADLLSDNRPLLKDTIGYLDVIQAPLVEQKQEVSDILVQMPQALKIIG
Mb0176|M.bovis_AF2122/97            GTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTALG
Rv0170|M.tuberculosis_H37Rv         GTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTALG
MLBr_02590|M.leprae_Br4923          GTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQIG
MAV_5014|M.avium_104                GTVADLLAEDRSLLHKTLNYLDAVQQPLIDQQDQLQDYLKKVPTALNMIG
MMAR_0413|M.marinum_M               GTVADLLGEDRALLHKTVNYLDAVQQPLIDQRQELADFLHKVPTALNMIG
MUL_1063|M.ulcerans_Agy99           GTVADLLGEDRALLHKTVNYLDAVQQPLIDQRQELADFLHKVPTALNMIG
MAB_4152c|M.abscessus_ATCC_199      SSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYLRLN
                                    .:: .:* : :. :  ::     :   : ::  ::   : : .     :.

Mflv_0710|M.gilvum_PYR-GCK          RSGGIYGDFFNFYACDVTLKLNGLQPGGPVRTVRVWSQPT-GRCTPQ--
Mvan_0135|M.vanbaalenii_PYR-1       RSGGVYGDFFNFYACDVTLKLNGLQPGGPVRTVKVWSQPS-GRCTPQ--
TH_3551|M.thermoresistible__bu      RAGGVYGDFFNFYACDISLKLNGLQPGGPVRTVKITTQPS-GRCTPQ--
MSMEG_0135|M.smegmatis_MC2_155      RAGGIYGDFFNFYACDLTLKLNGLQPGGPVRTVRITTQPS-GRCTPK--
Mb0176|M.bovis_AF2122/97            RANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQPT-GRCTPQ--
Rv0170|M.tuberculosis_H37Rv         RANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQPT-GRCTPQ--
MLBr_02590|M.leprae_Br4923          RTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQPT-GRCTPQ--
MAV_5014|M.avium_104                RAIGSYGDFVNFYACDITLKINGLQAGGPVRTVRLFQQPT-GRCTPQ--
MMAR_0413|M.marinum_M               RAIGSYGDFVNFYSCDISLKINGLQPGGPVRTVRLFSQPT-GRCAPQ--
MUL_1063|M.ulcerans_Agy99           RAIGSYGDFVNFYSCDISLKINGLQPGGPVRTVRLFSQPT-GRCAPQ--
MAB_4152c|M.abscessus_ATCC_199      -ALGAYGSFFNIYYCSIRIKVNGPVGTDWLIPFGGPPDPSKGRCAFKNE
                                     : * **.* *:* *.: :* **    . : ..    :*: ***: :

species	id	gene	e-value	identity (len)	annotation
M. leprae Br4923	MLBr_02590	mce1B	-	100% (346)	putative secreted protein
M. leprae Br4923	MLBr_02591	mce1C	5e-14	23.99% (296)	putative secreted protein
M. leprae Br4923	MLBr_02592	mce1D	6e-13	22.26% (301)	putative secreted protein