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VRGSGRERSRESQSREERKEATRRAIIAAALKLLQDRSFSSLSLREVTREVGIVPAAFYRHFESMESLGL VLIDESFRSLRDTLRDARAGKLDPNRVIESSVEILVASVADRREHWRLIARERNSGLSVLRYAIRTEIRL ITSELATDLARFPGLHEWTTEDLNVLATLFVNAMIVIAEAIEDSQSAEAREDIRRLAVKQLRMIATGIAG WRSTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5169 | - | - | 100% (215) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2788 | - | 1e-07 | 23.59% (195) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_5253 | - | 4e-07 | 28.42% (190) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 2e-06 | 25.74% (136) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4816 | - | 2e-82 | 74.15% (205) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 2e-06 | 25.74% (136) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00064 | - | 1e-05 | 31.17% (77) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1424c | - | 7e-35 | 39.02% (205) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0334 | - | 4e-97 | 85.10% (208) | TetR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1741 | - | 3e-85 | 74.65% (213) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_1635 | - | 3e-07 | 32.88% (73) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4787 | - | 1e-96 | 84.13% (208) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1626 | - | 7e-86 | 74.65% (213) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0334|M.marinum_M ----------------MNERTPSSRPHRS--GRSRD-----SPSREERKE
MUL_4787|M.ulcerans_Agy99 ----------------MNERTPSSRPHRS--SRSRD-----SPSREERKE
MAV_5169|M.avium_104 -----------------------MRGSGR--ERSRE-----SQSREERKE
MSMEG_1741|M.smegmatis_MC2_155 ----------------MNRRTPSTRTRRSETSRSRD-----TLTREERKE
Mflv_4816|M.gilvum_PYR-GCK MGSRQEISAACGRFHTVNSRTPSSRRGHSSRSRSKDGNSRETLSREERKE
Mvan_1626|M.vanbaalenii_PYR-1 ----------------MNSRTPSSRSGRS-RSREKD-----TLSREERKE
MAB_1424c|M.abscessus_ATCC_199 -----------------------MR-----------------HSRAEKKL
Mb1998c|M.bovis_AF2122/97 -------------------------------------MASVAQPVRRRPK
Rv1963c|M.tuberculosis_H37Rv -------------------------------------MASVAQPVRRRPK
MLBr_00064|M.leprae_Br4923 ---------------MINSTAGQTSQSRS------------RRSTRPSGD
TH_1635|M.thermoresistible__bu --------------------VTTDSPARE--------------DRRSRGD
MMAR_0334|M.marinum_M ATRRAIIAAALKLVHDRSFSALSLREVTREAGIVPAAFYRHFESMEALGL
MUL_4787|M.ulcerans_Agy99 ATRRAIIAAALKLVHDRSFSALSLREVTREAGIVPAAFYRHFESMEALGL
MAV_5169|M.avium_104 ATRRAIIAAALKLLQDRSFSSLSLREVTREVGIVPAAFYRHFESMESLGL
MSMEG_1741|M.smegmatis_MC2_155 ATRRALIAAALKLLKDHSFSALSLREVTREAGIVPAAFYRHFDSMDALGL
Mflv_4816|M.gilvum_PYR-GCK ATRRAIVDAALHLLAERGFSALSLREVTREAGIVPAAFYRHFDSMEALGL
Mvan_1626|M.vanbaalenii_PYR-1 ATRRAIVAAALSLLAERSFSGLSLREVTREAGIVPAAFYRHFESMEALGL
MAB_1424c|M.abscessus_ATCC_199 HTRRTLLDGTLELLKVRGFAAVSLREVAKSAGLVPTAFYRHFESMEDLGT
Mb1998c|M.bovis_AF2122/97 DRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQAL--
Rv1963c|M.tuberculosis_H37Rv DRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQAL--
MLBr_00064|M.leprae_Br4923 DRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPTFYFYFASKEAVLL
TH_1635|M.thermoresistible__bu RQRDAIVAAVRELLEERSFADLSVSTISERAGVARSGFYFYFDSKYAVLA
. :: . *. : : :.: ::. .*: :* :: . :
MMAR_0334|M.marinum_M VLIDESFRTLRDTLRGAR---AGRLDPN-RVIESSVEILIGSVAERREHW
MUL_4787|M.ulcerans_Agy99 VLIDESFRTLRDTLRGAR---AGRLDPN-RVIESSVEILIGSVAERREHW
MAV_5169|M.avium_104 VLIDESFRSLRDTLRDAR---AGKLDPN-RVIESSVEILVASVADRREHW
MSMEG_1741|M.smegmatis_MC2_155 VLIDESFRSLRDMLRGAR---AGKLDPH-HVIESSAEILVSSFNERREHW
Mflv_4816|M.gilvum_PYR-GCK VLIDESFRSLREMLRGAR---AGKLDPN-RVIESSVDILIDGVQQRREHW
Mvan_1626|M.vanbaalenii_PYR-1 VLIDESFRALREMLRGAR---AGKLDPN-RVIESSVDILIDSVQQRREHW
MAB_1424c|M.abscessus_ATCC_199 VLAEESVHALRDTFRQARRE-AGSDNPA-KILR----LMVDRVNEHANNF
Mb1998c|M.bovis_AF2122/97 --LAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIAAAVASRALT
Rv1963c|M.tuberculosis_H37Rv --LAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIAAAVASRALT
MLBr_00064|M.leprae_Br4923 TLLDRVFNKANAALETLIK---NRDNKRGNKWRTGINVFFETFGSHKAVT
TH_1635|M.thermoresistible__bu VILGEAMEELDKLTQNFAP--RGAEETPAEFARRMVGSAAAVYASNDPVM
. .. . . : . .
MMAR_0334|M.marinum_M RFIVRERSTGLSVLRYAIRTEIRLITS-----------------------
MUL_4787|M.ulcerans_Agy99 RFIVRERSTGLSVLRYAIRTDIRLITS-----------------------
MAV_5169|M.avium_104 RLIARERNSGLSVLRYAIRTEIRLITS-----------------------
MSMEG_1741|M.smegmatis_MC2_155 RFIARERSGGASALRYAIRTEIRLITS-----------------------
Mflv_4816|M.gilvum_PYR-GCK RFIGRERSTGVTVLRYAIRTEIRLITS-----------------------
Mvan_1626|M.vanbaalenii_PYR-1 RFIGRERSTGVTVLRYAIRTEIRLITS-----------------------
MAB_1424c|M.abscessus_ATCC_199 RFLVRERHGGSPQIRRAINNEMRMLTN-----------------------
Mb1998c|M.bovis_AF2122/97 VLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAW
Rv1963c|M.tuberculosis_H37Rv VLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAW
MLBr_00064|M.leprae_Br4923 CAGQVTRDN--TEVRKLWSTFMQKWIS-----------------------
TH_1635|M.thermoresistible__bu RACS-AAQNTDAQIREMMGDLQAIVID-----------------------
*
MMAR_0334|M.marinum_M --------------------------ELATDLARFPGLNEWS--------
MUL_4787|M.ulcerans_Agy99 --------------------------ELATDLARFPGLNEWS--------
MAV_5169|M.avium_104 --------------------------ELATDLARFPGLHEWT--------
MSMEG_1741|M.smegmatis_MC2_155 --------------------------ELAIDLARFPALKDWS--------
Mflv_4816|M.gilvum_PYR-GCK --------------------------ELAIDLARFPALNTWS--------
Mvan_1626|M.vanbaalenii_PYR-1 --------------------------ELAIDLARFPNLNTWS--------
MAB_1424c|M.abscessus_ATCC_199 --------------------------DVVVELARNPATNHHT--------
Mb1998c|M.bovis_AF2122/97 AVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAA
Rv1963c|M.tuberculosis_H37Rv AVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAA
MLBr_00064|M.leprae_Br4923 ------------------------YTAAVIDAERKRGVAPDTLP------
TH_1635|M.thermoresistible__bu --------------------------KIVGVIEQDASAQPIT--------
: .
MMAR_0334|M.marinum_M TEDLNILATLFVNAMIVTAEAIEDAQSS--EALEEIRRIAVK--------
MUL_4787|M.ulcerans_Agy99 TEDLNILATMFVNAMIVTAEAIEDAQSS--EALEEIRRIAVK--------
MAV_5169|M.avium_104 TEDLNVLATLFVNAMIVIAEAIEDSQSA--EAREDIRRLAVK--------
MSMEG_1741|M.smegmatis_MC2_155 SEDLNILANLFVNSMISLAEALEDAADA--ESIEAIHRTAVK--------
Mflv_4816|M.gilvum_PYR-GCK SEDLNILASVFVNSMIAIAEQLEDVTDT--ASVDEIRRTAVK--------
Mvan_1626|M.vanbaalenii_PYR-1 SEDLNILASVFVNSMIVIAESLEDATDP--ASIAEIRRIAIK--------
MAB_1424c|M.abscessus_ATCC_199 TEDLEIAAELIASSILNTIGMLVDTDHPTKADADAALNRALR--------
Mb1998c|M.bovis_AF2122/97 RDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSF
Rv1963c|M.tuberculosis_H37Rv RDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSF
MLBr_00064|M.leprae_Br4923 ATELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVS--------
TH_1635|M.thermoresistible__bu ----DDLHALVRTLVATTALTLTHDSAFVGRATDISRAVDVV--------
:
MMAR_0334|M.marinum_M -----QLRMVAIGVAGWKSRP-----------------------------
MUL_4787|M.ulcerans_Agy99 -----QLRMVAIGVAGWKSRP-----------------------------
MAV_5169|M.avium_104 -----QLRMIATGIAGWRSTP-----------------------------
MSMEG_1741|M.smegmatis_MC2_155 -----QMRMIAVGVNGWRSTD-----------------------------
Mflv_4816|M.gilvum_PYR-GCK -----QLRMITVGVAGWRSG------------------------------
Mvan_1626|M.vanbaalenii_PYR-1 -----QLRMITVGVAGWRSS------------------------------
MAB_1424c|M.abscessus_ATCC_199 -----QLDLVTSGLAHTRTMTTIIAEPAARPSESSATTAAP---------
Mb1998c|M.bovis_AF2122/97 SSKQAILDALIRRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDA
Rv1963c|M.tuberculosis_H37Rv SSKQAILDALIRRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDA
MLBr_00064|M.leprae_Br4923 --------SIYNEIR-----------------------------------
TH_1635|M.thermoresistible__bu ------ERLWLYSLWGGGNLPER---------------------------
:
MMAR_0334|M.marinum_M --------------------------------------------------
MUL_4787|M.ulcerans_Agy99 --------------------------------------------------
MAV_5169|M.avium_104 --------------------------------------------------
MSMEG_1741|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1626|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1424c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 PDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGR
Rv1963c|M.tuberculosis_H37Rv PDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGR
MLBr_00064|M.leprae_Br4923 --------------------------------------------------
TH_1635|M.thermoresistible__bu --------------------------------------------------
MMAR_0334|M.marinum_M -----------------------------------------------
MUL_4787|M.ulcerans_Agy99 -----------------------------------------------
MAV_5169|M.avium_104 -----------------------------------------------
MSMEG_1741|M.smegmatis_MC2_155 -----------------------------------------------
Mflv_4816|M.gilvum_PYR-GCK -----------------------------------------------
Mvan_1626|M.vanbaalenii_PYR-1 -----------------------------------------------
MAB_1424c|M.abscessus_ATCC_199 -----------------------------------------------
Mb1998c|M.bovis_AF2122/97 LLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA
Rv1963c|M.tuberculosis_H37Rv LLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA
MLBr_00064|M.leprae_Br4923 -----------------------------------------------
TH_1635|M.thermoresistible__bu -----------------------------------------------