For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTRSDPQSDPESDPHHALEIVEQSAGLRGKGLAAGKVGTFSGAILGISSVAPGYTLTASIGLIVAAVGLK MPAIFIAGFIPMFLTAYAYRELNSRAPDCGASFTWSTKAFGPYVGWMCGWGMVIATIIVLSNLAAIAVEF FYLFVARILNTPEIADLADNKLVNILTTLVFIALATWVSSRGITTSEHVQYVLVGFQMTVLLAFAITAVI HVGAGNAPEGLAFDLDWFNPFTNLAFGAFVIGVTGSIFAFWGWDTCLTLGEESKDPTKVPGRAGLLCVTT ILLTYLLVAVAVMMYAGVGETGLGLGNPENSENVFGALADPVLGSWGGPLLFLAVLASSVASLQTTFLPA ARAMLAMGAYGAFPKRFSHVHPRFLVPSFSTLIAGIVTGVFYTVVSLLSEYALLDTIAALGIMICWYYGI TAFACIWYFRRELFTDAHNIVFKFLFPLIGGLVLAAVFGFSLKESMDPENGSGAELGGIGLVFYIGFGIL LLGAVLMLVMRTRSPEFFRGETLSRNTPVIPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1625 | - | - | 100% (522) | amino acid transporter, putative |
| M. smegmatis MC2 155 | MSMEG_1137 | - | 2e-21 | 21.73% (405) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_0446 | - | 3e-21 | 22.17% (433) | putrescine importer |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 1e-19 | 24.40% (455) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_4853 | - | 1e-119 | 44.35% (478) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1999c | - | 1e-19 | 24.40% (455) | integral membrane protein |
| M. leprae Br4923 | MLBr_01974 | - | 3e-10 | 23.96% (288) | putative permease |
| M. abscessus ATCC 19977 | MAB_4206 | - | 0.0 | 74.10% (502) | putative amino acid transporter |
| M. marinum M | MMAR_2609 | - | 0.0 | 72.12% (495) | hypothetical protein MMAR_2609 |
| M. avium 104 | MAV_2087 | - | 6e-17 | 23.56% (399) | amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 1e-17 | 24.62% (398) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2787 | - | 1e-105 | 40.78% (510) | hypothetical protein MUL_2787 |
| M. vanbaalenii PYR-1 | Mvan_1574 | - | 1e-121 | 44.22% (493) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2087|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MSMEG_1625|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4206|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2609|M.marinum_M --------------------------------------------------
Mflv_4853|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1574|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2787|M.ulcerans_Agy99 --------------------------------------------------
Mb2022c|M.bovis_AF2122/97 --------------------------------------------------
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MAV_2087|M.avium_104 -------------------------------------------MAPGTAD
TH_0471|M.thermoresistible__bu ----------------------------------MTDRLRVKSVEQSIAD
MSMEG_1625|M.smegmatis_MC2_155 -------------MTRSDPQSDPESDPHHA---LEIVE---------QSA
MAB_4206|M.abscessus_ATCC_1997 -------------MT--------EDLARAE---LDHAE---------RSE
MMAR_2609|M.marinum_M -------------MTDTPAPPLFARGPKGN---KLKVQPIVPQLSNTAAE
Mflv_4853|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1574|M.vanbaalenii_PYR-1 -------------------------------MAIT---------DEPAVP
MUL_2787|M.ulcerans_Agy99 -------------MGHLDADKKTNHQPIEGDCVSQ---------GEATSV
Mb2022c|M.bovis_AF2122/97 --------------------------------------------MRRPLD
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------MRRPLD
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MAV_2087|M.avium_104 H------LRRGIGTFQLTMFGVGSTIGTGIFFVMS-QAVP-----EAGPA
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTA-STAGN----ITGPA
MSMEG_1625|M.smegmatis_MC2_155 GLRGKGLAAGKVGTFSGAILGISSVAPGYTLTASIGLIVAA-----VGLK
MAB_4206|M.abscessus_ATCC_1997 GLVSKGLAAGRIGTFTGAVLGISTVAPGYTLTASIGLIVAA-----VGLK
MMAR_2609|M.marinum_M GVVSKGLAKGAVGTVSGAILGIACVAPGYTLTASIGLIVAA-----VGLK
Mflv_4853|M.gilvum_PYR-GCK -----------------MVIGLGAVAPAYSLAATLGYVVLN-----VQEK
Mvan_1574|M.vanbaalenii_PYR-1 AVGGKGLQAGALGLVGNVVIGLGAVAPAYSLAATLGYVVLN-----VQEK
MUL_2787|M.ulcerans_Agy99 AVEGKGLKGGAVGLLSSVVIGTASTAPAYSLAATLGLIVASRGELLCGVK
Mb2022c|M.bovis_AF2122/97 PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAA------GSG
Rv1999c|M.tuberculosis_H37Rv PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAA------GSG
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIA------GPF
::* : .
MAV_2087|M.avium_104 VIVSFLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAA
TH_0471|M.thermoresistible__bu ISVSFIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGW
MSMEG_1625|M.smegmatis_MC2_155 MPAIFIAGFIPMFLTAYAYRELNSRAPDCGASFTWSTKAFGPYVGWMCGW
MAB_4206|M.abscessus_ATCC_1997 MPAILIAGFIPMFLTAYAYRELNSRAPDCGASFTWSTKAFGPYVGWMCGW
MMAR_2609|M.marinum_M MPAIFVFGFIPMFLTAFAYRELNADTPDCGASFTWSTKAFGPYVGWMCGW
Mflv_4853|M.gilvum_PYR-GCK APSMFVLAFIPMLLVAFAYKELSQDTPDCGTTFTWATKAFGPWIGWIGGW
Mvan_1574|M.vanbaalenii_PYR-1 APAMFVLAFIPMLLVAFAYKELSQDTPDCGTTFTWGTKAFGPWIGWIGGW
MUL_2787|M.ulcerans_Agy99 APAIVLLSFIPMYMIAVAYQELNKAEPDCGTTFTWASRAFGPVTGWLGGW
Mb2022c|M.bovis_AF2122/97 LLLGLAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGW
Rv1999c|M.tuberculosis_H37Rv LLLGLAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGW
MLBr_01974|M.leprae_Br4923 APIAYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGV
. : * * :: : :* . .
MAV_2087|M.avium_104 CLLLEYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPGYVN
TH_0471|M.thermoresistible__bu DLILEFSVAAAVVAKGWSSYLGEVFE----------FAGATTRLGPITLD
MSMEG_1625|M.smegmatis_MC2_155 GMVIATIIVLSNLAAIAVEFFYLFVARILN-----TPEIADLADNKLVNI
MAB_4206|M.abscessus_ATCC_1997 GMVIATIIVLSNLASIGVQYGYQFLGAVTH-----NQTVAELANNKAVNI
MMAR_2609|M.marinum_M GMVIATVIVLSNLAAVAVQFFYLLIAGLFD-----SPGIASLAANRWVDI
Mflv_4853|M.gilvum_PYR-GCK GLAVSAIIVLANVSEIAAIYLYNFLG------------LTSLAESVPATV
Mvan_1574|M.vanbaalenii_PYR-1 GLAVSAIIVLANVSEIAAIYLYNFLG------------LDSLAESVPATV
MUL_2787|M.ulcerans_Agy99 GIIAADVIVMANLAQIAGAYSFTFVGELG------WQSASNLAHSTLWST
Mb2022c|M.bovis_AF2122/97 GFVVGKTASCAAMALTVGFYVWPAQAH-----------------------
Rv1999c|M.tuberculosis_H37Rv GFVVGKTASCAAMALTVGFYVWPAQAH-----------------------
MLBr_01974|M.leprae_Br4923 THAITASIAWGVLASSFVSTLLRVAFP--------EKIWADNDELISVKT
. ::
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
TH_0471|M.thermoresistible__bu WGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA
MSMEG_1625|M.smegmatis_MC2_155 LTTLVFIALATWVSSRGITTSEHVQYVLVGFQMTVLLAFAITAVIHVGAG
MAB_4206|M.abscessus_ATCC_1997 ISTVALLAIATYISSRGITTSEKVQYVLVGFQMIVLVLFAVVAIVKAPG-
MMAR_2609|M.marinum_M ASTLVFIAGATWVSSRGIQTSERVQGLLVIFQMTVILGFGVVAIIGAVRG
Mflv_4853|M.gilvum_PYR-GCK ALGCFFIIAMTLVSARGIVVSERVQNVLIAIQFGVLITVSIIALVRVFSG
Mvan_1574|M.vanbaalenii_PYR-1 ALGCFFIISMTLVSARGIVVSERVQNVLIAIQFGVLITVSVIALIRVFTG
MUL_2787|M.ulcerans_Agy99 VAGVAWIVVMTCICYRGTDVSARMQYVLLSVELVVLVALAAVALARVYTN
Mb2022c|M.bovis_AF2122/97 AVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYG-----
Rv1999c|M.tuberculosis_H37Rv AVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYG-----
MLBr_01974|M.leprae_Br4923 LTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQ
: : * . .: . .
MAV_2087|M.avium_104 HLDDFAP---------------------------FGVAGVGTAAGTIFFS
TH_0471|M.thermoresistible__bu NYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFA
MSMEG_1625|M.smegmatis_MC2_155 N-APEGLAFD-------------LDWFNPFTNLAFGA--FVIGVTGSIFA
MAB_4206|M.abscessus_ATCC_1997 --AAGHLDFD-------------LDWFNPMTGLTLSA--FVIGLVGSIFA
MMAR_2609|M.marinum_M H-GPANLSFD-------------FNWFDPFSGLAMGA--FVIGVTGSIFS
Mflv_4853|M.gilvum_PYR-GCK TAGAQAVMPE-------------VSWLWP-SGLDVSS--IAAAVILCIFI
Mvan_1574|M.vanbaalenii_PYR-1 TAGAQAISPQ-------------LSWLWP-SGLDVSS--IAAAVILCIFI
MUL_2787|M.ulcerans_Agy99 HGDVGSLRPS-------------LSWLWP-SGLDFGTQ-MAPALLITIFI
Mb2022c|M.bovis_AF2122/97 -----SGAAD-------------PARLDIGVDAHVWG--MLQAAGLLFFA
Rv1999c|M.tuberculosis_H37Rv -----SGAAD-------------PARLDIGVDAHVWG--MLQAAGLLFFA
MLBr_01974|M.leprae_Br4923 HVNNYVTSRSAYQP-------TTYSLLGVTEIGKSTAASMTLATIVALYA
. . ::
MAV_2087|M.avium_104 YIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQ
TH_0471|M.thermoresistible__bu FIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYT
MSMEG_1625|M.smegmatis_MC2_155 FWGWDTCLTLGEESKDPTKVPGRAGLLCVTTILLTYLLVAVAVMMYAGVG
MAB_4206|M.abscessus_ATCC_1997 FWGWDTCLTLGEESKDPTKVPGRAGLLCVLSILLTYLLVAVAVMMFAGIG
MMAR_2609|M.marinum_M FWGWDTCLTLGEECTDPKKVPGRAGVLCVVSILLTYLLVSVAMMMYAGVG
Mflv_4853|M.gilvum_PYR-GCK YWGWDACLAVGEETKDPGKTPGIAALITTVILVCTYVLVAYALQSFAGFS
Mvan_1574|M.vanbaalenii_PYR-1 YWGWDACLAVGEETKDPGRTPGIAALVTTVILVCTYVLVAFALQSFAGFS
MUL_2787|M.ulcerans_Agy99 YWGFDTAVACNDETDDPGRTLGRAAVISTFLLLATYAVVTVASIAFAGVG
Mb2022c|M.bovis_AF2122/97 FAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQ
Rv1999c|M.tuberculosis_H37Rv FAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQ
MLBr_01974|M.leprae_Br4923 FTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGS-D
: * :* * : . * . .
MAV_2087|M.avium_104 DFGGQQE-AGLATILDHVTHGS---------WASTILAAGAVISIFSVTL
TH_0471|M.thermoresistible__bu ELRAAGENANLATAFAANGID----------WAAKVISIGALAGLTTVVI
MSMEG_1625|M.smegmatis_MC2_155 ETGLGLGNPENSENVFGALA-----DPVLGSWGGPLLFLAVLASSVASLQ
MAB_4206|M.abscessus_ATCC_1997 DTDLGLANENNKDNVFGALA-----NPVLGSWFGPLLLLAIFASAIASLQ
MMAR_2609|M.marinum_M SQGLGLGNPDNSENVFGALA-----RPVLGPWGSQLLFLGILASTLSSLQ
Mflv_4853|M.gilvum_PYR-GCK EVGIGLNNPNNTDDVLTVLG-----EPVAGAIAASALLLTVSVSALSSTQ
Mvan_1574|M.vanbaalenii_PYR-1 EVGIGLNNPNNTDDVLTVLG-----KPVAGAIAASALLLTVSVSALSSTQ
MUL_2787|M.ulcerans_Agy99 VDGIGLGNPDNSNDVFAAVGPALFGDGVLGKIGLLLLSASILTSASASTQ
Mb2022c|M.bovis_AF2122/97 RLARAAAPLSEAMRVAGVN------------WLIPVVQIGAAVAALGSLL
Rv1999c|M.tuberculosis_H37Rv RLARAAAPLSEAMRVAGVN------------WLIPVVQIGAAVAALGSLL
MLBr_01974|M.leprae_Br4923 KIVATNHTVKLAAAVGNNTFR-------------TIIVVGALVSMFGINV
. : .
MAV_2087|M.avium_104 VTMYGITRILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAATLAAF
TH_0471|M.thermoresistible__bu VLVLGQTRVLFAMSRDGLLPRPLSKTGPR-GTPVRITVLVGALVAIAASV
MSMEG_1625|M.smegmatis_MC2_155 TTFLPAARAMLAMGAYGAFPKRFSHVHPRFLVPSFSTLIAGIVTGVFYTV
MAB_4206|M.abscessus_ATCC_1997 TTSLPAARTMLAMGTYGAFPKRFASVSPRFLTPTFSTVVAGVVTAAFYTI
MMAR_2609|M.marinum_M TTFLPASRCMLAMGAYRAFPQRFSAVSSRFQVPLFSTIAAAIASGAFYTL
Mflv_4853|M.gilvum_PYR-GCK TTILPTARGTLSMAVYEAIPRRFASVHPRYMTPAFGTIVMGISALFFYLV
Mvan_1574|M.vanbaalenii_PYR-1 TTILPTARGTLSMAVYEAIPKRFANVHPRYMTPAFGTIVMGLSALFFYLV
MUL_2787|M.ulcerans_Agy99 TTILPTARTTLSMAVYKALPASFAKIHPRYLTPTVSTIAMGAVSILFYVL
Mb2022c|M.bovis_AF2122/97 ALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAAT
Rv1999c|M.tuberculosis_H37Rv ALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAAT
MLBr_01974|M.leprae_Br4923 AASFGAPRLWTALSDGRILPTRLS-SKNRFGVPIVAFGITAFLTLAFPLS
. .* ::. :* :: * .* .
MAV_2087|M.avium_104 IPLQN----LADMVSIGTLTAFVVVSVGVIVLRVREPDLPRGFR----VP
TH_0471|M.thermoresistible__bu FPVGN----LEEMVNIGTLFAFALVSAGVIVLRRTRPDLKRGFR----VP
MSMEG_1625|M.smegmatis_MC2_155 VSLLSEYALLDTIAALGIMICWYYGITAFACIWYFRRELFTDAHNIVFKF
MAB_4206|M.abscessus_ATCC_1997 VSLLSDRTLLDTIAALGIMICWYYGITAFACVWYFRAELFQNAHNLVYKF
MMAR_2609|M.marinum_M ARLLSERTLLDTIAALGMLVCWYYGITAFACMWYFRKELFTSLRNVVFKF
Mflv_4853|M.gilvum_PYR-GCK LKMLSENALLDSVASLGLAVAFYYGITAFACVWYFRRTLFSSARNLFFRG
Mvan_1574|M.vanbaalenii_PYR-1 LKALSENALLDSVASLGLAVAFYYGITAFACVWYFRRTLFESTRNLFFRG
MUL_2787|M.ulcerans_Agy99 FTLVSRNLLSALIGSVGLVIAFYYGLTGYACAHYYRATLTKSLRNFVMRG
Mb2022c|M.bovis_AF2122/97 ADIR------GAIGFSSFGVLVYYAIANASALTLG----LDEGRPRRLIP
Rv1999c|M.tuberculosis_H37Rv ADIR------GAIGFSSFGVLVYYAIANASALTLG----LDEGRPRRLIP
MLBr_01974|M.leprae_Br4923 LRFDSLN--LTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTD
: . :
MAV_2087|M.avium_104 GYPVTPVLSIMACGYILASLHW-------------------YTWIAFSGW
TH_0471|M.thermoresistible__bu FVPWLPLAAIAACLWLMLNLTG-------------------LTWVRFLGW
MSMEG_1625|M.smegmatis_MC2_155 LFPLIGGLVLAAVFGFSLKES----MDPE-NGSGAELGGIGLVFYIGFGI
MAB_4206|M.abscessus_ATCC_1997 LFPLLGGLMLAAVFVISVQES----MDPEKTGSGASIGGIGLVFYLGFGI
MMAR_2609|M.marinum_M LCPLLGGMMLLLVFVVSVRES----MDPR-HGSGASIAGVGLVFYLGFGI
Mflv_4853|M.gilvum_PYR-GCK VFPLLGGLSMLAAFAISAKD------MIQPDYGHTAFGSIGGVFVLGVGM
Mvan_1574|M.vanbaalenii_PYR-1 VFPLLGGLSMLAAFTISAKD------MIQPDYGYTAFGPVGGVFVLGVGM
MUL_2787|M.ulcerans_Agy99 VVPLTGGVVLTVVFIFGLIEYAKRDWLVENGHNVTIFG-FGAVAVVGVGS
Mb2022c|M.bovis_AF2122/97 LVGLIGCVVLAFALPLSSVAAG--------------------AAVLGVGV
Rv1999c|M.tuberculosis_H37Rv LVGLIGCVVLAFALPLSSVAAG--------------------AAVLGVGV
MLBr_01974|M.leprae_Br4923 KVLPITAVVVSAGLMVSFDYRS--------------------IFLTRGGP
: . *
MAV_2087|M.avium_104 VLLALIFYFVWGRHHSALNDAAVDPS-------GQER-------------
TH_0471|M.thermoresistible__bu MALGLVLYFFYGRHHSMLGRGMTDIS-------ARRTG------------
MSMEG_1625|M.smegmatis_MC2_155 LLLGAVLMLVMRTRSPE-FFRGETLS------RNTPVIPG----------
MAB_4206|M.abscessus_ATCC_1997 LAFGALLMGIMRWYQPA-FFRGELLT------MDTPPLRE----------
MMAR_2609|M.marinum_M LSLGAVLMVVMRVRQPG-FFLGHTLT------PSTPALTDDAAIATASHP
Mflv_4853|M.gilvum_PYR-GCK LVLGIPLMLACFAFGTKRFFRGETLN-------ADTAVKVPDTF------
Mvan_1574|M.vanbaalenii_PYR-1 LVLGIPLMLACFAFGTKRFFRGETLN-------ADTEVKVPDTF------
MUL_2787|M.ulcerans_Agy99 MLLGVVVMLIWWAISPG-FFRGRTLRRHSADLLLEPAVSPPAHLALPDSG
Mb2022c|M.bovis_AF2122/97 AAYGVRRIITRRARQTD---SGDTQR------SGHPSAT-----------
Rv1999c|M.tuberculosis_H37Rv AAYGVRRIITRRARQTD---SGDTQR------SGHPSAT-----------
MLBr_01974|M.leprae_Br4923 NYFSISLIAITFIGIPAVAYLHYYRT---------SGIK-----------
. .
MAV_2087|M.avium_104 ------------------------------------
TH_0471|M.thermoresistible__bu ------------------------------------
MSMEG_1625|M.smegmatis_MC2_155 ------------------------------------
MAB_4206|M.abscessus_ATCC_1997 ------------------------------------
MMAR_2609|M.marinum_M DAGPDQHH----------------------------
Mflv_4853|M.gilvum_PYR-GCK ------------------------------------
Mvan_1574|M.vanbaalenii_PYR-1 ------------------------------------
MUL_2787|M.ulcerans_Agy99 DMQTVIAADLSNLPAGETAVNPQTGQHLTKDTSGAS
Mb2022c|M.bovis_AF2122/97 ------------------------------------
Rv1999c|M.tuberculosis_H37Rv ------------------------------------
MLBr_01974|M.leprae_Br4923 ------------------------------------