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TETTSDQADSTFVDSSRERSSALFGAGEFFRVGNYAPVADELTAFDLPVEGAIPSELDGWYLRNGPNPRQ PTGHWFTGDGMIHGVRIENGRAAWYRNRWVRTDSFVDPFPLYNADGTRNLRASVANTHVVNHAGKTLALV ESSLPYEITNDLETVGAYDFGGKLVDAMTAHPKICPTTGELHFFGYGNIFTPHVTYHRADANGELVIDRP LDVPALTMMHDFALTANYVVFMDLPIVFNVDIAVSGRGDMPYRWDDGYGARFGVLRRDDPFGQVRWFDID PCYIFHVANAHDDGRTLVLQAVRYPELWRENGGFDADGVMWTWTIDLQNGTVRESQLDDRVVEFPRIDDR LATLPARYAVSVGDAGLIRHDLVTGAAVEHRFGTDSAPGGPGEAVFVPSTSGPADESSGWYLGYVYDPER DGSDLVIIDASDFGAPPVAKIKLPQRVPYGFHGNWISA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5460 | - | - | 100% (459) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_4595 | - | 2e-90 | 40.75% (481) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_4940 | - | 4e-49 | 31.67% (502) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0673 | - | 1e-81 | 39.47% (489) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1332 | - | 0.0 | 82.51% (463) | carotenoid oxygenase |
| M. tuberculosis H37Rv | Rv0654 | - | 1e-81 | 39.47% (489) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 8e-76 | 36.59% (492) | putative dioxygenase |
| M. marinum M | MMAR_0993 | - | 1e-78 | 39.18% (485) | dioxygenase |
| M. avium 104 | MAV_0560 | - | 6e-88 | 41.05% (475) | carotenoid oxygenase |
| M. smegmatis MC2 155 | MSMEG_6224 | - | 0.0 | 78.34% (434) | retinal pigment epithelial membrane protein |
| M. thermoresistible (build 8) | TH_3959 | - | 4e-91 | 41.29% (482) | PUTATIVE Carotenoid oxygenase |
| M. ulcerans Agy99 | MUL_0744 | - | 1e-78 | 39.18% (485) | dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0560|M.avium_104 ---------MA-----------------NRYLQGPFAPMHHEYTLTGLEV
TH_3959|M.thermoresistible__bu ---------VS-----------------NRYLTGAFAPLTEEYTLTDLEV
Mb0673|M.bovis_AF2122/97 -MTTAQAAESQ-----------------NPYLEGFLAPVSTEVTATDLPV
Rv0654|M.tuberculosis_H37Rv -MTTAQAAESQ-----------------NPYLEGFLAPVSTEVTATDLPV
MMAR_0993|M.marinum_M -MTTMRSAQPR-----------------NPYLEGFLAPVRAEVTATDLEV
MUL_0744|M.ulcerans_Agy99 -MTTMRSAQPR-----------------NPYLEGFLAPVRAEVTATDLEV
MAB_3874c|M.abscessus_ATCC_199 MTATAQPAAST-----------------SPYLSGIWEPVQQEMDSVDLEV
Mvan_5460|M.vanbaalenii_PYR-1 MTETTSDQADSTFVDSSRERSSALFGAGEFFRVGNYAPVADELTAFDLPV
Mflv_1332|M.gilvum_PYR-GCK MTETAPDQTES---------------ARSIFEVGNYAPVPDELTTFDLPV
MSMEG_6224|M.smegmatis_MC2_155 MTDTDLTNLPG---------------TGEFFRRGNYAPVPDELTDYDLPV
. : * *: * .* *
MAV_0560|M.avium_104 VGTIPDYLDGRYLRNGANPIGDVDPERYHWFLGDGMVHGIRIRDGKAEWY
TH_3959|M.thermoresistible__bu TGTIPDYLDGRYLRNGPNPVGEIDPELYHWFVGDGMVHGIRLRDGRAEWY
Mb0673|M.bovis_AF2122/97 TGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWY
Rv0654|M.tuberculosis_H37Rv TGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWY
MMAR_0993|M.marinum_M TGRIPDYLDGRYLRNGPNPVAEVNPATYHWFTGDGMVHGVALRDGRASWY
MUL_0744|M.ulcerans_Agy99 TGRIPDYLDGRYLRNGPNPVAEVNPATYHWFTGDGMVHGVALRDGRASWY
MAB_3874c|M.abscessus_ATCC_199 TGTLPAHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQWY
Mvan_5460|M.vanbaalenii_PYR-1 EGAIPSELDGWYLRNGPNPR----QPTGHWFTGDGMIHGVRIENGRAAWY
Mflv_1332|M.gilvum_PYR-GCK EGTIPAELDGWYLRNGPNPR----EATGHWFTGDGMIHGVRIENGRAAWY
MSMEG_6224|M.smegmatis_MC2_155 TGAIPPELDGWYLRNGPNPR----QATAHWFTGDGMIHGVRIENGAAKWY
* :* *** *****.** * * **.*:**: :.:* * **
MAV_0560|M.avium_104 RNRWVRSPATSKALGQPAPPG---HFGFFPIGANTNVIGHAGKTLALIEG
TH_3959|M.thermoresistible__bu RNRWVRGPLTARALGERPPSE---ECSVSGIGANTNVIGHAGKTIALVES
Mb0673|M.bovis_AF2122/97 RNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEA
Rv0654|M.tuberculosis_H37Rv RNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEA
MMAR_0993|M.marinum_M RNRWVRSMPVCAALGESPPSRLDPRAGMLGLGANTNVLSHAGRTLALVEG
MUL_0744|M.ulcerans_Agy99 RNRWVRSMPVCAALGESPPARRDPRAGMLGLGANTNVLSHAGRTLALVEG
MAB_3874c|M.abscessus_ATCC_199 RNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNVLGHAGRTLALVEG
Mvan_5460|M.vanbaalenii_PYR-1 RNRWVRTDSFVDPFPLYNADG---TRNLRASVANTHVVNHAGKTLALVES
Mflv_1332|M.gilvum_PYR-GCK RNRWVRTDSFIDPFPLYREDG---TRDLRASVANTHVVNHAGKTLALVES
MSMEG_6224|M.smegmatis_MC2_155 RNRWVRTDSFIESFPVYNADG---TRNLRASVANTHIVNHAGKTLALVES
****** .: .. .**::: ***:*:**:*.
MAV_0560|M.avium_104 GIANYELTEELDTVGVCDFAGTLTGGYAAHPHRDPETGELHAVSYNPYRG
TH_3959|M.thermoresistible__bu GVTNYELTEELDTVGPCDFDGTLTGGYTAHPKRDPETGELHAVSYSMYRG
Mb0673|M.bovis_AF2122/97 GVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARG
Rv0654|M.tuberculosis_H37Rv GVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARG
MMAR_0993|M.marinum_M GVANYELTDDLDTVGTCDFDGTLPGGYTAHPHRDPQTGELHAVSYSFTRG
MUL_0744|M.ulcerans_Agy99 GVANYELTDDLDTVGTCDFDGTLPGGYTAHPHRDPQTGELHAVSYSFTRG
MAB_3874c|M.abscessus_ATCC_199 GIANYELTEDLDTIGTCDFDGTLPGGYTAHPHTDPDTGEMHAVSYSFARG
Mvan_5460|M.vanbaalenii_PYR-1 SLP-YEITNDLETVGAYDFGGKLVDAMTAHPKICPTTGELHFFGYGNIFT
Mflv_1332|M.gilvum_PYR-GCK SLP-YEITNDLRAVGAYDFGGKLADAMTAHPKICPTTGELHFFGYGNIFT
MSMEG_6224|M.smegmatis_MC2_155 SLP-YEITGDLETVGAYDFGGKLVDSMTAHPKICPTTGEMHFFGYGSLFE
.: **:* :* ::* ** *.* .. :***: * ***:* ..*.
MAV_0560|M.avium_104 NRVQYSVIDVEGRARRTVDVTVGGSPMMHDFSLTERYVVFYDLPVTFDAA
TH_3959|M.thermoresistible__bu NTVQYSVIGTDGRARRTVDIEVTGSPMMHDFSLTERHIVLYDLPVTFDAR
Mb0673|M.bovis_AF2122/97 HRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPM
Rv0654|M.tuberculosis_H37Rv HRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPM
MMAR_0993|M.marinum_M HTVQYSVIDTQGRARRTVDIEVTGSPMMHDFSLTDKYVVIYDLPVTFDSA
MUL_0744|M.ulcerans_Agy99 HMVQYSVIDTQGRARRTVDIEVTGSPMMHDFSLTDKYVVIYDLPVTFDSA
MAB_3874c|M.abscessus_ATCC_199 STVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMS
Mvan_5460|M.vanbaalenii_PYR-1 PHVTYHRADANGELVIDRPLDVPALTMMHDFALTANYVVFMDLPIVFNVD
Mflv_1332|M.gilvum_PYR-GCK PHVTYHRADAHGELVINRPLDVPALTMMHDFALTQNHVVFMDLPIVFDLD
MSMEG_6224|M.smegmatis_MC2_155 PYVTYHRADADGELTINRPVDVKAHTMMHDFAMTSGHVIFMDLPVVFDLD
* * ...*. : * . .***.*::* :::: ***:.::
MAV_0560|M.avium_104 VGAA-MTAPRGLRPIARLMLSALIGRVAIPDPIAARLP-AATTDRRMPYS
TH_3959|M.thermoresistible__bu QAVS-MTVPRGLRLPARLVLSALIGRVRVPDPIAARQPRGNSSDRRFPYS
Mb0673|M.bovis_AF2122/97 QVVP-ASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYA
Rv0654|M.tuberculosis_H37Rv QVVP-ASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYA
MMAR_0993|M.marinum_M QVMP-VKMPSWLGVPARLVMASLIGNVRVPSPIAAMMNRNPKPSNRLPYA
MUL_0744|M.ulcerans_Agy99 QVMP-VKMPSWLGVPARLVMASLIGNVRVPSLIAAMLNRNPKPSNRLPYA
MAB_3874c|M.abscessus_ATCC_199 MISQSVPVPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYS
Mvan_5460|M.vanbaalenii_PYR-1 IAVS--------------------------------------GRGDMPYR
Mflv_1332|M.gilvum_PYR-GCK IAMR--------------------------------------GEGDMPYR
MSMEG_6224|M.smegmatis_MC2_155 IALK--------------------------------------GTGDMPYR
:**
MAV_0560|M.avium_104 WNPNYPARVGVMPRDGEDAD----VRWFDVEPCYVFHPMNAYEED----G
TH_3959|M.thermoresistible__bu WNPRYPARIGVMPRDGSNKD----VRWFDVEPCYVFHPMNAYDDG----D
Mb0673|M.bovis_AF2122/97 WNPSYPARVGVMPREGGNED----VRWFDIEPCYVYHPLNAYSECRNGAE
Rv0654|M.tuberculosis_H37Rv WNPSYPARVGVMPREGGNED----VRWFDIEPCYVYHPLNAYSECRNGAE
MMAR_0993|M.marinum_M WNPAYPARIGVMPREGGNRD----VRWFDIEPCYVYHPLNAYSEHRDGAE
MUL_0744|M.ulcerans_Agy99 WNPAYPARIGVMPREGGNRD----VRWFDIEPCYVYHPLNAYSEHRDGAE
MAB_3874c|M.abscessus_ATCC_199 WNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAE
Mvan_5460|M.vanbaalenii_PYR-1 WDDGYGARFGVLRRDDPFGQ----VRWFDIDPCYIFHVANAHD----DGR
Mflv_1332|M.gilvum_PYR-GCK WDDGYGARFGLLRRDDPFGD----VRWFDIGPCYIFHVANAYETTSADGD
MSMEG_6224|M.smegmatis_MC2_155 WSDTYGARFGLLRRDDPFGE----IRWFDIDPCYIFHVVNAYE----HGN
*. * **.*:: *:. . :***:: ***::* *.:.
MAV_0560|M.avium_104 TIVLDVVRNPKMFDRDRTGPN-EGPPTLDRWVIDLAAGKVRESRIDDRGQ
TH_3959|M.thermoresistible__bu TIVLDVIRHPKMFDTDNLGPN-EGPPTLDRWTVDLADGKVRESRIDDRGQ
Mb0673|M.bovis_AF2122/97 VLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQ
Rv0654|M.tuberculosis_H37Rv VLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQ
MMAR_0993|M.marinum_M VLILDVVRYRRMFDRDRRGPG-DTTPSLDRWVINLTTGAVSTECRDDRSQ
MUL_0744|M.ulcerans_Agy99 VLILDVVRYRRMFDRDRRGPG-DTSPSLDRWVINLTTGAVSTECRDDRSQ
MAB_3874c|M.abscessus_ATCC_199 VIVIDLVRYDSMFSQDVLGPS-DAKGQLDRWTIDLAKGTVHMERKDDRHL
Mvan_5460|M.vanbaalenii_PYR-1 TLVLQAVRYPELWRENG---GFDADGVMWTWTIDLQNGTVRESQLDDRVV
Mflv_1332|M.gilvum_PYR-GCK RLVLQAVRYPELWRDNG---GFDAEGVMWTWTVDLRTGAVSESQLDDRSV
MSMEG_6224|M.smegmatis_MC2_155 TVVVQAVRYPELWRDNG---SFDAQAVLWSWTIDLQTGAVTERQLDDLAV
:::: :* :: : . : : *.::* * * **
MAV_0560|M.avium_104 EFPRIDERLVGKRHRYGYTP------TVLEGIEGGDCLLKHDLIGGSTQS
TH_3959|M.thermoresistible__bu EFPRVDERLVGRRHRYGYAP------TVGEGTSGGNVLLKHDFVGGNTQS
Mb0673|M.bovis_AF2122/97 EFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTV
Rv0654|M.tuberculosis_H37Rv EFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTV
MMAR_0993|M.marinum_M EFPRINETLLGKRHRFGYTLGVDGGYLTGGTSDMSTSLYKQDYATGSSQV
MUL_0744|M.ulcerans_Agy99 EFPRINETLLGKRHRFGYTLGVDGGYLTGGTSDMSTSLYKQDYATGSSQV
MAB_3874c|M.abscessus_ATCC_199 EFPRINETFTGKKHRYGYLPDVEN--FFGSGEAAGASIVKYDYETGSTLS
Mvan_5460|M.vanbaalenii_PYR-1 EFPRIDDRLATLPARY-------------AVSVGDAGLIRHDLVTGAAVE
Mflv_1332|M.gilvum_PYR-GCK EFPRIDDRLATLPARY-------------AVSVGDKNLIRHDLTTGAAEV
MSMEG_6224|M.smegmatis_MC2_155 EFPRIDDRLAGLHARY-------------SVAAGDHGWVRYDMTTGDAQR
****::: : *: . : * * :
MAV_0560|M.avium_104 RSLGPQ---KALGEFVFHPSSPTAAEDE-GVLMGYVYDRATNRSELAILD
TH_3959|M.thermoresistible__bu RVFEPY---HELGEFVFQPSSADAAEDD-GVVMGYVYDRTTDRSELAILD
Mb0673|M.bovis_AF2122/97 ASLDPD---LLIGEMVFVPNPSARAEDD-GILMGYGWHRGRDEGQLLLLD
Rv0654|M.tuberculosis_H37Rv ASLDPD---LLIGEMVFVPNPSARAEDD-GILMGYGWHRGRDEGQLLLLD
MMAR_0993|M.marinum_M APLDSD---LLLGEMAFVPSPTAAAEDD-GVLMGYGYHRGSDEGQLVLLD
MUL_0744|M.ulcerans_Agy99 APLDPD---LLLGEMAFVPSPTAAAEDH-GVLMGYGYHRGSDEGQLVLLD
MAB_3874c|M.abscessus_ATCC_199 SRLDPA---IVLGEMSFVPNPTCAAEDD-GVLIGFAVDRRSDEGQLLLLD
Mvan_5460|M.vanbaalenii_PYR-1 HRFGTDSAPGGPGEAVFVPSTSGPADESSGWYLGYVYDPERDGSDLVIID
Mflv_1332|M.gilvum_PYR-GCK HRFGS----GGPGEAVFVPSTSGPADESSGWYLGYVYDPERNGSDLVVID
MSMEG_6224|M.smegmatis_MC2_155 HDLGT----GGPGEAVFVPG-AGPADESNGWYLGYVYDPERDGSDLVILD
: . ** * *. . *:: * :*: . : .:* ::*
MAV_0560|M.avium_104 AQTLED--VASIKLPHRVPAGFHGNWVPSTN
TH_3959|M.thermoresistible__bu AQTLED--VARIRLPHRVPAGFHGNWVPSDG
Mb0673|M.bovis_AF2122/97 AQTLES--IATVHLPQRVPMGFHGNWAPTT-
Rv0654|M.tuberculosis_H37Rv AQTLES--IATVHLPQRVPMGFHGNWAPTT-
MMAR_0993|M.marinum_M AQTLEL--AACVHLPQRVPLGFHGNWSAST-
MUL_0744|M.ulcerans_Agy99 AQTLEL--AACVHLPQRVPLGFHGNWSAST-
MAB_3874c|M.abscessus_ATCC_199 ATSLDL--MATVHLPQRVPAGFHGNWAPR--
Mvan_5460|M.vanbaalenii_PYR-1 ASDFGAPPVAKIKLPQRVPYGFHGNWISA--
Mflv_1332|M.gilvum_PYR-GCK ASDFSGPPVARVHLPQRVPYGFHGNWISA--
MSMEG_6224|M.smegmatis_MC2_155 ASDFGGKPVARIELPRRVPYGFHGNWISA--
* : * :.**:*** ****** .