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SWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPGKGGGFHDGGFW AITKLNDVKEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVG RLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHI DPKASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGM MAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVF QDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHW QVDYTGRCPVAH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | - | 100% (433) | PROBABLE CYTOCHROME P450 125 CYP125 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 5e-82 | 42.03% (395) | cytochrome P450 124 CYP124 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 1e-63 | 36.17% (412) | cytochrome P450 126 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 0.0 | 100.00% (433) | cytochrome P450 125 |
| M. gilvum PYR-GCK | Mflv_3290 | - | 0.0 | 74.04% (416) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-33 | 27.55% (294) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | 0.0 | 76.32% (418) | putative cytochrome P450 |
| M. marinum M | MMAR_5032 | cyp125A7 | 0.0 | 90.41% (417) | cytochrome P450 125A7 Cyp125A7 |
| M. avium 104 | MAV_0616 | - | 0.0 | 82.73% (417) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_5995 | - | 0.0 | 75.47% (428) | P450 heme-thiolate protein |
| M. thermoresistible (build 8) | TH_1956 | - | 0.0 | 73.11% (409) | PROBABLE CYTOCHROME P450 125 CYP125 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 0.0 | 90.41% (417) | cytochrome P450 125A7 Cyp125A7 |
| M. vanbaalenii PYR-1 | Mvan_5258 | - | 0.0 | 74.29% (420) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3545c|M.tuberculosis_H37Rv MSWNHQSVEIAVRRTTVPSPN---LPPGFDFTDP----AIYAERLPVAEF
Mb3575c|M.bovis_AF2122/97 MSWNHQSVEIAVRRTTVPSPN---LPPGFDFTDP----AIYAERLPVAEF
MMAR_5032|M.marinum_M ----------------MPCPN---LPPGFDFTDP----DIYAERLPVEEF
MUL_4106|M.ulcerans_Agy99 ----------------MPCPN---LPPGFDFTDP----DIYAERLPVEEF
MSMEG_5995|M.smegmatis_MC2_155 ----------------MPTPN---IPSDFDFLDA----TLNLERLPVEEL
Mvan_5258|M.vanbaalenii_PYR-1 ----------------MPGPNSCPISPEFDFLDA----SLNLERLPVEEL
MAV_0616|M.avium_104 ----------------MPSPN---LPPGFDLLDP----DVCVKGLPVAEL
MAB_0613|M.abscessus_ATCC_1997 ----------------MVHPS---LPAGFDFTDP----EIYAERLPVEEL
Mflv_3290|M.gilvum_PYR-GCK ----------------MATPT---LPPGFDFTDP----DLNRERLPVEEL
TH_1956|M.thermoresistible__bu ----------------MPTPN---IPPGFDFTDP----DIYAVRLPVEEL
MLBr_02088|M.leprae_Br4923 --------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQM
*. : . :: . * ::
Rv3545c|M.tuberculosis_H37Rv AELRSAAPIWWNGQDPGKGGGFHDG-------GFWAITKLNDVKEISRHS
Mb3575c|M.bovis_AF2122/97 AELRSAAPIWWNGQDPGKGGGFHDG-------GFWAITKLNDVKEISRHS
MMAR_5032|M.marinum_M AELRSSEPIWWDEQLPGQGGGFHDG-------GFWAITKLKDVKEVSRRS
MUL_4106|M.ulcerans_Agy99 AELRSSEPIWWDEQFPGQGGGFHDG-------GFWAITKLKDVKEVSRRS
MSMEG_5995|M.smegmatis_MC2_155 AELRKSEPIHWVD-VPGGTGGFGDK-------GYWLVTKHADVKEVSRRS
Mvan_5258|M.vanbaalenii_PYR-1 AELRKSEPVHWVD-VPGGTGGFGDR-------GYWLVTKHADVKEVSKHN
MAV_0616|M.avium_104 AELRKSAPIYWMD-VPGGTGGFGDK-------GYWAITKHKDVKEISVRS
MAB_0613|M.abscessus_ATCC_1997 KELRKTAPIWWQE-QPDGVGGFNDG-------GYWVVTKHKDVKEVSLRS
Mflv_3290|M.gilvum_PYR-GCK AELRRCAPIWWNE-QPDGIGGFGDG-------GFWVVTKHHDVKEISKRS
TH_1956|M.thermoresistible__bu AELRRSAPIWWNE-QPMGAGGFDDG-------GFWLVTRHSDVKEVSRRS
MLBr_02088|M.leprae_Br4923 LLLRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHP
** * * . : .: * .* :
Rv3545c|M.tuberculosis_H37Rv DVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFT
Mb3575c|M.bovis_AF2122/97 DVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFT
MMAR_5032|M.marinum_M DVFSSYENGVIPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFT
MUL_4106|M.ulcerans_Agy99 DVFSSYENGVIPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFT
MSMEG_5995|M.smegmatis_MC2_155 DVFGSSPDGAIPVWPQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFT
Mvan_5258|M.vanbaalenii_PYR-1 EIFGSSPDGAIPVWPQEMTREAIDLQKAVLLNMDAPQHTRLRKIISRGFT
MAV_0616|M.avium_104 DIFSSQQDCAIPVWPKEMTREQIDLQRNVMLNMDAPHHTRLRKIISRGFT
MAB_0613|M.abscessus_ATCC_1997 DVFSSWENTAIPRFQDDITREAIELQRYVMLNMDAPHHTRLRKIISRGFT
Mflv_3290|M.gilvum_PYR-GCK DVFSSEVKTALPRYPEGSTGEQIETGSLVLLNMDAPRHTHLRKIISRGFT
TH_1956|M.thermoresistible__bu DVFSSQRKTALPRYRDGTVAEQIDRGKYVLLNMDAPHHTRLRKIISRAFT
MLBr_02088|M.leprae_Br4923 LSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFA
.. . .:. * :: :*.* **:***::*:.*:
Rv3545c|M.tuberculosis_H37Rv PRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVP
Mb3575c|M.bovis_AF2122/97 PRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVP
MMAR_5032|M.marinum_M PRAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIP
MUL_4106|M.ulcerans_Agy99 PRAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIP
MSMEG_5995|M.smegmatis_MC2_155 PRAIGRLEDELRSRAQKIAQTAAAQGAGDFVEQVSCELPLQAIAELLGVP
Mvan_5258|M.vanbaalenii_PYR-1 PRAVGRLEDELRARAQRIAATAATEGSGDFVEQVSCELPLQAIAELLGVP
MAV_0616|M.avium_104 PRAVGRLRDELDARAQNIAKTAAAAGAGDFVEQVSCELPLQAIAGLLGVP
MAB_0613|M.abscessus_ATCC_1997 PRAIGRLRDELNERAQEIAKAAAASGTGDFVEQVSCELPLQAIAGLLGVP
Mflv_3290|M.gilvum_PYR-GCK PRAVERLRDDLNARAQNIAKTAASAGSGDFVEQVSCELPLQAIAGLLGVP
TH_1956|M.thermoresistible__bu PRAVERLRDELNERAHRIVMEAAAAGSGDFVEQVACELPLQAIAGLMGVP
MLBr_02088|M.leprae_Br4923 PKVVQALEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVP
*:.: *..:: .. : .*: * *.: ::: *.: .*. *:*:*
Rv3545c|M.tuberculosis_H37Rv QEDRGKLFHWSNEMTGNED--------PEYAHIDPKASSAELIGYAMKMA
Mb3575c|M.bovis_AF2122/97 QEDRGKLFHWSNEMTGNED--------PEYAHIDPKASSAELIGYAMKMA
MMAR_5032|M.marinum_M QEDRGKLFDWSNEMTGTED--------PEFAHIDAKASSVELIGYAMKMA
MUL_4106|M.ulcerans_Agy99 QEDRGKLFDWSNEMTGTED--------PEFAHIDAKASSVELIGYAMKMA
MSMEG_5995|M.smegmatis_MC2_155 QDDRDKLFRWSNEMTAGED--------PEYADVDPAMSSFELISYAMKMA
Mvan_5258|M.vanbaalenii_PYR-1 QEDRDKLFRWSNEMTAGED--------PEYADVDPAMSSFELITYAMKMA
MAV_0616|M.avium_104 QEDRDKIFRWSNEMTGNED--------PEYAHIDPAMSSAELIMYAMKMA
MAB_0613|M.abscessus_ATCC_1997 IEDRGKLFNWSNEMTSYDD--------PEYADIDPAASSMEILAYSMEMA
Mflv_3290|M.gilvum_PYR-GCK VDDRKKLFDWSNQMVSDDD--------PEYAHYDNRNAATELIMYAMQLA
TH_1956|M.thermoresistible__bu QEDRKKLFDWSNQMVGDQD--------PEFADNDAIGASIELIGYGMQLA
MLBr_02088|M.leprae_Br4923 YEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLV
:* :: * :. * * * : :. : * ::.
Rv3545c|M.tuberculosis_H37Rv EEKAKNPADDIVTQLIQADIDGE-KLSDDEFGFFVVMLAVAGNETTRNSI
Mb3575c|M.bovis_AF2122/97 EEKAKNPADDIVTQLIQADIDGE-KLSDDEFGFFVVMLAVAGNETTRNSI
MMAR_5032|M.marinum_M EEKAKNPGDDIVTQLIQADIDGE-KLSDDEFGFFVVMLAVAGNETTRNSI
MUL_4106|M.ulcerans_Agy99 EEKAKNPGDDIVTQLIQADIDGE-KLSDDEFGFFVVMLAVAGNETTRNSI
MSMEG_5995|M.smegmatis_MC2_155 EERAVNPTEDIVTKLIEADIDGE-KLSDDEFGFFVVMLAVAGNETTRNSI
Mvan_5258|M.vanbaalenii_PYR-1 EERAKNPTEDIVTKLIEADIEGE-KLSDDEFGFFVVMLAVAGNETTRNSI
MAV_0616|M.avium_104 EERAKNPGDDIVTQLIQADLDGE-KLSDDEFGFFVVMLAVAGNETTRNSI
MAB_0613|M.abscessus_ATCC_1997 KQKAENPGEDIVTTLINAEVEGEGKLSDDEFGFFVIMLAVAGNETSRNSI
Mflv_3290|M.gilvum_PYR-GCK AVRAEQPGEDIVTKLIEADVDGH-KLSDDEFGFFMVLLAVAGNETTRNSI
TH_1956|M.thermoresistible__bu ADRQRNPRDDLVTTLVQADVDGH-KLSDDEFGFFVILLAVAGNETTRNSI
MLBr_02088|M.leprae_Br4923 KCRRGTPGEDLISRLIELDESGD-QLTEEEIIATCGLLLVAGHETTVNLI
: * :*::: *:: : .*. :*:::*: :* ***:**: * *
Rv3545c|M.tuberculosis_H37Rv TQGMMAFAEHPDQWELYKK--VRPETAADEIVRWATPVTAFQRTALRDYE
Mb3575c|M.bovis_AF2122/97 TQGMMAFAEHPDQWELYKK--VRPETAADEIVRWATPVTAFQRTALRDYE
MMAR_5032|M.marinum_M TQGMMAFADNPEQWELYKR--ERPETAADEIVRWATPVTSFQRTALEDYE
MUL_4106|M.ulcerans_Agy99 TQGMMAFADNPEQWELYKR--ERPGTAADEIVRWATPVTSFQRTALEDYE
MSMEG_5995|M.smegmatis_MC2_155 THGMIAFAQNPDQWELYKK--ERPETAADEIVRWATPVSAFQRTALEDVE
Mvan_5258|M.vanbaalenii_PYR-1 THGMIAFSRNPDQWELYKK--ERPETAADEIVRWATPVSAFQRTALEDTE
MAV_0616|M.avium_104 THGMIAFADNPDQWELFKK--ERPETAPDEIVRWATPVTAFQRTALEDYE
MAB_0613|M.abscessus_ATCC_1997 TQGMMAFTQFPEQWELYKK--ERPETAADEIVRWATPVTSFQRTALEDTE
Mflv_3290|M.gilvum_PYR-GCK THGMIAFTEHPDQWELYKR--ERPITAVDEIVRWATPVTSFQRTALTDYE
TH_1956|M.thermoresistible__bu TQGMMAFTEHPDQWELFKE--QRPPTTADEIVRWATPVTSFQRTALADVE
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMT
::.::*: *.**: . *. . :* :*: ..: : *.* *
Rv3545c|M.tuberculosis_H37Rv LSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAH
Mb3575c|M.bovis_AF2122/97 LSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAH
MMAR_5032|M.marinum_M LSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGAH
MUL_4106|M.ulcerans_Agy99 LSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGAH
MSMEG_5995|M.smegmatis_MC2_155 LGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHVGFGGTGAH
Mvan_5258|M.vanbaalenii_PYR-1 LGGVQIKKGQRVVMSYRSANFDEEVFENPHSFDIMRNPNPHVGFGGTGAH
MAV_0616|M.avium_104 LSGVQIKKGQRVVMFYRSANFDEEVFEDPHRFNILRNPNPHVGFGGTGAH
MAB_0613|M.abscessus_ATCC_1997 LDGVKIKKGQRVVMMYRSANFDEDVFEDPFSFNIMRNPNPHMGFGGSGAH
Mflv_3290|M.gilvum_PYR-GCK LSGVQITKGQRVVMSYRSANFDEEVFDDPFTFDILRDPNPHVGFGGTGAH
TH_1956|M.thermoresistible__bu LSGVQIKAGQRVVMCYRSANFDDTVFDDPYTFNILRDPNPHLGFGGTGAH
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGSH
:. . :. *: ::: :** * *:. * *: * .. *:.*. *:*
Rv3545c|M.tuberculosis_H37Rv YCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDY
Mb3575c|M.bovis_AF2122/97 YCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDY
MMAR_5032|M.marinum_M YCIGANLARMTINLIFNAVADHMPDLTPIAAPERLRSGWLNGIKHWQVDY
MUL_4106|M.ulcerans_Agy99 YCIGANLARMTINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVDY
MSMEG_5995|M.smegmatis_MC2_155 YCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNGIKHWQVDY
Mvan_5258|M.vanbaalenii_PYR-1 YCIGANLAKMTINLMFNAIADAMPDLKPIGDPERLKSGWLNGIKHWQVDY
MAV_0616|M.avium_104 YCIGANLARMTISLIFNAVADHMPDLKPLSAPERLRSGWLNGIKHWQVDY
MAB_0613|M.abscessus_ATCC_1997 YCIGANLARLTINLMFNAIADHMPNLAPAGDPKRLQSGWLNGIKHWQVDF
Mflv_3290|M.gilvum_PYR-GCK YCIGANLARMTIDLMFNAIADHMPDLSAIGSPDRLRSGWLNGIKHWQVDY
TH_1956|M.thermoresistible__bu YCIGANLARLTIDLIFAAIAEHLPDLRPLGPPERLRSGWLNGIKHWPVDY
MLBr_02088|M.leprae_Br4923 FCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV
:*:** **:: : : *:: :*:: . . :.*:. *:
Rv3545c|M.tuberculosis_H37Rv T-----------GRCPVAH-------
Mb3575c|M.bovis_AF2122/97 T-----------GRCPVAH-------
MMAR_5032|M.marinum_M T-----------GKCPVSH-------
MUL_4106|M.ulcerans_Agy99 T-----------GKCPVSH-------
MSMEG_5995|M.smegmatis_MC2_155 TGAGKASVSGAPGTCPVAH-------
Mvan_5258|M.vanbaalenii_PYR-1 T-----------GQCPVQH-------
MAV_0616|M.avium_104 T-----------GKCPVAH-------
MAB_0613|M.abscessus_ATCC_1997 TG---------ASGCPVLQ-------
Mflv_3290|M.gilvum_PYR-GCK SG----------RGCPVAH-------
TH_1956|M.thermoresistible__bu G----------APRVPTGAAGPQRCG
MLBr_02088|M.leprae_Br4923 --------------------------