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KATSTQWSQAMGLAAPIVNAPMGGVAGGALAAAVSRAGGLGMIGIGSAGSADRLHTELRHVSDLVDRPFG IGLISWAVAEQPRLLEAALAARPALLSVSFGDDWAWVRRAHDAGCVTATQVADVDGAQRAADAGVDVLVT RGAEAGGHGQPRVGTLPLLVEVLDRVAVPVLAAGGIASGRGLAAALAAGASGGWLGTAFAACPESTLPDA AAEVMLAARNTDTVTTRVFDIALGYPWPPTIPERVLRNAFTDSWHGRESELAADTEAVTELRAAIAADDY RLAPVNVGQGVSELTAIEPAARVIQRLCDEAREVGQQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4537 | - | - | 100% (318) | 2-nitropropane dioxygenase, NPD |
| M. vanbaalenii PYR-1 | Mvan_5586 | - | 4e-34 | 32.78% (299) | 2-nitropropane dioxygenase, NPD |
| M. vanbaalenii PYR-1 | Mvan_5269 | - | 6e-31 | 34.96% (266) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0021c | - | 6e-57 | 42.17% (313) | hypothetical protein Mb0021c |
| M. gilvum PYR-GCK | Mflv_5156 | - | 1e-114 | 65.08% (315) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv0021c | - | 2e-57 | 42.49% (313) | hypothetical protein Rv0021c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0159 | - | 2e-58 | 41.64% (317) | 2-nitropropane dioxygenase |
| M. marinum M | MMAR_2084 | - | 8e-98 | 59.16% (311) | hypothetical protein MMAR_2084 |
| M. avium 104 | MAV_3496 | - | 4e-93 | 56.27% (311) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_1660 | - | 4e-86 | 54.10% (305) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. thermoresistible (build 8) | TH_1976 | - | 5e-89 | 58.03% (305) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. ulcerans Agy99 | MUL_1961 | - | 6e-58 | 40.19% (316) | hypothetical protein MUL_1961 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4537|M.vanbaalenii_PYR-1 MKATSTQWSQAMGLAAPIVNAPMGGVAGGALAAAVSRAGGLGMIGIGSAG
Mflv_5156|M.gilvum_PYR-GCK MDTLSTPWSAELGLDVPIVNAPMGGAAGGTLAAAVSRAGGLGMVGMGSSA
MSMEG_1660|M.smegmatis_MC2_155 -MSLATTWSKAMGIDVPIVNAPMGGAAGARLAAAVSEAGGLGMVGMGSSA
TH_1976|M.thermoresistible__bu -----------MGIEVPIVNAPMGGTAGAELAAAVSAAGGLGMIGMGSSA
MMAR_2084|M.marinum_M --MLATGWSRGFGLRVPIVNAPMGGVAGGRLAAAVTAAGGLGMIGMGSRA
MAV_3496|M.avium_104 --MLSTPWSAGFGLRVPIVNAPMGGVAGGRLAAAVTAAGGLGMVGMGSVA
Mb0021c|M.bovis_AF2122/97 -MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGG-YG
Rv0021c|M.tuberculosis_H37Rv -MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGG-YG
MAB_0159|M.abscessus_ATCC_1997 -MTFNTRLTDRFGIEHPVVLAPMDDVADARLASAVSAAGGLGLLGGG-YA
MUL_1961|M.ulcerans_Agy99 -MSLNTRLTEFLGVQHPILLAPMAMTSGGRLAAAVTAAGGLGLIGGG-YG
:*: *:: *** :.. **:**: *****::* * .
Mvan_4537|M.vanbaalenii_PYR-1 SADRLHTELRHVSDLVDRPFGIGLISWAVAEQPRLLEAALAARPALLSVS
Mflv_5156|M.gilvum_PYR-GCK SAAQLRAQLAELGELK-RPFGIGVIDWVIRKEPELLTTALDARPTALSVS
MSMEG_1660|M.smegmatis_MC2_155 TPEQLRRELADLAKPS-RPFGIGLVHWVMTERPDLFDIALEARPALLSVS
TH_1976|M.thermoresistible__bu TAAVLRRELAGPIT---RPFGIGLVQWVVDAEPELLDVALAARPTLLSVS
MMAR_2084|M.marinum_M TRAALAEQLRQVSG----RFGIGLVDWVMRSEAGLLEDALAAGPALLSVS
MAV_3496|M.avium_104 TRRLLAEQLQYVDG----RFGIGLVDWVMRNEAGLLEDALAARPALLSVS
Mb0021c|M.bovis_AF2122/97 DRDWLARQFDLAAG---APVGCGFITWSLARQPQLLDLALQYEPVAVMLS
Rv0021c|M.tuberculosis_H37Rv DRDWLARQFDLAAG---APVGCGFITWSLARQPQLLDLALQYEPVAVMLS
MAB_0159|M.abscessus_ATCC_1997 DADWVRQQFDQVS----AAVGCGFITWTLKGNEHVLEHALARGPAALFLS
MUL_1961|M.ulcerans_Agy99 EAEWLQRQLEQAQG---QRVGCGFITWSLARNPELLDLILAANPAAIMLS
: :: .* *.: * : . :: * *. : :*
Mvan_4537|M.vanbaalenii_PYR-1 FGDDWAWVRRAHDAGCVTATQVADVDGAQRAADAGVDVLVTRGAEAGGHG
Mflv_5156|M.gilvum_PYR-GCK FGTEWDWVARARDAGCVSVTQVADVEAALRAVDAGVQVLVARGAEAGGHG
MSMEG_1660|M.smegmatis_MC2_155 FGDDWAWVRRAHDVGVTVATQVATVGDALRAAEAGVDVLVARGAEAGGHG
TH_1976|M.thermoresistible__bu FGADYGWVERAHAEGISAAAQVADVESGVRAQDAGVDVVVARGAEGGGHG
MMAR_2084|M.marinum_M FGTDWSWVGPARDAGIPTVTQVYDALGARRAADAGVDIVVARGAEGGGHG
MAV_3496|M.avium_104 FGTDWSWVAKAHDAGIPTVTQVYDSLGARQAVDAGVDILVARGSEGGGHG
Mb0021c|M.bovis_AF2122/97 FGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHG
Rv0021c|M.tuberculosis_H37Rv FGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHG
MAB_0159|M.abscessus_ATCC_1997 FGDPAPYAPRIRAAGVPLICQVHNIRQAARAIEVGADVIVAQGGEAGGHG
MUL_1961|M.ulcerans_Agy99 FGDPHNFAGPIHDAGIPLICQIHTREQALRVLEVGPDIIVAQGSESGGHG
** :. : * *: . :. :.* :::*::* *.****
Mvan_4537|M.vanbaalenii_PYR-1 QPRVGTLPLLVEVLDRVA-----VPVLAAGGIASGRGLAAALAAGASGGW
Mflv_5156|M.gilvum_PYR-GCK TPAVATLPLLAAILDRVE-----VPVLAAGGIASGRALAAVLAAGAAGAW
MSMEG_1660|M.smegmatis_MC2_155 RPALGTLPLLTQVLDAVE-----LPVLAAGGVASPRGLAAVLAAGAAAAW
TH_1976|M.thermoresistible__bu EPRLGTLPLLTELLDRLT-----VPVLAAGGITSGRGLAAVLAAGAAGAW
MMAR_2084|M.marinum_M EVRLGTLPLLDAVLAAVS-----VPVLAGGGIASPRSLAAVLAAGAAGAW
MAV_3496|M.avium_104 EVKLGLLPLLDAVLDAVS-----VPVLAGGGVASARSLAAVLAAGASGAW
Mb0021c|M.bovis_AF2122/97 HGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVL
Rv0021c|M.tuberculosis_H37Rv HGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVL
MAB_0159|M.abscessus_ATCC_1997 EGRRSTFTLVPEVVDLVAGTAPQILVLAAGGVTDGRGLAASLALGADGVL
MUL_1961|M.ulcerans_Agy99 MSVRSTFTLVPDVVDLVAQRSAETLVVAAGGIADGRGLAAALALGADGAL
. :.*: :: : *:*.**::. *.*** * ** .
Mvan_4537|M.vanbaalenii_PYR-1 LGTAFAACPESTLPDAAAEVMLAARNTDTVTTRVFDIALGYPWPPTIPER
Mflv_5156|M.gilvum_PYR-GCK IGTAFATCPESLFPDEARRALLTADATDTLTTRVFDVALGYPWPAHFPER
MSMEG_1660|M.smegmatis_MC2_155 LGTVFTTCVEASTPAAARDRLLAANGENTMLTSEFDIRAGYRWPADVPER
TH_1976|M.thermoresistible__bu LGTVFTACAEALTAPDARAALLAAPSTATTTTREFDIAAGYRWPATIPER
MMAR_2084|M.marinum_M VGTRLAACPEALTGEPSRQALIAARETDTSTTRVFDVADGLPWPQRFPSR
MAV_3496|M.avium_104 VGTRLSACPEALTADGNRRALVEAAETDTAVTRAFDVAKGLPWPARFPSR
Mb0021c|M.bovis_AF2122/97 VGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMS
Rv0021c|M.tuberculosis_H37Rv VGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMS
MAB_0159|M.abscessus_ATCC_1997 VGTRFWAAGEAAISRAAQRHALQVGGDDTIRQHVYDIVRGKRWPSAYSGR
MUL_1961|M.ulcerans_Agy99 VGTRFWACPEALVSPRAHQRAVEASGDDTIRTRVYDIVRQRDWPAEYDLR
:** : : *: : . :* **
Mvan_4537|M.vanbaalenii_PYR-1 VLRNAFTDSWHGRESELAAD-TEAVTELRAAIAADDYRLAPVNVGQGVSE
Mflv_5156|M.gilvum_PYR-GCK VLRNAFTAAWDGR----TPD-DDARARLAEAIADDDFRVAPVNAGQGVDD
MSMEG_1660|M.smegmatis_MC2_155 VLT------------------------------DENGAATPVNAGQGVGM
TH_1976|M.thermoresistible__bu VLT------------------------------DPAGDPTPVNAGQGVGM
MMAR_2084|M.marinum_M VLTNDFVARWNGNETALAAD-ADARAELAAASAAEDLRVAPVDAGQGVGM
MAV_3496|M.avium_104 VLANDFVERWTGREETL--D-AGACEELAAAIAAGDCRVAPVDAGQGVGM
Mb0021c|M.bovis_AF2122/97 VLSNALTDQFEDTELDILHR-EEAMARYWRAVPARDYSIANVTAGQAAGL
Rv0021c|M.tuberculosis_H37Rv VLSNALTDQFEDTELDILHR-EEAMARYWRAVAARDYSIANVTAGQAAGL
MAB_0159|M.abscessus_ATCC_1997 VLRNDFVDKWHRREAELAQHLDQARSEYQSGVAAEDYRTANLIVGEGIGQ
MUL_1961|M.ulcerans_Agy99 LLSNSLIQAWHGNESELIRRLPDLLGAFENAVAAEDFEMATVLVGEAVGL
:* : : .*:. .
Mvan_4537|M.vanbaalenii_PYR-1 LTAIEPAARVIQRLCDEAREVGQQ----
Mflv_5156|M.gilvum_PYR-GCK ITAVEPAAMVIARLCDDARRLLAKPPTR
MSMEG_1660|M.smegmatis_MC2_155 VNQSLTVAETMSRLCWGAEALLRRWS--
TH_1976|M.thermoresistible__bu VTAAQPAAAVIERLCSRAEQLLTRWGG-
MMAR_2084|M.marinum_M IPDGAPAGEVIEQMCSGARELLARWA--
MAV_3496|M.avium_104 IRNDATVAEVIDEMCSGAEQLLSRWGS-
Mb0021c|M.bovis_AF2122/97 VNAVLPAADVITGMAQQAARTLTAMRAV
Rv0021c|M.tuberculosis_H37Rv VNAVLPAADVITGMAQQAARTLTAMRAV
MAB_0159|M.abscessus_ATCC_1997 VRSVESVADIIESMVAQAAAINSTSRS-
MUL_1961|M.ulcerans_Agy99 ISRVGPAADIVSEMVCDATRILNRSG--
: ... : : *