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DGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVT HLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGGHVVFT ASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTT GSPGPLPLQDDNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0851c | - | - | 100% (275) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3057c | - | 4e-32 | 39.80% (201) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1245c | - | 7e-30 | 36.62% (213) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0874c | - | 1e-158 | 99.27% (275) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4610 | - | 6e-37 | 37.55% (245) | short-chain dehydrogenase/reductase SDR |
| M. leprae Br4923 | MLBr_01740 | - | 1e-30 | 38.78% (196) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4478c | - | 2e-35 | 39.18% (245) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4755 | - | 1e-122 | 76.98% (278) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0895 | - | 1e-125 | 78.62% (276) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2291 | - | 4e-32 | 38.58% (197) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 6e-31 | 36.36% (187) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0326 | - | 1e-119 | 75.90% (278) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0852 | - | 7e-36 | 45.36% (183) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4323|M.thermoresistible__bu MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWDSVAPLLAD
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_2291|M.smegmatis_MC2_155 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0895|M.avium_104 --------------------------------------------------
MMAR_4755|M.marinum_M --------------------------------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0852|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4323|M.thermoresistible__bu RFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAPGQRVHVLA
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_2291|M.smegmatis_MC2_155 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0895|M.avium_104 --------------------------------------------------
MMAR_4755|M.marinum_M --------------------------------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0852|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4323|M.thermoresistible__bu HDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDGLAAPYRPR
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_2291|M.smegmatis_MC2_155 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0895|M.avium_104 --------------------------------------------------
MMAR_4755|M.marinum_M --------------------------------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0852|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4323|M.thermoresistible__bu RFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRLRDGVPADR
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_2291|M.smegmatis_MC2_155 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0895|M.avium_104 --------------------------------------------------
MMAR_4755|M.marinum_M --------------------------------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0852|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4323|M.thermoresistible__bu LHHSDTFAADAARSIKVYGANFLRTLRHARTDHFVRVPVQLIVNTRDPYV
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_2291|M.smegmatis_MC2_155 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0895|M.avium_104 --------------------------------------------------
MMAR_4755|M.marinum_M --------------------------------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0852|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4323|M.thermoresistible__bu RPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVTELADHLAGAPA
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_2291|M.smegmatis_MC2_155 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0895|M.avium_104 --------------------------------------------------
MMAR_4755|M.marinum_M --------------------------------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0852|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK ---MDILRWDRPPRLSRRANAVVTGAGSGIGRAFAVELARRGGRVVCADI
MAB_4478c|M.abscessus_ATCC_199 --MVSLLGFGRGERRTRKVDAVVTGAASGIGRAFAVELARRGGRVVCADV
TH_4323|M.thermoresistible__bu GRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFAREGAEVIVSDI
MLBr_01740|M.leprae_Br4923 --------MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDR
MSMEG_2291|M.smegmatis_MC2_155 --------MAQGSD-FAGKRCFVTGAASGIGRATALALAAAGAELYLTDR
Rv0851c|M.tuberculosis_H37Rv --------MDGFP----GRGAVITGGASGIGLATGTEFARRGARVVLGDV
Mb0874c|M.bovis_AF2122/97 --------MDGFP----GRGAVITGGASGIGLATGTEFARRGARVVLGDV
MAV_0895|M.avium_104 --------MDGFLSGFDGRAAVVTGGASGIGLATATEFARRGARLVLSDV
MMAR_4755|M.marinum_M --------MDGFA----GRGAVITGGASGIGLATATEFARRGAKVVLADI
MUL_0326|M.ulcerans_Agy99 --------MDGFA----GSGAVITGGASGIGLATATEFARRGAKVVLADI
Mvan_0852|M.vanbaalenii_PYR-1 ---MVSNHFR-------GKVCVVTGAASGIGLAVGAALLDHGATVVLADF
:**...*** . : *. : *
Mflv_4610|M.gilvum_PYR-GCK DPVRAKETVGLVVQAGG-EGLDIACDVTDEEQVRELADSAEKWFGAAASL
MAB_4478c|M.abscessus_ATCC_199 DLPGAKETAALIGER----AIEAACDVSVFDEVEALADTAEEWFGKPSDL
TH_4323|M.thermoresistible__bu DEATAKDTAAEIAARGG-VAHAYQLDVSDAAAVDRFADEVCARHGVP-DI
MLBr_01740|M.leprae_Br4923 HCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHPSM-DI
MSMEG_2291|M.smegmatis_MC2_155 DADGLVQTVADARALGAEVPAHRALDISDYDQVREFAKDIHAAHGSM-DV
Rv0851c|M.tuberculosis_H37Rv DKPGLRQAVNHLRAEGF-DVHSVMCDVRHREEVTHLADEAFRLLGHV-DV
Mb0874c|M.bovis_AF2122/97 DKPGLRQAVNHLRAEGF-DVHGVMCDVRHREEVTHLADEAFRLLGHF-DV
MAV_0895|M.avium_104 DQPALEQAVNGLRGQGF-DAHGVVCDVRHLDEMVRLADEAFRLLGGV-DV
MMAR_4755|M.marinum_M DKPGLERSVEHLRGKGF-DAHGVMCDVRHLSEVNHLAAESARLLGQI-DV
MUL_0326|M.ulcerans_Agy99 DKPGLERSVEHLRGKGF-DAHGVMCDVRHLSEVNHLAAESARLLGQI-DV
Mvan_0852|M.vanbaalenii_PYR-1 DADRLTTVAEGLCMHDG-RVHSAVVDVTVQEAVQALVEGAARAHGSL-DF
. . *: : : ..
Mflv_4610|M.gilvum_PYR-GCK VINNAGIGIGGNVIGATPKRDWEATLSVNLWGVIYGCEIFVPRLRAKGSG
MAB_4478c|M.abscessus_ATCC_199 VINNAGIGAGGQVVGAAPLADWQKTLGVNLWGVIHGSHVFAPRLRALGRG
TH_4323|M.thermoresistible__bu VVNNAGIGHAGRFL-DTPRDQWDRVLEVNLGGVVNGCRAFAPRLVERGTG
MLBr_01740|M.leprae_Br4923 VMNIAGVSVWGTVD-RLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRG
MSMEG_2291|M.smegmatis_MC2_155 VMNIAGVSAWGTVD-RLSHQQWRSMVDINLMGPIHVIEEFIPPMIEARRG
Rv0851c|M.tuberculosis_H37Rv VFSNAGIVVGGPIV-EMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTG
Mb0874c|M.bovis_AF2122/97 VFSNAGIVVGGPIV-EMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTG
MAV_0895|M.avium_104 VFSNAGIVVAGPLA-QMNHDDWRWVIDIDLWGSIHAVEAFLPRLLEQGTG
MMAR_4755|M.marinum_M VFSNAGIVVAGPIA-DMTHDDWRWVIDIDLWGSIHTVEAFLPKLLEHG--
MUL_0326|M.ulcerans_Agy99 VFSNAGIVVAGPIA-DMTHDVWRWVIDIDLWGSIHTVEAFLPKLLEHG--
Mvan_0852|M.vanbaalenii_PYR-1 LFNNAGVGGTMPIG-VATLEQWRRIVDLNLWGVIYGVHAAVPIMVRQGS-
:.. **: . * : ::* * : . * :
Mflv_4610|M.gilvum_PYR-GCK G-IINVASAASFGAAPRMGAYNVSKAGVLSLSETLAAELSGTGVAVTVLC
MAB_4478c|M.abscessus_ATCC_199 G-IINVASAASFAAAPRMGAYNVSKAGVLALSETLAAELSGTGVAVTVLC
TH_4323|M.thermoresistible__bu GHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAELDSAGIMLTTIC
MLBr_01740|M.leprae_Br4923 GHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSVVV
MSMEG_2291|M.smegmatis_MC2_155 GHLVNVSSAAGLVALPWHGAYSASKFGLRGVSEVLRFDLARHRIGVSVVV
Rv0851c|M.tuberculosis_H37Rv GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIGVSVLC
Mb0874c|M.bovis_AF2122/97 GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIGVSVLC
MAV_0895|M.avium_104 GHIAFTASFAGLVPNAGLGTYGVAKYGVVGLAETLAREVKPNGIGVSVLC
MMAR_4755|M.marinum_M GHIAFTASFAGLVPNAGLGAYGVAKYGVVGLAETLSREMKDRGVGVTVLC
MUL_0326|M.ulcerans_Agy99 GHIAFTASFAGLVPNAGLGAYGVAKYGVVGLAETLSREMKDRGVGVTVLC
Mvan_0852|M.vanbaalenii_PYR-1 GHIVNTASLAGLVPFPYQSLYCTTKYGVVGLSESLRYELAADGVRVSVVC
* : :* *. . * .:* .: .:: * :: : ::.:
Mflv_4610|M.gilvum_PYR-GCK PTFVKTNIVDNP---------GIEESAAKLATNLMKWTGVSAESVARKTL
MAB_4478c|M.abscessus_ATCC_199 PTFVKTSIVDSG---------IIEESAARLAATAMKWTGVSADSVARGCL
TH_4323|M.thermoresistible__bu PSTVNTNIIGSTRFNAPDGLDDVVDTRREQLQKLFALRRFGPDKAAKAIV
MLBr_01740|M.leprae_Br4923 PGAVRTPLVDTIEIAG----VDRQDPRFSRWVDRFRGHAVSAERAAEKIL
MSMEG_2291|M.smegmatis_MC2_155 PGAVKTGLVQTVEIAG----VDREDPDVKKWVDRFAGHAISPEKAAAKIL
Rv0851c|M.tuberculosis_H37Rv PMVVETNLVANSERIRGAACAQSST---TGSPGPLPLQDDNLGVDDIAQL
Mb0874c|M.bovis_AF2122/97 PMVVETNLVANSERIRGAACAQSST---TGSPGPLPLQDDNLGVDDIAQL
MAV_0895|M.avium_104 PMVVETKLVSNSERIRGADYGMSATP--EGAFGPLPTQDESVSADDVARL
MMAR_4755|M.marinum_M PMVVETRLVSNSERIRGADYGLSSAPQVTGDMGSLPAQDDSLSVDELARL
MUL_0326|M.ulcerans_Agy99 PMVVETQLVSNSERIRGADYGLSSAPQVTGDMGSLPAQDDSLSVDELARL
Mvan_0852|M.vanbaalenii_PYR-1 PGNVVSRIFGTPILGRPVDAAPPEDSIPAEEAARLILAG-VAAGEGIIAF
* * : :. . : .
Mflv_4610|M.gilvum_PYR-GCK DANDRGQLHVLPQVDAKILWLFKRAVPATYTRALGLVERIAR--------
MAB_4478c|M.abscessus_ATCC_199 DAHDRGQLYVLPQFDARFMWQAKRLAPDTYTKALGIAERFSRQRGN----
TH_4323|M.thermoresistible__bu SAVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTARGRVL-----------
MLBr_01740|M.leprae_Br4923 AGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPA
MSMEG_2291|M.smegmatis_MC2_155 AGVRRNRFLIYTSADIRALYTFKRVAWWPYSVAMRQVNVLFTRALRSG--
Rv0851c|M.tuberculosis_H37Rv TADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH-------
Mb0874c|M.bovis_AF2122/97 TADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH-------
MAV_0895|M.avium_104 TADAILANRLYILPHAAARESIRRRFERIDRTFDEQAAEGWTH-------
MMAR_4755|M.marinum_M TADAILANRLYVLPHEGARTSIQRRFARIDRTFDEQAAEGWRH-------
MUL_0326|M.ulcerans_Agy99 TADAILANGLYVLPHEGARTSIQRRFARIDRTFDEQAAEGWRH-------
Mvan_0852|M.vanbaalenii_PYR-1 PEKPRELWRSYAESPDSVEGYLKEVARQRRAAFATGDAQALFRATQSAGG
.
Mflv_4610|M.gilvum_PYR-GCK --------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------
TH_4323|M.thermoresistible__bu --------------------------
MLBr_01740|M.leprae_Br4923 TMRCVEPIKVGVYSQPRSGEGGKSGN
MSMEG_2291|M.smegmatis_MC2_155 -------------TSPR---------
Rv0851c|M.tuberculosis_H37Rv --------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------
MAV_0895|M.avium_104 --------------------------
MMAR_4755|M.marinum_M --------------------------
MUL_0326|M.ulcerans_Agy99 --------------------------
Mvan_0852|M.vanbaalenii_PYR-1 T-------------------------