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MELAGRTAIVTGAASGIGAALATELARRGVSVVIGDLDDDGAHATASAIRADGGAAAALRADATSVADIE ALITLASREFTPVDIYVANAGVIGKPGLGTESDWDVILDVNLRAHVRAARLLVPHWQSVGSGYFVSVASA AGLLTQLGAAGYAVSKHAAVGFAEWLAVTYGDDGIGVSCVCPLGVKTPLLQGIRGIDDPDARLGASSIEQ SAGVISAADVATVTVEAIREERFLVLPHAELLEMYRRKGGDYDRWISGMRRYQRTLRSL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4800 | - | - | 100% (269) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3370 | - | 1e-27 | 33.47% (248) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4610 | - | 5e-27 | 34.27% (248) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0874c | - | 3e-33 | 36.50% (263) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0851c | - | 6e-34 | 36.88% (263) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 4e-25 | 31.64% (256) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3103c | - | 4e-85 | 58.80% (267) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4755 | - | 7e-33 | 32.57% (261) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0895 | - | 1e-34 | 35.25% (261) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1760 | - | 2e-99 | 67.42% (267) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3454 | - | 1e-96 | 65.79% (266) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0326 | - | 1e-30 | 31.42% (261) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1642 | - | 1e-128 | 84.39% (269) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0874c|M.bovis_AF2122/97 -----------------------------MDGFP----GRGAVITGGASG
Rv0851c|M.tuberculosis_H37Rv -----------------------------MDGFP----GRGAVITGGASG
MAV_0895|M.avium_104 -----------------------------MDGFLSGFDGRAAVVTGGASG
MMAR_4755|M.marinum_M -----------------------------MDGFA----GRGAVITGGASG
MUL_0326|M.ulcerans_Agy99 -----------------------------MDGFA----GSGAVITGGASG
Mflv_4800|M.gilvum_PYR-GCK --------------------------MELAG--------RTAIVTGAASG
Mvan_1642|M.vanbaalenii_PYR-1 MRERACLRPTRRLWDELCARSRHTLGMELAR--------KTAIVTGGASG
MSMEG_1760|M.smegmatis_MC2_155 --------------------------MDIDG--------TTAVVTGGGSG
TH_3454|M.thermoresistible__bu --------------------------MRIDN--------SVFVVTGAGSG
MAB_3103c|M.abscessus_ATCC_199 --------------------------MDING--------SVAIVTGAGSG
MLBr_01094|M.leprae_Br4923 ----------------------------MEGFAG-----KVAVVTGAGSG
::**..**
Mb0874c|M.bovis_AF2122/97 IGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHGVMCDVRHR
Rv0851c|M.tuberculosis_H37Rv IGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHR
MAV_0895|M.avium_104 IGLATATEFARRGARLVLSDVDQPALEQAVNGLRGQGFDAHGVVCDVRHL
MMAR_4755|M.marinum_M IGLATATEFARRGAKVVLADIDKPGLERSVEHLRGKGFDAHGVMCDVRHL
MUL_0326|M.ulcerans_Agy99 IGLATATEFARRGAKVVLADIDKPGLERSVEHLRGKGFDAHGVMCDVRHL
Mflv_4800|M.gilvum_PYR-GCK IGAALATELARRGVSVVIGDLDDDGAHATASAIRADGGAAAALRADATSV
Mvan_1642|M.vanbaalenii_PYR-1 IGAAIASELAAHGVSVVVGDLDEAGAHTTAAAIRDSGGAATALRADASDV
MSMEG_1760|M.smegmatis_MC2_155 IGAALAEAFAAAGARVVVADLDEPGAAATAARIESAGGNAVAVRADASAT
TH_3454|M.thermoresistible__bu IGRALALSFADAGARVVAGDIDESAADTTAATIRDSGGHAVPIRADATTP
MAB_3103c|M.abscessus_ATCC_199 IGQALAWGLVDAGATVVASDIDADAVGRTAAARDG----IVGQRADASAV
MLBr_01094|M.leprae_Br4923 IGQALAIELARSGAKLAISDVDGEGLAQTEGQLKAIGASARTDRLDVTER
** * . :. *. :. .*:* . : *.
Mb0874c|M.bovis_AF2122/97 EEVTHLADEAFRLLGHFDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWG
Rv0851c|M.tuberculosis_H37Rv EEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWG
MAV_0895|M.avium_104 DEMVRLADEAFRLLGGVDVVFSNAGIVVAGPLAQMNHDDWRWVIDIDLWG
MMAR_4755|M.marinum_M SEVNHLAAESARLLGQIDVVFSNAGIVVAGPIADMTHDDWRWVIDIDLWG
MUL_0326|M.ulcerans_Agy99 SEVNHLAAESARLLGQIDVVFSNAGIVVAGPIADMTHDVWRWVIDIDLWG
Mflv_4800|M.gilvum_PYR-GCK ADIEALITLASREFTPVDIYVANAGVIGKPGLGT--ESDWDVILDVNLRA
Mvan_1642|M.vanbaalenii_PYR-1 VDIEGLITLAGREFAPVDIYVANAGITGKPGLGT--ESDWDVVLDVNLRA
MSMEG_1760|M.smegmatis_MC2_155 ADIEALT---RTEFGPVDIYVANAGIIGASGLGT--DEEWDRILAVNLRA
TH_3454|M.thermoresistible__bu AGIDAMISLAQETFGPVDGYVANAGVIGPPGLGT--DTGWDRVLDVNLRA
MAB_3103c|M.abscessus_ATCC_199 SDIEDLIALAEKEFGPVDLYAANAGIAGGLGLGIG-EAAWDLTIDVNLRA
MLBr_01094|M.leprae_Br4923 EAFLTYADVVHENFGKVNQIYNNAGIAFTGDVEVSHFKDIERVMDVDYWG
. : .: ***: : : :: .
Mb0874c|M.bovis_AF2122/97 SIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLA
Rv0851c|M.tuberculosis_H37Rv SIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLA
MAV_0895|M.avium_104 SIHAVEAFLPRLLEQGTGGHIAFTASFAGLVPNAGLGTYGVAKYGVVGLA
MMAR_4755|M.marinum_M SIHTVEAFLPKLLEHG--GHIAFTASFAGLVPNAGLGAYGVAKYGVVGLA
MUL_0326|M.ulcerans_Agy99 SIHTVEAFLPKLLEHG--GHIAFTASFAGLVPNAGLGAYGVAKYGVVGLA
Mflv_4800|M.gilvum_PYR-GCK HVRAARLLVPHWQSVGS-GYFVSVASAAGLLTQLGAAGYAVSKHAAVGFA
Mvan_1642|M.vanbaalenii_PYR-1 HVRAARLVVPHWQSRGS-GYFVSVASAAGLLTQLGAAGYAVTKHAAVGFA
MSMEG_1760|M.smegmatis_MC2_155 HIRAADVLVPQWISRGR-GYFVSVASAAGLLSQIGAAGYAVTKHAAVGFA
TH_3454|M.thermoresistible__bu HVRAADALVPQWISRGT-GYFVSVASAAGLLTQLGAAAYAVSKHAAVGFA
MAB_3103c|M.abscessus_ATCC_199 HIRAATLLVPGWVERGR-GYFLSVASAAGLLTQIGSPAYSVTKHAAVGFA
MLBr_01094|M.leprae_Br4923 VVNGTKAFLPYLISSGD-GHVINISSVFGLFSVPGQAAYNSAKFAVRGFT
:. . .:* . * *:. :* **.. * * :*... *::
Mb0874c|M.bovis_AF2122/97 ETLAREVTADG--IGVSVLCPMVVETNLVANSERIRGAACAQSST---TG
Rv0851c|M.tuberculosis_H37Rv ETLAREVTADG--IGVSVLCPMVVETNLVANSERIRGAACAQSST---TG
MAV_0895|M.avium_104 ETLAREVKPNG--IGVSVLCPMVVETKLVSNSERIRGADYGMSATP--EG
MMAR_4755|M.marinum_M ETLSREMKDRG--VGVTVLCPMVVETRLVSNSERIRGADYGLSSAPQVTG
MUL_0326|M.ulcerans_Agy99 ETLSREMKDRG--VGVTVLCPMVVETQLVSNSERIRGADYGLSSAPQVTG
Mflv_4800|M.gilvum_PYR-GCK EWLAVTYGDDG--IGVSCVCPLGVKTPLLQGIRGIDDPDARLGAS-----
Mvan_1642|M.vanbaalenii_PYR-1 EWLAITYGDDG--IGVSCVCPLGVDTPLLQAIRSTDDPDSRLGAS-----
MSMEG_1760|M.smegmatis_MC2_155 EWLAITYGDDG--VGVSCVCPLGVDTPLLHAVRNSAETDALVGAE-----
TH_3454|M.thermoresistible__bu EWLAITYGDRG--IGVSCVCPMGVRTPLLGAVRDSTDTTAQLAAR-----
MAB_3103c|M.abscessus_ATCC_199 EWLSITYGGQG--VGVSCLCPMGVKTALLDGLTESDDPDVRVAGT-----
MLBr_01094|M.leprae_Br4923 EALREEMALAGRPVNVTTVYPGGIKTAIARNATAAEGLDVSKIAS-----
* * * :.*: : * : * : .
Mb0874c|M.bovis_AF2122/97 SPGPLPLQDDNLGVDDIAQLTADAILAN--RLYVLPHAASRASIRRR--F
Rv0851c|M.tuberculosis_H37Rv SPGPLPLQDDNLGVDDIAQLTADAILAN--RLYVLPHAASRASIRRR--F
MAV_0895|M.avium_104 AFGPLPTQDESVSADDVARLTADAILAN--RLYILPHAAARESIRRR--F
MMAR_4755|M.marinum_M DMGSLPAQDDSLSVDELARLTADAILAN--RLYVLPHEGARTSIQRR--F
MUL_0326|M.ulcerans_Agy99 DMGSLPAQDDSLSVDELARLTADAILAN--GLYVLPHEGARTSIQRR--F
Mflv_4800|M.gilvum_PYR-GCK ---SIEQSAGVISAADVATVTVEAIREE--RFLVLPHAELLEMYRRK--G
Mvan_1642|M.vanbaalenii_PYR-1 ---SIEQSGSVISAADVAAVTVEAIRTD--RFLVLPHPELLEMYRNK--G
MSMEG_1760|M.smegmatis_MC2_155 ---SIVQSGDVITPQDVATVTVEAVQAG--RFLVLPHPHVLDLYRRK--G
TH_3454|M.thermoresistible__bu ---SITSAGAVLDAAEVADLTVAAVREG--RFLVLPHPEVLDMYRQK--G
MAB_3103c|M.abscessus_ATCC_199 ---SITAAGDVLEPAVVAAMALDAIRDE--KFLVLPHPQVLDMYRQK--G
MLBr_01094|M.leprae_Br4923 ---RFDTWVAHTSPQHAARIILKAVRKKKARVLVGPDAKVANVVVRFSGG
: * : *: . : *. .
Mb0874c|M.bovis_AF2122/97 ERIDRTFDEQAAEGWRH--------
Rv0851c|M.tuberculosis_H37Rv ERIDRTFDEQAAEGWRH--------
MAV_0895|M.avium_104 ERIDRTFDEQAAEGWTH--------
MMAR_4755|M.marinum_M ARIDRTFDEQAAEGWRH--------
MUL_0326|M.ulcerans_Agy99 ARIDRTFDEQAAEGWRH--------
Mflv_4800|M.gilvum_PYR-GCK GDYDRWISGMRRYQRTLRSL-----
Mvan_1642|M.vanbaalenii_PYR-1 GDYDRWIGGMRRYQRTLRAL-----
MSMEG_1760|M.smegmatis_MC2_155 SDYDRWIAGMRRYQRSLRGTAVPGT
TH_3454|M.thermoresistible__bu ADYDRWIAGMRRYQRSLAAER----
MAB_3103c|M.abscessus_ATCC_199 ADYDRWIAGMRRYQAILEDQIIR--
MLBr_01094|M.leprae_Br4923 AGYQRLFAQVASRLILNQR------
:* :