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MRALPAGRHFFRGSDGYEAARRGTVWHRRVPDRYPEVIVQAVSADDIVSAIRYATVNGHKVSVVSGGHSF AASHLRDGAVLLDVSRIDHASIDADKGRAVVGPGKGGSVLMAELEAQGLFFPGGHCRGVCLGGYLLQGGY GWNSRIYGPACESVIGLDVITADGAQIHCDADNHADLYWAARGAGPGFFGVVTSFYLKLYPRPATCGTSV YVYPFDLADEVFTWARAVSAEVDPRVELQALASRGEPSMGIDVPVISLASPAFADSPEEAEQALALFGTC PVVEQALVKVPYMPTDLPAWYDVAMTHYLSDHHYAVDNMWTSASAEDLLPGIRSILDTLPPHPAHFLWLN WGPCPPRQDMAYSIEADIYLALYGSWKDPADEAKYADWARSHMAAMSHLAVGIQLADENLGARPARFASD AAMAKLDRVRAEYDPDGLFNSWMGRI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1803 | - | - | 100% (446) | oxidoreductase |
| M. bovis AF2122 / 97 | Mb0064 | - | 4e-25 | 33.67% (196) | oxidoreductase |
| M. bovis AF2122 / 97 | Mb1755 | - | 3e-21 | 29.39% (245) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4651 | - | 4e-25 | 31.20% (266) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1774 | - | 0.0 | 100.00% (446) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 3e-07 | 24.29% (210) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 6e-20 | 23.78% (450) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_0110 | - | 3e-23 | 30.14% (219) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 5e-22 | 28.27% (237) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 1e-22 | 28.89% (270) | 6-hydroxy-D-nicotine oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 1e-164 | 59.19% (446) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 8e-21 | 29.44% (197) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0156 | - | 1e-179 | 64.84% (438) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1803|M.bovis_AF2122/97 -----MRALPAGRHFFRGSDGYEAAR------------------------
Rv1774|M.tuberculosis_H37Rv -----MRALPAGRHFFRGSDGYEAAR------------------------
Mvan_0156|M.vanbaalenii_PYR-1 ------MELPT-RHFFRGDDGYEQAR------------------------
TH_1540|M.thermoresistible__bu -----MAALPA-LSFRRGAQGYEQAR------------------------
MMAR_0110|M.marinum_M -----MAREISRQAFLRGAAGALAAG---AVFGSVRAAAEPNPSGWEGLS
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
Mflv_4651|M.gilvum_PYR-GCK ---MTVPTDLRRDEALRSLRDQVATP------------------------
MSMEG_1746|M.smegmatis_MC2_155 -MLQVHPTMVDELAMSMPERVHLPGS------------------------
MLBr_01103|M.leprae_Br4923 --MGVLTSLIAGLPDGMVVTDSAVTDG-----------------------
Mb1803|M.bovis_AF2122/97 ------------------RGTVWHRRVPDRYPEVIVQAVSADDIVSAIRY
Rv1774|M.tuberculosis_H37Rv ------------------RGTVWHRRVPDRYPEVIVQAVSADDIVSAIRY
Mvan_0156|M.vanbaalenii_PYR-1 ------------------ARTVWNARTPERYPDLVAQAADVDDVVAAVRY
TH_1540|M.thermoresistible__bu ------------------RTTVWNGLLPDRFPDVIVQAVTVDDVVTAVRY
MMAR_0110|M.marinum_M SALGGKVLRPDDGPQFATAKQVFNTNYNDFTPAAVVTPTSAADVQKAMAF
MAV_0089|M.avium_104 TALGGKVLLPDS-PQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAB_2456|M.abscessus_ATCC_1997 RSLSG-ALVVRGDAAMDESGRAFNPLFDVNHPGAVAFCASDQDVARCVEF
Mflv_4651|M.gilvum_PYR-GCK --------VALPGEPGYERCRPWNVVAP-VEPAAVVLATSPEDVAGTVRF
MSMEG_1746|M.smegmatis_MC2_155 -------------PEYGDAVAIWNGAVT-ERPAAVVRPTSSGDVRNVVRF
MLBr_01103|M.leprae_Br4923 ------------------YRHDRALDPSAGKPLAVVQPRRTDEVQTVLRW
* :. :: : :
Mb1803|M.bovis_AF2122/97 ATVNGHKVSVVSGGHSFAASHLRDGA-VLLDVSRID-HASIDADKGRAVV
Rv1774|M.tuberculosis_H37Rv ATVNGHKVSVVSGGHSFAASHLRDGA-VLLDVSRID-HASIDADKGRAVV
Mvan_0156|M.vanbaalenii_PYR-1 AAAHDLQIGIRSGGHSWAGNHIRDGG-VLLDVHGLD-RCEVDAEAGTAVV
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWAASHLRDGG-MLLDVSRLD-HCGIDADRMVAVA
MMAR_0110|M.marinum_M ATAHNLKVAPRSGGHSYIGASTANGA-MVLDLRQLPGDINYDAATGQVTV
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYTGASTANGT-MVLDLRQLPGDANYDAATGQVTV
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYIGASTAVGA-MVIDLRGLPGGVNFDAGSGTVTV
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYAAYCIPNDG-LVVDLARMA---AVSVTGTRAVV
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAVG--VGPDT-ILIQTSAMR-HVSVDVVNGTARV
MSMEG_1746|M.smegmatis_MC2_155 AHEQRIPITVRAGGHDWGGRALNEGG-LVIDLSSMR-KVYIDPAAREALV
MLBr_01103|M.leprae_Br4923 ASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITVDPVTRTAVC
* : . * . . . :::. : . .
Mb1803|M.bovis_AF2122/97 GPGKGGSVLMAELEAQGLFFPGG--HCRGVCLGGYLLQGGYGWNSRIYGP
Rv1774|M.tuberculosis_H37Rv GPGKGGSVLMAELEAQGLFFPGG--HCRGVCLGGYLLQGGYGWNSRIYGP
Mvan_0156|M.vanbaalenii_PYR-1 GPGVGGSVLAGRLWEQDLFFPAG--HCKGVCIGGYLLQGGYGWNSRVLGP
TH_1540|M.thermoresistible__bu GPGKIGSELAGELDKLDLFFPAG--HCEGICLGGYLLQGGYGWNSRVLGP
MMAR_0110|M.marinum_M TPSTGLYEMHQVLAGAGRGIPTG--TCPSVGAAGHALGGGLGAHSRHAGL
MAV_0089|M.avium_104 TPATSLYTMHRTLAAVGRGVPTG--TCPSVGAAGHALGGGMGAQSRHAGL
MUL_1431|M.ulcerans_Agy99 PAGVSLTDVHQVLAGAGRAIPTG--SCPTVGVGGLALGGGMGADSRHAGL
MAB_2456|M.abscessus_ATCC_1997 GAGARLIDVYAGIAGAGRMLAGG--SCPTVGIAGLTLGGGVGVLTRRFGL
Mflv_4651|M.gilvum_PYR-GCK GAGARWQDVLDVATPHGLAPLCG--SAPGVGVIGYLTGGGIGPLVRTYGL
MSMEG_1746|M.smegmatis_MC2_155 EGGATAEDVVQAAERHGLTAAAP--NLADVGFTGFTLGGGYGPLNGIAGL
MLBr_01103|M.leprae_Br4923 QPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGV
. : . * .. * *
Mb1803|M.bovis_AF2122/97 ACESVIGLDVITADGAQIHCDADNHADLY----WAARGAGPGFFGVVTSF
Rv1774|M.tuberculosis_H37Rv ACESVIGLDVITADGAQIHCDADNHADLY----WAARGAGPGFFGVVTSF
Mvan_0156|M.vanbaalenii_PYR-1 ACESVLGLDVVTADGEQIYIDGENHADLY----WAARGSGPGFFAVVTAF
TH_1540|M.thermoresistible__bu ACESIVGVDVVTADGEVLYCDDETNADLF----WAARGSGPGFFAVVTSF
MMAR_0110|M.marinum_M LCDALTSAAVVLPSGQAVTASAASNPDLF----WALRGGGGGNFGVTTSL
MAV_0089|M.avium_104 LCDQLTSASVVLPSGQAVTASTASNPDLF----WALRGGGGGNFGVTTSL
MUL_1431|M.ulcerans_Agy99 TCNALRSATVVLPSGETVTASAEDHPDLF----WALRGGGGGNFGVTTAM
MAB_2456|M.abscessus_ATCC_1997 TCDQLISARVVTADGKIRVVSADTESDLF----WAIRGVGGGNFCIATEL
Mflv_4651|M.gilvum_PYR-GCK SSDHVRSFDVVTGGGRLLRAAPDENADLF----WGLRG-GKATLGIVTSA
MSMEG_1746|M.smegmatis_MC2_155 GVDNLLEAHVVLADGRSVTANAADEADLL----WALRG-GGANFGVVTHL
MLBr_01103|M.leprae_Br4923 TGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEV
: : *: .* *: . . : : *
Mb1803|M.bovis_AF2122/97 YLKLYPRPATCGTSVYVYPFDLADEVFTWARAVSAEVDPRVELQALASR-
Rv1774|M.tuberculosis_H37Rv YLKLYPRPATCGTSVYVYPFDLADEVFTWARAVSAEVDPRVELQALASR-
Mvan_0156|M.vanbaalenii_PYR-1 HLKLHRRPRVCGSSLYVYPIELAEQIYPWARSISAEVDRRVEFQMVASR-
TH_1540|M.thermoresistible__bu HLRLHPRPPVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIASR-
MMAR_0110|M.marinum_M TFATFATKDLDAVNLDFPPESFAQVLLGWQQWLRTADRN---NWALADA-
MAV_0089|M.avium_104 TFATFPTKDVDAVNLNFPPQSFAQVLVGWQNWLRTADPN---SWALADA-
MUL_1431|M.ulcerans_Agy99 TFETFPVADSDVVRVDFTPSSAAQVLAGWQTWLAAADRD---TWGLVDM-
MAB_2456|M.abscessus_ATCC_1997 AFETAASTDLTVFTLDYAAGEMAPIVHRWLTFMAGAPDELWTTLHAIGG-
Mflv_4651|M.gilvum_PYR-GCK EIDLLPVPEFYGGAVYFAADDVADVLRAWAAWCVDLPETINTSIAIQQLP
MSMEG_1746|M.smegmatis_MC2_155 RVRLHPVPHLATGVLMFPWEQAADVMRRYDALAPSLPDGLTAQIGVIPAP
MLBr_01103|M.leprae_Br4923 TLRLLPTQNTSSIVVATFASVQAAVDAVLGVAARLRPAMLEFMDSVAIN-
. :
Mb1803|M.bovis_AF2122/97 ---GEPSMGIDVPVISLASPAFADSPEEAEQALALFGTCPVVEQALVKVP
Rv1774|M.tuberculosis_H37Rv ---GEPSMGIDVPVISLASPAFADSPEEAEQALALFGTCPVVEQALVKVP
Mvan_0156|M.vanbaalenii_PYR-1 ---AVPGAGLDSPGIVMASPVFADTEQEAIDALALLETCPVRDRALVAVP
TH_1540|M.thermoresistible__bu ---DLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAIIKIP
MMAR_0110|M.marinum_M ---TVDQMGTHCRILATCPVGSGGSVASAITSAVGVQPIGTDHHTFNYLD
MAV_0089|M.avium_104 ---TVDAMGVHCRILATCPAGSGNSAAAAITQAVGIQPSGVETHTFNYMD
MUL_1431|M.ulcerans_Agy99 ---SVSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIETKTFNHME
MAB_2456|M.abscessus_ATCC_1997 ---AIPQCRIVG---CVAQGVNSQDVIESLRGGIGVRAADSFIAEMTFLD
Mflv_4651|M.gilvum_PYR-GCK PLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDTVGVLP
MSMEG_1746|M.smegmatis_MC2_155 ---------DGGPVVFVAPYWVGDPDEGDRWVAELRRLGTPVVDQVAPMS
MLBr_01103|M.leprae_Br4923 ---AVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGATQ
.
Mb1803|M.bovis_AF2122/97 YMPTD-----------LPAWYDVAMTHYLSDHHYAVDNMWTSASAEDLLP
Rv1774|M.tuberculosis_H37Rv YMPTD-----------LPAWYDVAMTHYLSDHHYAVDNMWTSASAEDLLP
Mvan_0156|M.vanbaalenii_PYR-1 YAPTD-----------LETWYAGVMSNYPDGYRYATDNIWTSASADELMP
TH_1540|M.thermoresistible__bu YATTD-----------LAGWYGAIMTNYPTGHRYATDNMWTSASPEALLP
MMAR_0110|M.marinum_M LVRYL-----------AVGNLNPAPLGYVGGSDVLPTINAGAAKGIASAI
MAV_0089|M.avium_104 LVNYL-----------AVGNLNPQPLGYVGGSDVFPTVNAAVAQGIAAAV
MUL_1431|M.ulcerans_Agy99 LVKYL-----------AGGSSASSPRGFVAGSDVIGTVNSAAAQAIVAAV
MAB_2456|M.abscessus_ATCC_1997 AMKFMGGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARI
Mflv_4651|M.gilvum_PYR-GCK YAAIG------------AVHADPVDPMPINEDQALLRELPPEAVEALLAA
MSMEG_1746|M.smegmatis_MC2_155 PSAQLR------------LLDPLVPRGRHYEMRTVNVDTLSPGVIDALVA
MLBr_01103|M.leprae_Br4923 VSSTN---------------DPDEGEAFVAARRFCIPAVESKGSLLLEDV
Mb1803|M.bovis_AF2122/97 GIRSILDTLPPHPAHFLWLNWGPCPPRQDMAYSIEADIYLALYGSWKDPA
Rv1774|M.tuberculosis_H37Rv GIRSILDTLPPHPAHFLWLNWGPCPPRQDMAYSIEADIYLALYGSWKDPA
Mvan_0156|M.vanbaalenii_PYR-1 GITRILETMPPHPAHFLWLNWGPSPQRQDMAYSMEDEVYLALYGVWRDAA
TH_1540|M.thermoresistible__bu GIHRIIETLPPAPSHFLMFNWSPTSTRDNLFYGLEADFNLALYAVWNDPE
MMAR_0110|M.marinum_M DAFPRGAGRALAIMHALDGALATVAPGATAFPWRRQSALVQWYVETP--G
MAV_0089|M.avium_104 NAFPRNAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVETS--G
MUL_1431|M.ulcerans_Agy99 GKSPPASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSG
MAB_2456|M.abscessus_ATCC_1997 ETLLAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG--A
Mflv_4651|M.gilvum_PYR-GCK AGPESGSPQAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAP-E
MSMEG_1746|M.smegmatis_MC2_155 AGSSRTSPASVLALHHFHGASTRVGLTDTAFGLRTPHFLVEIVAAWDADS
MLBr_01103|M.leprae_Br4923 GVPLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMT
: :
Mb1803|M.bovis_AF2122/97 DEAK--YADWARSHMAAMSHLA-VGIQLADENLGAR--PARFASDAAMAK
Rv1774|M.tuberculosis_H37Rv DEAK--YADWARSHMAAMSHLA-VGIQLADENLGAR--PARFASDAAMAK
Mvan_0156|M.vanbaalenii_PYR-1 DDEK--YGDWARSNMAAMEPLQ-TGIQLADENLGRR--PAPFATPEAMAR
TH_1540|M.thermoresistible__bu DDER--FSAWPGTNMAALAHLA-MGVGLADENLGRR--PARFATDANMAR
MMAR_0110|M.marinum_M SPAA--ASGWLNTAHQAVQPYS-AGGYVNYLEANQP--ASRYFG-PNLSR
MAV_0089|M.avium_104 DPAA--ATNWLASAHQAVQQYS-VGGYVNYLEANQS--PARYFG-PNLSR
MUL_1431|M.ulcerans_Agy99 QTAA--ATKWINSAHQAVQQFS-VGGYVNYLEANTA--LSRYFG-SNLSR
MAB_2456|M.abscessus_ATCC_1997 DPAV--AHERVSQARDGLGDICGPAAYVNYIDPGMPDWATAYYG-DNLPR
Mflv_4651|M.gilvum_PYR-GCK IADM--VIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTDDTLHW
MSMEG_1746|M.smegmatis_MC2_155 DDDGERHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQADTAYG-PNAER
MLBr_01103|M.leprae_Br4923 ERAH----RAFGEIMDMAVGLGGTITGEHGVGRLKRPWLDDYLGPDVMEL
Mb1803|M.bovis_AF2122/97 LDRVRAEYDPDGLFNSWMGRI-----
Rv1774|M.tuberculosis_H37Rv LDRVRAEYDPDGLFNSWMGRI-----
Mvan_0156|M.vanbaalenii_PYR-1 LDRVRAEYDPQGRFHSWMGRA-----
TH_1540|M.thermoresistible__bu LDGIRARRDPAGRFHGWMGRV-----
MMAR_0110|M.marinum_M LSAVRQKYDPGRVMFSGLNL------
MAV_0089|M.avium_104 LSAVRQKYDPGRVMFSGLNY------
MUL_1431|M.ulcerans_Agy99 LTQIRQRYDPSRLMYSGLNF------
MAB_2456|M.abscessus_ATCC_1997 LRGIAAAYDPKGIFRFAQAVRP----
Mflv_4651|M.gilvum_PYR-GCK LAGLADRYDPARTLATGQVIRTVV--
MSMEG_1746|M.smegmatis_MC2_155 LLAAKDRWDAGNVFTAIPLPSRSSTS
MLBr_01103|M.leprae_Br4923 NQRIKHALDPYGILNPGAAI------
*. :