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MTATQSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTAPVWWNEQADSIFDDGGYWVISRHEDVKAISRN STQWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEDRLADAAREIV RSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFHWTNAIMNTDDPEFDADPTMANAELMGYAYS MAEERRRCPADDIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDNPAQWELFKR ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPH LAFGGNGAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5151 | - | - | 100% (410) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3012 | - | e-140 | 59.36% (406) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5258 | - | e-137 | 56.31% (412) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 1e-139 | 57.07% (410) | cytochrome P450 125 |
| M. gilvum PYR-GCK | Mflv_1607 | - | 0.0 | 86.95% (406) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 1e-139 | 57.07% (410) | cytochrome P450 125 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-42 | 30.14% (345) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | 1e-136 | 55.42% (406) | putative cytochrome P450 |
| M. marinum M | MMAR_5032 | cyp125A7 | 1e-143 | 58.72% (407) | cytochrome P450 125A7 Cyp125A7 |
| M. avium 104 | MAV_2811 | - | 1e-146 | 60.64% (409) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_5853 | - | 0.0 | 79.81% (411) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_1263 | - | 0.0 | 77.94% (417) | PROBABLE CYTOCHROME P450 125 CYP125 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 1e-142 | 58.48% (407) | cytochrome P450 125A7 Cyp125A7 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3575c|M.bovis_AF2122/97 ----------MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPV
Rv3545c|M.tuberculosis_H37Rv ----------MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPV
MMAR_5032|M.marinum_M --------------------------MPCPNLPPGFDFTDPDIYAERLPV
MUL_4106|M.ulcerans_Agy99 --------------------------MPCPNLPPGFDFTDPDIYAERLPV
MAB_0613|M.abscessus_ATCC_1997 --------------------------MVHPSLPAGFDFTDPEIYAERLPV
MAV_2811|M.avium_104 ------------------MATVEPTTKPVPNLPPGFDFTDPDIYAERLPV
Mvan_5151|M.vanbaalenii_PYR-1 ------------------MTAT----QSCPFLPHGYDFTDPDVLLKGIPV
Mflv_1607|M.gilvum_PYR-GCK ------------------MTAEDARVQSCPFLPDGYDFTDPDVLLEGVPV
MSMEG_5853|M.smegmatis_MC2_155 ----------------------MATMNTCPFG-NGYDFTDPDVLFRGIPV
TH_1263|M.thermoresistible__bu MVGVERVPCHTKEVVAMSAAHSSPALGQSPFG-AGFDFTDPDVLLRGIPV
MLBr_02088|M.leprae_Br4923 ------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLL
. . * : : :
Mb3575c|M.bovis_AF2122/97 AEFAELRSAAPIWWNGQDPGKGGGFHDGGF--WAITKLNDVKEISRHS-D
Rv3545c|M.tuberculosis_H37Rv AEFAELRSAAPIWWNGQDPGKGGGFHDGGF--WAITKLNDVKEISRHS-D
MMAR_5032|M.marinum_M EEFAELRSSEPIWWDEQLPGQGGGFHDGGF--WAITKLKDVKEVSRRS-D
MUL_4106|M.ulcerans_Agy99 EEFAELRSSEPIWWDEQFPGQGGGFHDGGF--WAITKLKDVKEVSRRS-D
MAB_0613|M.abscessus_ATCC_1997 EELKELRKTAPIWWQEQPDGVGG-FNDGGY--WVVTKHKDVKEVSLRS-D
MAV_2811|M.avium_104 EELAEMRRVAPIWWNEQPIGAGG-FDDGGF--WVVTKHKDVKEVSLRS-D
Mvan_5151|M.vanbaalenii_PYR-1 TEFAELRRTAPVWWNEQAD---SIFDDGGY--WVISRHEDVKAISRNS-T
Mflv_1607|M.gilvum_PYR-GCK AEFAQLRRTAPVWWNAQQE---SIFDDGGY--WVVSRHEDIKSISRNS-A
MSMEG_5853|M.smegmatis_MC2_155 EEFAVLRKTAPVWWNQQGE---SIFDDGGY--WVISRHEDIKTISRDGGE
TH_1263|M.thermoresistible__bu REFAELRKTAPVWWCEQPE---TIFGDTGY--WVISRHEDIKNISRNS-D
MLBr_02088|M.leprae_Br4923 LRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHP-L
.: : : : * ..: .* .
Mb3575c|M.bovis_AF2122/97 VFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTP
Rv3545c|M.tuberculosis_H37Rv VFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTP
MMAR_5032|M.marinum_M VFSSYENGVIPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFTP
MUL_4106|M.ulcerans_Agy99 VFSSYENGVIPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFTP
MAB_0613|M.abscessus_ATCC_1997 VFSSWENTAIPRFQDDITREAIELQRYVMLNMDAPHHTRLRKIISRGFTP
MAV_2811|M.avium_104 VFSSLQKTALPRYKDGTVAEQVERGKFVLLNMDAPQHTRLRKIISRAFTP
Mvan_5151|M.vanbaalenii_PYR-1 QWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTP
Mflv_1607|M.gilvum_PYR-GCK LWSTNAKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTP
MSMEG_5853|M.smegmatis_MC2_155 VWSTNAKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKLVSRLFTP
TH_1263|M.thermoresistible__bu LWSTNRKGAVMVMPEGATPEQLELTKALLINHDPPEHTRLRKLVSRLFTP
MLBr_02088|M.leprae_Br4923 SASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP
* : .: * :: *.*.******::*: *:*
Mb3575c|M.bovis_AF2122/97 RAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQ
Rv3545c|M.tuberculosis_H37Rv RAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQ
MMAR_5032|M.marinum_M RAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQ
MUL_4106|M.ulcerans_Agy99 RAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQ
MAB_0613|M.abscessus_ATCC_1997 RAIGRLRDELNERAQEIAKAAAASGTGDFVEQVSCELPLQAIAGLLGVPI
MAV_2811|M.avium_104 RAVERLRDDLRERARRIVEAAAAEGSGDFVEQVSCELPLQAIASLMGVPQ
Mvan_5151|M.vanbaalenii_PYR-1 RAIAGMEDRLADAAREIVRSAAEKDSGDFVDDVAMMLPLQAIADLIGVPE
Mflv_1607|M.gilvum_PYR-GCK RAIAGMEAKLADSARQIVGEAADKAGGNFVDDVATLLPLQAIADLIGVPE
MSMEG_5853|M.smegmatis_MC2_155 RSVAALEEKLAVAAHDIVAEAKAEGSGNFVEDIAMKLPLLAIADLIGVPE
TH_1263|M.thermoresistible__bu RAVAELESKLAVAARDIVARARERGSGNFVEDIAMNLPLLAIADLIGVPE
MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPY
: : :. : . : . :.: ::: *.: .*. *:*:*
Mb3575c|M.bovis_AF2122/97 EDRGKLFHWSNEMTG--------NEDPEYAHIDPKASSAELIGYAMKMAE
Rv3545c|M.tuberculosis_H37Rv EDRGKLFHWSNEMTG--------NEDPEYAHIDPKASSAELIGYAMKMAE
MMAR_5032|M.marinum_M EDRGKLFDWSNEMTG--------TEDPEFAHIDAKASSVELIGYAMKMAE
MUL_4106|M.ulcerans_Agy99 EDRGKLFDWSNEMTG--------TEDPEFAHIDAKASSVELIGYAMKMAE
MAB_0613|M.abscessus_ATCC_1997 EDRGKLFNWSNEMTS--------YDDPEYADIDPAASSMEILAYSMEMAK
MAV_2811|M.avium_104 EDRKKLFHWSNEMVG--------DQDPEFASNDAITASVELIMYGMQMAA
Mvan_5151|M.vanbaalenii_PYR-1 EDREKLFHWTNAIMN--------TDDPEFD-ADPTMANAELMGYAYSMAE
Mflv_1607|M.gilvum_PYR-GCK EDREKLFHWSNAIMN--------TDDPDFD-SDPTIANAELMGYAYTMAE
MSMEG_5853|M.smegmatis_MC2_155 ADREKIFAWSNAIIN--------TDDPDFD-SDPTVANAELMGYAYTMAE
TH_1263|M.thermoresistible__bu EDREKVFHWSNCIIN--------TDDPDFD-SDPTAANAELMGYAYTMAE
MLBr_02088|M.leprae_Br4923 EDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVK
* :. : : :* : :. : * :.
Mb3575c|M.bovis_AF2122/97 EKAKNPADDIVTQLIQADID--GE-KLSDDEFGFFVVMLAVAGNETTRNS
Rv3545c|M.tuberculosis_H37Rv EKAKNPADDIVTQLIQADID--GE-KLSDDEFGFFVVMLAVAGNETTRNS
MMAR_5032|M.marinum_M EKAKNPGDDIVTQLIQADID--GE-KLSDDEFGFFVVMLAVAGNETTRNS
MUL_4106|M.ulcerans_Agy99 EKAKNPGDDIVTQLIQADID--GE-KLSDDEFGFFVVMLAVAGNETTRNS
MAB_0613|M.abscessus_ATCC_1997 QKAENPGEDIVTTLINAEVE--GEGKLSDDEFGFFVIMLAVAGNETSRNS
MAV_2811|M.avium_104 DRAKNPGEDLVTKLVQADID--GH-KLSDDEFGFFVILLAVAGNETTRNS
Mvan_5151|M.vanbaalenii_PYR-1 ERRRCPADDIVTRLVQADID---GESLGEVEFAFFVILLAVAGNETTRNA
Mflv_1607|M.gilvum_PYR-GCK QRRRCPADDIVTRLVEADLD---GDALGEVEFAFFVILLAVAGNETTRNA
MSMEG_5853|M.smegmatis_MC2_155 ERRRCPADDIVTRLVQADV---SGESLGEVEFAFFVILLAVAGNETTRNA
TH_1263|M.thermoresistible__bu QRRRHPQDDIVTRLVQADLEDGSGEALGEVEFAFFVILLAVAGNETTRNA
MLBr_02088|M.leprae_Br4923 CRRGTPGEDLISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNL
: * :*::: *:: : * : *: :* ***:**: *
Mb3575c|M.bovis_AF2122/97 ITQGMMAFAEHPDQWELYKK--VRPETAADEIVRWATPVTAFQRTALRDY
Rv3545c|M.tuberculosis_H37Rv ITQGMMAFAEHPDQWELYKK--VRPETAADEIVRWATPVTAFQRTALRDY
MMAR_5032|M.marinum_M ITQGMMAFADNPEQWELYKR--ERPETAADEIVRWATPVTSFQRTALEDY
MUL_4106|M.ulcerans_Agy99 ITQGMMAFADNPEQWELYKR--ERPGTAADEIVRWATPVTSFQRTALEDY
MAB_0613|M.abscessus_ATCC_1997 ITQGMMAFTQFPEQWELYKK--ERPETAADEIVRWATPVTSFQRTALEDT
MAV_2811|M.avium_104 ITQGMMAFTDFPDQWELFKR--ERPATAADEIVRWATPVTSFQRTALQDY
Mvan_5151|M.vanbaalenii_PYR-1 MTHGMNAFFDNPAQWELFKR--ERPETAIDEIIRWATPVHCFQRTALEDV
Mflv_1607|M.gilvum_PYR-GCK MTHGMNAFLDHPDQWELFKR--ERPETAIDEIIRWATPVHCFQRTALDDV
MSMEG_5853|M.smegmatis_MC2_155 ITHGMNAFFENPDQWELFKR--ERPITAVDEIVRWATPVHCFQRTAVVDT
TH_1263|M.thermoresistible__bu MTHGMNAFFENPDQWELFKR--ERPETAIDEIVRWSTPVHCFQRTALADV
MLBr_02088|M.leprae_Br4923 IANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDM
:::.: *: * **: . *. . :* :*: ..: : *.* *
Mb3575c|M.bovis_AF2122/97 ELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGA
Rv3545c|M.tuberculosis_H37Rv ELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGA
MMAR_5032|M.marinum_M ELSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGA
MUL_4106|M.ulcerans_Agy99 ELSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGA
MAB_0613|M.abscessus_ATCC_1997 ELDGVKIKKGQRVVMMYRSANFDEDVFEDPFSFNIMRNPNPHMGFGGSGA
MAV_2811|M.avium_104 ELSGVKIKKGQRVVMFYRSANFDEDVFDDPFTFNILRDPNPHVGFGGTGA
Mvan_5151|M.vanbaalenii_PYR-1 EVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPHLAFGGNGA
Mflv_1607|M.gilvum_PYR-GCK EIGGVTVARGQRVGLFYSSANFDEDVFDNPFNFDILRNPNPHLAFGGNGA
MSMEG_5853|M.smegmatis_MC2_155 EIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGFGGNGA
TH_1263|M.thermoresistible__bu EIGGVTIREGERAGLFYSSANYDEEVFDRPFEFDILRDPNPHLGFGGHGA
MLBr_02088|M.leprae_Br4923 TIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGS
:. . : *: :: :** * *:. * *: * .. *:.*. *:
Mb3575c|M.bovis_AF2122/97 HYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVD
Rv3545c|M.tuberculosis_H37Rv HYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVD
MMAR_5032|M.marinum_M HYCIGANLARMTINLIFNAVADHMPDLTPIAAPERLRSGWLNGIKHWQVD
MUL_4106|M.ulcerans_Agy99 HYCIGANLARMTINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVD
MAB_0613|M.abscessus_ATCC_1997 HYCIGANLARLTINLMFNAIADHMPNLAPAGDPKRLQSGWLNGIKHWQVD
MAV_2811|M.avium_104 HYCIGANLARMTIDLMFNAIADAMPDLESIGKPERLRSGWLNGIKHWQVD
Mvan_5151|M.vanbaalenii_PYR-1 HFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVA
Mflv_1607|M.gilvum_PYR-GCK HYCIGANLARMEIKLMFEAIADRLPDISKRAEPQRLRSGWINGVKDLQVA
MSMEG_5853|M.smegmatis_MC2_155 HYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVKDLQVS
TH_1263|M.thermoresistible__bu HYCIGANLARMEIKLIFNEIADQIPDIAKLSEPVRLRSGWLNGVKELRVS
MLBr_02088|M.leprae_Br4923 HFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQ
*:*:** ***: : :. :: :*:: . . :.*:. *
Mb3575c|M.bovis_AF2122/97 Y--TGR--CPVAH
Rv3545c|M.tuberculosis_H37Rv Y--TGR--CPVAH
MMAR_5032|M.marinum_M Y--TGK--CPVSH
MUL_4106|M.ulcerans_Agy99 Y--TGK--CPVSH
MAB_0613|M.abscessus_ATCC_1997 F--TGASGCPVLQ
MAV_2811|M.avium_104 YHTNGSSKCPVAH
Mvan_5151|M.vanbaalenii_PYR-1 Y--R---------
Mflv_1607|M.gilvum_PYR-GCK Y--R---------
MSMEG_5853|M.smegmatis_MC2_155 Y--RG--------
TH_1263|M.thermoresistible__bu Y--VG--------
MLBr_02088|M.leprae_Br4923 V------------