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MPADAITLGGADLADPDTYLAGMPYDAFRTLRREAPVAWHPQVDKPGFWALTGYDEIYAVSRDSETWSSQ ATGVFLDVPAPEDSYQLALMMLTMDPPRHTALRALVSRGFTPRHVARLGARTADMARAIVDDALAHGQCE FVDEVAGALPSYVIAELLGIPLEDGRRLYTLTDIMNTRPLHDPELVAAQMQMFEYAAELAARKRSEPGDD IATALLHAEVDGRRLTDLEFNLFFLLLINAGGDTTRNLVAAGTLALIEHPDQWRRLAADPSLMPTAVEEM LRWTSPVTVFSRTATRDTDVGGIRLREGERVAMFYPSANRDEKHFADPDRFDIGRMPNPHLAFGGGGTHF CLGASLARVEAAAIFRELITRTREIGLVGPVERVRSVLMNGIRSMPAQFTPAVVPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0425 | - | - | 100% (406) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1607 | - | 2e-83 | 41.10% (399) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1908 | - | 3e-83 | 42.65% (408) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 3e-80 | 40.05% (407) | cytochrome P450 125 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 3e-80 | 40.05% (407) | cytochrome P450 125 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-48 | 32.34% (402) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1211c | - | 1e-79 | 41.09% (404) | cytochrome P450 |
| M. marinum M | MMAR_5032 | cyp125A7 | 2e-79 | 39.66% (406) | cytochrome P450 125A7 Cyp125A7 |
| M. avium 104 | MAV_1339 | - | 6e-81 | 43.73% (391) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_5853 | - | 6e-83 | 41.00% (400) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_1956 | - | 1e-81 | 39.71% (408) | PROBABLE CYTOCHROME P450 125 CYP125 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 3e-79 | 39.66% (406) | cytochrome P450 125A7 Cyp125A7 |
| M. vanbaalenii PYR-1 | Mvan_0246 | - | 0.0 | 83.00% (406) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0425|M.gilvum_PYR-GCK ----------------MPADAITLGGADLADPDTYLAGMPYDAFRTLRRE
Mvan_0246|M.vanbaalenii_PYR-1 ----------------MATDAISIGGVDLADPDTYVGGMPHGAFRELRRH
MMAR_5032|M.marinum_M ----------------MPCPNLPPG-FDFTDPDIYAERLPVEEFAELRSS
MUL_4106|M.ulcerans_Agy99 ----------------MPCPNLPPG-FDFTDPDIYAERLPVEEFAELRSS
Mb3575c|M.bovis_AF2122/97 MSWNHQSVEIAVRRTTVPSPNLPPG-FDFTDPAIYAERLPVAEFAELRSA
Rv3545c|M.tuberculosis_H37Rv MSWNHQSVEIAVRRTTVPSPNLPPG-FDFTDPAIYAERLPVAEFAELRSA
TH_1956|M.thermoresistible__bu ----------------MPTPNIPPG-FDFTDPDIYAVRLPVEELAELRRS
MSMEG_5853|M.smegmatis_MC2_155 -------------MATMNTCPFGNG-YDFTDPDVLFRGIPVEEFAVLRKT
MAB_1211c|M.abscessus_ATCC_199 ----------MTAMKTAAELGLPEG-FDFTDPELYGNRMPHEEFATLRRE
MAV_1339|M.avium_104 ---------------MQTHPPLRSPSFPLHSPDFYAG-NPYPAYRELRAT
MLBr_02088|M.leprae_Br4923 ---MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTR
*
Mflv_0425|M.gilvum_PYR-GCK AP--VAWHPQ-------VDKPGFWALTGYDEIYAVSRDS-ETWSSQATGV
Mvan_0246|M.vanbaalenii_PYR-1 AP--VAWHPY-------GDNPGFWALTGYDEVLAVSRDS-RTWSSQTTGV
MMAR_5032|M.marinum_M EP--IWWDEQLPGQGGGFHDGGFWAITKLKDVKEVSRRS-DVFSSYENGV
MUL_4106|M.ulcerans_Agy99 EP--IWWDEQFPGQGGGFHDGGFWAITKLKDVKEVSRRS-DVFSSYENGV
Mb3575c|M.bovis_AF2122/97 AP--IWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHS-DVFSSYENGV
Rv3545c|M.tuberculosis_H37Rv AP--IWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHS-DVFSSYENGV
TH_1956|M.thermoresistible__bu AP--IWWNEQ-PMGAGGFDDGGFWLVTRHSDVKEVSRRS-DVFSSQRKTA
MSMEG_5853|M.smegmatis_MC2_155 AP--VWWNQQ---GESIFDDGGYWVISRHEDIKTISRDGGEVWSTNAKGA
MAB_1211c|M.abscessus_ATCC_199 AP--VWWNPQ-PRTVGGFADEGYWVISKHRDVREVSLHT-DTFSSGRKGA
MAV_1339|M.avium_104 AP--VCWNDV----------TNFWALLKYEDIRFVSSNP-ALFTSTRGIT
MLBr_02088|M.leprae_Br4923 ADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHP-LSASDRLKAT
: . : : .
Mflv_0425|M.gilvum_PYR-GCK FLDVP---APEDSYQLALMMLTMDPPRHTALRALVSRGFTPRHVARLGAR
Mvan_0246|M.vanbaalenii_PYR-1 FLDVP---APEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNAR
MMAR_5032|M.marinum_M IPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFTPRAIGRLHDE
MUL_4106|M.ulcerans_Agy99 IPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFTPRAIGRLHDE
Mb3575c|M.bovis_AF2122/97 IPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDE
Rv3545c|M.tuberculosis_H37Rv IPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDE
TH_1956|M.thermoresistible__bu LPRYRDGTVAEQIDRGKYVLLNMDAPHHTRLRKIISRAFTPRAVERLRDE
MSMEG_5853|M.smegmatis_MC2_155 VMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKLVSRLFTPRSVAALEEK
MAB_1211c|M.abscessus_ATCC_199 IPRLEDHISPEEFQATLSVLINKDAPEHTQLRGLVSRMFTPRSIAALRIT
MAV_1339|M.avium_104 IPDPQ---LPNPVQQG--SLIFTDPPRHRQLRKLINSGFTRRRVSVLEPK
MLBr_02088|M.leprae_Br4923 LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGD
. : :: *.* * ** ::. *: : : *
Mflv_0425|M.gilvum_PYR-GCK TADMARAIVDDALAHGQCEFVDEVAGALPSYVIAELLGIPLEDGRRLYTL
Mvan_0246|M.vanbaalenii_PYR-1 TADMARDILDAALQRGECEFVDDVAGALPSYVIAELLGIPLDDGRRLYAL
MMAR_5032|M.marinum_M LNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQEDRGKLFDW
MUL_4106|M.ulcerans_Agy99 LNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQEDRGKLFDW
Mb3575c|M.bovis_AF2122/97 LQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHW
Rv3545c|M.tuberculosis_H37Rv LQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHW
TH_1956|M.thermoresistible__bu LNERAHRIVMEAAAAGSGDFVEQVACELPLQAIAGLMGVPQEDRKKLFDW
MSMEG_5853|M.smegmatis_MC2_155 LAVAAHDIVAEAKAEGSGNFVEDIAMKLPLLAIADLIGVPEADREKIFAW
MAB_1211c|M.abscessus_ATCC_199 LEERAERIVRAALEGGHGEFVREVASELPMQAIAELIGVPEEDRVKLFEW
MAV_1339|M.avium_104 IREIVRGILDGIERGAVHEFAEQIAAPLPTRMIAELIGAPPDDWEQFRAW
MLBr_02088|M.leprae_Br4923 IAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
. : . :. ::: *. *. *:* * * .:
Mflv_0425|M.gilvum_PYR-GCK TDIMN-----------TRPLHDPELVAAQMQMFEYAAELAARKRSEPGDD
Mvan_0246|M.vanbaalenii_PYR-1 TEIMN-----------TRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD
MMAR_5032|M.marinum_M SNEMTG--------TEDPEFAHIDAKASSVELIGYAMKMAEEKAKNPGDD
MUL_4106|M.ulcerans_Agy99 SNEMTG--------TEDPEFAHIDAKASSVELIGYAMKMAEEKAKNPGDD
Mb3575c|M.bovis_AF2122/97 SNEMTG--------NEDPEYAHIDPKASSAELIGYAMKMAEEKAKNPADD
Rv3545c|M.tuberculosis_H37Rv SNEMTG--------NEDPEYAHIDPKASSAELIGYAMKMAEEKAKNPADD
TH_1956|M.thermoresistible__bu SNQMVG--------DQDPEFADNDAIGASIELIGYGMQLAADRQRNPRDD
MSMEG_5853|M.smegmatis_MC2_155 SNAIIN--------TDDPDFD-SDPTVANAELMGYAYTMAEERRRCPADD
MAB_1211c|M.abscessus_ATCC_199 SNQMTG--------YDEADVE-IDPRVGAAQILGYSYQLAEQRRDCPGND
MAV_1339|M.avium_104 SDAATG--------TADPEIE-LDPAVAAGQLYEYFQRLIAARRARPRAD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
: : : * : : * *
Mflv_0425|M.gilvum_PYR-GCK IATALLHAEVDGRRLTDLEFNLFFLLLINAGGDTTRNLVAAGTLALIEHP
Mvan_0246|M.vanbaalenii_PYR-1 IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHP
MMAR_5032|M.marinum_M IVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFADNP
MUL_4106|M.ulcerans_Agy99 IVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFADNP
Mb3575c|M.bovis_AF2122/97 IVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHP
Rv3545c|M.tuberculosis_H37Rv IVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHP
TH_1956|M.thermoresistible__bu LVTTLVQADVDGHKLSDDEFGFFVILLAVAGNETTRNSITQGMMAFTEHP
MSMEG_5853|M.smegmatis_MC2_155 IVTRLVQADVSGESLGEVEFAFFVILLAVAGNETTRNAITHGMNAFFENP
MAB_1211c|M.abscessus_ATCC_199 VVSRLLTGTVDGEQLTPEQFGFFVVMLSVAGNETTRNATTMGMMAFLEHP
MAV_1339|M.avium_104 LLSVLAEAEIDEHRLTDEDLLNFAFLLLVAGNETTRNLIALGTLALIAHP
MLBr_02088|M.leprae_Br4923 LISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNP
: : * . * :: :* ** :** * : . *: :*
Mflv_0425|M.gilvum_PYR-GCK DQWRRLAADPSLMPTAVEEMLRWTSPVTVFSRTATRDTDVGGIRLREGER
Mvan_0246|M.vanbaalenii_PYR-1 EQWARLAADPSLMPTAIEEMLRWTSPVNVFTRTATRDTEVGGVPLRAGER
MMAR_5032|M.marinum_M EQWELYKRER--PETAADEIVRWATPVTSFQRTALEDYELSGVQIKKGQR
MUL_4106|M.ulcerans_Agy99 EQWELYKRER--PGTAADEIVRWATPVTSFQRTALEDYELSGVQIKKGQR
Mb3575c|M.bovis_AF2122/97 DQWELYKKVR--PETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQR
Rv3545c|M.tuberculosis_H37Rv DQWELYKKVR--PETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQR
TH_1956|M.thermoresistible__bu DQWELFKEQR--PPTTADEIVRWATPVTSFQRTALADVELSGVQIKAGQR
MSMEG_5853|M.smegmatis_MC2_155 DQWELFKRER--PITAVDEIVRWATPVHCFQRTAVVDTEIGGVPIKAGQR
MAB_1211c|M.abscessus_ATCC_199 GQWELFKSAR--PSTTVDEIVRYTSPLISQQRTALQDTVISDVRIRAGER
MAV_1339|M.avium_104 DQYRLLVEEPARIPLAVEEMLRWNSPVVHMARTATADVEIRGQRIRAGEV
MLBr_02088|M.leprae_Br4923 SQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDT
*: . :* :*: ..: *.* * : : *:
Mflv_0425|M.gilvum_PYR-GCK VAMFYPSANRDEKHFA-DPDRFDIGRMPNPHLAFGGGGTHFCLGASLARV
Mvan_0246|M.vanbaalenii_PYR-1 VAMFYPSANRDEKHFA-DPDRFDIGRAPNHHLAFGGGGTHFCLGASLARV
MMAR_5032|M.marinum_M VLMFYRSANFDEEVFE-DPFSFNILRNPNPHVGFGGTGAHYCIGANLARM
MUL_4106|M.ulcerans_Agy99 VLMFYRSANFDEEVFE-DPFSFNILRNPNPHVGFGGTGAHYCIGANLARM
Mb3575c|M.bovis_AF2122/97 VVMFYRSANFDEEVFQ-DPFTFNILRNPNPHVGFGGTGAHYCIGANLARM
Rv3545c|M.tuberculosis_H37Rv VVMFYRSANFDEEVFQ-DPFTFNILRNPNPHVGFGGTGAHYCIGANLARM
TH_1956|M.thermoresistible__bu VVMCYRSANFDDTVFD-DPYTFNILRDPNPHLGFGGTGAHYCIGANLARL
MSMEG_5853|M.smegmatis_MC2_155 AGLFYSSANYDEDVFD-DPFRFDILRDPNPHLGFGGNGAHYCIGANLARM
MAB_1211c|M.abscessus_ATCC_199 VVMLYPSANFDEEVFE-NPHTFDITRDPNPHLGFGGTGAHYCLGANLAKA
MAV_1339|M.avium_104 VVMLYGSANRDEDVFGPDSEEFDVTRHPNPHIAFG-CGEHSCVGAQLARL
MLBr_02088|M.leprae_Br4923 MVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLAFA-VGSHFCLGAALARL
: :** * : . *: * .. *:.*. * * *:** **:
Mflv_0425|M.gilvum_PYR-GCK EAAAIFRELITRTREIGLVGPVERVRSVLMNGIRSMPAQFTPAVVPA---
Mvan_0246|M.vanbaalenii_PYR-1 EATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA---
MMAR_5032|M.marinum_M TINLIFNAVADHMPDLTPIAAPERLRSGWLNGIKHWQVDYTG-KCPVSH-
MUL_4106|M.ulcerans_Agy99 TINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVDYTG-KCPVSH-
Mb3575c|M.bovis_AF2122/97 TINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTG-RCPVAH-
Rv3545c|M.tuberculosis_H37Rv TINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTG-RCPVAH-
TH_1956|M.thermoresistible__bu TIDLIFAAIAEHLPDLRPLGPPERLRSGWLNGIKHWPVDYGAPRVPTGAA
MSMEG_5853|M.smegmatis_MC2_155 EIRLMFDEIADQIPDITKVGEPQRLRSGWINGVKDLQVSYRG--------
MAB_1211c|M.abscessus_ATCC_199 ELEIIFNKIADRMPDISRIGDAPRFHSGWINGIKKFDTAYCP----VTH-
MAV_1339|M.avium_104 EATVFFEELLRRYPRIELVGEVDRMRATMVPGVKRMPVRMGA--------
MLBr_02088|M.leprae_Br4923 EATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV----------
: : : : . : *: .
Mflv_0425|M.gilvum_PYR-GCK ------
Mvan_0246|M.vanbaalenii_PYR-1 ------
MMAR_5032|M.marinum_M ------
MUL_4106|M.ulcerans_Agy99 ------
Mb3575c|M.bovis_AF2122/97 ------
Rv3545c|M.tuberculosis_H37Rv ------
TH_1956|M.thermoresistible__bu GPQRCG
MSMEG_5853|M.smegmatis_MC2_155 ------
MAB_1211c|M.abscessus_ATCC_199 ------
MAV_1339|M.avium_104 ------
MLBr_02088|M.leprae_Br4923 ------