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TISVAERAELRTAVGKLLADKCTEDDVRRVRESDEGFDRDLWRRLADQGVLGMLVDSEYGGLGFGAQELE AVAEETGAALLPAPFISSAVLTVALINAVGSDEDKQRLLPGLADGTAIGTVALTGPAGSWSEDGVDVRAG ADGALDGVAHFVTWGQVADVVLVVARTDDGVGVFEIATDATGFERTAATVFDPTVRLSTYTFAGTPARRL GTAGWEAVREAMDYAVVASAGEQVGGAKRIFDITIAYLKTRFQFGRAIGSFQALKHMAADLLLEVESATS AAQHAAAVFDDPEARDGAVALAGFACAEAYVKTAMAAVQMHGGIGFTWEHPCHLYVRRARSGLQLFGDSG LHRERYLISKGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2335 | - | - | 100% (363) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0345 | - | 2e-56 | 39.17% (360) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1477 | - | 1e-41 | 36.07% (341) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 6e-50 | 37.39% (337) | acyl-CoA dehydrogenase FADE18 |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 7e-50 | 37.39% (337) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-21 | 28.57% (357) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 4e-57 | 39.66% (358) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1954 | fadE18_1 | 7e-53 | 39.77% (352) | acyl-CoA dehydrogenase FadE18_1 |
| M. avium 104 | MAV_1838 | - | 7e-59 | 40.33% (367) | acyl-CoA dehydrogenase protein |
| M. smegmatis MC2 155 | MSMEG_1905 | - | 1e-142 | 71.05% (373) | acyl-CoA dehydrogenase protein |
| M. thermoresistible (build 8) | TH_4038 | - | 2e-78 | 45.33% (353) | PUTATIVE putative acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2176 | fadE18_1 | 3e-53 | 39.77% (352) | acyl-CoA dehydrogenase FadE18_1 |
| M. vanbaalenii PYR-1 | Mvan_4312 | - | 1e-167 | 80.22% (364) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2335|M.gilvum_PYR-GCK -----------------MT-ISVAERA--------------ELRTAVGKL
Mvan_4312|M.vanbaalenii_PYR-1 -----------------MT-ISVAERA--------------ELRTAVGEL
MSMEG_1905|M.smegmatis_MC2_155 -----------------MT-ISVAERA--------------ELAAAVREL
MAV_1838|M.avium_104 -----------------MTGLSLDESR--------------ELARSVRAA
TH_4038|M.thermoresistible__bu ---VSTPPAERTKEVDEMTDIPDAFAATDAQ---------DELRRTVRGF
MMAR_1954|M.marinum_M --------------MSTGDLLYSDTEE--------------ALRASVGQL
MUL_2176|M.ulcerans_Agy99 --------------MSTGDLLYSDTEE--------------ALRASVGQL
Mb1968c|M.bovis_AF2122/97 -----------------MDFRYSTEQD--------------DFRASLRGF
Rv1933c|M.tuberculosis_H37Rv -----------------MDFRYSTEQD--------------DFRASLRGF
MAB_3123|M.abscessus_ATCC_1997 MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSW
MLBr_00737|M.leprae_Br4923 --------MVGWSGNPLFDLFKLPEEHN-------------ELRATIRAL
: :
Mflv_2335|M.gilvum_PYR-GCK LADKCTEDDVRRVRES----DEGFDRDLWRRLADQ-GVLGMLVDSEYGGL
Mvan_4312|M.vanbaalenii_PYR-1 LAERCTESDVRRVMTS----DEGFDRDLWRQLANQ-GVLGMLVDGEYGGL
MSMEG_1905|M.smegmatis_MC2_155 LQNECTEQDVRQTISS----DEGYDPQLWRKLAAQ-GVTGLLIDPEYGGV
MAV_1838|M.avium_104 CERFAPEERVRAIAYNGGGVDAGFDTELWKVLCAQVGVAAIGMPEDLGGA
TH_4038|M.thermoresistible__bu FEKKMPEHEVRRIMET----PEGYDRAVWRQMADQLGLQGVAIPEEFGGS
MMAR_1954|M.marinum_M FAERCPPESVVAAYDSPP----ADFAKLWRTLAAELGVAGLLVPESLGGA
MUL_2176|M.ulcerans_Agy99 FAERCPPESVVAAYDSPP----ADFAKLWRTLAAELGVAGLLVPESLGGA
Mb1968c|M.bovis_AF2122/97 LGRGAPVREMAAADGSD--------RRLWQRLCTELELPALHVPPEHGGL
Rv1933c|M.tuberculosis_H37Rv LGRGAPVREMAAADGSD--------RRLWQRLCTELELPALHVPPEHGGL
MAB_3123|M.abscessus_ATCC_1997 CERVWTPKHVRQIAEAG-----SVDLDAWRALGSELGVVGLSLPEQHGGG
MLBr_00737|M.leprae_Br4923 AEKEIAPHAADVDQRAR------FPEEALAALNAS-GFNAIHVPEEYGGQ
. : . . .: : . **
Mflv_2335|M.gilvum_PYR-GCK GFGAQELEAVAEETGAALLPAPFISSA-VLT-VALINAVG-SDEDKQRLL
Mvan_4312|M.vanbaalenii_PYR-1 GFGALELEAVAEETGTAALPAPFISSA-VLT-VALINAAG-SDEDKQRLL
MSMEG_1905|M.smegmatis_MC2_155 GLGALELEAVAEETGAALLPAPFIGSA-VLA-TALIEAAG-TAEDKQRLL
MAV_1838|M.avium_104 GFDATALGVVAHELGRALAPVPFVASA-VLA-TGLLLATRESDPDSEQRL
TH_4038|M.thermoresistible__bu GFGYSELGVVVEETGRALLPGPFFGSV-VLAGTALLCSAD--DAAKSRYL
MMAR_1954|M.marinum_M GASAREAAVVMEEVGRAVAPVPFLSSA-VLATVALLHSGE--TETLSELA
MUL_2176|M.ulcerans_Agy99 GASAREAAVVMEEVGRAVAPVPFLSSA-VLATVALLHSGE--TETLSELA
Mb1968c|M.bovis_AF2122/97 GATLVETAIAFAELGRALTPIPFAAT--VFAIEAILRMGD--DEQRKRLL
Rv1933c|M.tuberculosis_H37Rv GATLVETAIAFAELGRALTPIPFAAT--VFAIEAILRMGD--DEQRKRLL
MAB_3123|M.abscessus_ATCC_1997 GLGVIELSIVAEELGRALACLPWISSA-ALGATALVSSGD--DSALAEWV
MLBr_00737|M.leprae_Br4923 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGS--EELKKQVL
* . * . . . : : .:: .
Mflv_2335|M.gilvum_PYR-GCK PGLADGTAIGTVALTGPAGSWSEDGVDVRA--GADG-ALDGVAHFVTWGQ
Mvan_4312|M.vanbaalenii_PYR-1 PALADGTAIGTVALTGKSGSWTPEGVDVQA--AADG-TLTGSAHYVTWGQ
MSMEG_1905|M.smegmatis_MC2_155 PGLAEGTSIATVAVTGARGTWAKEGVAVKATERADGHTLNGNAHYVLSGQ
MAV_1838|M.avium_104 SGLMEGHRTAAAAVTGDGGLWQRDSVTLVANANIDGWAVNGTVRHVLNGC
TH_4038|M.thermoresistible__bu PGIATGETIAALALTEQSGRWSADAVQTTARHDGGRWIINGSKTFVLDGH
MMAR_1954|M.marinum_M QGELTAALVVPLAT--------APGDPVAGVSR-GSAGLSGRVCGVAGAR
MUL_2176|M.ulcerans_Agy99 QGELTAALVVPLAT--------APGDPVAGASR-GSAGLSGRVCGVAGAR
Mb1968c|M.bovis_AF2122/97 AGLLTGARIGTIAVSGHD---VASATTVRAVRRDGRPALTGECTPVLHGH
Rv1933c|M.tuberculosis_H37Rv AGLLTGARIGTIAVSGHD---VASATTVRAVRRDGRPALTGECTPVLHGH
MAB_3123|M.abscessus_ATCC_1997 PALAAGEKTITLAGGRTR---LADAITVSAESDTDGWKLTGDTEHVPDGA
MLBr_00737|M.leprae_Br4923 PSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGG
. . * . . . : * : .
Mflv_2335|M.gilvum_PYR-GCK VADVVLVVARTDD-----GVGVFEIATDATGFERTAATVFDPTV--RLST
Mvan_4312|M.vanbaalenii_PYR-1 VADVVLVVARTDD-----GFGVFEVSVGADGFERSAATVFDPTV--RLST
MSMEG_1905|M.smegmatis_MC2_155 IADVLLVVARTGGDDVG-GVGIFEVTPDATGLTRAAATVFDPSV--RLST
MAV_1838|M.avium_104 AANDLVVVAKADD-----QPALFLIDPMAEGVAVEAERVLDGTR--PMAT
TH_4038|M.thermoresistible__bu AADLLLVAARTDS-----GISLLAVD-QTEGLTRRMLSTLDPTR--RQGR
MMAR_1954|M.marinum_M EADVLVVPVAGAD-----GVELHTVRANAPGVEIVPLLAFDMTR--PLAD
MUL_2176|M.ulcerans_Agy99 EADVLVVPVAGAD-----GVELHTVRANAPGVEIVPLLAFDMTR--PLAD
Mb1968c|M.bovis_AF2122/97 VADLFVVPAVADG-----SIVLHVVAADAPGVTVTPLPSFDITR--PVAT
Rv1933c|M.tuberculosis_H37Rv VADLFVVPAVADG-----SIVLHVVAADAPGVTVTPLPSFDITR--PVAT
MAB_3123|M.abscessus_ATCC_1997 TADVILVLADTDS-----GPSLFAVDGDAPGVDRHSLATLDMTR--RQAN
MLBr_00737|M.leprae_Br4923 KSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTE
: * . : *.
Mflv_2335|M.gilvum_PYR-GCK YTFAGT---PARRLG--TAGWEAVREAMDYAVVASAGEQVGGAKRIFDIT
Mvan_4312|M.vanbaalenii_PYR-1 FSFAGT---PARRLG--TAGWDAAKEALDHAVIASAGEQVGGARRIFDMT
MSMEG_1905|M.smegmatis_MC2_155 FTFTDT---PARRIG--TAGWDAVSHALDLAVIALAGEQVGGTRRIFDIT
MAV_1838|M.avium_104 ITFTGA---TALKLTGREAVDTIIEHNIDVALAVLSAEQVGACERVLEIA
TH_4038|M.thermoresistible__bu IDFTDT---PAELIGAEGQAWPSLSHALDIAAALLALEQVGGAQRCLEIA
MMAR_1954|M.marinum_M VVFSGA---ASAPVG-LGSAEAALAEALQTGAALLASEQLGIAQWCFDTT
MUL_2176|M.ulcerans_Agy99 VVFSGA---ASAPVG-LGSAEAALAEALQTGAALLASEQLGIAQWCFDTT
Mb1968c|M.bovis_AF2122/97 LRLAGS---PAEPLT-AG-TPDDMERVLDVARVLLAAEMLGGAEACLDLA
Rv1933c|M.tuberculosis_H37Rv LRLAGS---PAEPLT-AG-TPDDMERVLDVARVLLAAEMLGGAEACLDLA
MAB_3123|M.abscessus_ATCC_1997 IHFNSA---PARLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVT
MLBr_00737|M.leprae_Br4923 LYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAA
: : :: . : * :: :
Mflv_2335|M.gilvum_PYR-GCK IAYLKTRFQFGRAIGSFQALKHMAADLLLEVESATSAAQHAAAVFD--DP
Mvan_4312|M.vanbaalenii_PYR-1 VDYLKTRIQFGRQIGSFQALKHMAADLLIEVENATSAAQHAASEKAG-NS
MSMEG_1905|M.smegmatis_MC2_155 IDYLKTRIQFGRAIGSFQALKHMAADLLVQVESSTSAAQHAAAEKAA-GS
MAV_1838|M.avium_104 CEYARTREQFGRPIGSFQAIKHKCADMLVDLEWARSASQ--AALEAV-VS
TH_4038|M.thermoresistible__bu VDYAKTRHQFGKPIGSFQAIRHRFADLMLEIECARGAAQYAVYAAAR-GL
MMAR_1954|M.marinum_M LAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTCAR-GD
MUL_2176|M.ulcerans_Agy99 LAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTCAR-GD
Mb1968c|M.bovis_AF2122/97 VQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAAN-GD
Rv1933c|M.tuberculosis_H37Rv VQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAAN-GD
MAB_3123|M.abscessus_ATCC_1997 TEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHDHPSL
MLBr_00737|M.leprae_Br4923 IVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAER-GE
* * **.. *.::*:::. **: .
Mflv_2335|M.gilvum_PYR-GCK EARDGAVALAGFACAEAYVKTAMAAVQMHGGIGFTWEHPCHLYVRRARSG
Mvan_4312|M.vanbaalenii_PYR-1 ENADGAVALAGFACAEAYETIAMNAIQMHGGIGFTWEHPAHIFLRRARTG
MSMEG_1905|M.smegmatis_MC2_155 DDAAGAIALAGFFCAEAYNTTAMQAVQMHGGIGFTWEHPAHLFVRRARTG
MAV_1838|M.avium_104 GERDWRASMAKAVCSESLRNAAHANVQIHGGIGFTWEDSAHLYLRRARTD
TH_4038|M.thermoresistible__bu DELPAAASLAKAYCTDVYTKAAGANIQIHGGIGFTWEHPAHMYFKRAKSS
MMAR_1954|M.marinum_M EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLYLKRAKSD
MUL_2176|M.ulcerans_Agy99 EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLYLKRAKSD
Mb1968c|M.bovis_AF2122/97 E-LQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTT
Rv1933c|M.tuberculosis_H37Rv E-LQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTT
MAB_3123|M.abscessus_ATCC_1997 DDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSN
MLBr_00737|M.leprae_Br4923 PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKIT
. : : :* .*. . * : . : : *
Mflv_2335|M.gilvum_PYR-GCK LQLFGDSGLHRERYLISKGA---
Mvan_4312|M.vanbaalenii_PYR-1 LHLFGGPRLHRERYLVSKGA---
MSMEG_1905|M.smegmatis_MC2_155 LQLFGSSAQHRERYLTAKGA---
MAV_1838|M.avium_104 EVLLGGPGQHWDRVGLRVL----
TH_4038|M.thermoresistible__bu EHLLGDAAYHRGLLADRAGI---
MMAR_1954|M.marinum_M QLALGTAYRHRGRLAKLVNLPVS
MUL_2176|M.ulcerans_Agy99 QLALGTAYRHRGRLAKLVNLPVS
Mb1968c|M.bovis_AF2122/97 EALFGSSARNRALLAERAGLVKA
Rv1933c|M.tuberculosis_H37Rv EALFGSSARNRALLAERAGLVKA
MAB_3123|M.abscessus_ATCC_1997 SALFGGRAVHAERIAKEVIDA--
MLBr_00737|M.leprae_Br4923 QIYEGTNQIQRVVMSRALLR---
* :