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VTNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQRYTAVFANVSGLTSGDFVRIAGVEVGKVRTL TVRDDSTVAVEFGADDSVVLTDGSRAVIKYDNLIGDRYLAIEEGAGGTTKLRPGDAIPLDRTAPALDLDA VIGGFRPLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELIGQTIVNLNVVLGSL AGHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYANEAARSIADLLAQARPPLQKAVHETDRTAIAYL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0501 | - | - | 100% (278) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4603 | - | 1e-98 | 65.45% (275) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0364 | - | 3e-96 | 64.31% (269) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0176 | mce1B | 2e-62 | 45.39% (271) | MCE-family protein MCE1B |
| M. gilvum PYR-GCK | Mflv_0651 | - | 1e-150 | 99.28% (278) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 3e-93 | 64.44% (270) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 2e-61 | 45.39% (271) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 1e-51 | 39.46% (261) | MCE-family protein |
| M. marinum M | MMAR_4052 | mce3B_1 | 1e-95 | 65.80% (269) | MCE-family protein Mce3B_1 |
| M. avium 104 | MAV_2533 | - | 1e-103 | 70.00% (270) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 3e-84 | 57.66% (274) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-109 | 72.22% (270) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3919 | mce3B_1 | 2e-95 | 65.43% (269) | MCE-family protein Mce3B_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0176|M.bovis_AF2122/97 --MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTN-GYTAEFSNVS
MLBr_02590|M.leprae_Br4923 --MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTN-GYTAEFTNIS
Mvan_0501|M.vanbaalenii_PYR-1 MTNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQ-RYTAVFANVS
Mflv_0651|M.gilvum_PYR-GCK MTNKISAVLWRLGIFVVVCALGAFALIAVFAQLRFEREQ-RYTAVFANVS
TH_3222|M.thermoresistible__bu LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEED-TYHAIFTSVT
MAV_2533|M.avium_104 MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSEK-TYKAQFANVS
Rv1967|M.tuberculosis_H37Rv MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDGK-TYYAEFANVS
MMAR_4052|M.marinum_M MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFSNVT
MUL_3919|M.ulcerans_Agy99 MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFSNVT
MSMEG_0347|M.smegmatis_MC2_155 MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGERK-QYTAQFSDIS
MAB_4152c|M.abscessus_ATCC_199 ---MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGK-RYHAMFSTAS
:: * . :. *.:.** * * *: :
Mb0176|M.bovis_AF2122/97 GLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQI
MLBr_02590|M.leprae_Br4923 GLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQI
Mvan_0501|M.vanbaalenii_PYR-1 GLTSGDFVRIAGVEVGKVRTLTVRDD-STVAVEFGADDSVVLTDGSRAVI
Mflv_0651|M.gilvum_PYR-GCK GLTSGDFVRIAGVEVGKVRTLTVRDD-STVAVEFGADDSVVLTDGSRAVI
TH_3222|M.thermoresistible__bu GLENGNFVRIAGVEVGKVKHVSVRDD-STVLVKFSADRSVVLTEGSRAII
MAV_2533|M.avium_104 GLEGGNFVRIAGVEVGKVKNITVEPD-STVLVEFTAAEKVVLTEGTRAAI
Rv1967|M.tuberculosis_H37Rv NLRTGKLVRIAGVEVGKVTRISINPD-ATVRVQFTADNSVTLTRGTRAVI
MMAR_4052|M.marinum_M GLEQNDFVRIAGVEVGQVKKVAIQPD-TTALVEFTADSSVVLTQGSRAVI
MUL_3919|M.ulcerans_Agy99 GLEQNDFVRIAGVEVGQVKKVAIQPD-TTALVEFTADSSVVLTQGSRAVI
MSMEG_0347|M.smegmatis_MC2_155 GLKEGDFVRIAGVEVGQVQKVSMDEN-ALVLVEFAMEDSVELTSTSTAVI
MAB_4152c|M.abscessus_ATCC_199 DLRSGQKVRIAGVPVGRVKNVSLNRD-NSVEVTFDVDSKYQLYSSSRAII
.* .. ** :** :*:* : : . . * * . * : * *
Mb0176|M.bovis_AF2122/97 RYSDLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFK
MLBr_02590|M.leprae_Br4923 RYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFK
Mvan_0501|M.vanbaalenii_PYR-1 KYDNLIGDRYLAIE--EGAGGTTKLRPGDAIPLDRTAPALDLDAVIGGFR
Mflv_0651|M.gilvum_PYR-GCK KYDNLIGDRYLAIE--EGAGGTTKLRPGDAIPLDRTAPALDLDAVIGGFR
TH_3222|M.thermoresistible__bu RYDNLIGGRYLALE--EGAGGTTKLAPGETIPLDRTAPALDLDALIGGFR
MAV_2533|M.avium_104 RFADLTGGRYVALE--EGAGNIRRLSPGATIPLARTEPALDLDALIGGFR
Rv1967|M.tuberculosis_H37Rv RYDNLFGDRYLALE--EGAGGLAVLRPGHTIPLARTQPALDLDALIGGFK
MMAR_4052|M.marinum_M RYDDLIGGRYLALE--EGAGSPKQLKPGDTIPMTHTSPALDLDALIGGFR
MUL_3919|M.ulcerans_Agy99 RYDDLIGGRYLALE--EGAGSPKQLKPGDTIPMTHTSPALDLDALIGGFR
MSMEG_0347|M.smegmatis_MC2_155 RYDNLIGGRYLELK--QGEEPGAVLQAGATIPLARTRPALDLDELIGGFR
MAB_4152c|M.abscessus_ATCC_199 RYENLVGDRYLEIT--AGPGELHKLPDGGTLDKEHTQPALDLDALLGGLR
:: :* *.**: : * : * : :* ****** ::**::
Mb0176|M.bovis_AF2122/97 PVFRALDPAKVNNIANALITVFQGQGGTINDTLDQTAQLTSQIAERDQAI
MLBr_02590|M.leprae_Br4923 PLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAI
Mvan_0501|M.vanbaalenii_PYR-1 PLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELI
Mflv_0651|M.gilvum_PYR-GCK PLLNALDPTQVNTLTSQLIAAFQGQGATIGSILAQTAALTNTLADRDELI
TH_3222|M.thermoresistible__bu PLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRDELI
MAV_2533|M.avium_104 PLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRDHLI
Rv1967|M.tuberculosis_H37Rv PLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLI
MMAR_4052|M.marinum_M PLLKALDPEQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRDQLI
MUL_3919|M.ulcerans_Agy99 PLLKALDPDQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRDQLI
MSMEG_0347|M.smegmatis_MC2_155 PLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQLI
MAB_4152c|M.abscessus_ATCC_199 PVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLI
*::..::. ::* :: :: : *:* *:.. * ::: .*. :.:**. *
Mb0176|M.bovis_AF2122/97 GEVVKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHIS
MLBr_02590|M.leprae_Br4923 GEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHIS
Mvan_0501|M.vanbaalenii_PYR-1 GQTIVNLNVVLGSLAGHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYAN
Mflv_0651|M.gilvum_PYR-GCK GQTIVNLNVVLGSLAGHSDQFGKAIDSLSQLVHGLQARKQDISNGVAYAN
TH_3222|M.thermoresistible__bu GQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLAKAG
MAV_2533|M.avium_104 GQVIVNLNTVLGSLGGQSGQFARAVDSLSELVAGLEARKQDISNGMAYAN
Rv1967|M.tuberculosis_H37Rv GQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTN
MMAR_4052|M.marinum_M GDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGVAYTN
MUL_3919|M.ulcerans_Agy99 GDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGMAYTN
MSMEG_0347|M.smegmatis_MC2_155 GEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIANSD
MAB_4152c|M.abscessus_ATCC_199 GDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLA
*:.: :*: :* : : .: :: * *: * : :: ...
Mb0176|M.bovis_AF2122/97 NGAGTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALT
MLBr_02590|M.leprae_Br4923 NAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLN
Mvan_0501|M.vanbaalenii_PYR-1 EAARSIADLLAQARPPLQKAVHETDRTAIAYL------------------
Mflv_0651|M.gilvum_PYR-GCK EAARSIADLLAQARPPLQKAVHETDRTATAVLADRDYFDNLLNTLPDTYR
TH_3222|M.thermoresistible__bu EGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPDAYR
MAV_2533|M.avium_104 AAAGSITDLLAQARPPVKKVVHEADRTAGTMLADREWLEKYLDHWPDAFK
Rv1967|M.tuberculosis_H37Rv AAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQ
MMAR_4052|M.marinum_M AAASSIADLLSQARPPLTKTVQETDRASAIVLADHEYFDNLINTLPDAYQ
MUL_3919|M.ulcerans_Agy99 AAASSIADLLSQARPPLAKTVQETDRASAIVLADHEYFDNLINTLPDAYQ
MSMEG_0347|M.smegmatis_MC2_155 NAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPDKYR
MAB_4152c|M.abscessus_ATCC_199 STASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYL
* : .:* : : : :
Mb0176|M.bovis_AF2122/97 ALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQP---TGRCT
MLBr_02590|M.leprae_Br4923 QIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TGRCT
Mvan_0501|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0651|M.gilvum_PYR-GCK VMLRQ-GLYGNYFTFYLCDLLLKVNGK--GGQPVYIKLVEQS---SGRCT
TH_3222|M.thermoresistible__bu VLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TGRCA
MAV_2533|M.avium_104 ILNRQ-GLYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQA---SGRCT
Rv1967|M.tuberculosis_H37Rv ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SGRCA
MMAR_4052|M.marinum_M ALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TGRCA
MUL_3919|M.ulcerans_Agy99 ALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TGRCA
MSMEG_0347|M.smegmatis_MC2_155 VLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TGRCA
MAB_4152c|M.abscessus_ATCC_199 RLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRCA
Mb0176|M.bovis_AF2122/97 PQ--
MLBr_02590|M.leprae_Br4923 PQ--
Mvan_0501|M.vanbaalenii_PYR-1 ----
Mflv_0651|M.gilvum_PYR-GCK PQ--
TH_3222|M.thermoresistible__bu PR--
MAV_2533|M.avium_104 PR--
Rv1967|M.tuberculosis_H37Rv PK--
MMAR_4052|M.marinum_M PR--
MUL_3919|M.ulcerans_Agy99 PR--
MSMEG_0347|M.smegmatis_MC2_155 PK--
MAB_4152c|M.abscessus_ATCC_199 FKNE