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VLATGWSRGFGLRVPIVNAPMGGVAGGRLAAAVTAAGGLGMIGMGSRATRAALAEQLRQVSGRFGIGLVD WVMRSEAGLLEDALAAGPALLSVSFGTDWSWVGPARDAGIPTVTQVYDALGARRAADAGVDIVVARGAEG GGHGEVRLGTLPLLDAVLAAVSVPVLAGGGIASPRSLAAVLAAGAAGAWVGTRLAACPEALTGEPSRQAL IAARETDTSTTRVFDVADGLPWPQRFPSRVLTNDFVARWNGNETALAADADARAELAAASAAEDLRVAPV DAGQGVGMIPDGAPAGEVIEQMCSGARELLARWA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2084 | - | - | 100% (314) | hypothetical protein MMAR_2084 |
| M. marinum M | MMAR_1721 | - | 2e-57 | 41.51% (318) | hypothetical protein MMAR_1721 |
| M. marinum M | MMAR_5042 | - | 6e-21 | 32.45% (265) | 2-nitropropane dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0021c | - | 9e-50 | 38.61% (316) | hypothetical protein Mb0021c |
| M. gilvum PYR-GCK | Mflv_5156 | - | 3e-97 | 60.51% (314) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv0021c | - | 2e-50 | 38.92% (316) | hypothetical protein Rv0021c |
| M. leprae Br4923 | MLBr_02066 | guaB1 | 5e-06 | 26.11% (226) | inosine 5-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0159 | - | 6e-56 | 40.59% (303) | 2-nitropropane dioxygenase |
| M. avium 104 | MAV_3496 | - | 1e-137 | 78.91% (313) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_1660 | - | 2e-79 | 51.90% (316) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. thermoresistible (build 8) | TH_1976 | - | 8e-83 | 56.25% (304) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. ulcerans Agy99 | MUL_1961 | - | 1e-57 | 41.51% (318) | hypothetical protein MUL_1961 |
| M. vanbaalenii PYR-1 | Mvan_4537 | - | 8e-98 | 59.16% (311) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0021c|M.bovis_AF2122/97 ------------------------------MVLSTAFSQMFGIDYPIVSA
Rv0021c|M.tuberculosis_H37Rv ------------------------------MVLSTAFSQMFGIDYPIVSA
MAB_0159|M.abscessus_ATCC_1997 ------------------------------MTFNTRLTDRFGIEHPVVLA
MUL_1961|M.ulcerans_Agy99 ------------------------------MSLNTRLTEFLGVQHPILLA
MMAR_2084|M.marinum_M -------------------------------MLATGWSRGFGLRVPIVNA
MAV_3496|M.avium_104 -------------------------------MLSTPWSAGFGLRVPIVNA
MSMEG_1660|M.smegmatis_MC2_155 ------------------------------MSLATTWSKAMGIDVPIVNA
TH_1976|M.thermoresistible__bu ----------------------------------------MGIEVPIVNA
Mflv_5156|M.gilvum_PYR-GCK -----------------------------MDTLSTPWSAELGLDVPIVNA
Mvan_4537|M.vanbaalenii_PYR-1 -----------------------------MKATSTQWSQAMGLAAPIVNA
MLBr_02066|M.leprae_Br4923 MRFLDGHQPRFDLTYKDVFIVPHRSDVASRFDVDLSTYDGSGTTIPVVVA
* *:: *
Mb0021c|M.bovis_AF2122/97 PMDLIAGGELAAAVSGAGGLGLIGGG-YGDRDWLARQFDLAAG-------
Rv0021c|M.tuberculosis_H37Rv PMDLIAGGELAAAVSGAGGLGLIGGG-YGDRDWLARQFDLAAG-------
MAB_0159|M.abscessus_ATCC_1997 PMDDVADARLASAVSAAGGLGLLGGG-YADADWVRQQFDQVS--------
MUL_1961|M.ulcerans_Agy99 PMAMTSGGRLAAAVTAAGGLGLIGGG-YGEAEWLQRQLEQAQG-------
MMAR_2084|M.marinum_M PMGGVAGGRLAAAVTAAGGLGMIGMGSRATRAALAEQLRQVSG-------
MAV_3496|M.avium_104 PMGGVAGGRLAAAVTAAGGLGMVGMGSVATRRLLAEQLQYVDG-------
MSMEG_1660|M.smegmatis_MC2_155 PMGGAAGARLAAAVSEAGGLGMVGMGSSATPEQLRRELADLAKPS-----
TH_1976|M.thermoresistible__bu PMGGTAGAELAAAVSAAGGLGMIGMGSSATAAVLRRELAGPIT-------
Mflv_5156|M.gilvum_PYR-GCK PMGGAAGGTLAAAVSRAGGLGMVGMGSSASAAQLRAQLAELGELK-----
Mvan_4537|M.vanbaalenii_PYR-1 PMGGVAGGALAAAVSRAGGLGMIGIGSAGSADRLHTELRHVSDLVD----
MLBr_02066|M.leprae_Br4923 NMTTVAGQRMAETVARRGGLVILPQDLPIATVQQAVEFVKSRDLVIDTPV
* :. :* :*: *** :: . ::
Mb0021c|M.bovis_AF2122/97 -----------------------------APVGCG---------------
Rv0021c|M.tuberculosis_H37Rv -----------------------------APVGCG---------------
MAB_0159|M.abscessus_ATCC_1997 -----------------------------AAVGCG---------------
MUL_1961|M.ulcerans_Agy99 -----------------------------QRVGCG---------------
MMAR_2084|M.marinum_M ------------------------------RFGIG---------------
MAV_3496|M.avium_104 ------------------------------RFGIG---------------
MSMEG_1660|M.smegmatis_MC2_155 -----------------------------RPFGIG---------------
TH_1976|M.thermoresistible__bu -----------------------------RPFGIG---------------
Mflv_5156|M.gilvum_PYR-GCK -----------------------------RPFGIG---------------
Mvan_4537|M.vanbaalenii_PYR-1 -----------------------------RPFGIG---------------
MLBr_02066|M.leprae_Br4923 LLTPNDSVSDATTLIHKRAHGVAVVAFEGRPIGLVRESSCLGVDRFTRVR
.*
Mb0021c|M.bovis_AF2122/97 ------FITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTR
Rv0021c|M.tuberculosis_H37Rv ------FITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTR
MAB_0159|M.abscessus_ATCC_1997 ------FITWTLKGNEHVLEHALARGPAALFLSFGDPAPYAPRIRAAGVP
MUL_1961|M.ulcerans_Agy99 ------FITWSLARNPELLDLILAANPAAIMLSFGDPHNFAGPIHDAGIP
MMAR_2084|M.marinum_M ------LVDWVMRSEAGLLEDALAAGPALLSVSFGTDWSWVGPARDAGIP
MAV_3496|M.avium_104 ------LVDWVMRNEAGLLEDALAARPALLSVSFGTDWSWVAKAHDAGIP
MSMEG_1660|M.smegmatis_MC2_155 ------LVHWVMTERPDLFDIALEARPALLSVSFGDDWAWVRRAHDVGVT
TH_1976|M.thermoresistible__bu ------LVQWVVDAEPELLDVALAARPTLLSVSFGADYGWVERAHAEGIS
Mflv_5156|M.gilvum_PYR-GCK ------VIDWVIRKEPELLTTALDARPTALSVSFGTEWDWVARARDAGCV
Mvan_4537|M.vanbaalenii_PYR-1 ------LISWAVAEQPRLLEAALAARPALLSVSFGDDWAWVRRAHDAGCV
MLBr_02066|M.leprae_Br4923 DVATTDFVTAPVGTDPRKIFDLLEHAPIDVAVLTNADGTLAGVLTRTGAI
.: : : * * : : . . *
Mb0021c|M.bovis_AF2122/97 LVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVP------
Rv0021c|M.tuberculosis_H37Rv LVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVP------
MAB_0159|M.abscessus_ATCC_1997 LICQVHNIRQAARAIEVGADVIVAQGGEAGGHGEGRRSTFTLVP------
MUL_1961|M.ulcerans_Agy99 LICQIHTREQALRVLEVGPDIIVAQGSESGGHGMSVRSTFTLVP------
MMAR_2084|M.marinum_M TVTQVYDALGARRAADAGVDIVVARGAEGGGHGEVRLGTLPLLD------
MAV_3496|M.avium_104 TVTQVYDSLGARQAVDAGVDILVARGSEGGGHGEVKLGLLPLLD------
MSMEG_1660|M.smegmatis_MC2_155 VATQVATVGDALRAAEAGVDVLVARGAEAGGHGRPALGTLPLLT------
TH_1976|M.thermoresistible__bu AAAQVADVESGVRAQDAGVDVVVARGAEGGGHGEPRLGTLPLLT------
Mflv_5156|M.gilvum_PYR-GCK SVTQVADVEAALRAVDAGVQVLVARGAEAGGHGTPAVATLPLLA------
Mvan_4537|M.vanbaalenii_PYR-1 TATQVADVDGAQRAADAGVDVLVTRGAEAGGHGQPRVGTLPLLV------
MLBr_02066|M.leprae_Br4923 RAGIYTPATDARGRLRIGAAVGINGDVAGKAQSLAEAGVDVLVVDTAHGY
. * : : . . .:. . *:
Mb0021c|M.bovis_AF2122/97 -----EIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFY
Rv0021c|M.tuberculosis_H37Rv -----EIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFY
MAB_0159|M.abscessus_ATCC_1997 -----EVVDLVAGTAPQILVLAAGGVTDGRGLAASLALGADGVLVGTRFW
MUL_1961|M.ulcerans_Agy99 -----DVVDLVAQRSAETLVVAAGGIADGRGLAAALALGADGALVGTRFW
MMAR_2084|M.marinum_M -----AVLAAVS-----VPVLAGGGIASPRSLAAVLAAGAAGAWVGTRLA
MAV_3496|M.avium_104 -----AVLDAVS-----VPVLAGGGVASARSLAAVLAAGASGAWVGTRLS
MSMEG_1660|M.smegmatis_MC2_155 -----QVLDAVE-----LPVLAAGGVASPRGLAAVLAAGAAAAWLGTVFT
TH_1976|M.thermoresistible__bu -----ELLDRLT-----VPVLAAGGITSGRGLAAVLAAGAAGAWLGTVFT
Mflv_5156|M.gilvum_PYR-GCK -----AILDRVE-----VPVLAAGGIASGRALAAVLAAGAAGAWIGTAFA
Mvan_4537|M.vanbaalenii_PYR-1 -----EVLDRVA-----VPVLAAGGIASGRGLAAALAAGASGGWLGTAFA
MLBr_02066|M.leprae_Br4923 QVKTLEAIKCVASLNLGVPLVAG-NVVSAEGTRELLNAGATIVKVGVGPG
: : ::*. .:.. .. * ** :*.
Mb0021c|M.bovis_AF2122/97 ATVEALSTPQARD----PLLAATGDDMCRTTIYDQLRRYPWP-------Q
Rv0021c|M.tuberculosis_H37Rv ATVEALSTPQARD----PLLAATGDDMCRTTIYDQLRRYPWP-------Q
MAB_0159|M.abscessus_ATCC_1997 AAGEAAISRAAQR----HALQVGGDDTIRQHVYDIVRGKRWP-------S
MUL_1961|M.ulcerans_Agy99 ACPEALVSPRAHQ----RAVEASGDDTIRTRVYDIVRQRDWP-------A
MMAR_2084|M.marinum_M ACPEALTGEPSRQ----ALIAARETDTSTTRVFDVADGLPWP-------Q
MAV_3496|M.avium_104 ACPEALTADGNRR----ALVEAAETDTAVTRAFDVAKGLPWP-------A
MSMEG_1660|M.smegmatis_MC2_155 TCVEASTPAAARD----RLLAANGENTMLTSEFDIRAGYRWP-------A
TH_1976|M.thermoresistible__bu ACAEALTAPDARA----ALLAAPSTATTTTREFDIAAGYRWP-------A
Mflv_5156|M.gilvum_PYR-GCK TCPESLFPDEARR----ALLTADATDTLTTRVFDVALGYPWP-------A
Mvan_4537|M.vanbaalenii_PYR-1 ACPESTLPDAAAE----VMLAARNTDTVTTRVFDIALGYPWP-------P
MLBr_02066|M.leprae_Br4923 AMCTTRMMTGVGRPQFSAVLECASAARKLNRHVWADGGVRHPRDVALALA
: : : *
Mb0021c|M.bovis_AF2122/97 GHTMSVLSNALTDQFEDTELDILHR-EEAMARYWRAVPARDYSIANVTAG
Rv0021c|M.tuberculosis_H37Rv GHTMSVLSNALTDQFEDTELDILHR-EEAMARYWRAVAARDYSIANVTAG
MAB_0159|M.abscessus_ATCC_1997 AYSGRVLRNDFVDKWHRREAELAQHLDQARSEYQSGVAAEDYRTANLIVG
MUL_1961|M.ulcerans_Agy99 EYDLRLLSNSLIQAWHGNESELIRRLPDLLGAFENAVAAEDFEMATVLVG
MMAR_2084|M.marinum_M RFPSRVLTNDFVARWNGNETALAAD-ADARAELAAASAAEDLRVAPVDAG
MAV_3496|M.avium_104 RFPSRVLANDFVERWTGREETL--D-AGACEELAAAIAAGDCRVAPVDAG
MSMEG_1660|M.smegmatis_MC2_155 DVPERVLT------------------------------DENGAATPVNAG
TH_1976|M.thermoresistible__bu TIPERVLT------------------------------DPAGDPTPVNAG
Mflv_5156|M.gilvum_PYR-GCK HFPERVLRNAFTAAWDGR----TPD-DDARARLAEAIADDDFRVAPVNAG
Mvan_4537|M.vanbaalenii_PYR-1 TIPERVLRNAFTDSWHGRESELAAD-TEAVTELRAAIAADDYRLAPVNVG
MLBr_02066|M.leprae_Br4923 AGASNVMIGSWFAGTYESPGDLMRDRHDQPYKESYGMASKRAVVARTVAD
:: : ..
Mb0021c|M.bovis_AF2122/97 -----------------QAAGLVNAVLPAADVITGMAQQAARTLTAMRAV
Rv0021c|M.tuberculosis_H37Rv -----------------QAAGLVNAVLPAADVITGMAQQAARTLTAMRAV
MAB_0159|M.abscessus_ATCC_1997 -----------------EGIGQVRSVESVADIIESMVAQAAAINSTSRS-
MUL_1961|M.ulcerans_Agy99 -----------------EAVGLISRVGPAADIVSEMVCDATRILNRSG--
MMAR_2084|M.marinum_M -----------------QGVGMIPDGAPAGEVIEQMCSGARELLARWA--
MAV_3496|M.avium_104 -----------------QGVGMIRNDATVAEVIDEMCSGAEQLLSRWGS-
MSMEG_1660|M.smegmatis_MC2_155 -----------------QGVGMVNQSLTVAETMSRLCWGAEALLRRWS--
TH_1976|M.thermoresistible__bu -----------------QGVGMVTAAQPAAAVIERLCSRAEQLLTRWGG-
Mflv_5156|M.gilvum_PYR-GCK -----------------QGVDDITAVEPAAMVIARLCDDARRLLAKPPTR
Mvan_4537|M.vanbaalenii_PYR-1 -----------------QGVSELTAIEPAARVIQRLCDEAREVGQQ----
MLBr_02066|M.leprae_Br4923 SSFDRARKALFDEGISTSRMGLDPDHGGVEDLIDHITSGVRSTCTYVGAS
. . . : : .
Mb0021c|M.bovis_AF2122/97 -----------------------------
Rv0021c|M.tuberculosis_H37Rv -----------------------------
MAB_0159|M.abscessus_ATCC_1997 -----------------------------
MUL_1961|M.ulcerans_Agy99 -----------------------------
MMAR_2084|M.marinum_M -----------------------------
MAV_3496|M.avium_104 -----------------------------
MSMEG_1660|M.smegmatis_MC2_155 -----------------------------
TH_1976|M.thermoresistible__bu -----------------------------
Mflv_5156|M.gilvum_PYR-GCK -----------------------------
Mvan_4537|M.vanbaalenii_PYR-1 -----------------------------
MLBr_02066|M.leprae_Br4923 TLAELHEKAVVGVQSAAGFAEGHPLPSGW