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EHMFDGSLPEPATLAAASDTDLAHAINRWAAASAAAEARKLAAIAELHRRATEGQLHERDAVDDTDAAAA HICCALTISHGHALALIDLATTLRDRLPNTGARFLAGDLAPTMITVIAWRTALVTPAALPAIDTAIAQRA HTWGPLTQKKLAAAIDVWVHRYDPDAVRRTRNAMRGRYFAVETATRADTAGDPATGTVAVHGRLSATDAA LTRQRLAVMIATVCPDDPRTMDQRRADALGAVMAGSTFLACACDDPDCPAKIDDGRATSITVHVLADPDS LHAEPDPDFHGDTPPATHAEHTQAEAQAREAGVEAEDGTAAEQAHAEVEADQAEVEAEVEVEAEAEIEVE IEVEVEVEGDADTEPGWAQPEAPSPVEPAAPVGDLPAVIIGGGIVPAPLLAELIARGATIRFVHAEGLGD EPRYRPSRALQRFVHARDITCRFPGCDRPATHADIDHTQPWPTGATHPANTKSYCRLHHLIKTFRPGWTD TQHPDGTLVITTPTGTQCTTKPLSTLLFPNWNTTTPQPPTPRPHTPTPPDQHHRNLKMPTRRRTRAHNRA AYITRERHLNNLERTTQQAREPLPQTGIPEGTPNPLPQSDCDTPRPARPHDYGSDPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3422 | - | - | 100% (620) | hypothetical protein Mflv_3422 |
| M. gilvum PYR-GCK | Mflv_4927 | - | e-150 | 48.63% (621) | hypothetical protein Mflv_4927 |
| M. gilvum PYR-GCK | Mflv_1272 | - | 5e-93 | 36.38% (613) | HNH endonuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-107 | 42.43% (575) | hypothetical protein Mb2126 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-107 | 42.43% (575) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 4e-33 | 35.51% (276) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 1e-41 | 43.44% (221) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 5e-45 | 43.51% (239) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_0144 | - | 1e-93 | 37.69% (597) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-36 | 38.02% (263) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 1e-34 | 37.72% (281) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5188 | - | 1e-108 | 41.03% (624) | hypothetical protein Mvan_5188 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Mflv_3422|M.gilvum_PYR-GCK -----------------------------------MEHMFDGSLPEPATL
Mvan_5188|M.vanbaalenii_PYR-1 --------------------------------------MFDSGLAG----
MMAR_5187|M.marinum_M ------------------------MFESMGVAAGVDHPCDALAERRQLRT
MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMER-CYPS
MUL_2679|M.ulcerans_Agy99 --------------------------------------MDQHIIEYVFDT
TH_0334|M.thermoresistible__bu ----------------------------------------------MFES
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------MFDE
MSMEG_0144|M.smegmatis_MC2_155 --------MSWGYPQTRVHPQIAVLRCRGGFTVGRFERMYEGLLVQIAEF
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGR-RTGA--DQRADWA
Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGR-RTGA--DQRADWA
Mflv_3422|M.gilvum_PYR-GCK AAASDTDLAHAINRWAAASAAAEARKLAAIAELHRR-ATEG--QLHERDA
Mvan_5188|M.vanbaalenii_PYR-1 --LDEPALLAAIERAACEESRAGARKSAAIAALVHESVTFD--DVRDQWV
MMAR_5187|M.marinum_M PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA
MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA
MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV
TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA
MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
MSMEG_0144|M.smegmatis_MC2_155 SALSDLELEGQARGWAQAEASASAHKHAAMAELFIRATSTPSADERRWWF
. . * . . :. *
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Mflv_3422|M.gilvum_PYR-GCK VDDTDAAAAHICCALTISHGHALALIDLATTLRDRLPNTGARFLAGDLAP
Mvan_5188|M.vanbaalenii_PYR-1 WDSWIETACELGAVLNTSHRRASALMRIAVALRDRLPKVAALFAAGRLST
MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
MSMEG_0144|M.smegmatis_MC2_155 VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE
* . ..: . . . :. ** * ** :
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Mflv_3422|M.gilvum_PYR-GCK TMITVIAWRTALVT-PAALPAIDTAIAQRAHTWGPLTQKKLAAAIDVWVH
Mvan_5188|M.vanbaalenii_PYR-1 RLIGQVTWRTRLVQDPQLLALLDTAIADKATRWEPLSDDKLTAALDAVIE
MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
MSMEG_0144|M.smegmatis_MC2_155 MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL
. : : : :. :*: :. * : : :* :
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDP-------DEDAGTAALWGRLYATDAA
Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDP-------DEDAGTAALWGRLYATDAA
Mflv_3422|M.gilvum_PYR-GCK RYDPDAVRRTRNAMRGRYFAVETATRADTAGDPATGTVAVHGRLSATDAA
Mvan_5188|M.vanbaalenii_PYR-1 RYDPDAVIRAREHVSGLDFRVGAS-------DDPDALVTVWGKILGCDAA
MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQD-------ADG--ISRIDGSMFTIDAH
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEM-------GEG--LSHLEGTVSSPDAH
MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPL-------EPG--MALVNRQVFSATAE
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPA-------GQG--MVDVSARLTFEAGF
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPL-------GNGEPVAEVWGTLQAVHAV
MSMEG_0144|M.smegmatis_MC2_155 KHDPGSFRRGRASRRGRYFDIGSP-------TDAPGVLTVTGRLQAHLGN
: * .. . . . : : .
Mb2126|M.bovis_AF2122/97 MLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPS
Rv2100|M.tuberculosis_H37Rv MLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPS
Mflv_3422|M.gilvum_PYR-GCK LTRQRLAVMIATVCPDDPRTMDQRRADALGAVMAGSTFLACACDDPDCPA
Mvan_5188|M.vanbaalenii_PYR-1 VLAARIAELLKGLCDNDPRSVCVRRSHAVGAIVRGQDHLRCRCGSPDCTA
MMAR_5187|M.marinum_M ALDRRLSALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC--
MAV_4456|M.avium_104 ALDKRLDALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--
MUL_2679|M.ulcerans_Agy99 ALARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-
TH_0334|M.thermoresistible__bu AFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-
MAB_4752|M.abscessus_ATCC_1997 ALDKRLDLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--
MSMEG_0144|M.smegmatis_MC2_155 AYDARIAELIEGVCPDDPRTLNELRHDALGAILD-HTTLACECEDPDCV-
*: : :* ***: * .*:..: : * * **
Mb2126|M.bovis_AF2122/97 GAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEAL
Rv2100|M.tuberculosis_H37Rv GAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEAL
Mflv_3422|M.gilvum_PYR-GCK KID-DGRATSITVHVLADPDSLHAEPDPDFHGDTPPATHAEHTQAEAQAR
Mvan_5188|M.vanbaalenii_PYR-1 AAVVPGSSN-VVISVLADPAALDAVRQLIADQDRDQQDKLADKQAKAKEQ
MMAR_5187|M.marinum_M AAGARPAAQPVVIHVIAERATLDGDGG-----------------------
MAV_4456|M.avium_104 AAGTRPAAGPVVIHLIAERASVEGTGG-----------------------
MUL_2679|M.ulcerans_Agy99 AAGAPQQPSRVVIHVVAGCQTVDGAGE-----------------------
TH_0334|M.thermoresistible__bu ADPADTAATRLVINVIAEQATVEGRSD-----------------------
MAB_4752|M.abscessus_ATCC_1997 -SGRDTADVPVVVNVVINQSTLAGSDD-----------------------
MSMEG_0144|M.smegmatis_MC2_155 RGREQSPRGHLVVHVIAREDTVTAAQHAATTTNTPDDAPADTPAADTEPA
:.: :: :: .
Mb2126|M.bovis_AF2122/97 TP------------------------------------------------
Rv2100|M.tuberculosis_H37Rv TP------------------------------------------------
Mflv_3422|M.gilvum_PYR-GCK EAGVEAEDGTAAEQAHAEVEADQAEVEAEVEVEAEAEIEVEIEVEVEVEG
Mvan_5188|M.vanbaalenii_PYR-1 GKAESQPQTEPIPQP-----------EAEAEAEPEPEAEVEVEPEAETET
MMAR_5187|M.marinum_M --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0144|M.smegmatis_MC2_155 EPAEPAEPAEPAEPAEPAEPAEPVEPVDDPDIAPAASATETATDTTASPT
Mb2126|M.bovis_AF2122/97 --DPEP--------------DPPATHAP--------AELITTGGGVVPAP
Rv2100|M.tuberculosis_H37Rv --DPEP--------------DPPATHAP--------AELITTGGGVVPAP
Mflv_3422|M.gilvum_PYR-GCK DADTEPGWAQPEAPSPV---EPAAPVGD--------LPAVIIGGGIVPAP
Mvan_5188|M.vanbaalenii_PYR-1 AIESEPAPVKPVAPS-----NPAACVRDS-------GVALLPGVKILPLV
MMAR_5187|M.marinum_M --------------------APAWEVGA---------------DGLVTPE
MAV_4456|M.avium_104 --------------------GPAVEVGA---------------EGLLPAQ
MUL_2679|M.ulcerans_Agy99 --------------------APGVLPG----------------DGIIPAE
TH_0334|M.thermoresistible__bu --------------------NPGYLPG----------------YGAVPAS
MAB_4752|M.abscessus_ATCC_1997 --------------------CPAHVPG----------------FGVLAAE
MSMEG_0144|M.smegmatis_MC2_155 GTDCDPESVSVTEFTDNSSDTPSAFLDPDEHPLDRVPPAVLFGGGVLPAY
* :.
Mb2126|M.bovis_AF2122/97 LLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCD
Rv2100|M.tuberculosis_H37Rv LLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCD
Mflv_3422|M.gilvum_PYR-GCK LLAELIARGATIRFVHAEG-LGDEPRYRPSRALQRFVHARDITCRFPGCD
Mvan_5188|M.vanbaalenii_PYR-1 ALAEAIRSGAATKTLWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCD
MMAR_5187|M.marinum_M LVAELAKS-AKLVPLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCD
MAV_4456|M.avium_104 LVAELAAS-ARLMPLVHPADAPPENRYTPSAALADFVRCRDLTCRWPGCD
MUL_2679|M.ulcerans_Agy99 IVRELAKS-AKLQPMSTP--ILAETGYVPSPALMDFVRARDLTCRAPGCD
TH_0334|M.thermoresistible__bu ILRAKAAT-ATLRPVALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCD
MAB_4752|M.abscessus_ATCC_1997 SARAAVAG-TPTRNLTDS----RSTGYRPSAKLAAFVRSRDQLCRFPGCE
MSMEG_0144|M.smegmatis_MC2_155 ALAEIINN-ATIRPLKHPGDTAPEDRYIPSRALADYVRCRDLTCRFPGCD
: : . * ** * ::: ** ** ***:
Mb2126|M.bovis_AF2122/97 VPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQL
Rv2100|M.tuberculosis_H37Rv VPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQL
Mflv_3422|M.gilvum_PYR-GCK RPATHADIDHTQPWPTG-ATHPANTKSYCRLHHLIKTFRPG---WTDTQH
Mvan_5188|M.vanbaalenii_PYR-1 VPAEHCDLDHVVPYPYG-PTHPSNLNCKRRTHHLGKTFAEG---WQEQQL
MMAR_5187|M.marinum_M HPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQL
MAV_4456|M.avium_104 RPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQL
MUL_2679|M.ulcerans_Agy99 RPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQL
TH_0334|M.thermoresistible__bu APAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRF----THDQHK
MAB_4752|M.abscessus_ATCC_1997 AVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQE
MSMEG_0144|M.smegmatis_MC2_155 KPADRCDLDHTVPYPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQH
* .::** *:. * .* :* : * : : :
Mb2126|M.bovis_AF2122/97 PDGTVIWTAPNGHTYTTHPGSR--IFFPTWHTTTAELPQT---STAAVNV
Rv2100|M.tuberculosis_H37Rv PDGTVIWTAPNGHTYTTHPGSR--IFFPTWHTTTAELPQT---STAAVNV
Mflv_3422|M.gilvum_PYR-GCK PDGTLVITTPTGTQCTTKPLST--LLFPNWNTTTPQPPTPRPHTPTPPDQ
Mvan_5188|M.vanbaalenii_PYR-1 PDGTVLWTTPAGQRCTTVPGSW--LFFPGWDTTTAELPPM----AQPPPD
MMAR_5187|M.marinum_M PDGTLILTSPAGHTYVTTPGSA--LLFPSLCHSTGGLPAAEA-DPPSDHC
MAV_4456|M.avium_104 PDATLILTSPAGRTYVTTPGSA--LLFPSLCVPTG-EPARPV-AAGSQPC
MUL_2679|M.ulcerans_Agy99 PDATVIWSLPDGQTYVTTPGSA--WLLPGLFAPSPELPPP----------
TH_0334|M.thermoresistible__bu HQSSCLP------AYFQRPHG-----------------------------
MAB_4752|M.abscessus_ATCC_1997 PDGTVIWKSPTGHRYATTPVSW--FLFPAL--------------------
MSMEG_0144|M.smegmatis_MC2_155 PDGTIVWTSPSGRQYTTVPGSHRRLSITELAAPTGALDLPAT-PIPTADP
:.: : * .
Mb2126|M.bovis_AF2122/97 DARGLMMPRRRRTRAAELAHRINAERALN---------------------
Rv2100|M.tuberculosis_H37Rv DARGLMMPRRRRTRAAELAHRINAERALN---------------------
Mflv_3422|M.gilvum_PYR-GCK HHRNLKMPTRRRTRAHNRAAYITRERHLNNLERTTQQAREPLPQTGIPEG
Mvan_5188|M.vanbaalenii_PYR-1 PDRLAKMPKRRRTRAADQAARIKVEREHNATQRALETERAKTPEQARRAE
MMAR_5187|M.marinum_M DQRSAMMPRRQRTRAQDRARRVATERRQNHHAR-----------------
MAV_4456|M.avium_104 GERTAMMPTRRRTRGQNRAARVAAERRANRAAR-----------------
MUL_2679|M.ulcerans_Agy99 -------PRSEATGSLRKPRRDDAQTRPNSRPK-----------------
TH_0334|M.thermoresistible__bu -------PATRRPPSARGLREAVPRQGVDPRRV-----------------
MAB_4752|M.abscessus_ATCC_1997 --------TRHHTRQQARDRRRRTERNLNREQR-----------------
MSMEG_0144|M.smegmatis_MC2_155 DLRGVKMPKRRRTRAQNTARTIAAERKLNDDLV-----------------
. . . :
Mb2126|M.bovis_AF2122/97 ----------DAYMAER-----NKPPSF
Rv2100|M.tuberculosis_H37Rv ----------DAYMAER-----NKPPSF
Mflv_3422|M.gilvum_PYR-GCK TPNPLPQSDCDTPRPARPHDYGSDPPPF
Mvan_5188|M.vanbaalenii_PYR-1 QVRYAGLPPPASPQPDYG----NDPPPF
MMAR_5187|M.marinum_M STQPGGQPRSAAPPTPPQSEPQSHPPPF
MAV_4456|M.avium_104 LARATRPAPAASQSWPAGHGPDADPPPF
MUL_2679|M.ulcerans_Agy99 LGR------THCDRTQPQHD--------
TH_0334|M.thermoresistible__bu SGQ-------------------------
MAB_4752|M.abscessus_ATCC_1997 LQREAALAALAAKDPPPF----------
MSMEG_0144|M.smegmatis_MC2_155 ---------AEHNKPPPF----------