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FEGLRRLSANSLAPAVWRFDQYYWFTAILTARGFQTATGRLVAACIAAFGLLPLGVIAGVFGPQSLVAQI LAGIVVIASLAMAMLWLREHWPTRAQSLACVAAGALGIGISSLLVADPFVGFLGTAAFVPLTIFIVCFHA ARVLALSWTVGALVLAVLVVRMGSTDLAVALTGLVIAVLINVFVAISCRTVIRLLKPDAHHRDIEQLTGL LHRDAFYNSVATLLASRSRSDDQYLVFVAVNIDSFSLLLGLSGSGGGNRARVTVGQALRETVRHNAIVAH VSDDDFVIADTFTTSDASPLVERIRGAIAATPQRLTASIGVVVTPLPPLAAEPPDEVLDKLIAISQQAIE QARMAGGNQVRYVLRPDLGEGDDNGDDWPEQNRPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4894 | - | - | 100% (386) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_4783 | - | 9e-42 | 29.84% (372) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1453 | - | 9e-42 | 31.36% (354) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_00397 | - | 2e-05 | 26.81% (138) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 9e-30 | 25.07% (359) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 3e-40 | 30.26% (347) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 4e-75 | 43.14% (350) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 8e-83 | 44.76% (353) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4819 | - | 8e-47 | 31.99% (347) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4894|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATRILGLRAHD
Mflv_4894|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 VVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVGIDQHSGQR
Mflv_4894|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 LWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEATHDCLTGLA
Mflv_4894|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 -------------------------------------------------M
MLBr_00397|M.leprae_Br4923 NRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQT
Mflv_4894|M.gilvum_PYR-GCK -MFEGLRRLSANSLAPAVWRFDQYYWFTAILTARGFQTATGRLVAACIAA
MSMEG_2774|M.smegmatis_MC2_155 --------MSP---------FDHYYARTAMLSAQGQRSRMRRIIGVTITA
TH_3406|M.thermoresistible__bu -MLKALRRTWR--------KPDHYYWFTSFLAARRARTSTCRFIASITLI
MAV_1995|M.avium_104 ----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGAS
Mvan_4819|M.vanbaalenii_PYR-1 ----------MQWDQ---RRVDHYEWFSGFLDARGAKPAVRLLIASIALL
MAB_3940c|M.abscessus_ATCC_199 IVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALI
MLBr_00397|M.leprae_Br4923 VAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMNANDVAKRLHTTLSES
. *
Mflv_4894|M.gilvum_PYR-GCK FGLLPLGVIAGVFG-----PQSLVAQILAGIVVIASLAMAMLWLREHWPT
MSMEG_2774|M.smegmatis_MC2_155 LAFVPVLMLASPAG-----PAGALRYVPLGATACG-VLMSVWWWRRKWPS
TH_3406|M.thermoresistible__bu LGLMPMVMLAGPAG-----PQSMPGRLIAVAVTVTALVITLIWLRDRWPS
MAV_1995|M.avium_104 LVLVPANVLWGATP-----FFPGLTLTVSVLAGMVGLGMAVLWLHG-WPT
Mvan_4819|M.vanbaalenii_PYR-1 MAGSVLLLIFSAGG-----PEGQPQRAMMWLSVAGGVAGVMLWLWH-WPS
MAB_3940c|M.abscessus_ATCC_199 FAAICIAVQFSDTG-----PRSMIGRVIVGLCAVGSLGWALRWAVGPWPS
MLBr_00397|M.leprae_Br4923 LVVDQLTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAKNKKQCAVT
: : . :
Mflv_4894|M.gilvum_PYR-GCK RAQSLACVAAGALGIGISSLL------VADPFVGFLGTAAFVPLTIFIVC
MSMEG_2774|M.smegmatis_MC2_155 RNQSWLVVGIGTVGIAVTLSS------MSDPTVGLLSSSVFSLVTTYSAF
TH_3406|M.thermoresistible__bu RNQSRVVSLAAGLAIAVFAFT------LPDPSAGLVWTAAFAVLAGYVAL
MAV_1995|M.avium_104 RRQSVVFALTGSVAIGAGCLW------QTEPLVGLMACSALSVTGGYNAF
Mvan_4819|M.vanbaalenii_PYR-1 RLQSAAFATVTAFSVALAGLA------YPDPLAALLGCIAFTTNGAYLAF
MAB_3940c|M.abscessus_ATCC_199 LREAVAFVAFADIGIAVACWQ------DSDPLAGLVGTVLFTPVGAYVSF
MLBr_00397|M.leprae_Br4923 PQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGMTF
: . : .: . : :
Mflv_4894|M.gilvum_PYR-GCK FHAARVLALSWTVGALVLAVLVVRMGSTD----LAVALTGLVIAVLINVF
MSMEG_2774|M.smegmatis_MC2_155 LHSRRVLVLSWIASGLTVGFLAIRVAFTS----IPMALSGALVSGLVIAT
TH_3406|M.thermoresistible__bu FHSARYATFTVLFAAITAGVLSFELAKTAG---VAAAVCGFVFITVVTFA
MAV_1995|M.avium_104 FHTAKFMGLNFGLAGAIGALQAARLAASG---QAMLAFTGYFLVLELNVI
Mvan_4819|M.vanbaalenii_PYR-1 FHTTRLLLGNIVIAIGVATVEAIQLAAQG---RIALAAVDLFLVVQINIA
MAB_3940c|M.abscessus_ATCC_199 FLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVL
MLBr_00397|M.leprae_Br4923 VIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGMVNGI
. : * :
Mflv_4894|M.gilvum_PYR-GCK VAISCRTVIRLLKPD--AHHRDIEQLTGLLHRDAFYNSVATLLASRSRSD
MSMEG_2774|M.smegmatis_MC2_155 TSMLCRMAIRLLDAGNVQHPNEIDRLTGLLNREAFEIQAATMLGSHSRHD
TH_3406|M.thermoresistible__bu VVCACNLLVGLLDVD--VLDADIEPLTGLLNRDAFYRSAGHLIS-RSRDD
MAV_1995|M.avium_104 VPLSIQIVVRALWLD--LLRANRDPLTGLLNRR---ACNRAIIGRMLTG-
Mvan_4819|M.vanbaalenii_PYR-1 VPLAIRILLHALRGD--LHYADHDPLTGLLNRR---AFRRQILSLLARSH
MAB_3940c|M.abscessus_ATCC_199 IPAVIQFGIAVVRWD--ALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQ
MLBr_00397|M.leprae_Br4923 VFAYGKIPSFVSTLG--MLQVCRGITLMISDSSAKPMPFHGILGAMGAMP
. . : . : .
Mflv_4894|M.gilvum_PYR-GCK ----DQYLVFVAVNIDSFSLLLGLSGSGGGNRARVTVGQALRETVRHNAI
MSMEG_2774|M.smegmatis_MC2_155 ----DQYLVILAVGIDDMSLLSDMDGTHSTLHARVAVAQALRETVRHRVP
TH_3406|M.thermoresistible__bu ----DRQLVIALINIDNLRLLRDTQGQAAADRARVAIGQTLRENTRHNAF
MAV_1995|M.avium_104 --ASHMFLAVAMVDLDRFKALNDTHGHAAGDEALIAVAGALTAACGDTTV
Mvan_4819|M.vanbaalenii_PYR-1 --GEGRYLVVALMDLDHFKALNDARGHIAGDQALIAVADALRTTATSTAV
MAB_3940c|M.abscessus_ATCC_199 PLDGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLIDVAHALTCGTTGTSV
MLBr_00397|M.leprae_Br4923 WILIVCLFVTILAGILFQFTMFGRWVKAIGGNERVATLAGVPTRGIKVAI
. .: : . . : :
Mflv_4894|M.gilvum_PYR-GCK VAHVSDDD----FVIADTFTTSDASPLVERIRGAIAATPQR---LTASIG
MSMEG_2774|M.smegmatis_MC2_155 LAHVSDSE----FLIADVFKTNDPSPLVERMRLAISTTPMR---LTASIG
TH_3406|M.thermoresistible__bu VAHLGQDE----FLIADTFSSTDSFPLVERVRGAIATTPPR---LTASIG
MAV_1995|M.avium_104 VGRVGGEE----FLVADIVTTEQLPGWGQQLCEAVAALDPP---VTASVG
Mvan_4819|M.vanbaalenii_PYR-1 VARSGGEE----FLIADVTGSPSAAAHYQQVCDAITALPVG---LTASIG
MAB_3940c|M.abscessus_ATCC_199 VGRSGGEE----FLVVTVCPASAVAEFATRLRQAVTASMPAGIAVTASVG
MLBr_00397|M.leprae_Br4923 FAICGLTAGLGGIVLASRLGAGTPTAATGFEIDVIAAVVIGGTPLTGGLG
.. . :::. : .::: :*..:*
Mflv_4894|M.gilvum_PYR-GCK VVVTPLPPLAAEPPDEVLDKLIAISQQAIEQARMAGGNQVRYVLRPDLGE
MSMEG_2774|M.smegmatis_MC2_155 TVCSPLAPLASLPAEQVLQELIDVAMRAMNESRAAGGNQTISVNYPTPTP
TH_3406|M.thermoresistible__bu VVSTPMRGLAVCPPETLLDELIAVASATMYEARRAGGNQARYRKYPNPTA
MAV_1995|M.avium_104 TATLPLRDLVSEYAEHAFHQLVAQADSAMYEAKRCGGNQTRHRPAQVST-
Mvan_4819|M.vanbaalenii_PYR-1 TAVAALRDVPVEAFESTIDRLVSAADMAMYRAKRNGGNQCHHLDAWPPPG
MAB_3940c|M.abscessus_ATCC_199 VAAQAVSRVVSATSQEAIEVLTACADRAMYEAKHDGGDQSRILHADDDSE
MLBr_00397|M.leprae_Br4923 RLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKGIMLAAAVFVFLQRRKI
.: : . : :
Mflv_4894|M.gilvum_PYR-GCK GDDNGDDWPEQNRPA
MSMEG_2774|M.smegmatis_MC2_155 NQE------------
TH_3406|M.thermoresistible__bu VTEAHYPEQAADDF-
MAV_1995|M.avium_104 ---------------
Mvan_4819|M.vanbaalenii_PYR-1 PA-------------
MAB_3940c|M.abscessus_ATCC_199 GRYLWRSGA------
MLBr_00397|M.leprae_Br4923 GIIK-----------