For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. gilvum PYR-GCK Mflv_3422 (-)

annotation: hypothetical protein Mflv_3422
coordinates: 3640189 - 3642051
length: 620

EHMFDGSLPEPATLAAASDTDLAHAINRWAAASAAAEARKLAAIAELHRRATEGQLHERDAVDDTDAAAA
HICCALTISHGHALALIDLATTLRDRLPNTGARFLAGDLAPTMITVIAWRTALVTPAALPAIDTAIAQRA
HTWGPLTQKKLAAAIDVWVHRYDPDAVRRTRNAMRGRYFAVETATRADTAGDPATGTVAVHGRLSATDAA
LTRQRLAVMIATVCPDDPRTMDQRRADALGAVMAGSTFLACACDDPDCPAKIDDGRATSITVHVLADPDS
LHAEPDPDFHGDTPPATHAEHTQAEAQAREAGVEAEDGTAAEQAHAEVEADQAEVEAEVEVEAEAEIEVE
IEVEVEVEGDADTEPGWAQPEAPSPVEPAAPVGDLPAVIIGGGIVPAPLLAELIARGATIRFVHAEGLGD
EPRYRPSRALQRFVHARDITCRFPGCDRPATHADIDHTQPWPTGATHPANTKSYCRLHHLIKTFRPGWTD
TQHPDGTLVITTPTGTQCTTKPLSTLLFPNWNTTTPQPPTPRPHTPTPPDQHHRNLKMPTRRRTRAHNRA
AYITRERHLNNLERTTQQAREPLPQTGIPEGTPNPLPQSDCDTPRPARPHDYGSDPPPF*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_3422--100% (620)hypothetical protein Mflv_3422
M. gilvum PYR-GCKMflv_4927-e-15048.63% (621) hypothetical protein Mflv_4927
M. gilvum PYR-GCKMflv_1272-5e-9336.38% (613) HNH endonuclease

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2126-1e-10742.43% (575) hypothetical protein Mb2126
M. tuberculosis H37RvRv2100-1e-10742.43% (575) hypothetical protein Rv2100
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4752-4e-3335.51% (276) hypothetical protein MAB_4752
M. marinum MMMAR_5187-1e-4143.44% (221) 13e12 repeat-containing protein
M. avium 104MAV_4456-5e-4543.51% (239) 13e12 repeat-containing protein
M. smegmatis MC2 155MSMEG_0144-1e-9337.69% (597) HNH endonuclease
M. thermoresistible (build 8)TH_0334-2e-3638.02% (263) HNH endonuclease
M. ulcerans Agy99MUL_2679-1e-3437.72% (281) 13e12 repeat-containing protein
M. vanbaalenii PYR-1Mvan_5188-1e-10841.03% (624) hypothetical protein Mvan_5188

CLUSTAL 2.0.9 multiple sequence alignment


Mb2126|M.bovis_AF2122/97            MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv         MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Mflv_3422|M.gilvum_PYR-GCK          -----------------------------------MEHMFDGSLPEPATL
Mvan_5188|M.vanbaalenii_PYR-1       --------------------------------------MFDSGLAG----
MMAR_5187|M.marinum_M               ------------------------MFESMGVAAGVDHPCDALAERRQLRT
MAV_4456|M.avium_104                ------------------------------MCEDATAWFDELMER-CYPS
MUL_2679|M.ulcerans_Agy99           --------------------------------------MDQHIIEYVFDT
TH_0334|M.thermoresistible__bu      ----------------------------------------------MFES
MAB_4752|M.abscessus_ATCC_1997      ----------------------------------------------MFDE
MSMEG_0144|M.smegmatis_MC2_155      --------MSWGYPQTRVHPQIAVLRCRGGFTVGRFERMYEGLLVQIAEF
                                                                                      

Mb2126|M.bovis_AF2122/97            CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGR-RTGA--DQRADWA
Rv2100|M.tuberculosis_H37Rv         CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGR-RTGA--DQRADWA
Mflv_3422|M.gilvum_PYR-GCK          AAASDTDLAHAINRWAAASAAAEARKLAAIAELHRR-ATEG--QLHERDA
Mvan_5188|M.vanbaalenii_PYR-1       --LDEPALLAAIERAACEESRAGARKSAAIAALVHESVTFD--DVRDQWV
MMAR_5187|M.marinum_M               PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA
MAV_4456|M.avium_104                ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA
MUL_2679|M.ulcerans_Agy99           ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV
TH_0334|M.thermoresistible__bu      --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA
MAB_4752|M.abscessus_ATCC_1997      --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
MSMEG_0144|M.smegmatis_MC2_155      SALSDLELEGQARGWAQAEASASAHKHAAMAELFIRATSTPSADERRWWF
                                        .             .  * . .   :. *                 

Mb2126|M.bovis_AF2122/97            CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv         CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Mflv_3422|M.gilvum_PYR-GCK          VDDTDAAAAHICCALTISHGHALALIDLATTLRDRLPNTGARFLAGDLAP
Mvan_5188|M.vanbaalenii_PYR-1       WDSWIETACELGAVLNTSHRRASALMRIAVALRDRLPKVAALFAAGRLST
MMAR_5187|M.marinum_M               VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL
MAV_4456|M.avium_104                VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MUL_2679|M.ulcerans_Agy99           ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
TH_0334|M.thermoresistible__bu      IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
MAB_4752|M.abscessus_ATCC_1997      LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
MSMEG_0144|M.smegmatis_MC2_155      VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE
                                     *    . ..: .        .      .  :. **      * ** :  

Mb2126|M.bovis_AF2122/97            RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv         RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Mflv_3422|M.gilvum_PYR-GCK          TMITVIAWRTALVT-PAALPAIDTAIAQRAHTWGPLTQKKLAAAIDVWVH
Mvan_5188|M.vanbaalenii_PYR-1       RLIGQVTWRTRLVQDPQLLALLDTAIADKATRWEPLSDDKLTAALDAVIE
MMAR_5187|M.marinum_M               RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA
MAV_4456|M.avium_104                RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MUL_2679|M.ulcerans_Agy99           RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
TH_0334|M.thermoresistible__bu      RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
MAB_4752|M.abscessus_ATCC_1997      RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
MSMEG_0144|M.smegmatis_MC2_155      MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL
                                      .  :   :  :     :. :*: :.     *   :   :   :*  : 

Mb2126|M.bovis_AF2122/97            RYDPGALRRSRISARTRDLCIGDP-------DEDAGTAALWGRLYATDAA
Rv2100|M.tuberculosis_H37Rv         RYDPGALRRSRISARTRDLCIGDP-------DEDAGTAALWGRLYATDAA
Mflv_3422|M.gilvum_PYR-GCK          RYDPDAVRRTRNAMRGRYFAVETATRADTAGDPATGTVAVHGRLSATDAA
Mvan_5188|M.vanbaalenii_PYR-1       RYDPDAVIRAREHVSGLDFRVGAS-------DDPDALVTVWGKILGCDAA
MMAR_5187|M.marinum_M               RADADAVRRRKERHADREIWIGQD-------ADG--ISRIDGSMFTIDAH
MAV_4456|M.avium_104                KADADAVRRTEKQAASRHVWIAEM-------GEG--LSHLEGTVSSPDAH
MUL_2679|M.ulcerans_Agy99           KFDRDAVRRSRRDAADRYVDCAPL-------EPG--MALVNRQVFSATAE
TH_0334|M.thermoresistible__bu      RFDPTGVREPRSPGEDRYVVVTPA-------GQG--MVDVSARLTFEAGF
MAB_4752|M.abscessus_ATCC_1997      HFDQDAVRRNRSATDKRHLEIRPL-------GNGEPVAEVWGTLQAVHAV
MSMEG_0144|M.smegmatis_MC2_155      KHDPGSFRRGRASRRGRYFDIGSP-------TDAPGVLTVTGRLQAHLGN
                                    : *  .. . .       .                    :   :    . 

Mb2126|M.bovis_AF2122/97            MLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPS
Rv2100|M.tuberculosis_H37Rv         MLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPS
Mflv_3422|M.gilvum_PYR-GCK          LTRQRLAVMIATVCPDDPRTMDQRRADALGAVMAGSTFLACACDDPDCPA
Mvan_5188|M.vanbaalenii_PYR-1       VLAARIAELLKGLCDNDPRSVCVRRSHAVGAIVRGQDHLRCRCGSPDCTA
MMAR_5187|M.marinum_M               ALDRRLSALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC--
MAV_4456|M.avium_104                ALDKRLDALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--
MUL_2679|M.ulcerans_Agy99           ALARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-
TH_0334|M.thermoresistible__bu      AFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-
MAB_4752|M.abscessus_ATCC_1997      ALDKRLDLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--
MSMEG_0144|M.smegmatis_MC2_155      AYDARIAELIEGVCPDDPRTLNELRHDALGAILD-HTTLACECEDPDCV-
                                        *:  :   :*  ***:    * .*:..:      : * *   **  

Mb2126|M.bovis_AF2122/97            GAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEAL
Rv2100|M.tuberculosis_H37Rv         GAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEAL
Mflv_3422|M.gilvum_PYR-GCK          KID-DGRATSITVHVLADPDSLHAEPDPDFHGDTPPATHAEHTQAEAQAR
Mvan_5188|M.vanbaalenii_PYR-1       AAVVPGSSN-VVISVLADPAALDAVRQLIADQDRDQQDKLADKQAKAKEQ
MMAR_5187|M.marinum_M               AAGARPAAQPVVIHVIAERATLDGDGG-----------------------
MAV_4456|M.avium_104                AAGTRPAAGPVVIHLIAERASVEGTGG-----------------------
MUL_2679|M.ulcerans_Agy99           AAGAPQQPSRVVIHVVAGCQTVDGAGE-----------------------
TH_0334|M.thermoresistible__bu      ADPADTAATRLVINVIAEQATVEGRSD-----------------------
MAB_4752|M.abscessus_ATCC_1997      -SGRDTADVPVVVNVVINQSTLAGSDD-----------------------
MSMEG_0144|M.smegmatis_MC2_155      RGREQSPRGHLVVHVIAREDTVTAAQHAATTTNTPDDAPADTPAADTEPA
                                              :.: ::    :: .                          

Mb2126|M.bovis_AF2122/97            TP------------------------------------------------
Rv2100|M.tuberculosis_H37Rv         TP------------------------------------------------
Mflv_3422|M.gilvum_PYR-GCK          EAGVEAEDGTAAEQAHAEVEADQAEVEAEVEVEAEAEIEVEIEVEVEVEG
Mvan_5188|M.vanbaalenii_PYR-1       GKAESQPQTEPIPQP-----------EAEAEAEPEPEAEVEVEPEAETET
MMAR_5187|M.marinum_M               --------------------------------------------------
MAV_4456|M.avium_104                --------------------------------------------------
MUL_2679|M.ulcerans_Agy99           --------------------------------------------------
TH_0334|M.thermoresistible__bu      --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_0144|M.smegmatis_MC2_155      EPAEPAEPAEPAEPAEPAEPAEPVEPVDDPDIAPAASATETATDTTASPT
                                                                                      

Mb2126|M.bovis_AF2122/97            --DPEP--------------DPPATHAP--------AELITTGGGVVPAP
Rv2100|M.tuberculosis_H37Rv         --DPEP--------------DPPATHAP--------AELITTGGGVVPAP
Mflv_3422|M.gilvum_PYR-GCK          DADTEPGWAQPEAPSPV---EPAAPVGD--------LPAVIIGGGIVPAP
Mvan_5188|M.vanbaalenii_PYR-1       AIESEPAPVKPVAPS-----NPAACVRDS-------GVALLPGVKILPLV
MMAR_5187|M.marinum_M               --------------------APAWEVGA---------------DGLVTPE
MAV_4456|M.avium_104                --------------------GPAVEVGA---------------EGLLPAQ
MUL_2679|M.ulcerans_Agy99           --------------------APGVLPG----------------DGIIPAE
TH_0334|M.thermoresistible__bu      --------------------NPGYLPG----------------YGAVPAS
MAB_4752|M.abscessus_ATCC_1997      --------------------CPAHVPG----------------FGVLAAE
MSMEG_0144|M.smegmatis_MC2_155      GTDCDPESVSVTEFTDNSSDTPSAFLDPDEHPLDRVPPAVLFGGGVLPAY
                                                         *                        :.  

Mb2126|M.bovis_AF2122/97            LLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCD
Rv2100|M.tuberculosis_H37Rv         LLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCD
Mflv_3422|M.gilvum_PYR-GCK          LLAELIARGATIRFVHAEG-LGDEPRYRPSRALQRFVHARDITCRFPGCD
Mvan_5188|M.vanbaalenii_PYR-1       ALAEAIRSGAATKTLWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCD
MMAR_5187|M.marinum_M               LVAELAKS-AKLVPLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCD
MAV_4456|M.avium_104                LVAELAAS-ARLMPLVHPADAPPENRYTPSAALADFVRCRDLTCRWPGCD
MUL_2679|M.ulcerans_Agy99           IVRELAKS-AKLQPMSTP--ILAETGYVPSPALMDFVRARDLTCRAPGCD
TH_0334|M.thermoresistible__bu      ILRAKAAT-ATLRPVALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCD
MAB_4752|M.abscessus_ATCC_1997      SARAAVAG-TPTRNLTDS----RSTGYRPSAKLAAFVRSRDQLCRFPGCE
MSMEG_0144|M.smegmatis_MC2_155      ALAEIINN-ATIRPLKHPGDTAPEDRYIPSRALADYVRCRDLTCRFPGCD
                                             :    :        .  * **  *  ::: **  ** ***:

Mb2126|M.bovis_AF2122/97            VPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQL
Rv2100|M.tuberculosis_H37Rv         VPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQL
Mflv_3422|M.gilvum_PYR-GCK          RPATHADIDHTQPWPTG-ATHPANTKSYCRLHHLIKTFRPG---WTDTQH
Mvan_5188|M.vanbaalenii_PYR-1       VPAEHCDLDHVVPYPYG-PTHPSNLNCKRRTHHLGKTFAEG---WQEQQL
MMAR_5187|M.marinum_M               HPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQL
MAV_4456|M.avium_104                RPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQL
MUL_2679|M.ulcerans_Agy99           RPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQL
TH_0334|M.thermoresistible__bu      APAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRF----THDQHK
MAB_4752|M.abscessus_ATCC_1997      AVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQE
MSMEG_0144|M.smegmatis_MC2_155      KPADRCDLDHTVPYPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQH
                                      *  .::**  *:. * .*  :* :     *     :        : : 

Mb2126|M.bovis_AF2122/97            PDGTVIWTAPNGHTYTTHPGSR--IFFPTWHTTTAELPQT---STAAVNV
Rv2100|M.tuberculosis_H37Rv         PDGTVIWTAPNGHTYTTHPGSR--IFFPTWHTTTAELPQT---STAAVNV
Mflv_3422|M.gilvum_PYR-GCK          PDGTLVITTPTGTQCTTKPLST--LLFPNWNTTTPQPPTPRPHTPTPPDQ
Mvan_5188|M.vanbaalenii_PYR-1       PDGTVLWTTPAGQRCTTVPGSW--LFFPGWDTTTAELPPM----AQPPPD
MMAR_5187|M.marinum_M               PDGTLILTSPAGHTYVTTPGSA--LLFPSLCHSTGGLPAAEA-DPPSDHC
MAV_4456|M.avium_104                PDATLILTSPAGRTYVTTPGSA--LLFPSLCVPTG-EPARPV-AAGSQPC
MUL_2679|M.ulcerans_Agy99           PDATVIWSLPDGQTYVTTPGSA--WLLPGLFAPSPELPPP----------
TH_0334|M.thermoresistible__bu      HQSSCLP------AYFQRPHG-----------------------------
MAB_4752|M.abscessus_ATCC_1997      PDGTVIWKSPTGHRYATTPVSW--FLFPAL--------------------
MSMEG_0144|M.smegmatis_MC2_155      PDGTIVWTSPSGRQYTTVPGSHRRLSITELAAPTGALDLPAT-PIPTADP
                                     :.: :            * .                             

Mb2126|M.bovis_AF2122/97            DARGLMMPRRRRTRAAELAHRINAERALN---------------------
Rv2100|M.tuberculosis_H37Rv         DARGLMMPRRRRTRAAELAHRINAERALN---------------------
Mflv_3422|M.gilvum_PYR-GCK          HHRNLKMPTRRRTRAHNRAAYITRERHLNNLERTTQQAREPLPQTGIPEG
Mvan_5188|M.vanbaalenii_PYR-1       PDRLAKMPKRRRTRAADQAARIKVEREHNATQRALETERAKTPEQARRAE
MMAR_5187|M.marinum_M               DQRSAMMPRRQRTRAQDRARRVATERRQNHHAR-----------------
MAV_4456|M.avium_104                GERTAMMPTRRRTRGQNRAARVAAERRANRAAR-----------------
MUL_2679|M.ulcerans_Agy99           -------PRSEATGSLRKPRRDDAQTRPNSRPK-----------------
TH_0334|M.thermoresistible__bu      -------PATRRPPSARGLREAVPRQGVDPRRV-----------------
MAB_4752|M.abscessus_ATCC_1997      --------TRHHTRQQARDRRRRTERNLNREQR-----------------
MSMEG_0144|M.smegmatis_MC2_155      DLRGVKMPKRRRTRAQNTARTIAAERKLNDDLV-----------------
                                              . .           .   :                     

Mb2126|M.bovis_AF2122/97            ----------DAYMAER-----NKPPSF
Rv2100|M.tuberculosis_H37Rv         ----------DAYMAER-----NKPPSF
Mflv_3422|M.gilvum_PYR-GCK          TPNPLPQSDCDTPRPARPHDYGSDPPPF
Mvan_5188|M.vanbaalenii_PYR-1       QVRYAGLPPPASPQPDYG----NDPPPF
MMAR_5187|M.marinum_M               STQPGGQPRSAAPPTPPQSEPQSHPPPF
MAV_4456|M.avium_104                LARATRPAPAASQSWPAGHGPDADPPPF
MUL_2679|M.ulcerans_Agy99           LGR------THCDRTQPQHD--------
TH_0334|M.thermoresistible__bu      SGQ-------------------------
MAB_4752|M.abscessus_ATCC_1997      LQREAALAALAAKDPPPF----------
MSMEG_0144|M.smegmatis_MC2_155      ---------AEHNKPPPF----------