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MDTLSTPWSAELGLDVPIVNAPMGGAAGGTLAAAVSRAGGLGMVGMGSSASAAQLRAQLAELGELKRPFG IGVIDWVIRKEPELLTTALDARPTALSVSFGTEWDWVARARDAGCVSVTQVADVEAALRAVDAGVQVLVA RGAEAGGHGTPAVATLPLLAAILDRVEVPVLAAGGIASGRALAAVLAAGAAGAWIGTAFATCPESLFPDE ARRALLTADATDTLTTRVFDVALGYPWPAHFPERVLRNAFTAAWDGRTPDDDARARLAEAIADDDFRVAP VNAGQGVDDITAVEPAAMVIARLCDDARRLLAKPPTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5156 | - | - | 100% (317) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_1222 | - | 6e-30 | 30.93% (291) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_1487 | - | 7e-29 | 31.62% (272) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0021c | - | 2e-53 | 41.69% (319) | hypothetical protein Mb0021c |
| M. tuberculosis H37Rv | Rv0021c | - | 6e-54 | 42.01% (319) | hypothetical protein Rv0021c |
| M. leprae Br4923 | MLBr_00388 | guaB3 | 1e-08 | 26.11% (226) | inosine 5-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0159 | - | 1e-48 | 36.19% (315) | 2-nitropropane dioxygenase |
| M. marinum M | MMAR_2084 | - | 4e-97 | 60.51% (314) | hypothetical protein MMAR_2084 |
| M. avium 104 | MAV_3496 | - | 7e-95 | 60.26% (312) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_1660 | - | 9e-89 | 55.31% (311) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. thermoresistible (build 8) | TH_1976 | - | 6e-91 | 58.94% (302) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. ulcerans Agy99 | MUL_1961 | - | 7e-55 | 38.87% (319) | hypothetical protein MUL_1961 |
| M. vanbaalenii PYR-1 | Mvan_4537 | - | 1e-114 | 65.08% (315) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0021c|M.bovis_AF2122/97 -------------------------MVLSTAFS-QMFGIDYPIVSAPMDL
Rv0021c|M.tuberculosis_H37Rv -------------------------MVLSTAFS-QMFGIDYPIVSAPMDL
MAB_0159|M.abscessus_ATCC_1997 -------------------------MTFNTRLT-DRFGIEHPVVLAPMDD
MUL_1961|M.ulcerans_Agy99 -------------------------MSLNTRLT-EFLGVQHPILLAPMAM
Mflv_5156|M.gilvum_PYR-GCK ------------------------MDTLSTPWS-AELGLDVPIVNAPMGG
Mvan_4537|M.vanbaalenii_PYR-1 ------------------------MKATSTQWS-QAMGLAAPIVNAPMGG
MMAR_2084|M.marinum_M --------------------------MLATGWS-RGFGLRVPIVNAPMGG
MAV_3496|M.avium_104 --------------------------MLSTPWS-AGFGLRVPIVNAPMGG
MSMEG_1660|M.smegmatis_MC2_155 -------------------------MSLATTWS-KAMGIDVPIVNAPMGG
TH_1976|M.thermoresistible__bu ------------------------------------MGIEVPIVNAPMGG
MLBr_00388|M.leprae_Br4923 MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDA
. *:: *
Mb0021c|M.bovis_AF2122/97 IAGGELAAAVSGAGGLGLIGGG-YGDRDWLARQFDLAAG---APVGCGFI
Rv0021c|M.tuberculosis_H37Rv IAGGELAAAVSGAGGLGLIGGG-YGDRDWLARQFDLAAG---APVGCGFI
MAB_0159|M.abscessus_ATCC_1997 VADARLASAVSAAGGLGLLGGG-YADADWVRQQFDQVS----AAVGCGFI
MUL_1961|M.ulcerans_Agy99 TSGGRLAAAVTAAGGLGLIGGG-YGEAEWLQRQLEQAQG---QRVGCGFI
Mflv_5156|M.gilvum_PYR-GCK AAGGTLAAAVSRAGGLGMVGMGSSASAAQLRAQLAELGELK-RPFGIGVI
Mvan_4537|M.vanbaalenii_PYR-1 VAGGALAAAVSRAGGLGMIGIGSAGSADRLHTELRHVSDLVDRPFGIGLI
MMAR_2084|M.marinum_M VAGGRLAAAVTAAGGLGMIGMGSRATRAALAEQLRQV----SGRFGIGLV
MAV_3496|M.avium_104 VAGGRLAAAVTAAGGLGMVGMGSVATRRLLAEQLQYV----DGRFGIGLV
MSMEG_1660|M.smegmatis_MC2_155 AAGARLAAAVSEAGGLGMVGMGSSATPEQLRRELADLAKP-SRPFGIGLV
TH_1976|M.thermoresistible__bu TAGAELAAAVSAAGGLGMIGMGSSATAAVLRRELAGPIT---RPFGIGLV
MLBr_00388|M.leprae_Br4923 LVSPEFAIELGRLGGLGVLNGE-----GLIGRHADVGAK------VAQLI
. :* : ****::. : . .:
Mb0021c|M.bovis_AF2122/97 TWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNR
Rv0021c|M.tuberculosis_H37Rv TWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNR
MAB_0159|M.abscessus_ATCC_1997 TWTLKGNEHVLEHALARGPAALFLSFGDPAPYAPRIRAAGVPLICQVHNI
MUL_1961|M.ulcerans_Agy99 TWSLARNPELLDLILAANPAAIMLSFGDPHNFAGPIHDAGIPLICQIHTR
Mflv_5156|M.gilvum_PYR-GCK DWVIRKEPELLTTALDARPTALSVSFGTEWDWVARARDAGCVSVTQVADV
Mvan_4537|M.vanbaalenii_PYR-1 SWAVAEQPRLLEAALAARPALLSVSFGDDWAWVRRAHDAGCVTATQVADV
MMAR_2084|M.marinum_M DWVMRSEAGLLEDALAAGPALLSVSFGTDWSWVGPARDAGIPTVTQVYDA
MAV_3496|M.avium_104 DWVMRNEAGLLEDALAARPALLSVSFGTDWSWVAKAHDAGIPTVTQVYDS
MSMEG_1660|M.smegmatis_MC2_155 HWVMTERPDLFDIALEARPALLSVSFGDDWAWVRRAHDVGVTVATQVATV
TH_1976|M.thermoresistible__bu QWVVDAEPELLDVALAARPTLLSVSFGADYGWVERAHAEGISAAAQVADV
MLBr_00388|M.leprae_Br4923 EAAEKEPEPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQ
* :. . . : * ::
Mb0021c|M.bovis_AF2122/97 TQAER---ALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGT
Rv0021c|M.tuberculosis_H37Rv TQAER---ALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGT
MAB_0159|M.abscessus_ATCC_1997 RQAAR---AIEVGADVIVAQGGEAGGHGEGRRSTFTLVPEVVDLVAGTAP
MUL_1961|M.ulcerans_Agy99 EQALR---VLEVGPDIIVAQGSESGGHGMSVRSTFTLVPDVVDLVAQRSA
Mflv_5156|M.gilvum_PYR-GCK EAALR---AVDAGVQVLVARGAEAGGHGTPAVATLPLLAAILDRVE----
Mvan_4537|M.vanbaalenii_PYR-1 DGAQR---AADAGVDVLVTRGAEAGGHGQPRVGTLPLLVEVLDRVA----
MMAR_2084|M.marinum_M LGARR---AADAGVDIVVARGAEGGGHGEVRLGTLPLLDAVLAAVS----
MAV_3496|M.avium_104 LGARQ---AVDAGVDILVARGSEGGGHGEVKLGLLPLLDAVLDAVS----
MSMEG_1660|M.smegmatis_MC2_155 GDALR---AAEAGVDVLVARGAEAGGHGRPALGTLPLLTQVLDAVE----
TH_1976|M.thermoresistible__bu ESGVR---AQDAGVDVVVARGAEGGGHGEPRLGTLPLLTELLDRLT----
MLBr_00388|M.leprae_Br4923 NAQVLTPVLLAAGIDLLVVQGSIVSAECVASGGEPLNLKTFISELD----
.* :::*.:* ... . : .: :
Mb0021c|M.bovis_AF2122/97 DIPVIAAGGIADGRGLAAALMLGAAGVLVG---------------TRFYA
Rv0021c|M.tuberculosis_H37Rv DIPVIAAGGIADGRGLAAALMLGAAGVLVG---------------TRFYA
MAB_0159|M.abscessus_ATCC_1997 QILVLAAGGVTDGRGLAASLALGADGVLVG---------------TRFWA
MUL_1961|M.ulcerans_Agy99 ETLVVAAGGIADGRGLAAALALGADGALVG---------------TRFWA
Mflv_5156|M.gilvum_PYR-GCK -VPVLAAGGIASGRALAAVLAAGAAGAWIG---------------TAFAT
Mvan_4537|M.vanbaalenii_PYR-1 -VPVLAAGGIASGRGLAAALAAGASGGWLG---------------TAFAA
MMAR_2084|M.marinum_M -VPVLAGGGIASPRSLAAVLAAGAAGAWVG---------------TRLAA
MAV_3496|M.avium_104 -VPVLAGGGVASARSLAAVLAAGASGAWVG---------------TRLSA
MSMEG_1660|M.smegmatis_MC2_155 -LPVLAAGGVASPRGLAAVLAAGAAAAWLG---------------TVFTT
TH_1976|M.thermoresistible__bu -VPVLAAGGITSGRGLAAVLAAGAAGAWLG---------------TVFTA
MLBr_00388|M.leprae_Br4923 -VPVVAGG-VLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPM
*:*.* : . * : ** . :* .
Mb0021c|M.bovis_AF2122/97 TVEALSTPQARDPLLAATG---------DDMCRTTIYDQLRRYPWPQGHT
Rv0021c|M.tuberculosis_H37Rv TVEALSTPQARDPLLAATG---------DDMCRTTIYDQLRRYPWPQGHT
MAB_0159|M.abscessus_ATCC_1997 AGEAAISRAAQRHALQVGG---------DDTIRQHVYDIVRGKRWPSAYS
MUL_1961|M.ulcerans_Agy99 CPEALVSPRAHQRAVEASG---------DDTIRTRVYDIVRQRDWPAEYD
Mflv_5156|M.gilvum_PYR-GCK CPESLFPDEARRALLTADA---------TDTLTTRVFDVALGYPWPAHFP
Mvan_4537|M.vanbaalenii_PYR-1 CPESTLPDAAAEVMLAARN---------TDTVTTRVFDIALGYPWPPTIP
MMAR_2084|M.marinum_M CPEALTGEPSRQALIAARE---------TDTSTTRVFDVADGLPWPQRFP
MAV_3496|M.avium_104 CPEALTADGNRRALVEAAE---------TDTAVTRAFDVAKGLPWPARFP
MSMEG_1660|M.smegmatis_MC2_155 CVEASTPAAARDRLLAANG---------ENTMLTSEFDIRAGYRWPADVP
TH_1976|M.thermoresistible__bu CAEALTAPDARAALLAAPS---------TATTTTREFDIAAGYRWPATIP
MLBr_00388|M.leprae_Br4923 ATAIADAAAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVL
:
Mb0021c|M.bovis_AF2122/97 MSVLSNALTDQFEDTELDILHR--EEAMARYWRAVPARDYSIANVTAGQA
Rv0021c|M.tuberculosis_H37Rv MSVLSNALTDQFEDTELDILHR--EEAMARYWRAVAARDYSIANVTAGQA
MAB_0159|M.abscessus_ATCC_1997 GRVLRNDFVDKWHRREAELAQHL-DQARSEYQSGVAAEDYRTANLIVGEG
MUL_1961|M.ulcerans_Agy99 LRLLSNSLIQAWHGNESELIRRL-PDLLGAFENAVAAEDFEMATVLVGEA
Mflv_5156|M.gilvum_PYR-GCK ERVLRNAFTAAWDGR----TPD--DDARARLAEAIADDDFRVAPVNAGQG
Mvan_4537|M.vanbaalenii_PYR-1 ERVLRNAFTDSWHGRESELAAD--TEAVTELRAAIAADDYRLAPVNVGQG
MMAR_2084|M.marinum_M SRVLTNDFVARWNGNETALAAD--ADARAELAAASAAEDLRVAPVDAGQG
MAV_3496|M.avium_104 SRVLANDFVERWTGREETL--D--AGACEELAAAIAAGDCRVAPVDAGQG
MSMEG_1660|M.smegmatis_MC2_155 ERVLT-------------------------------DENGAATPVNAGQG
TH_1976|M.thermoresistible__bu ERVLT-------------------------------DPAGDPTPVNAGQG
MLBr_00388|M.leprae_Br4923 GTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVGERPSLQQVLNGPS
* : * .
Mb0021c|M.bovis_AF2122/97 AGLVNAVLPAADVITGMAQQAARTLTAMRAV------
Rv0021c|M.tuberculosis_H37Rv AGLVNAVLPAADVITGMAQQAARTLTAMRAV------
MAB_0159|M.abscessus_ATCC_1997 IGQVRSVESVADIIESMVAQAAAINSTSRS-------
MUL_1961|M.ulcerans_Agy99 VGLISRVGPAADIVSEMVCDATRILNRSG--------
Mflv_5156|M.gilvum_PYR-GCK VDDITAVEPAAMVIARLCDDARRLLAKPPTR------
Mvan_4537|M.vanbaalenii_PYR-1 VSELTAIEPAARVIQRLCDEAREVGQQ----------
MMAR_2084|M.marinum_M VGMIPDGAPAGEVIEQMCSGARELLARWA--------
MAV_3496|M.avium_104 VGMIRNDATVAEVIDEMCSGAEQLLSRWGS-------
MSMEG_1660|M.smegmatis_MC2_155 VGMVNQSLTVAETMSRLCWGAEALLRRWS--------
TH_1976|M.thermoresistible__bu VGMVTAAQPAAAVIERLCSRAEQLLTRWGG-------
MLBr_00388|M.leprae_Br4923 DNPFGTLNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI
. . .. : .