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KAAVYHGPNKLEIADLPEPQPGPGTVKVKVGFNGICGTDLHEYYAGPIFVPTEPHPLTGQVMPLTMGHEF AGTITDVGAGVTGFAPGDRVAIEPIYRCGHCAPCRAGNYNVCQQIGFHGLMCDGGMAEYTVVPVDMLHKL PDNVSLQLGALVEPMSVAYHAATLGDVGAGDTAVVFGAGPIGIGLWFALRGKGLESVYVAEPSPTRRAAI EALGAQTLDPTQVDVPAFIADVTGGRGADAAFDAAGVAPAIEAATASVGSRRPTISVAIYEKPLTTPLLN LVMNESRIQGSLCYTSADFEAVIALMADGVYDTTGWVTTIGIDDVIDEGFEALHAGRKMKVLIDPAI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5021 | - | - | 100% (348) | alcohol dehydrogenase, zinc-containing |
| M. smegmatis MC2 155 | MSMEG_3605 | - | 1e-42 | 32.86% (350) | sorbitol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3603 | - | 4e-41 | 32.09% (349) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 1e-28 | 28.50% (393) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0125 | - | 1e-170 | 82.08% (346) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3726 | - | 1e-28 | 28.50% (393) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-20 | 25.63% (355) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 6e-31 | 29.68% (374) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0343 | - | 4e-35 | 30.88% (353) | zinc-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_4173 | - | 2e-30 | 30.94% (307) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4349 | - | 2e-30 | 30.84% (347) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_4777 | - | 3e-35 | 30.88% (353) | zinc-dependent alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | 1e-174 | 83.53% (346) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0125|M.gilvum_PYR-GCK ----MRAAVYYGPNK-LEVDDVPEPEARPGTVKLKVGFNGICGTDLHEYY
Mvan_0788|M.vanbaalenii_PYR-1 ----MRAAVYYGPNK-LEVDDVAEPEPGPGTVKLKVGFNGICGTDLHEYY
MSMEG_5021|M.smegmatis_MC2_155 ----MKAAVYHGPNK-LEIADLPEPQPGPGTVKVKVGFNGICGTDLHEYY
MMAR_0343|M.marinum_M MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
MUL_4777|M.ulcerans_Agy99 MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
Mb3753|M.bovis_AF2122/97 ------MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
Rv3726|M.tuberculosis_H37Rv ------MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
TH_4349|M.thermoresistible__bu ----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHLMH
MAV_4173|M.avium_104 ---------MVTSPDRAEVIDVERPGVGPRDVLVRMRACGICGSDAFYIS
: : : : * * :*
Mflv_0125|M.gilvum_PYR-GCK AG----PIFVPTAPHPLTGAQLPLTMGHEFSGTITAVGDGVTGWQEGDRV
Mvan_0788|M.vanbaalenii_PYR-1 AG----PIFVPTEPHPLTGQQLPLTMGHEFSGTIAAVGDGVTGWSEGDRV
MSMEG_5021|M.smegmatis_MC2_155 AG----PIFVPTEPHPLTGQVMPLTMGHEFAGTITDVGAGVTGFAPGDRV
MMAR_0343|M.marinum_M G--------------TFPTQAPVVTQGHEASGTIAKLGPEVDGWSEGDRV
MUL_4777|M.ulcerans_Agy99 G--------------TFPTQAPVVTQGHEASGTIVKLGPEVDGWSEGDRV
Mb3753|M.bovis_AF2122/97 HCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGP-------GTRR
Rv3726|M.tuberculosis_H37Rv HCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGP-------GTRR
MLBr_01784|M.leprae_Br4923 GG---------------INDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFV
MAB_2084|M.abscessus_ATCC_1997 GD---------------LPIPLPVVGGHEGAGTVVECGEGVEDLSEGDSV
TH_4349|M.thermoresistible__bu DFEP-----------GMMPWQLPFTLGHENAGWVAAVGAGVGTVTEGDAV
MAV_4173|M.avium_104 IG-------------GVPPRQGHTPLGHEPAGEVVEVGAEVTGLAVGDHV
*** .* : * *
Mflv_0125|M.gilvum_PYR-GCK AVEPIYKCDQCGPCRAGNYNVCQQIG--------------------FHGL
Mvan_0788|M.vanbaalenii_PYR-1 AVEPIYKCGHCGPCRAGNYNVCQQIG--------------------FHGL
MSMEG_5021|M.smegmatis_MC2_155 AIEPIYRCGHCAPCRAGNYNVCQQIG--------------------FHGL
MMAR_0343|M.marinum_M VVAAGRPCQSCPNCRRGDTVNCLRIQ--------------------LMAF
MUL_4777|M.ulcerans_Agy99 VVAAGRPCQSCPNCRRGDTVNCLRIQ--------------------LMAF
Mb3753|M.bovis_AF2122/97 TPRRGTPVVAMPLLRRGNK-EVHGIG--------------------LSTM
Rv3726|M.tuberculosis_H37Rv TPRRGTPVVAMPLLRRGNK-EVHGIG--------------------LSTM
MLBr_01784|M.leprae_Br4923 ILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLI-------DGTELTPA
MAB_2084|M.abscessus_ATCC_1997 ILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQM
TH_4349|M.thermoresistible__bu AVYGPWGCGTCERCMGGAENYCENPAGAPVLSG-------------GAGL
MAV_4173|M.avium_104 VINPMAAPSGIIGNG-----------------------------------
Mflv_0125|M.gilvum_PYR-GCK MSDGGMAEYTVVPTG----MLHRLPDTVS-LELGALVEPMSVAYHAATL-
Mvan_0788|M.vanbaalenii_PYR-1 MSDGGMAEYTVVPTS----MLHKLPDNVS-LELGALVEPMSVAYHAATL-
MSMEG_5021|M.smegmatis_MC2_155 MCDGGMAEYTVVPVD----MLHKLPDNVS-LQLGALVEPMSVAYHAATL-
MMAR_0343|M.marinum_M AYDGAWAEYTVAQAA----GLTRVPDNVS-LDQAAILADAVSTPFGAVVR
MUL_4777|M.ulcerans_Agy99 AYDGAWAEYTVAQAA----GLTRVPDNVS-LDQAAILADAVSTPFGAVVR
Mb3753|M.bovis_AF2122/97 AP-GAYAERLVVEQS----LTFPVPNGLA-PEIAALTEPMAVGWHAVRR-
Rv3726|M.tuberculosis_H37Rv AP-GAYAERLVVEQS----LTFPVPNGLA-PEIAALTEPMAVGWHAVRR-
MLBr_01784|M.leprae_Br4923 LGIGAFADKTLVHSG----QCTKVDPAAD-PAVAGLLGCGVMAGLGAAIN
MAB_2084|M.abscessus_ATCC_1997 CLLGTFSEYTVVPQA----SVVKIDGGIP-LDRAALIGCGVTTGYGSAVR
TH_4349|M.thermoresistible__bu GMDGGMAEYLLVPAER---LVVKLPESMTPVTAAALTDAGLTPYHAIRRS
MAV_4173|M.avium_104 GASGALADYLLIENAVRGTSLEVIPDHIP-WEVAALNEPMAVARHGVNR-
* :: : : ..: .
Mflv_0125|M.gilvum_PYR-GCK -GEVSAGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRTAIEAL
Mvan_0788|M.vanbaalenii_PYR-1 -GDVSPGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRAAIEVL
MSMEG_5021|M.smegmatis_MC2_155 -GDVGAGDTAVVFGAGPIGIGLWFALRGKGLESVYVAEPSPTRRAAIEAL
MMAR_0343|M.marinum_M TGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALEL
MUL_4777|M.ulcerans_Agy99 TGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALEL
Mb3753|M.bovis_AF2122/97 -GEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATAC
Rv3726|M.tuberculosis_H37Rv -GEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATAC
MLBr_01784|M.leprae_Br4923 TAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTF
MAB_2084|M.abscessus_ATCC_1997 TGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGF
TH_4349|M.thermoresistible__bu WPKLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRSEALELAREM
MAV_4173|M.avium_104 -CQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRI
. . * * * :* : . :
Mflv_0125|M.gilvum_PYR-GCK GAR-TLDPTADDVPAFIADHTGGD--------------------------
Mvan_0788|M.vanbaalenii_PYR-1 GAR-TLDPTSADVPAFIADHTRGD--------------------------
MSMEG_5021|M.smegmatis_MC2_155 GAQ-TLDPTQVDVPAFIADVTGGR--------------------------
MMAR_0343|M.marinum_M GADYAFDSRDDQLHDKLAEITGGR--------------------------
MUL_4777|M.ulcerans_Agy99 GADYAFDSRDDQLHDKLAEITGGR--------------------------
Mb3753|M.bovis_AF2122/97 GADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLP
Rv3726|M.tuberculosis_H37Rv GADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVERLQRLRLP
MLBr_01784|M.leprae_Br4923 GATHTVNALELEVVKTIQDLTSGFG-------------------------
MAB_2084|M.abscessus_ATCC_1997 GATHTAASMD-EAWSLVSDMTRGK--------------------------
TH_4349|M.thermoresistible__bu GADHVVRSDE-QAVEAIWELTGGR--------------------------
MAV_4173|M.avium_104 GADAVVNSAEEDVAARLVELHGPGESMFPG--------------------
** . . .
Mflv_0125|M.gilvum_PYR-GCK ----------------GADAVFDAAGVTPAVATALGCVGSRKPMISVAIY
Mvan_0788|M.vanbaalenii_PYR-1 ----------------GADAVFDAAGVTPAVSTALACVGSRKPMISVAIY
MSMEG_5021|M.smegmatis_MC2_155 ----------------GADAAFDAAGVAPAIEAATASVGSRRPTISVAIY
MMAR_0343|M.marinum_M ----------------MLDVAFDAVGLKATFEQALGSLTAGGRLVGVGMS
MUL_4777|M.ulcerans_Agy99 ----------------MLDVAFDAVGLKATFEQALGSLTAGGRLVGVGTS
Mb3753|M.bovis_AF2122/97 WWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC
Rv3726|M.tuberculosis_H37Rv WWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC
MLBr_01784|M.leprae_Br4923 -----------------VDVVIDTVGRPETWKQAFYARDLAGTVVLVGVP
MAB_2084|M.abscessus_ATCC_1997 --------------LADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIG
TH_4349|M.thermoresistible__bu ----------------GADVLLDFVGADATIELARAAARPLGDVTIVGIA
MAV_4173|M.avium_104 --------------KAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVH
.. ..
Mflv_0125|M.gilvum_PYR-GCK EK--PLETPLLNLVMNESRIQGSLCY----TGADFESVIALMADGRYDTT
Mvan_0788|M.vanbaalenii_PYR-1 EK--PLETPLLNLVMNESRIQGSLCY----TGADFEAVIALMGQGKYDTT
MSMEG_5021|M.smegmatis_MC2_155 EK--PLTTPLLNLVMNESRIQGSLCY----TSADFEAVIALMADGVYDTT
MMAR_0343|M.marinum_M AES-PTVGPTSMFGLTHKQVLGHLGY----QNVDIETLAKLVSLGRLDLS
MUL_4777|M.ulcerans_Agy99 AES-PTVGPTSMFGLTHKQVLGHLGY----QNVDIETLAKLVSLGRLDLS
Mb3753|M.bovis_AF2122/97 MGS-DHIRPAMAINKEIN-LRFVLGY----TPLEFRDTLHMLADGKVNAA
Rv3726|M.tuberculosis_H37Rv MGS-DHIRPAMAINKEIN-LRFVLGY----TPLEFRDTLHMLADGKVNAA
MLBr_01784|M.leprae_Br4923 TPD-MRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLG
MAB_2084|M.abscessus_ATCC_1997 HPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLD
TH_4349|M.thermoresistible__bu GGS----VPLSFFSQPYEVSIQTTYWG------TRPELVELLDLAARGLV
MAV_4173|M.avium_104 KEP--VPVDLINVMSNEITIVGSMGY-----PDEIFEVTGDLVRNWEKYA
:
Mflv_0125|M.gilvum_PYR-GCK GWVTRIPIDDVVDEGFEALH--AGTKMKVLVDPNGAQ---------
Mvan_0788|M.vanbaalenii_PYR-1 GWVTRIPIDDVVDEGFEALH--AGTKMKVLVDPNGA----------
MSMEG_5021|M.smegmatis_MC2_155 GWVTTIGIDDVIDEGFEALH--AGRKMKVLIDPAI-----------
MMAR_0343|M.marinum_M RSISEIVPLEDLPLGIEKLERQDGNPIRILVQP-------------
MUL_4777|M.ulcerans_Agy99 RSISEIVPLEDLSLGIEKLERQDGNPIRILVQP-------------
Mb3753|M.bovis_AF2122/97 PLITGTVGLPGVAAAFDALG-DPEAHAKIMIDPKSNAASPQPFRVE
Rv3726|M.tuberculosis_H37Rv PLITGTVGLPGVAAAFDALG-DPEAHAKIMIDPKSNAASPQPFRVE
MLBr_01784|M.leprae_Br4923 KFVSERIGLGDVEEAFHKIHGGKVLRSVVML---------------
MAB_2084|M.abscessus_ATCC_1997 ELVTREYSLDQINEGYQDMRSGRNIRGLVRF---------------
TH_4349|M.thermoresistible__bu HVESTTYPLDDALQAYRDLRAGRVRGRAVIVP--------------
MAV_4173|M.avium_104 LIVSHTIPFDRVGEALELARTPGAADKVVVTFC-------------
: . :