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MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSEKTYKAQFANVSGLEGGNFVRIAGVEVGKVKNI TVEPDSTVLVEFTAAEKVVLTEGTRAAIRFADLTGGRYVALEEGAGNIRRLSPGATIPLARTEPALDLDA LIGGFRPLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRDHLIGQVIVNLNTVLGSL GGQSGQFARAVDSLSELVAGLEARKQDISNGMAYANAAAGSITDLLAQARPPVKKVVHEADRTAGTMLAD REWLEKYLDHWPDAFKILNRQGLYGDFFSFYLCDIVLKLNGKGGQPVYVKVAGQASGRCTPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2533 | - | - | 100% (342) | virulence factor Mce family protein |
| M. avium 104 | MAV_2062 | - | e-115 | 58.48% (342) | virulence factor Mce family protein |
| M. avium 104 | MAV_5014 | - | 2e-77 | 45.06% (344) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 2e-80 | 48.10% (343) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_2102 | - | 1e-134 | 69.76% (334) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-120 | 63.16% (342) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 7e-74 | 43.60% (344) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 2e-59 | 35.84% (332) | MCE-family protein |
| M. marinum M | MMAR_4052 | mce3B_1 | 1e-126 | 64.43% (343) | MCE-family protein Mce3B_1 |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-110 | 57.31% (342) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-127 | 65.79% (342) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3919 | mce3B_1 | 1e-127 | 65.01% (343) | MCE-family protein Mce3B_1 |
| M. vanbaalenii PYR-1 | Mvan_4603 | - | 1e-130 | 68.56% (334) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 -----MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHT-TGYSAVFT
MLBr_02590|M.leprae_Br4923 -----MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRT-NGYTAEFT
MAV_2533|M.avium_104 ---MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSE-KTYKAQFA
TH_3222|M.thermoresistible__bu ---LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEE-DTYHAIFT
Mflv_2102|M.gilvum_PYR-GCK ---MSVSIRRDATRLGAFLAVCLLGVFGLFAVFGQMRFGEKTQQYRAEFV
Mvan_4603|M.vanbaalenii_PYR-1 MPGLTTRVRHDALRLGVFLTVCLVGVFGLFAVFGQMRFGEKTHSYKAAFS
MMAR_4052|M.marinum_M ---MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFS
MUL_3919|M.ulcerans_Agy99 ---MRARLIRDAIRLGTFLLVCFLGVIGLFAVFGQLRFGEKTSTYKAEFS
Rv1967|M.tuberculosis_H37Rv ---MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDG-KTYYAEFA
MSMEG_0347|M.smegmatis_MC2_155 ---MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGER-KQYTAQFS
MAB_4152c|M.abscessus_ATCC_199 ------MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSG-KRYHAMFS
:: * : :. *.:.** * * *
Mb0605|M.bovis_AF2122/97 HVSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATT
MLBr_02590|M.leprae_Br4923 NISGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTT
MAV_2533|M.avium_104 NVSGLEGGNFVRIAGVEVGKVKNITVEP-DSTVLVEFTAAEKVVLTEGTR
TH_3222|M.thermoresistible__bu SVTGLENGNFVRIAGVEVGKVKHVSVRD-DSTVLVKFSADRSVVLTEGSR
Mflv_2102|M.gilvum_PYR-GCK NVTGLETNDFVRIAGVEVGKVENVEIQP-DTTAVVEFTADDSVVLTQGSR
Mvan_4603|M.vanbaalenii_PYR-1 NVTGLENGDFVRIAGVEVGQVKKVAIQP-DTTALVEFTADQSVVLTEGSR
MMAR_4052|M.marinum_M NVTGLEQNDFVRIAGVEVGQVKKVAIQP-DTTALVEFTADSSVVLTQGSR
MUL_3919|M.ulcerans_Agy99 NVTGLEQNDFVRIAGVEVGQVKKVAIQP-DTTALVEFTADSSVVLTQGSR
Rv1967|M.tuberculosis_H37Rv NVSNLRTGKLVRIAGVEVGKVTRISINP-DATVRVQFTADNSVTLTRGTR
MSMEG_0347|M.smegmatis_MC2_155 DISGLKEGDFVRIAGVEVGQVQKVSMDE-NALVLVEFAMEDSVELTSTST
MAB_4152c|M.abscessus_ATCC_199 TASDLRSGQKVRIAGVPVGRVKNVSLNR-DNSVEVTFDVDSKYQLYSSSR
:.*. .. ** :** **:* : : . . * * . * :
Mb0605|M.bovis_AF2122/97 ASIRYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLG
MLBr_02590|M.leprae_Br4923 AQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIG
MAV_2533|M.avium_104 AAIRFADLTGGRYVALEEGA--GNIRRLSPGATIPLARTEPALDLDALIG
TH_3222|M.thermoresistible__bu AIIRYDNLIGGRYLALEEGA--GGTTKLAPGETIPLDRTAPALDLDALIG
Mflv_2102|M.gilvum_PYR-GCK AVIRYDDLIGGRYLALEEGA--GGTQKLNPGGTIPLARTSPALDLDALIG
Mvan_4603|M.vanbaalenii_PYR-1 AVIRYDDLIGGRYLALQEGA--GATTTLKPGETIPLARTAPALDLDALIG
MMAR_4052|M.marinum_M AVIRYDDLIGGRYLALEEGA--GSPKQLKPGDTIPMTHTSPALDLDALIG
MUL_3919|M.ulcerans_Agy99 AVIRYDDLIGGRYLALEEGA--GSPKQLKPGDTIPMTHTSPALDLDALIG
Rv1967|M.tuberculosis_H37Rv AVIRYDNLFGDRYLALEEGA--GGLAVLRPGHTIPLARTQPALDLDALIG
MSMEG_0347|M.smegmatis_MC2_155 AVIRYDNLIGGRYLELKQGE--EPGAVLQAGATIPLARTRPALDLDELIG
MAB_4152c|M.abscessus_ATCC_199 AIIRYENLVGDRYLEITAGP--GELHKLPDGGTLDKEHTQPALDLDALLG
* **: :* *.**: : * : * : :* ****** *:*
Mb0605|M.bovis_AF2122/97 GFRPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRD
MLBr_02590|M.leprae_Br4923 GFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERD
MAV_2533|M.avium_104 GFRPLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRD
TH_3222|M.thermoresistible__bu GFRPLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRD
Mflv_2102|M.gilvum_PYR-GCK GFRPLFRALDPDQINALSGQLISALQGQGGTINSFLAQTAALTSTLADRD
Mvan_4603|M.vanbaalenii_PYR-1 GFRPLFRALDPEQVNALSGQLISALQGQGGTINSFLAQTATLTSTLADRD
MMAR_4052|M.marinum_M GFRPLLKALDPEQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRD
MUL_3919|M.ulcerans_Agy99 GFRPLLKALDPDQVNALSGQLIRALQGEGATINSFLAQTAALTTTLADRD
Rv1967|M.tuberculosis_H37Rv GFKPLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRD
MSMEG_0347|M.smegmatis_MC2_155 GFRPLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRD
MAB_4152c|M.abscessus_ATCC_199 GLRPVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERD
*::*::: ::. ::* :: :: : *:* *:..:* ::: .* :.:**
Mb0605|M.bovis_AF2122/97 HAIGEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAA
MLBr_02590|M.leprae_Br4923 QAIGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFA
MAV_2533|M.avium_104 HLIGQVIVNLNTVLGSLGGQSGQFARAVDSLSELVAGLEARKQDISNGMA
TH_3222|M.thermoresistible__bu ELIGQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLA
Mflv_2102|M.gilvum_PYR-GCK QLIGEVIINLNTVLGSLGDQSDQFAKAVDSLSQLVEGLSDRRQEISDGLA
Mvan_4603|M.vanbaalenii_PYR-1 QLIGEVITNLNVVLGSLGDQNDQFAKAIDSLADLVQTLRDRKEDVSNGLA
MMAR_4052|M.marinum_M QLIGDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGVA
MUL_3919|M.ulcerans_Agy99 QLIGDVIINLNVVLGSLGDQNKQFAKAVDALAELMEGLQARKEDITKGMA
Rv1967|M.tuberculosis_H37Rv RLIGQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVA
MSMEG_0347|M.smegmatis_MC2_155 QLIGEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIA
MAB_4152c|M.abscessus_ATCC_199 QLIGDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALP
. **:*: :*: :* : : .: :: * *: * : :: . .
Mb0605|M.bovis_AF2122/97 HISSAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPD
MLBr_02590|M.leprae_Br4923 HISNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPT
MAV_2533|M.avium_104 YANAAAGSITDLLAQARPPVKKVVHEADRTAGTMLADREWLEKYLDHWPD
TH_3222|M.thermoresistible__bu KAGEGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPD
Mflv_2102|M.gilvum_PYR-GCK YTNAAAGSIADFLTEARPPLKKTIDETDRAAGIVVADHEYFDNLINTLPD
Mvan_4603|M.vanbaalenii_PYR-1 YTNAAAASIADLLAQARPPLAKTIKETDRSAAIVVADHEYFDNFLNTLPD
MMAR_4052|M.marinum_M YTNAAASSIADLLSQARPPLTKTVQETDRASAIVLADHEYFDNLINTLPD
MUL_3919|M.ulcerans_Agy99 YTNAAASSIADLLSQARPPLAKTVQETDRASAIVLADHEYFDNLINTLPD
Rv1967|M.tuberculosis_H37Rv YTNAAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPD
MSMEG_0347|M.smegmatis_MC2_155 NSDNAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPD
MAB_4152c|M.abscessus_ATCC_199 PLASTASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAE
* : ..* : : . .: : .
Mb0605|M.bovis_AF2122/97 AYRIIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQP---TG
MLBr_02590|M.leprae_Br4923 VLNQIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TG
MAV_2533|M.avium_104 AFKILNRQ-GLYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQA---SG
TH_3222|M.thermoresistible__bu AYRVLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TG
Mflv_2102|M.gilvum_PYR-GCK AYQVLARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---SG
Mvan_4603|M.vanbaalenii_PYR-1 AYQALARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---TG
MMAR_4052|M.marinum_M AYQALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TG
MUL_3919|M.ulcerans_Agy99 AYQALSRQ-GIYGDFFSFYLCDVVLKLNGR--GGQPVYVKVAGQP---TG
Rv1967|M.tuberculosis_H37Rv KYQALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SG
MSMEG_0347|M.smegmatis_MC2_155 KYRVLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TG
MAB_4152c|M.abscessus_ATCC_199 NYLRLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKG
: . *.:. :* *.: :*:** * : . .*
Mb0605|M.bovis_AF2122/97 RCTPQ--
MLBr_02590|M.leprae_Br4923 RCTPQ--
MAV_2533|M.avium_104 RCTPR--
TH_3222|M.thermoresistible__bu RCAPR--
Mflv_2102|M.gilvum_PYR-GCK RCAPR--
Mvan_4603|M.vanbaalenii_PYR-1 RCAPR--
MMAR_4052|M.marinum_M RCAPR--
MUL_3919|M.ulcerans_Agy99 RCAPR--
Rv1967|M.tuberculosis_H37Rv RCAPK--
MSMEG_0347|M.smegmatis_MC2_155 RCAPK--
MAB_4152c|M.abscessus_ATCC_199 RCAFKNE
**: :