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VVIGLGAVAPAYSLAATLGYVVLNVQEKAPSMFVLAFIPMLLVAFAYKELSQDTPDCGTTFTWATKAFGP WIGWIGGWGLAVSAIIVLANVSEIAAIYLYNFLGLTSLAESVPATVALGCFFIIAMTLVSARGIVVSERV QNVLIAIQFGVLITVSIIALVRVFSGTAGAQAVMPEVSWLWPSGLDVSSIAAAVILCIFIYWGWDACLAV GEETKDPGKTPGIAALITTVILVCTYVLVAYALQSFAGFSEVGIGLNNPNNTDDVLTVLGEPVAGAIAAS ALLLTVSVSALSSTQTTILPTARGTLSMAVYEAIPRRFASVHPRYMTPAFGTIVMGISALFFYLVLKMLS ENALLDSVASLGLAVAFYYGITAFACVWYFRRTLFSSARNLFFRGVFPLLGGLSMLAAFAISAKDMIQPD YGHTAFGSIGGVFVLGVGMLVLGIPLMLACFAFGTKRFFRGETLNADTAVKVPDTF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4853 | - | - | 100% (476) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_0187 | - | 6e-19 | 25.58% (387) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_3084 | - | 3e-17 | 22.97% (357) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 1e-19 | 27.70% (379) | cationic amino acid transport integral membrane protein RocE |
| M. tuberculosis H37Rv | Rv2320c | rocE | 1e-19 | 27.70% (379) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3331c | - | 1e-116 | 44.47% (488) | putative amino acid permease |
| M. marinum M | MMAR_3554 | - | 1e-119 | 45.53% (492) | hypothetical protein MMAR_3554 |
| M. avium 104 | MAV_2087 | - | 2e-18 | 26.36% (368) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1625 | - | 1e-119 | 44.35% (478) | amino acid transporter, putative |
| M. thermoresistible (build 8) | TH_0471 | - | 7e-18 | 24.52% (363) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2787 | - | 1e-117 | 45.12% (492) | hypothetical protein MUL_2787 |
| M. vanbaalenii PYR-1 | Mvan_1574 | - | 0.0 | 94.54% (476) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4853|M.gilvum_PYR-GCK -----------------------------------------------MVI
Mvan_1574|M.vanbaalenii_PYR-1 ------------------MAITDEPAVPAVGGKGLQAGALGLVGN--VVI
MMAR_3554|M.marinum_M MGHLDADKKTSHQPIEGDCVSQGEATSVAVEGKGLKGGAVGLLSS--VVI
MUL_2787|M.ulcerans_Agy99 MGHLDADKKTNHQPIEGDCVSQGEATSVAVEGKGLKGGAVGLLSS--VVI
MAB_3331c|M.abscessus_ATCC_199 -----------------------MSSDIPVESKGLKGGALGLLSS--VVV
MSMEG_1625|M.smegmatis_MC2_155 ---MTRSDPQSDPESDPHHALEIVEQSAGLRGKGLAAGKVGTFSG--AIL
Mb2347c|M.bovis_AF2122/97 ------------MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTF
Rv2320c|M.tuberculosis_H37Rv ------------MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTF
MAV_2087|M.avium_104 ----------------------------------MAPGTADHLRRGIGTF
TH_0471|M.thermoresistible__bu -------------------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWW
Mflv_4853|M.gilvum_PYR-GCK GLGAVAPAYSLAATLGYVVLN-----VQEKAPSMFVLAFIPMLLVAFAYK
Mvan_1574|M.vanbaalenii_PYR-1 GLGAVAPAYSLAATLGYVVLN-----VQEKAPAMFVLAFIPMLLVAFAYK
MMAR_3554|M.marinum_M GTASTAPAYSLAATLGLIVASRGELLCGVKAPAIVLLSFIPMYMIAVAYQ
MUL_2787|M.ulcerans_Agy99 GTASTAPAYSLAATLGLIVASRGELLCGVKAPAIVLLSFIPMYMIAVAYQ
MAB_3331c|M.abscessus_ATCC_199 GLASTAPAYSLAATLGLIVASGGALLAGVKAPAIVLISFIPMYLIAVAYQ
MSMEG_1625|M.smegmatis_MC2_155 GISSVAPGYTLTASIGLIVAA-----VGLKMPAIFIAGFIPMFLTAYAYR
Mb2347c|M.bovis_AF2122/97 QLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSFIIAGIAAGLAAICYA
Rv2320c|M.tuberculosis_H37Rv QLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSFIIAGIAAGLAAICYA
MAV_2087|M.avium_104 QLTMFGVGSTIGTGIFFVMSQAVP-EAGPAVIVSFLLAGVAAGLAAVCYA
TH_0471|M.thermoresistible__bu DLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYA
. . : : : : .: . :. : * .*
Mflv_4853|M.gilvum_PYR-GCK ELSQDTPDCGTTFTWATKAFGPWIGWIGGWGLAVSAIIVLANVSEIAAIY
Mvan_1574|M.vanbaalenii_PYR-1 ELSQDTPDCGTTFTWGTKAFGPWIGWIGGWGLAVSAIIVLANVSEIAAIY
MMAR_3554|M.marinum_M ELNKAEPDCGTTFTWASRAFGPVTGWLGGWGIIAADVIVMANLAQIAGAY
MUL_2787|M.ulcerans_Agy99 ELNKAEPDCGTTFTWASRAFGPVTGWLGGWGIIAADVIVMANLAQIAGAY
MAB_3331c|M.abscessus_ATCC_199 ELNKAEPDCGTTFTWASRTFGPIVGWLGGWGIIAADVICLANLAQVAGAY
MSMEG_1625|M.smegmatis_MC2_155 ELNSRAPDCGASFTWSTKAFGPYVGWMCGWGMVIATIIVLSNLAAIAVEF
Mb2347c|M.bovis_AF2122/97 ELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGY
Rv2320c|M.tuberculosis_H37Rv ELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGY
MAV_2087|M.avium_104 ELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLEYGVATAAVSVNWSGY
TH_0471|M.thermoresistible__bu EFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSY
*: . * .*:::::. ::* . . : : : :: :
Mflv_4853|M.gilvum_PYR-GCK LYNFLG------------LTSLAESVPATVALGCFFIIAMTLVSARGIVV
Mvan_1574|M.vanbaalenii_PYR-1 LYNFLG------------LDSLAESVPATVALGCFFIISMTLVSARGIVV
MMAR_3554|M.marinum_M SFTFVGELG------WQSASNLAHSALWSTVAGVAWIVVMTYICYRGTDV
MUL_2787|M.ulcerans_Agy99 SFTFVGELG------WQSASNLAHSTLWSTVAGVAWIVVMTCICYRGTDV
MAB_3331c|M.abscessus_ATCC_199 SFTFVGDLG------WSAASGLADSVLWSTVAGVIWIVIMTYICYRGIEV
MSMEG_1625|M.smegmatis_MC2_155 FYLFVARILN-----TPEIADLADNKLVNILTTLVFIALATWVSSRGITT
Mb2347c|M.bovis_AF2122/97 VNKLLSNLFGFQMPHVLSAAPWDTHPGWVNLPAVILIGLCALLLIRGASE
Rv2320c|M.tuberculosis_H37Rv VNKLLSNLFGFQMPHVLSAAPWDTHPGWVNLPAVILIGLCALLLIRGASE
MAV_2087|M.avium_104 LNKLLSNVVGFQLPHALSAAPWDAQPGYVNLPAVMLIGMCALLLIRGASE
TH_0471|M.thermoresistible__bu LGEVFE----------FAGATTRLGPITLDWGALLIIGFVTVLLATGTKL
.. * : : *
Mflv_4853|M.gilvum_PYR-GCK SERVQNVLIAIQFGVLITVSIIALVRVFSGTAGAQAVMPEVSWLWP----
Mvan_1574|M.vanbaalenii_PYR-1 SERVQNVLIAIQFGVLITVSVIALIRVFTGTAGAQAISPQLSWLWP----
MMAR_3554|M.marinum_M SARMQYVLLSVELVVLVALAAVALARVYTNHGDVGSLRPSLSWLWP----
MUL_2787|M.ulcerans_Agy99 SARMQYVLLSVELVVLVALAAVALARVYTNHGDVGSLRPSLSWLWP----
MAB_3331c|M.abscessus_ATCC_199 SARLQYWLLTVEVVVLIAFAVVALIKVYTHNAESYSLLPSLSWFWP----
MSMEG_1625|M.smegmatis_MC2_155 SEHVQYVLVGFQMTVLLAFAITAVIHVGAGNAPEG-LAFDLDWFNPF---
Mb2347c|M.bovis_AF2122/97 SARVNAIMVLIKLGVLGMFMIIAFSAYSADHLKDFVP-------------
Rv2320c|M.tuberculosis_H37Rv SARVNAIMVLIKLGVLGMFMIIAFSAYSADHLKDFVP-------------
MAV_2087|M.avium_104 SAKVNAIMVMVKLGVLVVFGILAFTAFDMHHLDDFAP-------------
TH_0471|M.thermoresistible__bu SANVSLAITVIKVGVVLLVVIVGAFFIKAANYTPFIPPAEAGGEAGRSLD
* .:. : .:. *: . .
Mflv_4853|M.gilvum_PYR-GCK ----------SGLDVSS--IAAAVILCIFIYWGWDACLAVGEETKDPGKT
Mvan_1574|M.vanbaalenii_PYR-1 ----------SGLDVSS--IAAAVILCIFIYWGWDACLAVGEETKDPGRT
MMAR_3554|M.marinum_M ----------SGLDFGTQ-MAPALLITIFIYWGFDTAVACNEETDDPGRT
MUL_2787|M.ulcerans_Agy99 ----------SGLDFGTQ-MAPALLITIFIYWGFDTAVACNDETDDPGRT
MAB_3331c|M.abscessus_ATCC_199 ----------GGMDFGTV-IAPAVLTTIFIYWGWDTAVACNEESDDPGRT
MSMEG_1625|M.smegmatis_MC2_155 ----------TNLAFGA--FVIGVTGSIFAFWGWDTCLTLGEESKDPTKV
Mb2347c|M.bovis_AF2122/97 --------------FGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKT
Rv2320c|M.tuberculosis_H37Rv --------------FGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKT
MAV_2087|M.avium_104 --------------FGVAGVGTAAGTIFFSYIGLDAVSTAGDEVTNPQKT
TH_0471|M.thermoresistible__bu QSLFSLITGAEGSSYGWYGLLAGASIVFFAFIGFDIIATTAEETKNPQRD
. . . :* : * * : :* :* :
Mflv_4853|M.gilvum_PYR-GCK PGIAALITTVILVCTYVLVAYALQSFAGFSEVGIGLNNPNNTDDVLTVLG
Mvan_1574|M.vanbaalenii_PYR-1 PGIAALVTTVILVCTYVLVAFALQSFAGFSEVGIGLNNPNNTDDVLTVLG
MMAR_3554|M.marinum_M PGRAAVISTFLLLATYAVVTVASIAFAGVGVDGIGLGNPDNSNDVFAAVG
MUL_2787|M.ulcerans_Agy99 LGRAAVISTFLLLATYAVVTVASIAFAGVGVDGIGLGNPDNSNDVFAAVG
MAB_3331c|M.abscessus_ATCC_199 PGRAAVISTFLLLATYALVSVAAVAFAGVGTEGVGLGNQENAADVFKAIG
MSMEG_1625|M.smegmatis_MC2_155 PGRAGLLCVTTILLTYLLVAVAVMMYAGVGETGLGLGNPENSENVFGALA
Mb2347c|M.bovis_AF2122/97 MPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQ-----ETAGLAIILD
Rv2320c|M.tuberculosis_H37Rv MPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQ-----ETAGLAIILD
MAV_2087|M.avium_104 MPRALIAALLTVTGVYVFVALAALGTQPWQDFGGQ-----QEAGLATILD
TH_0471|M.thermoresistible__bu VARGIMATLGIVTVLYVAVSLVLTGMVHYTELRAAG----ENANLATAFA
. : : * *: . : .: .
Mflv_4853|M.gilvum_PYR-GCK -----EPVAGAIAASALLLTVSVSALSSTQTTILPTARGTLSMAVYEAIP
Mvan_1574|M.vanbaalenii_PYR-1 -----KPVAGAIAASALLLTVSVSALSSTQTTILPTARGTLSMAVYEAIP
MMAR_3554|M.marinum_M PALFGDGVLGKIGLLLLSASILTSASASTQTTILPTARTTLSMAVYKALP
MUL_2787|M.ulcerans_Agy99 PALFGDGVLGKIGLLLLSASILTSASASTQTTILPTARTTLSMAVYKALP
MAB_3331c|M.abscessus_ATCC_199 PELFGDSFVGHLGMLLLSASILTSASACTQTTILPTARTTLSMGVYKALP
MSMEG_1625|M.smegmatis_MC2_155 -----DPVLGSWGGPLLFLAVLASSVASLQTTFLPAARAMLAMGAYGAFP
Mb2347c|M.bovis_AF2122/97 N-----VTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP
Rv2320c|M.tuberculosis_H37Rv N-----VTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP
MAV_2087|M.avium_104 H-----VTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLP
TH_0471|M.thermoresistible__bu ------ANGIDWAAKVISIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLP
. : . : . . :* ::*. :*
Mflv_4853|M.gilvum_PYR-GCK RRFASVHPRYMTPAFGTIVMGISALFFYLVLKMLSENALLDSVASLGLAV
Mvan_1574|M.vanbaalenii_PYR-1 KRFANVHPRYMTPAFGTIVMGLSALFFYLVLKALSENALLDSVASLGLAV
MMAR_3554|M.marinum_M ASFAKIHPRYLTPTVSTIAMGAVSILFYVLFTLVSRNLLSALIGSVGLVI
MUL_2787|M.ulcerans_Agy99 ASFAKIHPRYLTPTVSTIAMGAVSILFYVLFTLVSRNLLSALIGSVGLVI
MAB_3331c|M.abscessus_ATCC_199 DSFASIHRTYLTPSTSTIAMGAISIVFYVLFTAISTNLLTALIGSVGLMI
MSMEG_1625|M.smegmatis_MC2_155 KRFSHVHPRFLVPSFSTLIAGIVTGVFYTVVSLLSEYALLDTIAALGIMI
Mb2347c|M.bovis_AF2122/97 ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDS----LADMVSIGTLT
Rv2320c|M.tuberculosis_H37Rv ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDS----LADMVSIGTLT
MAV_2087|M.avium_104 PRFARVNPRTMTPVNNTVIVAVAAATLAAFIPLQN----LADMVSIGTLT
TH_0471|M.thermoresistible__bu RPLSKTGPR-GTPVRITVLVGALVAIAASVFPVGN----LEEMVNIGTLF
:: .* *: . .. . : :*
Mflv_4853|M.gilvum_PYR-GCK AFYYGITAFACVWYFRRTLFSSARNLFFRGVFPLLGGLSMLAAFAISAKD
Mvan_1574|M.vanbaalenii_PYR-1 AFYYGITAFACVWYFRRTLFESTRNLFFRGVFPLLGGLSMLAAFTISAKD
MMAR_3554|M.marinum_M AFYYGLTGYACAHYYRATLTKSLRNFVMRGVVPLTGGVVLTVVFIFGLIE
MUL_2787|M.ulcerans_Agy99 AFYYGLTGYACAHYYRATLTKSLRNFVMRGVVPLTGGVVLTVVFIFGLIE
MAB_3331c|M.abscessus_ATCC_199 AFYYGLTGFACAWFYRKRLTTSFRDLMMRGVMPLAGGATLTVVFIYGLIQ
MSMEG_1625|M.smegmatis_MC2_155 CWYYGITAFACIWYFRRELFTDAHNIVFKFLFPLIGGLVLAAVFGFSLKE
Mb2347c|M.bovis_AF2122/97 AFSVVAVGVIVLRVREPDLPRGFK-------VPGYPVTPVLSVLACGYIL
Rv2320c|M.tuberculosis_H37Rv AFSVVAVGVIVLRVREPDLPRGFK-------VPGYPVTPVLSVLACGYIL
MAV_2087|M.avium_104 AFVVVSVGVIVLRVREPDLPRGFR-------VPGYPVTPVLSIMACGYIL
TH_0471|M.thermoresistible__bu AFALVSAGVIVLRRTRPDLKRGFR-------VPFVPWLPLAAIAACLWLM
.: .. . * . : .* :
Mflv_4853|M.gilvum_PYR-GCK MIQPDY-------GHTAFGSIGGVFVLGVGMLVLGIPLMLACFAFGTKRF
Mvan_1574|M.vanbaalenii_PYR-1 MIQPDY-------GYTAFGPVGGVFVLGVGMLVLGIPLMLACFAFGTKRF
MMAR_3554|M.marinum_M YAKRDWLVEN-GHNVTIFG-FGAVAVVGVGSMLLGVVVMLIWWAISPG-F
MUL_2787|M.ulcerans_Agy99 YAKRDWLVEN-GHNVTIFG-FGAVAVVGVGSMLLGVVVMLIWWAISPG-F
MAB_3331c|M.abscessus_ATCC_199 YAKPNWLIDDDGNNVTVFG-VGAVAVVGVGALVLGVVLMMLWRVAAPP-F
MSMEG_1625|M.smegmatis_MC2_155 SMDPEN------GSGAELGGIGLVFYIGFGILLLGAVLMLVMRTRSPE-F
Mb2347c|M.bovis_AF2122/97 AS-----------------LHWYTWLAFSGWVAVAVIFYLMWGRHHSALN
Rv2320c|M.tuberculosis_H37Rv AS-----------------LHWYTWLAFSGWVAVAVIFYLMWGRHHSALN
MAV_2087|M.avium_104 AS-----------------LHWYTWIAFSGWVLLALIFYFVWGRHHSALN
TH_0471|M.thermoresistible__bu LN-----------------LTGLTWVRFLGWMALGLVLYFFYGRHHSMLG
. * : :. . : .
Mflv_4853|M.gilvum_PYR-GCK FRGETLN-------------ADTAVKVPDTF-------------------
Mvan_1574|M.vanbaalenii_PYR-1 FRGETLN-------------ADTEVKVPDTF-------------------
MMAR_3554|M.marinum_M FRGRTLRRHSADLLLEPAVSPPAHLALPDSGD-MQTVIAADLSNLPAGET
MUL_2787|M.ulcerans_Agy99 FRGRTLRRHSADLLLEPAVSPPAHLALPDSGD-MQTVIAADLSNLPAGET
MAB_3331c|M.abscessus_ATCC_199 FQGQTLPRRSADLVLAPAAAT-THFGLPDAVEAQQTVIAGDLSNLPEGEV
MSMEG_1625|M.smegmatis_MC2_155 FRGETLSR--------------NTPVIPG---------------------
Mb2347c|M.bovis_AF2122/97 EEVP----------------------------------------------
Rv2320c|M.tuberculosis_H37Rv EEVP----------------------------------------------
MAV_2087|M.avium_104 DAAVDPSGQER---------------------------------------
TH_0471|M.thermoresistible__bu RGMTDISARRTG--------------------------------------
Mflv_4853|M.gilvum_PYR-GCK ------------------
Mvan_1574|M.vanbaalenii_PYR-1 ------------------
MMAR_3554|M.marinum_M AVNPQTGQHLTKDTSGAS
MUL_2787|M.ulcerans_Agy99 AVNPQTGQHLTKDTSGAS
MAB_3331c|M.abscessus_ATCC_199 AVNPQTGEEFTKD-----
MSMEG_1625|M.smegmatis_MC2_155 ------------------
Mb2347c|M.bovis_AF2122/97 ------------------
Rv2320c|M.tuberculosis_H37Rv ------------------
MAV_2087|M.avium_104 ------------------
TH_0471|M.thermoresistible__bu ------------------