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STPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNEL WINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIYV DKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITDF FRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQDQ LARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKFD VGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1302 | - | - | 100% (420) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_1301 | - | 0.0 | 73.81% (420) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_2021 | - | e-170 | 72.20% (410) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 2e-60 | 34.27% (426) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_5052 | - | 0.0 | 88.81% (420) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 2e-60 | 34.27% (426) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-38 | 29.71% (340) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 1e-164 | 67.48% (409) | cytochrome P450 |
| M. marinum M | MMAR_3999 | cyp108B4 | 1e-168 | 68.26% (419) | cytochrome P450 108B4 Cyp108B4 |
| M. avium 104 | MAV_1609 | - | 1e-175 | 71.60% (419) | cytochrome P450 family protein |
| M. smegmatis MC2 155 | MSMEG_1431 | - | 0.0 | 84.05% (420) | cytochrome P450-terp |
| M. thermoresistible (build 8) | TH_4183 | - | 0.0 | 87.38% (420) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 1e-168 | 68.26% (419) | cytochrome P450 108B4 Cyp108B4 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVR-DGAFAT
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVR-DGAFAT
Mvan_1302|M.vanbaalenii_PYR-1 ---------------MSTPVIDEAASDAARVLADPKAYTDEARLHAALAH
Mflv_5052|M.gilvum_PYR-GCK ---------------MSTPVID----DAAKVLAEPRAYAEEPRLHAALAH
TH_4183|M.thermoresistible__bu ---------------MSTPISSRLTDEAATVLADPQAYTDEDSLNAALTH
MSMEG_1431|M.smegmatis_MC2_155 MFLTPVKFSPSEVPDMSTPVIN----DAARVLAEPRAYADEPRLHAALAE
MMAR_3999|M.marinum_M ---------------MSAPTMD----EAA-LLADPLAYTDETRLHAALTR
MUL_3863|M.ulcerans_Agy99 ---------------MSAPTMD----EAA-LLADPLAYTDETRLHAALTR
MAV_1609|M.avium_104 ---------------MSTTTMD----EAAKLLADPMAYTDEQRLHAALTH
MAB_3825|M.abscessus_ATCC_1997 ---------------MATALSE--IEEAGRVLADPAAYADELRLHAAMTL
MLBr_02088|M.leprae_Br4923 ------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDP
. . : : :
Mb2289|M.bovis_AF2122/97 LRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPN-I
Rv2266|M.tuberculosis_H37Rv LRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPN-I
Mvan_1302|M.vanbaalenii_PYR-1 LRAHAPVSYVDVPDYR------PFWAVTKHSDIMAIERDNELWINEPRPL
Mflv_5052|M.gilvum_PYR-GCK LRANAPVAYVDVPDYY------PFWAVTKHADIMAIERANELWINEPRPM
TH_4183|M.thermoresistible__bu LRAHAPVSYVDVPNYR------PFWAITKHADIMDIERDNELWINAPRPM
MSMEG_1431|M.smegmatis_MC2_155 LRSQTPVAYVDVPGYY------PFWAITKHADVMAIERDNELFINAPRPM
MMAR_3999|M.marinum_M LRAQAPVALVDVPNYR------RFWAITRHADVMDIERDNTLFTNWPRPV
MUL_3863|M.ulcerans_Agy99 LRAQAPVALVDVPNYR------RFWAITRHADVMDIERDNTLFTNWPRPV
MAV_1609|M.avium_104 LRANAPVSWVEVPNYK------PFWAITKHADVMDIERENMLFTNWPRPV
MAB_3825|M.abscessus_ATCC_1997 LRREQPVTKVITDDYR------PFWAVTKHDDIMAVERDNALWINEPRPL
MLBr_02088|M.leprae_Br4923 GTRADPFPVYRALIDYG-PMQLPGMPLTVFSSFSDCDEALRHPLSASDRL
*.. . .:* . .. .. . . :
Mb2289|M.bovis_AF2122/97 TINDQTPELAEY-------FGSMIVLDDPRHQRLRSIVSRAFTPKVVARI
Rv2266|M.tuberculosis_H37Rv TINDQTPELAEY-------FGSMIVLDDPRHQRLRSIVSRAFTPKVVARI
Mvan_1302|M.vanbaalenii_PYR-1 LTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDL
Mflv_5052|M.gilvum_PYR-GCK LNTKATDDLAAANLANGGGLRTLIHMDDPLHRDIRKVGADWFRPKAMRAL
TH_4183|M.thermoresistible__bu LIPAATEDLAQANLAAGGGLRTLIHMDDPLHRDIRKIGADWFRPKAMRAL
MSMEG_1431|M.smegmatis_MC2_155 LITKEKDDLAKANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRAL
MMAR_3999|M.marinum_M LATVAGDELQAA-----AGVRTLIHLDDPQHRVARAIGADWFRPKAMRAL
MUL_3863|M.ulcerans_Agy99 LATVAGDELQAA-----AGVRTLIHLDDPQHRVARAIGADWFRPKAMRAL
MAV_1609|M.avium_104 LTTAEGDEMQAA-----AGVRTLIHMDDPQHRVVRAIGSDWFRPKAMRAL
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
::: :* * * * : : * **.: :
Mb2289|M.bovis_AF2122/97 EAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADH
Rv2266|M.tuberculosis_H37Rv EAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADH
Mvan_1302|M.vanbaalenii_PYR-1 KTRVDELAKIYVDKMVEKGPE--CDFVQEVAVNFPLYVILSLLGLPESDF
Mflv_5052|M.gilvum_PYR-GCK KERVDELAKRYVDRMVEIGPE--CDFVQEVAVNFPLYVILSLLGLPESDF
TH_4183|M.thermoresistible__bu KTRVDELARIYVDKMVEVGPE--CNFVQEVAVNFPLYVILSLLGLPESDF
MSMEG_1431|M.smegmatis_MC2_155 KERVDELAKIYVDKLVEKGPE--CDFVQEVAVNYPLYVILSLLGLPESDF
MMAR_3999|M.marinum_M KVRVDELAKNYVDAMMAAGPE--CDFVQQIAVNYPLYVIMSLLGLPEADF
MUL_3863|M.ulcerans_Agy99 KVRVDELAKNYVDAMMAAGPE--CDFVQQIAVNYPLYVIMSLLGLPEADF
MAV_1609|M.avium_104 KVRVDELAKIYVDKMLAAGPE--CDFVQEVAVNYPLYVIMSLLGLPEADF
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGS--CDFAQDIAVHFPLYVIMSLLGIPESDF
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAGQF---DVIADLAFPLAVAVICRLLGVPYEDA
: . :. . :. ::* .: :* ::*:* *
Mb2289|M.bovis_AF2122/97 QRIFHWTNVILGFGDPDLAT------DFDEFMQVSADIGAYATALAEDRR
Rv2266|M.tuberculosis_H37Rv QRIFHWTNVILGFGDPDLAT------DFDEFMQVSADIGAYATALAEDRR
Mvan_1302|M.vanbaalenii_PYR-1 GRMLKLTQEMFGGDDDELTRG----KSPEELHEVITDFFRYFTALTAERR
Mflv_5052|M.gilvum_PYR-GCK GRMLKLTQEMFGGDDDELSRG----KSAEELHEVITDFFRYFTKLTADRR
TH_4183|M.thermoresistible__bu PRMLKLTQEMFGGDDDEFTRG----KSPQELHEVITDFFRYFTKLTADRR
MSMEG_1431|M.smegmatis_MC2_155 DRMLKLTQELFGNDDDEMGRG----SSAEELNAVILDFFNYFTELTADRR
MMAR_3999|M.marinum_M PRMLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTTARR
MUL_3863|M.ulcerans_Agy99 PRMLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTTARR
MAV_1609|M.avium_104 PRMLKLTQELFGSDDSEFKRG----SSNEDQLPALLDMFGYFNGVTAARR
MAB_3825|M.abscessus_ATCC_1997 DRMLKLTQELFGGDDSEFQRG----TTPEEQLMALLDFFGYFSGLTASRR
MLBr_02088|M.leprae_Br4923 PEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRR
.: : : :. * : :: . : * :. **
Mb2289|M.bovis_AF2122/97 VNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVL
Rv2266|M.tuberculosis_H37Rv VNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVL
Mvan_1302|M.vanbaalenii_PYR-1 ANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGML
Mflv_5052|M.gilvum_PYR-GCK ENPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGLL
TH_4183|M.thermoresistible__bu ANPTEDLASAIANAKIDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGLL
MSMEG_1431|M.smegmatis_MC2_155 ANPTEDLASAIANAKLNGEYLNDVDCLSYYVIVASAGHDTTSAAISGGLL
MMAR_3999|M.marinum_M EHPTEDLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLH
MUL_3863|M.ulcerans_Agy99 AHPTADLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLH
MAV_1609|M.avium_104 EHPTEDLASAIANARVDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLQ
MAB_3825|M.abscessus_ATCC_1997 QHPTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLE
MLBr_02088|M.leprae_Br4923 GTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVL
** * : : .*: *.. : : :: **::** *: .:
Mb2289|M.bovis_AF2122/97 ALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGT
Rv2266|M.tuberculosis_H37Rv ALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGT
Mvan_1302|M.vanbaalenii_PYR-1 ALIENQDQLARLKAQPE-LMGTAVEEIIRWTTPVKEFMRTATADTEVRGV
Mflv_5052|M.gilvum_PYR-GCK ALIENQDQLARLKADPS-LMGTAVEEIIRWTAPVKEFMRTATADTEVRGV
TH_4183|M.thermoresistible__bu ALIENPDQLERLKAHPE-LMGTAVEEMIRWSTPVKEFMRTATRDTEVRGV
MSMEG_1431|M.smegmatis_MC2_155 ALTENQDQLARLKADMS-LMPLATEEIIRWSAPVKEFMRTATRDTEVRGV
MMAR_3999|M.marinum_M ALIEHPDQLARLQADPA-LIPLATEEMIRWVTPVKQFMRTASRDTVVRGI
MUL_3863|M.ulcerans_Agy99 ALIEHPDQLARLQADPA-LMSLATEEMIRWVTPVKQFMRTASSDTVVRGI
MAV_1609|M.avium_104 ALIENPDQLQRLRDNLD-LMPLATEEMIRWVTPVKEFMRTAAKDTVVRGV
MAB_3825|M.abscessus_ATCC_1997 ALLEHPDQLARLRENPG-LMPLAVDEMIRWVTPVKEFMRTATADTEIRGV
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
*: . .* . ..:* :*: ..: : *. : * :
Mb2289|M.bovis_AF2122/97 KMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLG
Rv2266|M.tuberculosis_H37Rv KMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLG
Mvan_1302|M.vanbaalenii_PYR-1 PIREGESVLLSYVSANRDEDIFDEPAKFDVGRDPNKHLSFGYG-VHFCLG
Mflv_5052|M.gilvum_PYR-GCK PIKKGEAVLLSYVSANRDEDVFDEPMRFDVGRDPNKHLSFGYG-VHFCLG
TH_4183|M.thermoresistible__bu PIKAGESVLLSYVSANRDEEVFDEPFRFDVGRDPNKHLSFGYG-VHFCLG
MSMEG_1431|M.smegmatis_MC2_155 PIKEGESVLLSYVSANRDEEIFENADKFDVGRDPNKHLSFGYG-VHFCLG
MMAR_3999|M.marinum_M PIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYG-VHFCMG
MUL_3863|M.ulcerans_Agy99 PIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYG-VHFCMG
MAV_1609|M.avium_104 PIAAGESVLLSYVSANRDEDVFDEPFRFDVGRDPNKHLAFGYG-VHFCMG
MAB_3825|M.abscessus_ATCC_1997 PITEGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFG-VHFCLG
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLG
: *: : * :.*** : . ** * .. *:.*. * ***:*
Mb2289|M.bovis_AF2122/97 ANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS--
Rv2266|M.tuberculosis_H37Rv ANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS--
Mvan_1302|M.vanbaalenii_PYR-1 AALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR
Mflv_5052|M.gilvum_PYR-GCK AALARMEINSFFTELLPRLESIELAGDPEFISTIFVGGLKHLPIRYSLR
TH_4183|M.thermoresistible__bu AALARMEINSFFTELVPRLESIELAGKPEFLATTFVGGLKHLPIRYSVR
MSMEG_1431|M.smegmatis_MC2_155 AALARMEINSFFTELIPRLESIELAGDPEFMATTFVGGLKHLPIRYSVR
MMAR_3999|M.marinum_M AALARMEVGSFFTELLPRLKSIELSGDPQFTATTFVGGLKHLPVSYSLV
MUL_3863|M.ulcerans_Agy99 AALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM
MAV_1609|M.avium_104 AALARMEVNSFFTELLPRLKSIELTGDPELVATTFVGGLKHLPVRYSLA
MAB_3825|M.abscessus_ATCC_1997 AALARMEVNSFFSALLPRLESIEVDGNIERTSTIFVGGIKHLPIRYTLR
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV---
* *** * : : :: .: . . : *:. **: