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HTATIDTATAPYAPRDDLHFESDDLDATEDFLVRAYTKMSISAEDGERASALIDRRWLGPVSYDELRLDF HMSYDAAPLGRICLCRVHEGCIEEDFIGEPQDVFVPGDVALLSPPELPYSGRVCEASYDLTMFDTALLDR VATPDRGRSAGSVRLLGHRPVSPEAQLQLNSAIECVRTVVHSDGPAPTRLVASTTASMIAAVVLSAFPTN AASEPTALDRIDAKPPLLRRATAYIEGNADADIALADIAGSVHVTPRALQYMFRKYLDMTPMEYLRRVRM DHAHRELIKADAGQTTVQIVAARWGFAHTGRFAAMYREAYGRNPSDTLRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0118 | - | - | 100% (331) | helix-turn-helix domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0336 | - | 4e-45 | 37.58% (314) | helix-turn-helix domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2363 | - | 3e-21 | 25.77% (326) | helix-turn-helix domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3863 | - | 5e-07 | 29.46% (129) | AraC family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0731 | - | 1e-137 | 72.51% (331) | helix-turn-helix domain-containing protein |
| M. tuberculosis H37Rv | Rv3833 | - | 5e-07 | 29.46% (129) | AraC family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2899c | - | 1e-06 | 30.43% (92) | AraC family transcriptional regulator |
| M. marinum M | MMAR_4426 | - | 6e-08 | 26.06% (142) | transcriptional regulatory protein |
| M. avium 104 | MAV_4063 | - | 2e-37 | 36.84% (228) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_2260 | - | 5e-18 | 29.70% (202) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_3937 | - | 5e-46 | 44.64% (224) | PUTATIVE putative transcriptional regulator, AraC family |
| M. ulcerans Agy99 | MUL_0821 | - | 3e-05 | 29.29% (99) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0118|M.vanbaalenii_PYR-1 -----------MHTATIDTATAPYAPRDDLHFESDDLDATEDFLVRAY--
Mflv_0731|M.gilvum_PYR-GCK -----------MHTSPSSTTSG-----DNLRFESDDLAETEDFLVRAY--
TH_3937|M.thermoresistible__bu -----------VSDDTMVATAERQGPITRSRTELTDPSEVGDFLEAVYGV
Mb3863|M.bovis_AF2122/97 --------------------------------------------------
Rv3833|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4063|M.avium_104 ----MGLTTMTVRDDGAPVGAPAEAARSDYGPVDPVLAVNGERRARPVAV
MSMEG_2260|M.smegmatis_MC2_155 MSRLTRLGFIDIRRTSDPVRRKVRSRGVPPALADHEIFYTEDVREAARLV
MMAR_4426|M.marinum_M MTSAEQVAAKPGMARRRVGGIMVNPSRPGQRCAATSARRNERFEAFQHAI
MUL_0821|M.ulcerans_Agy99 --------------------------------MDYLWRMAQAARLIQHRS
MAB_2899c|M.abscessus_ATCC_199 MRSARGPHSGEPGRSGEPHSGRLGRSGEPHSGRLGRSGEPHSGRLGRSGE
Mvan_0118|M.vanbaalenii_PYR-1 -TKMSISAEDGERA--------------------SALIDRRWLGPVSYDE
Mflv_0731|M.gilvum_PYR-GCK -TKMSIAAGEGESP--------------------SARIERWWLGSTTFDE
TH_3937|M.thermoresistible__bu RVSRVRPPRSHDGP--------------------LLTHVRADAGSFIVDR
Mb3863|M.bovis_AF2122/97 ---------------------------------------------MSENS
Rv3833|M.tuberculosis_H37Rv ---------------------------------------------MSENS
MAV_4063|M.avium_104 EYKQFRGADAQSARRFFATAYDPGWRIAGVTNHCVVSHRRSDTGSMTVDE
MSMEG_2260|M.smegmatis_MC2_155 GRTLSPLTLTVDAADAGG---------------FAATMHGVRLRNVSLLY
MMAR_4426|M.marinum_M SQTFVPLALCVDDVG----------------------TFRGQVRSASLGT
MUL_0821|M.ulcerans_Agy99 GVPIYGYRTDPDIP-------------------------RVSVRRPGPED
MAB_2899c|M.abscessus_ATCC_199 PHSVVVLALPGTIGFDLAT--------------AVEVFRRVYLADGSRPY
Mvan_0118|M.vanbaalenii_PYR-1 LRLDFHMSYDAAPLGR-ICLCRVHEGCIEEDFIGEPQDVFVPGDVALLSP
Mflv_0731|M.gilvum_PYR-GCK LELDFHMSYDAAPLGR-ICLCRVHDGRIEENFIGEEPDVFAPGQVALLSP
TH_3937|M.thermoresistible__bu LHIAGELHTTADPIHK-VVTLWPTSGRVVGRCAG-LEGRAGAGEIILSGQ
Mb3863|M.bovis_AF2122/97 HHRLATTSLTLPPGAR-IERHRHPSHQIVYPSAGAVSVTTHAGTWITP--
Rv3833|M.tuberculosis_H37Rv HHRLATTSLTLPPGAR-IERHRHPSHQIVYPSAGAVSVTTHAGTWITP--
MAV_4063|M.avium_104 VAIQGRMTLEIPAGDT-VVVIQPRAG-----ALNVAGGPLATPDFPLLVA
MSMEG_2260|M.smegmatis_MC2_155 LDLHVAATLDIPESGRYFAVHMPLNGSATVTHPAAEFDAGTTRSLVTSPG
MMAR_4426|M.marinum_M VQLSDVRVGNDVLVRRTAKLINHSAPDYLKVAMPLNGKCVVTQDGHEETL
MUL_0821|M.ulcerans_Agy99 LGDRARHIHDFP-----ALWYVPAAGLVYIAAAGQVLEPTQFGSLQAG--
MAB_2899c|M.abscessus_ATCC_199 LVRVCGTEPVVSAGPFGIATDLGLEAVSEAETIVVPARDNPTAPLPEGVL
Mvan_0118|M.vanbaalenii_PYR-1 PELPYSGRVCEASYDLTMFDTALLDR--VATPDRGRSAGSVRLLGHR-PV
Mflv_0731|M.gilvum_PYR-GCK PELPYSGRVCGATFDLTMFDTALLDR--VAAPANGRADQGIRLTGHR-PV
TH_3937|M.thermoresistible__bu PDLVRQTHCDDLAATVILLDPALVAH--VASGSAGDDAAAAIRFASL-RP
Mb3863|M.bovis_AF2122/97 -------------VNRAIWIPAGCWH--QHKFHGHTQFHGVALDPQR-YR
Rv3833|M.tuberculosis_H37Rv -------------VNRAIWIPAGCWH--QHKFHGHTQFHGVALDPQR-YR
MAV_4063|M.avium_104 HGMACVLHCHGARFDVVTIAAEVLQK--VAAEWHTALSQQTQFLNWR-PR
MSMEG_2260|M.smegmatis_MC2_155 DPVRMSFAHDSPQMLVRIEEEAMNAH--LTRLLGRNLVGPLKFEPEF-DL
MMAR_4426|M.marinum_M APRDFAVYDTTRPYSLAFSGAYRALV--IMFPRDQVRLSSAELTRLT-AR
MUL_0821|M.ulcerans_Agy99 -------------VAMFFDPAALGGD--GGSPWPSWRTHPLLFPFLHGHS
MAB_2899c|M.abscessus_ATCC_199 DALRGAYERGTRIASICAGAFTLAEAGILDGKRATTHWLAADLFRERYPA
Mvan_0118|M.vanbaalenii_PYR-1 SPEAQLQLNSAIECVRTVVHSD-GPAPTRLVASTTASMIAAVVLSAFPTN
Mflv_0731|M.gilvum_PYR-GCK SPQAQQRLSDAIDYVRTVVRSD-GLEATPLVASTTASMLAAVVLHTLPSN
TH_3937|M.thermoresistible__bu AVGATRLWQDTVRYVRDHVLVD-DTRATPLVVGQAARLLAAVTASAFP-N
Mb3863|M.bovis_AF2122/97 GGPATPTVLAVNPLMRELIIAC-SQADR--TDTDEHHRMLAVLQDQLPTT
Rv3833|M.tuberculosis_H37Rv GGPATPTVLAVNPLMRELVIAC-SQADR--TDTDEHHRMLAVLQDQLPTT
MAV_4063|M.avium_104 SRAAVRAWHRALDYAMLTLASP-DTARQPLIAAGMAGLLAGALLECYPSN
MSMEG_2260|M.smegmatis_MC2_155 TTEAATRWHAAVQLIHTEVYHAGSLVQRGCAIGPVEELAMSSLLYLQPST
MMAR_4426|M.marinum_M RLNGRDGLGAPVSAFLAEMGNR-LDDANTAGTLYLADAVLDMLAASFAAQ
MUL_0821|M.ulcerans_Agy99 GGILRLEVPAARRSTWDGAIAAIEAELTTRQQGYGQAVTAHLTLLLIELA
MAB_2899c|M.abscessus_ATCC_199 VHLDADVLYVDEGQVLTSAGAAAGLDLCLHIVARDHGAAVAAEAARVAVA
Mvan_0118|M.vanbaalenii_PYR-1 AASEPT-----ALDRIDAKPPLLRRATAYIEGNADADIALADIAGSVHVT
Mflv_0731|M.gilvum_PYR-GCK ASLEPT-----ATDRLDAKPALLRRAIAFIEGNADSDIALGDIAASVHVT
TH_3937|M.thermoresistible__bu SAAEPA-----GQTVNGQRPPLLRRALDYIDANAAADISLADIAAAVHVT
Mb3863|M.bovis_AF2122/97 SIREPL-----WVPSPTDRR--LRHACALIADNLTQPLTLQQIGGRIGVS
Rv3833|M.tuberculosis_H37Rv SIREPL-----WVPSPTDRR--LRHACALIADNLTQPLTLQQIGGRIGVS
MAV_4063|M.avium_104 LTEQDP-----VSDL--ALPETLKEAVSFIHRHAAEDIGINDVAAAVHLT
MSMEG_2260|M.smegmatis_MC2_155 YYSDIT-----RPTPATPRRAVIQQAVDYIEDHLAEKITMESLAEALHMS
MMAR_4426|M.marinum_M LSDETG-----GNAARGTRGLALRIRAFIESRLGDPGLDVSTIAAAHHVS
MUL_0821|M.ulcerans_Agy99 RLARDV-----VGDLRRSGEPLLAEVFEVIDRRHAEPLSLRDVAAEVGMT
MAB_2899c|M.abscessus_ATCC_199 PLHRDGGQAQYVIRNRRRAEVSLGEILAWIEHNAHRELSLEDLATEASTS
: : : :. :
Mvan_0118|M.vanbaalenii_PYR-1 PRALQYMFRKYLDMTPMEYLRRVRMDHAHRELIKADAGQ-TTVQIVAARW
Mflv_0731|M.gilvum_PYR-GCK PRALQYMFRRHLEMTPMEYLRRVRMDHAHRDLLQADPAT-TTIQMVASRW
TH_3937|M.thermoresistible__bu PRALQYMFRRHLQTTPLQYLRRIRLHRAHHDLLAQTPAS-DTVGAIAARW
Mb3863|M.bovis_AF2122/97 QRTLSRLFSDELGMTFPQWRTQLRLQHALVLLAER-----HDVTSVASEC
Rv3833|M.tuberculosis_H37Rv QRTLSRLFSDELGMTFPQWRTQLRLQHALVLLAER-----HDVTSVASEC
MAV_4063|M.avium_104 PRAVQYLFRRQLDTTPTEYMRRVRLSRAHQELVAATTAS-STVTEIAQRW
MSMEG_2260|M.smegmatis_MC2_155 VRSIQQGFRTELGMSPTTFIRERRLERVREELTDAIPSDGVTVTAVAERW
MMAR_4426|M.marinum_M VRYLQKLFE-SQGQTVTGWIRDRRIEHCRRDLEDHRLAE-VPVSSIAARW
MUL_0821|M.ulcerans_Agy99 PGHLTTIVRRRTGRTVQEWIIERRMAQARELLVATD----LAVGEVARRV
MAB_2899c|M.abscessus_ATCC_199 VRSLNRRFRAETGQTPMQWLTGVRVRHAQQLLERSA----DSVEWIGREV
: . : : *: : * : :. .
Mvan_0118|M.vanbaalenii_PYR-1 GFAHTGRFAAMYREAYGRNPSDTLRS----------------
Mflv_0731|M.gilvum_PYR-GCK GFGHTGRFASMYRDAYGRNPSDTLRN----------------
TH_3937|M.thermoresistible__bu GFAHAGRFAMQYRQTYGRSPHQTLRG----------------
Mb3863|M.bovis_AF2122/97 GWATPSAFIDTYRQAFGHTPGQAAKPMAATRLTRLRRARDRR
Rv3833|M.tuberculosis_H37Rv GWATPSAFIDTYRQAFGHTPGQAAKPMAATRLTRLRRARDRR
MAV_4063|M.avium_104 GFAHTGRFAVLYRQTYGQSPHTTLRQQTAV------------
MSMEG_2260|M.smegmatis_MC2_155 GFHHLGSFAVEYRKRWGETPSETLRR----------------
MMAR_4426|M.marinum_M GLVNASHFSRLFKAVHGSSPAEYRAQVSLRSPSASTDRG---
MUL_0821|M.ulcerans_Agy99 GISDPGYFSRLFSRAHGTSPRQWRALPPRH------------
MAB_2899c|M.abscessus_ATCC_199 GFGSPANFREQFRRLTGVSPLAYRNTFRAQSA----------
* . * : * .*