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TATVERPESAIRAAQLPPVLPLPKTVQGLAFSVARRWVVKQAARRYGDVVTLDIPVFGRTVLVTEPQLAK QVYAAHPDDVGNVQPNLSRMLGPGSVFALDGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAASWPD GQEFRTLEPMMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRNYGRLTPWGRLAAYR AEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGSSMSRKDIGDELLTLLAAGHETTASTLGWAFE RISRHPGVLEKLVAEAATDDNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAHI QEREEEFSDPHRFDPQRFVGNRPGLGWLPYGGGTRRCVGAVFANIEMDVVLRTILRHFVIETTTAPDEKV HPRGVAYTPASGGRVVMRRRREPLGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6478 | - | - | 100% (447) | putative cytochrome P450 135B1 |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 9e-67 | 37.65% (417) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 1e-22 | 27.51% (378) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0141 | cyp138 | 1e-168 | 66.28% (427) | cytochrome P450 138 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 0.0 | 75.88% (427) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | 1e-168 | 66.28% (427) | cytochrome P450 138 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-11 | 24.07% (324) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1427c | - | 1e-161 | 62.50% (424) | putative cytochrome P450 |
| M. marinum M | MMAR_0346 | cyp138A3 | 1e-170 | 65.97% (432) | cytochrome P450 138A3 Cyp138A3 |
| M. avium 104 | MAV_5160 | - | 1e-170 | 65.43% (431) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_0082 | - | 0.0 | 74.42% (434) | putative cytochrome P450 135B1 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 3e-22 | 27.23% (437) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 0.0 | 73.86% (440) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0141|M.bovis_AF2122/97 ----------MSEVVTAAPAPPVVR--LPPAVRGPKLFQGLAFVVSRRR-
Rv0136|M.tuberculosis_H37Rv ----------MSEVVTAAPAPPVVR--LPPAVRGPKLFQGLAFVVSRRR-
MMAR_0346|M.marinum_M ----------MNQAISDAPAVPAVK--MAQATRIPKLLQGLAFATSRRR-
MAV_5160|M.avium_104 ----------MSEVATAP--LAAVH--LPPAVRGPKLLQGIGFAVSRRT-
Mflv_1104|M.gilvum_PYR-GCK -----------------------MR--LPPTPRIPRFLQGLGFSLSRQW-
Mvan_5712|M.vanbaalenii_PYR-1 -MSEATIAAHRSTADAESAPPRPVR--LPPTPRIPKLLQGLGFSFSRQW-
MSMEG_6478|M.smegmatis_MC2_155 ---------MTATVERPESAIRAAQ--LPPVLPLPKTVQGLAFSVARRW-
TH_0082|M.thermoresistible__bu -------MTEATIAPDVDHAVRSQK--LPPAVPLPKSLQGIAFIASRRW-
MAB_1427c|M.abscessus_ATCC_199 ------MEGDVTEISTIDRAADVPKPIAPPLVTLPKLAQGIAFVASRRW-
MUL_0604|M.ulcerans_Agy99 ----------MVDPPDIRSLPLAPR----NPLPYWQQLKALKTLHVGSE-
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
Mb0141|M.bovis_AF2122/97 -LLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGN----
Rv0136|M.tuberculosis_H37Rv -LLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGN----
MMAR_0346|M.marinum_M -MMDWLSRRNGDVFALNVPIYGHMVVVNDPQLAKQVFTASPEDLGN----
MAV_5160|M.avium_104 -MMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPDELGN----
Mflv_1104|M.gilvum_PYR-GCK -TVAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTDDVGN----
Mvan_5712|M.vanbaalenii_PYR-1 -TVAQIVRRYGDVFSMTLPVFGPTVMVADPALAKQLFMANTDDVGN----
MSMEG_6478|M.smegmatis_MC2_155 -VVKQAARRYGDVVTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGN----
TH_0082|M.thermoresistible__bu -TLTTATRRYGDVFRLNIPVFGRTVVVSDPVLAKQVFSANPDDVGN----
MAB_1427c|M.abscessus_ATCC_199 -TTSRLAKKYGKVYTINIPKFGYTVVVADPDLTREVFTTSTEILGN----
MUL_0604|M.ulcerans_Agy99 -ALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGTL-
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
. :.
Mb0141|M.bovis_AF2122/97 --IQPNLSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEE
Rv0136|M.tuberculosis_H37Rv --IQPNLSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEE
MMAR_0346|M.marinum_M --IQPNLSRMFGSGSVFGLDGDDHRRRRRLLAPPFHGKSMKNYEIIIEQE
MAV_5160|M.avium_104 --IQPNLSRLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
Mflv_1104|M.gilvum_PYR-GCK --IQPNLSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEE
Mvan_5712|M.vanbaalenii_PYR-1 --IQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEE
MSMEG_6478|M.smegmatis_MC2_155 --VQPNLSRMLGPGSVFALDGTDHRRRRKLLTPPFHGRSIKNYERIFEEE
TH_0082|M.thermoresistible__bu --IQPNLSRVLGPGSVFALDGAEHRRRRKLLTPPFHGKSIKNYEKIFEEE
MAB_1427c|M.abscessus_ATCC_199 --IQPNLSQQLGPGSVFALERNEHRHRRKLLAPKFHGKAMVQYEQIIEEE
MUL_0604|M.ulcerans_Agy99 -PLLKDLRRAIG-ESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMSEA
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: : *.: * *: : * : : :
Mb0141|M.bovis_AF2122/97 TLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSE-LDELRRLIPP
Rv0136|M.tuberculosis_H37Rv TLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSE-LDELRRLIPP
MMAR_0346|M.marinum_M TLRETANWPEGQLFPTLPSMMRITLNAILRAVFGADGAE-LDELRRIIPP
MAV_5160|M.avium_104 TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEGAE-LDELRRLIPP
Mflv_1104|M.gilvum_PYR-GCK TLREAASWPEGQPFETLEPMMRITLNAILRAVFGADGAH-LDELRRIIPP
Mvan_5712|M.vanbaalenii_PYR-1 TLREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAH-LDELRRIIPP
MSMEG_6478|M.smegmatis_MC2_155 TLREAASWPDGQEFRTLEPMMRITLNVILRAVFGADGEQ-LDELRRIIPP
TH_0082|M.thermoresistible__bu TLAEAANWPEGREFPTLEPMMRITLNAILRAVFGAEGEH-LDELRRIIPP
MAB_1427c|M.abscessus_ATCC_199 TLRECATWPEGQQFETMEPMMRITLNAILRAVFGADGAE-LDVLRRLIPP
MUL_0604|M.ulcerans_Agy99 ANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVTL
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYED--------APE
. . . . .: ::* . .
Mb0141|M.bovis_AF2122/97 WVTLGSRLAALPKPKRDYGRLSPWGRLAEWRR--QYDTVIDKLIEAERAD
Rv0136|M.tuberculosis_H37Rv WVTLGSRLAALPKPKRDYGRLSPWGRLAEWRR--QYDTVIDKLIEAERAD
MMAR_0346|M.marinum_M WTTLGSRLASMPKPKRRYGRFSPWGRLAEYRR--QYDVIIDRLIDQERSD
MAV_5160|M.avium_104 WVTLGSRLAALPKPQR-YPRFGPWGQLDRWRR--QYDGVIERLIAAEQAD
Mflv_1104|M.gilvum_PYR-GCK WVTLGSRLAVLPTPHRTYGRFSPWGRLARYRR--RYDEVIGRLIDAVQAD
Mvan_5712|M.vanbaalenii_PYR-1 WVTLGSRLAVLPTPHRTYGRFSPWGRLAAYRR--QYDDVIGRLIDAVQAD
MSMEG_6478|M.smegmatis_MC2_155 WVTLGSRLAVLPTPKRNYGRLTPWGRLAAYRA--EYDDVVDRLIDRVEAD
TH_0082|M.thermoresistible__bu WVTLGSRVATLPTPSRNYGRFSPWGRLAAYRR--CYDEVIGRLIDKVQAD
MAB_1427c|M.abscessus_ATCC_199 WVVLASLTTRIPQPKRNYGRFSPWGRLKTYRA--HYDAVIGSLIEKALAA
MUL_0604|M.ulcerans_Agy99 AAKWAADRSARPVRAPHWLPTPARPRARGAYD--AMYKIAADMLAACRAD
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
.: . :: .
Mb0141|M.bovis_AF2122/97 PNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGW
Rv0136|M.tuberculosis_H37Rv PNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGW
MMAR_0346|M.marinum_M PNFSDRTDVLALMLRSTYDDGSRMSRKDIGDELLALLAAGHETTASTLSW
MAV_5160|M.avium_104 PNFAERTDVLALLLRSTYDDGAAMSHKEIGDELLTLLAAGHETTASTLAW
Mflv_1104|M.gilvum_PYR-GCK PNFESRDDVLALLLRSTYEDGSSMSRQDIGDELLTLLAAGHETTAATLGW
Mvan_5712|M.vanbaalenii_PYR-1 PDFDTRDDILALLLRSTYEDGSTMSRQDIGDELLTLLAAGHETTAATLGW
MSMEG_6478|M.smegmatis_MC2_155 PDFDQRDDILALLLRSAYEDGSSMSRKDIGDELLTLLAAGHETTASTLGW
TH_0082|M.thermoresistible__bu PHFEERDDVLALLLRSTYEDGTAMTRQDIADELLTLLAAGHETTASTMGW
MAB_1427c|M.abscessus_ATCC_199 PDFEDRTDILALLLRSTYDDGTTMSRSDVSDELLTLLAAGHETTATTLAW
MUL_0604|M.ulcerans_Agy99 PSR-EAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTY
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDE-----SGDQLTEEEIIATCGLLLVAGHETTVNLIAN
* : * * :: .:: :: *.:** :
Mb0141|M.bovis_AF2122/97 AFERLSRHPDVLAALVEEVDNGGHE-----------LRQAAILEVQRART
Rv0136|M.tuberculosis_H37Rv AFERLSRHPDVLAALVEEVDNGGHE-----------LRQAAILEVQRART
MMAR_0346|M.marinum_M AFERVTRHPELLAALVAEAEDAGGE-----------LRQATILEVQRART
MAV_5160|M.avium_104 AFERISRHPELLARLVEEADNGGNE-----------LRQAAILEVQRART
Mflv_1104|M.gilvum_PYR-GCK VFERISRHPDVLARLQAEADTDGNE-----------YRQAVILETQRVRT
Mvan_5712|M.vanbaalenii_PYR-1 AFERISRHPEVLAKLVAEAETDGNE-----------YRQATILEIQRSRT
MSMEG_6478|M.smegmatis_MC2_155 AFERISRHPGVLEKLVAEAATDDNE-----------YRQAAIAEVQRVRT
TH_0082|M.thermoresistible__bu VFERITRHPEVLARLAAEADTDENT-----------YRQATILEVQRART
MAB_1427c|M.abscessus_ATCC_199 AFERITRHPEVLSRLAEEAQGDSNE-----------YRQATILEVQRSRP
MUL_0604|M.ulcerans_Agy99 ALWALGQHCQLQDRLAAEAAELGDRPLTPADVPRLGYTIQVLQEAMRLRP
MLBr_02088|M.leprae_Br4923 AVLAMLRNPSQWKALSSNPQR----------------APLVVEETLRYDP
.. : :: * : .: * * .
Mb0141|M.bovis_AF2122/97 VIDFAARRVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQ
Rv0136|M.tuberculosis_H37Rv VIDFAARRVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQ
MMAR_0346|M.marinum_M VIDFAARHVYAPQYQLGQWMIPRGQSILVNIAQMHANPDIFPDPQRFDPQ
MAV_5160|M.avium_104 VIDFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQ
Mflv_1104|M.gilvum_PYR-GCK VIDFAGRHVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFDPQ
Mvan_5712|M.vanbaalenii_PYR-1 VIDFAGRHVYAPTFELGEWVIPQGYSIVVAIGQVHKRAQDFDDPDRFDPQ
MSMEG_6478|M.smegmatis_MC2_155 VIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAHIQEREEEFSDPHRFDPQ
TH_0082|M.thermoresistible__bu VIDFSGRHVYAPTLELGDWVIPRGYSIVVSISQLHERSAEFPRPDEFDPD
MAB_1427c|M.abscessus_ATCC_199 VIDFAGRHVLAPHVDIGPYRIPQGHSVVVSINLMHDDPVAFPCPERFDPE
MUL_0604|M.ulcerans_Agy99 PGPTVARRAMQ-DIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPD
MLBr_02088|M.leprae_Br4923 AIHLIG-RVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPD
. :. :. : * :: : : : * ***:
Mb0141|M.bovis_AF2122/97 RYIGSKPS---PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLET
Rv0136|M.tuberculosis_H37Rv RYIGSKPS---PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLET
MMAR_0346|M.marinum_M RFIGGRPS---TFGWIPFGGGTRRCVGAAFANMEMDVVLRTVLRNFTIEP
MAV_5160|M.avium_104 RFIDNKPS---ALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIET
Mflv_1104|M.gilvum_PYR-GCK RFVGQRPS---TLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIET
Mvan_5712|M.vanbaalenii_PYR-1 RYIGQRPP---TFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVIET
MSMEG_6478|M.smegmatis_MC2_155 RFVGNRP----GLGWLPYGGGTRRCVGAVFANIEMDVVLRTILRHFVIET
TH_0082|M.thermoresistible__bu RFVGSRPP---MFAWLPYGGGTRRCVGAVFANVEMDVVLRTVLRHFTLET
MAB_1427c|M.abscessus_ATCC_199 RFMGAKP----GNSWVPYGGGTRRCVGAAFANMEMDIVLRTVLRHFTIET
MUL_0604|M.ulcerans_Agy99 RFAPKKSKGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHS
MLBr_02088|M.leprae_Br4923 -----RPS----SRHLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQ
:. :.:. * : *:* :* :* :.* :: .
Mb0141|M.bovis_AF2122/97 TTAAGERSHGRGVAFTPKDGGRVVMRRR----------------
Rv0136|M.tuberculosis_H37Rv TTAAGERSHGRGVAFTPKDGGRVVMRRR----------------
MMAR_0346|M.marinum_M TTAAGERLFCRGVAYTPKNGGRIVVHRR----------------
MAV_5160|M.avium_104 TDAPDEPWHCRGVAFTPKHGGRIVVHRR----------------
Mflv_1104|M.gilvum_PYR-GCK TTAPGEKMHSRGVAYTPDDGGRVVMRRR----------------
Mvan_5712|M.vanbaalenii_PYR-1 TAAPGEKMHSRGVAYTPKDGGRVVMRRR----------------
MSMEG_6478|M.smegmatis_MC2_155 TTAPDEKVHPRGVAYTPASGGRVVMRRRREPLGA----------
TH_0082|M.thermoresistible__bu TTAPDEKVHSRGVAYTPKDGGRVTLHRR----------------
MAB_1427c|M.abscessus_ATCC_199 TTAPDEKWHSRGVASCPKNNGRVTVRRR----------------
MUL_0604|M.ulcerans_Agy99 LDGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS
MLBr_02088|M.leprae_Br4923 LAG--ELVYKPNVAMRGMSALPVQV-------------------
. :. :