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LTTPTGHAQRVAIIGAGFSGLAAAIALRQRGIEDFVIFEQSEGIGGTWWFNRYPGAEVDLESHVYSFSYA RSDWTRTHVGWQELQEYLERVAYDWDLPRRIRFNEKVVDVRWSDEKQTHTVTTSSGADHGEFTAVISAVG FLNIPLVPPFAREDNDFQGAMCHTSAWIDGLDLTGKSVGVVGTGSSAVQVVTEAEKVAGDVTIFQLEPNW IVPKHSRAFTPLERRLNKLRPVYAWRRWALYFDYDRRQLRSSHARSTGRFNRRRHQASLEFMRRELAGRP DLLEKVTPTFAFEGKRTVCSDTYYASLRSPKVTLVPHALKGLTRTGAVDANGDEHDLDVIVLATGFDAAN YLGNYQVYGQGGRELHSAWQGEPEAFLGMMVPGFPNFFIMYGPNTNSVPLVHFYEAQADFAASLIKRAAK TGHRVIDVRRSAFVIYNDWLQAQLAKTVWARTSNYFRAGTGKVVSQWPFGATPYILATKLLRRIAVRLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0615 | - | - | 100% (489) | cyclohexanone monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2243 | - | 5e-82 | 36.10% (482) | cyclohexanone monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1842 | - | 6e-61 | 32.64% (481) | hypothetical protein Mvan_1842 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 5e-67 | 33.62% (473) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4103 | - | 3e-81 | 36.85% (483) | cyclohexanone monooxygenase |
| M. tuberculosis H37Rv | Rv0892 | - | 5e-67 | 33.62% (473) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 3e-27 | 26.26% (476) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2077 | - | 4e-71 | 34.24% (476) | monooxygenase |
| M. marinum M | MMAR_0240 | - | 9e-94 | 39.75% (483) | monoooxygenase |
| M. avium 104 | MAV_5241 | - | 1e-92 | 40.16% (488) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_3832 | - | 0.0 | 77.50% (480) | 4-hydroxyacetophenone monooxygenase |
| M. thermoresistible (build 8) | TH_3452 | - | 2e-79 | 36.02% (483) | PUTATIVE lipolytic enzyme |
| M. ulcerans Agy99 | MUL_4873 | - | 5e-93 | 39.63% (487) | monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0615|M.vanbaalenii_PYR-1 -----------------------------MTTPTGHAQRVAIIGAGFSGL
MSMEG_3832|M.smegmatis_MC2_155 ---------------------------------MSGSPRVAIIGSGFSGI
Mb0916|M.bovis_AF2122/97 ------------------------MTG----RC----PTVAVVGAGMSGM
Rv0892|M.tuberculosis_H37Rv ------------------------MTG----RC----PTVAVVGAGMSGM
MAB_2077|M.abscessus_ATCC_1997 ------------------------MSSNFATACRAYDPSIVIIGAGFAGV
Mflv_4103|M.gilvum_PYR-GCK ---------------------------------MAKSLSVGIIGAGPGGL
TH_3452|M.thermoresistible__bu ---------------------------------MARNLSVGIIGAGPGGI
MMAR_0240|M.marinum_M -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
MUL_4873|M.ulcerans_Agy99 -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
MAV_5241|M.avium_104 MTETVGPARAKPVMSR-KAKWLYAIGRVRAATRRRRGPKVAIIGAGFGGL
MLBr_00065|M.leprae_Br4923 ----------------------------MVVMAETEYLDVVIVGAGISGV
: ::*:* .*:
Mvan_0615|M.vanbaalenii_PYR-1 AAAIALRQRG-IEDFVIFEQSEGIGGTWWFNRYPGAEVDLESHVYSFSYA
MSMEG_3832|M.smegmatis_MC2_155 AAAIALRNKG-IEDFVIFEKAPALGGTWWYNRYPGAEVDLESHIYSFSFE
Mb0916|M.bovis_AF2122/97 CVAITLLSAG-ITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFA
Rv0892|M.tuberculosis_H37Rv CVAITLLSAG-ITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFA
MAB_2077|M.abscessus_ATCC_1997 AMAHRLKKDG-FTNFTILEKAADIGGVWRDNTYPGAACDVPSALYSLSYK
Mflv_4103|M.gilvum_PYR-GCK ALGIFLRRAG-FDDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
TH_3452|M.thermoresistible__bu ALGIFLRRAG-FTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFE
MMAR_0240|M.marinum_M AAAVALRGAG-IDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MUL_4873|M.ulcerans_Agy99 AAAVALRGAG-IDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MAV_5241|M.avium_104 GAAVALRRAG-IDDLVIIEAADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MLBr_00065|M.leprae_Br4923 SAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFR
. * . * : :**.* *** * :
Mvan_0615|M.vanbaalenii_PYR-1 R-SDWTRTHVGWQELQEYLERVAYDWDLPRRIRFNEKVVDVRWSDEKQTH
MSMEG_3832|M.smegmatis_MC2_155 R-YDWTRTHAGWAELQEYLNHVADKWDLPRRIRFNEKVVDVRWSDADQTY
Mb0916|M.bovis_AF2122/97 KNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDD--GRW
Rv0892|M.tuberculosis_H37Rv KNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDD--GRW
MAB_2077|M.abscessus_ATCC_1997 PNPRWSRRYAEQPEILKYLQQLVESGGLAAHLRTQTEVVAMTFDDQLGRW
Mflv_4103|M.gilvum_PYR-GCK LNAHWSRLWSGQKEILEYFERCAQRYRLQEKLRCNTEIVSARWVPSERRW
TH_3452|M.thermoresistible__bu LNSEWTRLWPAQPEILRYFERCAQRHRLGPHLRLNTEITSARWNPTSRQW
MMAR_0240|M.marinum_M PNKFWTRTYARQPEILAYLESVVDDFDLRRHLMLSARVRSIRWDEDTWRW
MUL_4873|M.ulcerans_Agy99 ANKFWSRTYARQPEILAYLESVVDDFDLRRHLMLSAMVRSIRWDEDTWGW
MAV_5241|M.avium_104 PNASWSRTYARQPEILAYLESVADAFDLRRHLMLDTTVRSLRWNPHTAAW
MLBr_00065|M.leprae_Br4923 PWTKCQAIADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRW
: *:. . : : : :
Mvan_0615|M.vanbaalenii_PYR-1 TVTTSSGA--DHGEFTAVISAVGFLNIPL--VPPFAREDNDFQGAMCHTS
MSMEG_3832|M.smegmatis_MC2_155 TIRTESGD--DHGQFTAVISAVGFLNIPL--IPPFAREQNDFEGAICHTS
Mb0916|M.bovis_AF2122/97 VLRTDSG---TESTVDFLISATGVLHHPR--IPPIAGLD-DFRGTVFHSA
Rv0892|M.tuberculosis_H37Rv VLRTDSG---TESTVDFLISATGVLHHPR--IPPIAGLD-DFRGTVFHSA
MAB_2077|M.abscessus_ATCC_1997 TLVTNSN---ETITCDVVVSAVGQLSLPH--VPVIADAD-TFQGPRFHSA
Mflv_4103|M.gilvum_PYR-GCK RLRTSTG---AEHSFDVVVSAVGMFTQPV--MPDLVEEE-PFTGTVMHTA
TH_3452|M.thermoresistible__bu MLTTGAG---EQHNFDVVVSAVGMFTRPV--MPDLVEEE-PFTGTLMHSA
MMAR_0240|M.marinum_M VCQVDRAGGTATLTADVVVCATGLFGPRK--LPDIAGLT-DFGGTLMHTA
MUL_4873|M.ulcerans_Agy99 VCQVDRAGGTAILTADVVVCATGLFGPRK--LPDIAGLT-DFGGTLMHTA
MAV_5241|M.avium_104 DCRIDRGGHPATLSADVVVCAVGLFGAAK--LPDIDGLA-GFAGPVLHTA
MLBr_00065|M.leprae_Br4923 TVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSE-DFTGPIIHPQ
:. . * * : * *. *.
Mvan_0615|M.vanbaalenii_PYR-1 AWIDGLDLTGKSVGVVGTGSSAVQVVTEAEK-VAGDVTIFQLEPNWIVPK
MSMEG_3832|M.smegmatis_MC2_155 RWIDGLDMTGKKIGVLGTGSSAVQVVTEAER-VGAEVKIFQIEPNWILPK
Mb0916|M.bovis_AF2122/97 RWDHTVPLLGRRIAVIGTGSTGVQLVCGLAG-VAGKVTMFQRTAQWVLPW
Rv0892|M.tuberculosis_H37Rv RWDHTVPLLGRRIAVIGTGSTGVQLVCGLAG-VAGKVTMFQRTAQWVLPW
MAB_2077|M.abscessus_ATCC_1997 RWDRSVSLRGKQVAVIGTGASAIQFVPHIVQ-EAEHVTLYQRTAPWILPK
Mflv_4103|M.gilvum_PYR-GCK RWDHSVDLRGARVAVLGTGSTAAQLVPEVAK-QAAAVYSVQRSPTWVLPK
TH_3452|M.thermoresistible__bu RWDHGIDLHGKRIAVLGTGSTASQLIPELAK-IADRVYSVQRSPTWILPK
MMAR_0240|M.marinum_M GWDHRVDLTGKRVAVIGTGASGVQVVPELAK-LAGRLTVFQRTPPWMVPK
MUL_4873|M.ulcerans_Agy99 GWDHRVDLTGKRVAVIGTGASGVQVVPELAK-LAGRLTVFQRTPPWMVPK
MAV_5241|M.avium_104 QWDHDLDLAGRTVAVIGTGASGVQLVPELAG-TAGHVTVFQRTPPWMVPK
MLBr_00065|M.leprae_Br4923 HWPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQ
* : . : *:*:*::. .: . : * . :::.
Mvan_0615|M.vanbaalenii_PYR-1 HSRAFTPLERRLNKLRPVYAWRRWALYFDYDRRQLRSSHARSTGRFNRRR
MSMEG_3832|M.smegmatis_MC2_155 DSRDFSPLERRLNRLAPVYAYRRLKLYLGYDLRQIRSSHARSDGRTNQRK
Mb0916|M.bovis_AF2122/97 PNPRYSKLARVFHRAFPCLGS---LAYKAYSLSFETFAVALSNPGLHRKL
Rv0892|M.tuberculosis_H37Rv PNPRYSKLARVFHRAFPCLGS---LAYKAYSLSFETFAVALSNPGLHRKL
MAB_2077|M.abscessus_ATCC_1997 WDSRYGVLHDRVSELLPMALR---LERFAVWLIFELLAVTLVDAKPLSRV
Mflv_4103|M.gilvum_PYR-GCK PDRPYTDREKWMFAHVPFAKK---IYRTRLWLRSESNISVIEHGSDKTQE
TH_3452|M.thermoresistible__bu PDRPYSDRERWVFRHVPFAKR---IYRTRLWLRSEANISVIEDGSEKTEE
MMAR_0240|M.marinum_M DDRRYTATELRQFRRNPLAIR---RTRWQIWKFQHDNTATFADDPVVTSR
MUL_4873|M.ulcerans_Agy99 DDRRYTATELRQFRRNPLAIR---RTRWQIWKFQHDNTATFADDPVVTSR
MAV_5241|M.avium_104 DDRPYSATELARFKRNPLALR---RTRWQIWKFQHDNTATFADDPVVTAR
MLBr_00065|M.leprae_Br4923 PAKDKIAARLNRWLPDKYAYT---AVRWKNILRQSALYGACQKWP--QRM
.
Mvan_0615|M.vanbaalenii_PYR-1 HQASLEFMRRELAGRPDLLEKVTPTFAFEGKRTVCS--DTYYASLRSPKV
MSMEG_3832|M.smegmatis_MC2_155 HRAAVAYLQRELGDRPDLLELATPSFPYEGRRTVVS--DTYYQALRSPKV
Mb0916|M.bovis_AF2122/97 VGAVCRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDV
Rv0892|M.tuberculosis_H37Rv VGAVCRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDV
MAB_2077|M.abscessus_ATCC_1997 LGAIARRHLHRQVASPSLREQLMPSDAPGCKRVLFS--NDYYPAIASDRV
Mflv_4103|M.gilvum_PYR-GCK FKSIALRTLEATVSDDELRARLTPDHPLGCKRLVFA--TDYLKTLTEPHV
TH_3452|M.thermoresistible__bu FKAIALKMLEATVPDEEMRRRLTPDHPLGCKRLVFS--SDYLAALMRPNV
MMAR_0240|M.marinum_M TQ-IATSFLERVVADERLRRALTPGYPFRCKRVLLG--DDFYRALQHDHV
MUL_4873|M.ulcerans_Agy99 TQ-IATSFLERVVADERLRRALTPGYPFRCKRVLLG--DDFYRALQHAHV
MAV_5241|M.avium_104 SR-IATSFLDRTVADESLRRALTPDYPFRCKRVLLG--DDYYRALQRDNV
MLBr_00065|M.leprae_Br4923 RNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTV
: * :* :: *
Mvan_0615|M.vanbaalenii_PYR-1 TLVPHALKGLTRTGAVDANGDEHDLDVIVLATGFDAANYLGNYQVYGQGG
MSMEG_3832|M.smegmatis_MC2_155 TLVPHAVKGLSRTGAIDANGDEHELDIIVLATGFDAANYLGNYQVHGRNG
Mb0916|M.bovis_AF2122/97 ELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDG
Rv0892|M.tuberculosis_H37Rv ELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDG
MAB_2077|M.abscessus_ATCC_1997 SLVPKAIAELCDNGVKTVDGEFRPADVVIYGTGFRATDFLAPMSVRGSRG
Mflv_4103|M.gilvum_PYR-GCK DVVSSPARALRSRSLVTEDGTELDVDVVLCATGYAAADYLGQIDVRGADD
TH_3452|M.thermoresistible__bu EVVSSPARALRGDTLITEDGTERRVDVVVCATGYAAADYLGQIEVVGERQ
MMAR_0240|M.marinum_M ELVTDPIERVTETSVVTTAGQAVDVDAVVLATGFETSRYLSGIEVIGTGG
MUL_4873|M.ulcerans_Agy99 ELVTDPIERVTETSVVTTAGQGVDVDAVVLATGFETSRYLSGIEVIGTGG
MAV_5241|M.avium_104 ELVTDPIARIGRMSVITASGAEIEADVIVLATGFETSRYLSGIEVVGAGG
MLBr_00065|M.leprae_Br4923 DMVTDAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQP
:*. . * * :: .** : .
Mvan_0615|M.vanbaalenii_PYR-1 RELHSAWQGEPEAFLGMMVPGFPNFFIMYGPNTN--SVPLVHFYEAQADF
MSMEG_3832|M.smegmatis_MC2_155 VELHDAWQGEPEAFLGMMVPKFPNFFIMYGPNTN--SIPLVSFYEAQAAF
Mb0916|M.bovis_AF2122/97 IRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEH
Rv0892|M.tuberculosis_H37Rv IRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEH
MAB_2077|M.abscessus_ATCC_1997 VSLAEVWKTQAYAYLGITVPMFPNLFLLYGPNTNVGSGSILYMIESQVRH
Mflv_4103|M.gilvum_PYR-GCK IPLSQTWRDGAFAYLGMSVPGYPNFFMLYGPNTNVGSNSVIFVLEAQARY
TH_3452|M.thermoresistible__bu RSLREVWRDGAYAYLGMTVPGFPNFFMLYGPNTNVGSNSVLFILEAQARY
MMAR_0240|M.marinum_M QSLHERWGDDPAAYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGARL
MUL_4873|M.ulcerans_Agy99 QSLHERWGDDPAAYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGARL
MAV_5241|M.avium_104 RRLHEHWGEEPSAYLGVAVSGFPNFFMLYGPNTNQGGNSIVYILEAGARL
MLBr_00065|M.leprae_Br4923 VDLAQTMS-----YKGMMLSGLPNMIYTVG----YTNASWTLKADLVSEF
: . . : **:: * . . :
Mvan_0615|M.vanbaalenii_PYR-1 AASLIKRAAKTGHRVIDVRRSAFVIYNDWLQAQLAKTVW-ARTSNYFRAG
MSMEG_3832|M.smegmatis_MC2_155 AASLIARATKTRAGSIEVRRSAFVLYNDWIQAALAKTVW-AQVQNYFQAG
Mb0916|M.bovis_AF2122/97 IVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNK
Rv0892|M.tuberculosis_H37Rv IVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNK
MAB_2077|M.abscessus_ATCC_1997 IATLIKAVAAHPGHAIDVRTESAQRYNTRLRRRLRRSVWAL-CASWYRTS
Mflv_4103|M.gilvum_PYR-GCK IVRALKYLRRRNRSYIEVRSDVMKRYLDKIDSWMQGTVWLTRCSNYFRAP
TH_3452|M.thermoresistible__bu VVKALKRLRRRDTSYIAVRPDTAAAFLAKVDQWMQGKVWSTQCNNYFRAP
MMAR_0240|M.marinum_M VASAVSRLARRG-GYLDVRPEAERRYNDEISTDLERTIW-TQCQSYFRSP
MUL_4873|M.ulcerans_Agy99 VASAASRLARRG-GYLDVRPEAERRYNDEISADLERTIW-TQCQSYFRSP
MAV_5241|M.avium_104 VASAVSRLARRG-GFLEVRPEAEKRFNDRLSADLERTIW-TRCDSYFRSP
MLBr_00065|M.leprae_Br4923 FCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGS
: . . :
Mvan_0615|M.vanbaalenii_PYR-1 TGKVVSQWPFGATPYILATKLLRRIAVRLT--------------------
MSMEG_3832|M.smegmatis_MC2_155 TGRVVSQWPFGATPYILATKLLRRIAVRLS--------------------
Mb0916|M.bovis_AF2122/97 DG-IPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSR-------PQS
Rv0892|M.tuberculosis_H37Rv DG-IPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSR-------PQS
MAB_2077|M.abscessus_ATCC_1997 SGEIPTNWPGPTLVYRLLTRKPHSGDYVLRNVGRLKVGDP-------AEP
Mflv_4103|M.gilvum_PYR-GCK NGRVVTQWPRSARDFWALTRWFRAGDYVFEAPSARETISVG------AQA
TH_3452|M.thermoresistible__bu NGRVVTQWPRSARAFWAMTRRFRSADYLFEPAPDMSEVSAD------ARP
MMAR_0240|M.marinum_M SGRIVTQWPYTELEYARRTWRIKPRDWLHHKGVSPAAQRGGAGSAASAQT
MUL_4873|M.ulcerans_Agy99 SGRIVTQWPYTELEYARRTWRIRPRDWLHHKGVSPAAQRGGPGSAASAET
MAV_5241|M.avium_104 TGRIVTQWPYTELDYARWTWRLRRRDWIHHRCAPGAATVG-------AAQ
MLBr_00065|M.leprae_Br4923 RTPWRLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV------------
Mvan_0615|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_3832|M.smegmatis_MC2_155 ----------------------------------
Mb0916|M.bovis_AF2122/97 A---------------------------------
Rv0892|M.tuberculosis_H37Rv A---------------------------------
MAB_2077|M.abscessus_ATCC_1997 SLAD------------------------------
Mflv_4103|M.gilvum_PYR-GCK EAER------------------------------
TH_3452|M.thermoresistible__bu VASR------------------------------
MMAR_0240|M.marinum_M EIDHPADQLAGNQIGVGVVDAVERVALGDHLVQE
MUL_4873|M.ulcerans_Agy99 EIDDPADQLAGNQIGVGVVDAVERVALGDHRVQE
MAV_5241|M.avium_104 EF--------------------------------
MLBr_00065|M.leprae_Br4923 ----------------------------------