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EHMFDGSLPEPATLAAASDTDLAHAINRWAAASAAAEARKLAAIAELHRRATEGQLHERDAVDDTDAAAA HICCALTISHGHALALIDLATTLRDRLPNTGARFLAGDLAPTMITVIAWRTALVTPAALPAIDTAIAQRA HTWGPLTQKKLAAAIDVWVHRYDPDAVRRTRNAMRGRYFAVETATRADTAGDPATGTVAVHGRLSATDAA LTRQRLAVMIATVCPDDPRTMDQRRADALGAVMAGSTFLACACDDPDCPAKIDDGRATSITVHVLADPDS LHAEPDPDFHGDTPPATHAEHTQAEAQAREAGVEAEDGTAAEQAHAEVEADQAEVEAEVEVEAEAEIEVE IEVEVEVEGDADTEPGWAQPEAPSPVEPAAPVGDLPAVIIGGGIVPAPLLAELIARGATIRFVHAEGLGD EPRYRPSRALQRFVHARDITCRFPGCDRPATHADIDHTQPWPTGATHPANTKSYCRLHHLIKTFRPGWTD TQHPDGTLVITTPTGTQCTTKPLSTLLFPNWNTTTPQPPTPRPHTPTPPDQHHRNLKMPTRRRTRAHNRA AYITRERHLNNLERTTQQAREPLPQTGIPEGTPNPLPQSDCDTPRPARPHDYGSDPPPF*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_3422 | - | - | 100% (620) | hypothetical protein Mflv_3422 |
M. gilvum PYR-GCK | Mflv_4927 | - | e-150 | 48.63% (621) | hypothetical protein Mflv_4927 |
M. gilvum PYR-GCK | Mflv_1272 | - | 5e-93 | 36.38% (613) | HNH endonuclease |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2126 | - | 1e-107 | 42.43% (575) | hypothetical protein Mb2126 |
M. tuberculosis H37Rv | Rv2100 | - | 1e-107 | 42.43% (575) | hypothetical protein Rv2100 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_4752 | - | 4e-33 | 35.51% (276) | hypothetical protein MAB_4752 |
M. marinum M | MMAR_5187 | - | 1e-41 | 43.44% (221) | 13e12 repeat-containing protein |
M. avium 104 | MAV_4456 | - | 5e-45 | 43.51% (239) | 13e12 repeat-containing protein |
M. smegmatis MC2 155 | MSMEG_0144 | - | 1e-93 | 37.69% (597) | HNH endonuclease |
M. thermoresistible (build 8) | TH_0334 | - | 2e-36 | 38.02% (263) | HNH endonuclease |
M. ulcerans Agy99 | MUL_2679 | - | 1e-34 | 37.72% (281) | 13e12 repeat-containing protein |
M. vanbaalenii PYR-1 | Mvan_5188 | - | 1e-108 | 41.03% (624) | hypothetical protein Mvan_5188 |
CLUSTAL 2.0.9 multiple sequence alignment Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL Mflv_3422|M.gilvum_PYR-GCK -----------------------------------MEHMFDGSLPEPATL Mvan_5188|M.vanbaalenii_PYR-1 --------------------------------------MFDSGLAG---- MMAR_5187|M.marinum_M ------------------------MFESMGVAAGVDHPCDALAERRQLRT MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMER-CYPS MUL_2679|M.ulcerans_Agy99 --------------------------------------MDQHIIEYVFDT TH_0334|M.thermoresistible__bu ----------------------------------------------MFES MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------MFDE MSMEG_0144|M.smegmatis_MC2_155 --------MSWGYPQTRVHPQIAVLRCRGGFTVGRFERMYEGLLVQIAEF Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGR-RTGA--DQRADWA Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGR-RTGA--DQRADWA Mflv_3422|M.gilvum_PYR-GCK AAASDTDLAHAINRWAAASAAAEARKLAAIAELHRR-ATEG--QLHERDA Mvan_5188|M.vanbaalenii_PYR-1 --LDEPALLAAIERAACEESRAGARKSAAIAALVHESVTFD--DVRDQWV MMAR_5187|M.marinum_M PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA MSMEG_0144|M.smegmatis_MC2_155 SALSDLELEGQARGWAQAEASASAHKHAAMAELFIRATSTPSADERRWWF . . * . . :. * Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA Mflv_3422|M.gilvum_PYR-GCK VDDTDAAAAHICCALTISHGHALALIDLATTLRDRLPNTGARFLAGDLAP Mvan_5188|M.vanbaalenii_PYR-1 WDSWIETACELGAVLNTSHRRASALMRIAVALRDRLPKVAALFAAGRLST MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF MSMEG_0144|M.smegmatis_MC2_155 VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE * . ..: . . . :. ** * ** : Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID Mflv_3422|M.gilvum_PYR-GCK TMITVIAWRTALVT-PAALPAIDTAIAQRAHTWGPLTQKKLAAAIDVWVH Mvan_5188|M.vanbaalenii_PYR-1 RLIGQVTWRTRLVQDPQLLALLDTAIADKATRWEPLSDDKLTAALDAVIE MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL MSMEG_0144|M.smegmatis_MC2_155 MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL . : : : :. :*: :. * : : :* : Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDP-------DEDAGTAALWGRLYATDAA Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDP-------DEDAGTAALWGRLYATDAA Mflv_3422|M.gilvum_PYR-GCK RYDPDAVRRTRNAMRGRYFAVETATRADTAGDPATGTVAVHGRLSATDAA Mvan_5188|M.vanbaalenii_PYR-1 RYDPDAVIRAREHVSGLDFRVGAS-------DDPDALVTVWGKILGCDAA MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQD-------ADG--ISRIDGSMFTIDAH MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEM-------GEG--LSHLEGTVSSPDAH MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPL-------EPG--MALVNRQVFSATAE TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPA-------GQG--MVDVSARLTFEAGF MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPL-------GNGEPVAEVWGTLQAVHAV MSMEG_0144|M.smegmatis_MC2_155 KHDPGSFRRGRASRRGRYFDIGSP-------TDAPGVLTVTGRLQAHLGN : * .. . . . : : . Mb2126|M.bovis_AF2122/97 MLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPS Rv2100|M.tuberculosis_H37Rv MLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPS Mflv_3422|M.gilvum_PYR-GCK LTRQRLAVMIATVCPDDPRTMDQRRADALGAVMAGSTFLACACDDPDCPA Mvan_5188|M.vanbaalenii_PYR-1 VLAARIAELLKGLCDNDPRSVCVRRSHAVGAIVRGQDHLRCRCGSPDCTA MMAR_5187|M.marinum_M ALDRRLSALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC-- MAV_4456|M.avium_104 ALDKRLDALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC-- MUL_2679|M.ulcerans_Agy99 ALARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP- TH_0334|M.thermoresistible__bu AFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP- MAB_4752|M.abscessus_ATCC_1997 ALDKRLDLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC-- MSMEG_0144|M.smegmatis_MC2_155 AYDARIAELIEGVCPDDPRTLNELRHDALGAILD-HTTLACECEDPDCV- *: : :* ***: * .*:..: : * * ** Mb2126|M.bovis_AF2122/97 GAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEAL Rv2100|M.tuberculosis_H37Rv GAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEAL Mflv_3422|M.gilvum_PYR-GCK KID-DGRATSITVHVLADPDSLHAEPDPDFHGDTPPATHAEHTQAEAQAR Mvan_5188|M.vanbaalenii_PYR-1 AAVVPGSSN-VVISVLADPAALDAVRQLIADQDRDQQDKLADKQAKAKEQ MMAR_5187|M.marinum_M AAGARPAAQPVVIHVIAERATLDGDGG----------------------- MAV_4456|M.avium_104 AAGTRPAAGPVVIHLIAERASVEGTGG----------------------- MUL_2679|M.ulcerans_Agy99 AAGAPQQPSRVVIHVVAGCQTVDGAGE----------------------- TH_0334|M.thermoresistible__bu ADPADTAATRLVINVIAEQATVEGRSD----------------------- MAB_4752|M.abscessus_ATCC_1997 -SGRDTADVPVVVNVVINQSTLAGSDD----------------------- MSMEG_0144|M.smegmatis_MC2_155 RGREQSPRGHLVVHVIAREDTVTAAQHAATTTNTPDDAPADTPAADTEPA :.: :: :: . Mb2126|M.bovis_AF2122/97 TP------------------------------------------------ Rv2100|M.tuberculosis_H37Rv TP------------------------------------------------ Mflv_3422|M.gilvum_PYR-GCK EAGVEAEDGTAAEQAHAEVEADQAEVEAEVEVEAEAEIEVEIEVEVEVEG Mvan_5188|M.vanbaalenii_PYR-1 GKAESQPQTEPIPQP-----------EAEAEAEPEPEAEVEVEPEAETET MMAR_5187|M.marinum_M -------------------------------------------------- MAV_4456|M.avium_104 -------------------------------------------------- MUL_2679|M.ulcerans_Agy99 -------------------------------------------------- TH_0334|M.thermoresistible__bu -------------------------------------------------- MAB_4752|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0144|M.smegmatis_MC2_155 EPAEPAEPAEPAEPAEPAEPAEPVEPVDDPDIAPAASATETATDTTASPT Mb2126|M.bovis_AF2122/97 --DPEP--------------DPPATHAP--------AELITTGGGVVPAP Rv2100|M.tuberculosis_H37Rv --DPEP--------------DPPATHAP--------AELITTGGGVVPAP Mflv_3422|M.gilvum_PYR-GCK DADTEPGWAQPEAPSPV---EPAAPVGD--------LPAVIIGGGIVPAP Mvan_5188|M.vanbaalenii_PYR-1 AIESEPAPVKPVAPS-----NPAACVRDS-------GVALLPGVKILPLV MMAR_5187|M.marinum_M --------------------APAWEVGA---------------DGLVTPE MAV_4456|M.avium_104 --------------------GPAVEVGA---------------EGLLPAQ MUL_2679|M.ulcerans_Agy99 --------------------APGVLPG----------------DGIIPAE TH_0334|M.thermoresistible__bu --------------------NPGYLPG----------------YGAVPAS MAB_4752|M.abscessus_ATCC_1997 --------------------CPAHVPG----------------FGVLAAE MSMEG_0144|M.smegmatis_MC2_155 GTDCDPESVSVTEFTDNSSDTPSAFLDPDEHPLDRVPPAVLFGGGVLPAY * :. Mb2126|M.bovis_AF2122/97 LLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCD Rv2100|M.tuberculosis_H37Rv LLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCD Mflv_3422|M.gilvum_PYR-GCK LLAELIARGATIRFVHAEG-LGDEPRYRPSRALQRFVHARDITCRFPGCD Mvan_5188|M.vanbaalenii_PYR-1 ALAEAIRSGAATKTLWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCD MMAR_5187|M.marinum_M LVAELAKS-AKLVPLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCD MAV_4456|M.avium_104 LVAELAAS-ARLMPLVHPADAPPENRYTPSAALADFVRCRDLTCRWPGCD MUL_2679|M.ulcerans_Agy99 IVRELAKS-AKLQPMSTP--ILAETGYVPSPALMDFVRARDLTCRAPGCD TH_0334|M.thermoresistible__bu ILRAKAAT-ATLRPVALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCD MAB_4752|M.abscessus_ATCC_1997 SARAAVAG-TPTRNLTDS----RSTGYRPSAKLAAFVRSRDQLCRFPGCE MSMEG_0144|M.smegmatis_MC2_155 ALAEIINN-ATIRPLKHPGDTAPEDRYIPSRALADYVRCRDLTCRFPGCD : : . * ** * ::: ** ** ***: Mb2126|M.bovis_AF2122/97 VPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQL Rv2100|M.tuberculosis_H37Rv VPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQL Mflv_3422|M.gilvum_PYR-GCK RPATHADIDHTQPWPTG-ATHPANTKSYCRLHHLIKTFRPG---WTDTQH Mvan_5188|M.vanbaalenii_PYR-1 VPAEHCDLDHVVPYPYG-PTHPSNLNCKRRTHHLGKTFAEG---WQEQQL MMAR_5187|M.marinum_M HPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQL MAV_4456|M.avium_104 RPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQL MUL_2679|M.ulcerans_Agy99 RPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQL TH_0334|M.thermoresistible__bu APAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRF----THDQHK MAB_4752|M.abscessus_ATCC_1997 AVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQE MSMEG_0144|M.smegmatis_MC2_155 KPADRCDLDHTVPYPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQH * .::** *:. * .* :* : * : : : Mb2126|M.bovis_AF2122/97 PDGTVIWTAPNGHTYTTHPGSR--IFFPTWHTTTAELPQT---STAAVNV Rv2100|M.tuberculosis_H37Rv PDGTVIWTAPNGHTYTTHPGSR--IFFPTWHTTTAELPQT---STAAVNV Mflv_3422|M.gilvum_PYR-GCK PDGTLVITTPTGTQCTTKPLST--LLFPNWNTTTPQPPTPRPHTPTPPDQ Mvan_5188|M.vanbaalenii_PYR-1 PDGTVLWTTPAGQRCTTVPGSW--LFFPGWDTTTAELPPM----AQPPPD MMAR_5187|M.marinum_M PDGTLILTSPAGHTYVTTPGSA--LLFPSLCHSTGGLPAAEA-DPPSDHC MAV_4456|M.avium_104 PDATLILTSPAGRTYVTTPGSA--LLFPSLCVPTG-EPARPV-AAGSQPC MUL_2679|M.ulcerans_Agy99 PDATVIWSLPDGQTYVTTPGSA--WLLPGLFAPSPELPPP---------- TH_0334|M.thermoresistible__bu HQSSCLP------AYFQRPHG----------------------------- MAB_4752|M.abscessus_ATCC_1997 PDGTVIWKSPTGHRYATTPVSW--FLFPAL-------------------- MSMEG_0144|M.smegmatis_MC2_155 PDGTIVWTSPSGRQYTTVPGSHRRLSITELAAPTGALDLPAT-PIPTADP :.: : * . Mb2126|M.bovis_AF2122/97 DARGLMMPRRRRTRAAELAHRINAERALN--------------------- Rv2100|M.tuberculosis_H37Rv DARGLMMPRRRRTRAAELAHRINAERALN--------------------- Mflv_3422|M.gilvum_PYR-GCK HHRNLKMPTRRRTRAHNRAAYITRERHLNNLERTTQQAREPLPQTGIPEG Mvan_5188|M.vanbaalenii_PYR-1 PDRLAKMPKRRRTRAADQAARIKVEREHNATQRALETERAKTPEQARRAE MMAR_5187|M.marinum_M DQRSAMMPRRQRTRAQDRARRVATERRQNHHAR----------------- MAV_4456|M.avium_104 GERTAMMPTRRRTRGQNRAARVAAERRANRAAR----------------- MUL_2679|M.ulcerans_Agy99 -------PRSEATGSLRKPRRDDAQTRPNSRPK----------------- TH_0334|M.thermoresistible__bu -------PATRRPPSARGLREAVPRQGVDPRRV----------------- MAB_4752|M.abscessus_ATCC_1997 --------TRHHTRQQARDRRRRTERNLNREQR----------------- MSMEG_0144|M.smegmatis_MC2_155 DLRGVKMPKRRRTRAQNTARTIAAERKLNDDLV----------------- . . . : Mb2126|M.bovis_AF2122/97 ----------DAYMAER-----NKPPSF Rv2100|M.tuberculosis_H37Rv ----------DAYMAER-----NKPPSF Mflv_3422|M.gilvum_PYR-GCK TPNPLPQSDCDTPRPARPHDYGSDPPPF Mvan_5188|M.vanbaalenii_PYR-1 QVRYAGLPPPASPQPDYG----NDPPPF MMAR_5187|M.marinum_M STQPGGQPRSAAPPTPPQSEPQSHPPPF MAV_4456|M.avium_104 LARATRPAPAASQSWPAGHGPDADPPPF MUL_2679|M.ulcerans_Agy99 LGR------THCDRTQPQHD-------- TH_0334|M.thermoresistible__bu SGQ------------------------- MAB_4752|M.abscessus_ATCC_1997 LQREAALAALAAKDPPPF---------- MSMEG_0144|M.smegmatis_MC2_155 ---------AEHNKPPPF----------