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FEELIDAAGRSRGAAAIGAWARIENAAVAQRLSAMADLLESRLTDKDSAERDQWCLDNWDAVSAEVAAGQ HTSLGVASNELLDAWTLRRRLPRVAEVFASGAISYRLVKSVVKRTRLVVDPEVMAKIDAEIAAHIRGWGP LSVAKHEAEIDHWVDLYDPAAVVHAESAARSRHVDVTPAADGSGTCFVEAVLYAHDGEVMDRRLDDMARG VCLADPRTHEQRRADALAAIMNKADRLSCLCGAEDCEAGARTTSSVVVHVIAEESSLTDDTPVALNGDKP ASPEPEPESEPKPEPSRFESLLGPVPAAGPAKTNPAVVLGGGLLPGPLLAATLAQTATIRRLVHPGDSPA EPRYVPSAKLADFVRCRDMTCRFPGCDVAAYSCDLDHTIAYPVGPTQASNLACLCRKHHLLKTFWGWRDV QYPDGTVLWTSPGGQTFTTHPGSRVLFPSLCRPTAPVAVDAGVRAPTPSAPSGLGMPRRTQTRAQVRARR IHDQRAENQALLEGRNHAPPF*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0314 | - | - | 100% (512) | hypothetical protein Mflv_0314 |
M. gilvum PYR-GCK | Mflv_2756 | - | e-120 | 45.37% (529) | HNH nuclease |
M. gilvum PYR-GCK | Mflv_1180 | - | e-107 | 42.34% (522) | hypothetical protein Mflv_1180 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2126 | - | 1e-119 | 47.72% (505) | hypothetical protein Mb2126 |
M. tuberculosis H37Rv | Rv2100 | - | 1e-119 | 47.72% (505) | hypothetical protein Rv2100 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_4752 | - | 3e-69 | 37.50% (456) | hypothetical protein MAB_4752 |
M. marinum M | MMAR_2226 | - | 1e-102 | 44.24% (486) | 13e12 repeat-containing protein |
M. avium 104 | MAV_4456 | - | 1e-101 | 44.58% (498) | 13e12 repeat-containing protein |
M. smegmatis MC2 155 | MSMEG_3957 | - | 3e-99 | 42.16% (529) | 13e12 repeat-containing protein |
M. thermoresistible (build 8) | TH_0334 | - | 2e-66 | 39.90% (411) | HNH endonuclease |
M. ulcerans Agy99 | MUL_1813 | - | 3e-95 | 43.64% (456) | 13e12 repeat-containing protein |
M. vanbaalenii PYR-1 | Mvan_0426 | - | 0.0 | 68.65% (539) | hypothetical protein Mvan_0426 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0314|M.gilvum_PYR-GCK --------------------------------------MFEELIDA---- Mvan_0426|M.vanbaalenii_PYR-1 --------------------------------------MFEGLVES---- Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL MSMEG_3957|M.smegmatis_MC2_155 --------------------------------------MCET-------- MMAR_2226|M.marinum_M --------------------------------------MFEYWYASR--- MUL_1813|M.ulcerans_Agy99 -------------------------------------------------- MAV_4456|M.avium_104 ---------------------------MCEDATAWFDELMERCYPS---- MAB_4752|M.abscessus_ATCC_1997 --------------------------------------MFD--------- TH_0334|M.thermoresistible__bu --------------------------------------MFES-------- Mflv_0314|M.gilvum_PYR-GCK --AGRSRGAAAIGAWARIENAAVAQRLSAMADLLESRLTDKDSAERDQWC Mvan_0426|M.vanbaalenii_PYR-1 --AVRSRGAAAIGAWARMENAAAARRLFAMADLLEAKLADKDSAERDQWC Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA MSMEG_3957|M.smegmatis_MC2_155 --LDDAALIAGIAGESRAESAAAARRFAFIAEFVDRRTAD-SEDTVVWWA MMAR_2226|M.marinum_M PTAESNALLERAREASRREAAAAAERLDVVGALFVLR--CRESGDRAEWA MUL_1813|M.ulcerans_Agy99 --------MERAREASRREAAAAAERLDVVGALFVLR--CRESGDRAEWA MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYR--LSRCSECEDWA MAB_4752|M.abscessus_ATCC_1997 -ELGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPE-DDTERANWA * : * ...: :. : : . Mflv_0314|M.gilvum_PYR-GCK LDNWDAVSAEVAAGQHTSLGVASNELLDAWTLRRRLPRVAEVFASGAISY Mvan_0426|M.vanbaalenii_PYR-1 LDNWDAVSAEVAAAQNVSPGVASNELLDAWAMRERLPRVAEVFATGAISY Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA MSMEG_3957|M.smegmatis_MC2_155 CDDWDAASAEVAAALNIGQRSASRLMRIAVALRDRLPLVAAQFAEGAVST MMAR_2226|M.marinum_M TDTWEAVAAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAGDIDY MUL_1813|M.ulcerans_Agy99 TDTWEAVGAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAEDIDY MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF * . ::::* .: : : :. ** *. * :. Mflv_0314|M.gilvum_PYR-GCK RLVKSVVKRTRLVVDPEVMAKIDAEIAAHIRGWGPLSVAKHEAEIDHWVD Mvan_0426|M.vanbaalenii_PYR-1 RLARTVVKRTRLIADRDARAKVDVEIAAQLTAWGSLSVAKQEAEIDDWVD Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID MSMEG_3957|M.smegmatis_MC2_155 RVVETLTWRTRLIDDTQTMAAVDAQLASRIAEFGAMTIAELEGAVDKVVD MMAR_2226|M.marinum_M RAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVA MUL_1813|M.ulcerans_Agy99 RAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVA MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE * : *: : * : :*. :. : :* : Mflv_0314|M.gilvum_PYR-GCK LYDPAAVVHAESAARSRHVDVTPAADGSGTCFVEAVLYAHDGEVMDRRLD Mvan_0426|M.vanbaalenii_PYR-1 RFDPSAVVRAEGSSRSRHVDVIPAKNGSGVCYVEAVLHSHDGEALDRRLE Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT MSMEG_3957|M.smegmatis_MC2_155 SVDPAAVRRTRTAVRSRGVWFGHPDDETGITSVHARLTNVDAVALKNRVG MMAR_2226|M.marinum_M DVDRDAVRRVAEAADGRFVDVDVIADGSGLAALTGSVLATAGRAFDRRLD MUL_1813|M.ulcerans_Agy99 DVDRDVVRRVAEAADGRFVDVDVIADGSGLAALAGSVLATAGRAFDRRLD MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTP--AGQGMVDVSARLTFEAGFAFXTRLD * : . * : . : . : . : *: Mflv_0314|M.gilvum_PYR-GCK DMARGVCLADPRTHEQRRADALAAIMNKADRLSCLCGAEDCEAGART--- Mvan_0426|M.vanbaalenii_PYR-1 ELARSVCDRDPRTKDQLRSDAIGAMAAKADRLMCLCGIDDCEAAQRT--- Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER MSMEG_3957|M.smegmatis_MC2_155 AMSSGQCPDDPRTKGQRLSDAMGVLGHYGDRLTCRCGDPECP-AAGIDPR MMAR_2226|M.marinum_M ELANTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADCT--AAARSA MUL_1813|M.ulcerans_Agy99 ELANTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADCT--AAARSA MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADCA--AGTRPA MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDCS--GRD-TA TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADTA :: * ***: * :**:..: ::: * * :* Mflv_0314|M.gilvum_PYR-GCK TSSVVVHVIAEESSLTDDTPVALNGDKP--ASPEP--------------- Mvan_0426|M.vanbaalenii_PYR-1 PSAVVVHVIAHEDSLTDDTPFAGHGERPPDAAVEPDVHPGEDPDEKAGQD Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLTP------------- Rv2100|M.tuberculosis_H37Rv AAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLTP------------- MSMEG_3957|M.smegmatis_MC2_155 AANTMVHVFAEPAAVHGPVDRYLDGDHESNPIPYFEP------------- MMAR_2226|M.marinum_M PSNVVIHVVADQSTVDG------TGHTP---------------------- MUL_1813|M.ulcerans_Agy99 PSKVVIHVVADQSTVDG------TGHTP---------------------- MAV_4456|M.avium_104 AGPVVIHLIAERASVEG------TGGGP---------------------- MAB_4752|M.abscessus_ATCC_1997 DVPVVVNVVINQSTLAG------SDDCP---------------------- TH_0334|M.thermoresistible__bu ATRLVINVIAEQATVEG------RSDNP---------------------- ::::. . :: . Mflv_0314|M.gilvum_PYR-GCK -------EPESEPKPEPS--RFESLLGP---VPAAGPAKTNPAVVLGGGL Mvan_0426|M.vanbaalenii_PYR-1 AAEAHDLQPDGEPRQEPGSGRGKDLLAP---PPATGPAKTKPAMILGGGM Mb2126|M.bovis_AF2122/97 -------ETTLFEALTPD-----PEPDP----PATHAP--AELITTGGGV Rv2100|M.tuberculosis_H37Rv -------ETTLFEALTPD-----PEPDP----PATHAP--AELITTGGGV MSMEG_3957|M.smegmatis_MC2_155 -------TPTPEPEPTPEPVRKPPEPEPKPWTPQSAHPGRGGAVVLGGGV MMAR_2226|M.marinum_M ------------------------------------------AVLLGAEG MUL_1813|M.ulcerans_Agy99 ------------------------------------------AVLLGAEG MAV_4456|M.avium_104 ------------------------------------------AVEVGAEG MAB_4752|M.abscessus_ATCC_1997 ------------------------------------------AHVPGFG- TH_0334|M.thermoresistible__bu ------------------------------------------GYLPGYGA * Mflv_0314|M.gilvum_PYR-GCK LPGPLLAATLAQTATIRRLVHPGDSPAEPRYVPSAKLADFVRCRDMTCRF Mvan_0426|M.vanbaalenii_PYR-1 LPAPLLAATVAHTATIKRLVHPGQSPPEPRYTPSQKLADFVRCRDMTCRF Mb2126|M.bovis_AF2122/97 VPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRF Rv2100|M.tuberculosis_H37Rv VPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRF MSMEG_3957|M.smegmatis_MC2_155 VPAPLVAQLIADGAKVKELTVPDDICAS--YRPSVAMDCFVRMRDMTCRF MMAR_2226|M.marinum_M LIPASLIAELAKVATLRPLMRPSGRP-ESGYAPSAGLAEFVRCRDLTCRA MUL_1813|M.ulcerans_Agy99 LIPASLIAELAKVATLRPLMRPSGRP-ESGYAPSAGLAEFVRCRDLTCRA MAV_4456|M.avium_104 LLPAQLVAELAASARLMPLVHPADAPPENRYTPSAALADFVRCRDLTCRW MAB_4752|M.abscessus_ATCC_1997 ----VLAAESARAAVAGTPTRNLTDSRSTGYRPSAKLAAFVRSRDQLCRF TH_0334|M.thermoresistible__bu VPASILRAKAAT-ATLRPVALP-QPCAEAGYRPSAALTRFIRCRDLTCRF : * . * ** : *:* ** ** Mflv_0314|M.gilvum_PYR-GCK PGCDVAAYSCDLDHTIAYPVG-PTQASNLACLCRKHHLLKTFWG-WRDVQ Mvan_0426|M.vanbaalenii_PYR-1 PGCDVPADRCDLDHTIAYPAG-PTQASNLKALCRKHHLLKTFWG-WRDAQ Mb2126|M.bovis_AF2122/97 PGCDVPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTGWRDVQ Rv2100|M.tuberculosis_H37Rv PGCDVPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTGWRDVQ MSMEG_3957|M.smegmatis_MC2_155 PGCSRPADFCDVDHTTPWPTG-VTHPSNTKCLCRIHHLLKTFWLGWSDRQ MMAR_2226|M.marinum_M PGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWD-WRDLQ MUL_1813|M.ulcerans_Agy99 RGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWG-WRDLQ MAV_4456|M.avium_104 PGCDRPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG-WREQQ MAB_4752|M.abscessus_ATCC_1997 PGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ-WTELQ TH_0334|M.thermoresistible__bu PGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLC-------VFHCRQAELR **. * .::**: .: * * :* * .* : : Mflv_0314|M.gilvum_PYR-GCK YPDGTVLWTSPGGQTFTTHPGSRVLFPSLCRPTAPVAVDAG--------- Mvan_0426|M.vanbaalenii_PYR-1 DCDGTVVWTSPGGQVFTTHPGSRLLFPALCRPTAPVVVSSA--------- Mb2126|M.bovis_AF2122/97 LPDGTVIWTAPNGHTYTTHPGSRIFFPTWHTTTAELPQTST--------- Rv2100|M.tuberculosis_H37Rv LPDGTVIWTAPNGHTYTTHPGSRIFFPTWHTTTAELPQTST--------- MSMEG_3957|M.smegmatis_MC2_155 LPDGTVIWTSPTGHVYTTVPASRALFPQWDTTTAALPPPPTPPP------ MMAR_2226|M.marinum_M LPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGGLPPIVGTAG------ MUL_1813|M.ulcerans_Agy99 LPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIVGTAGKPPRWP MAV_4456|M.avium_104 LPDATLILTSPAGRTYVTTPGSALLFPSLCVPTGEPARPVAAGS------ MAB_4752|M.abscessus_ATCC_1997 EPDGTVIWKSPTGHRYATTPVSWFLFP----------------------- TH_0334|M.thermoresistible__bu FTHDQHKHQSSCLPAYFQRPHG---------------------------- . . : * . Mflv_0314|M.gilvum_PYR-GCK -----VRAPTPSAPSGLGMPRRTQTRAQVRARRIHDQRA----------E Mvan_0426|M.vanbaalenii_PYR-1 -----DLAPAPGRPSGLGMPRRKQTRAQARARRIAEQRR----------E Mb2126|M.bovis_AF2122/97 -------AAVNVDARGLMMPRRRRTRAAELAHRINAERA----------L Rv2100|M.tuberculosis_H37Rv -------AAVNVDARGLMMPRRRRTRAAELAHRINAERA----------L MSMEG_3957|M.smegmatis_MC2_155 -----PMTPSEIAARAAMMPRRRRTRAAEEARRLAAERA----------R MMAR_2226|M.marinum_M ---------SPRAGRAARMPTRARTRAQNRANRIDTERR---------CN MUL_1813|M.ulcerans_Agy99 SGEDADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRS MAV_4456|M.avium_104 ---------QPCGERTAMMPTRRRTRGQNRAARVAAERR----------A MAB_4752|M.abscessus_ATCC_1997 ------------------ALTRHHTRQQARDRRRRTERN----------L TH_0334|M.thermoresistible__bu --------PATRRPPSARGLREAVPRQGVDPRRVSGQ------------- . : * Mflv_0314|M.gilvum_PYR-GCK NQALLE-GRNHAPPF----------------------------------- Mvan_0426|M.vanbaalenii_PYR-1 NEALLKTVQDDAPPF----------------------------------- Mb2126|M.bovis_AF2122/97 NDAYMA-ERNKPPSF----------------------------------- Rv2100|M.tuberculosis_H37Rv NDAYMA-ERNKPPSF----------------------------------- MSMEG_3957|M.smegmatis_MC2_155 NEAYLA-QRDRPPPDAHGPGMQ---------------------------- MMAR_2226|M.marinum_M RRALEAVGGVHADRYDTP---EPTIGPDEPPPF----------------- MUL_1813|M.ulcerans_Agy99 RRAAALLAATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARP MAV_4456|M.avium_104 NRAARLARATRPAPAASQS-WPAGHGPDADPPPF---------------- MAB_4752|M.abscessus_ATCC_1997 NREQRLQREAALAALAAK-----------DPPPF---------------- TH_0334|M.thermoresistible__bu -------------------------------------------------- Mflv_0314|M.gilvum_PYR-GCK ------ Mvan_0426|M.vanbaalenii_PYR-1 ------ Mb2126|M.bovis_AF2122/97 ------ Rv2100|M.tuberculosis_H37Rv ------ MSMEG_3957|M.smegmatis_MC2_155 ------ MMAR_2226|M.marinum_M ------ MUL_1813|M.ulcerans_Agy99 RACVAG MAV_4456|M.avium_104 ------ MAB_4752|M.abscessus_ATCC_1997 ------ TH_0334|M.thermoresistible__bu ------