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MDGFAGRGAVITGGASGIGLATATEFARRGAKVVLADIDKPGLERSVEHLRGKGFDAHGVMCDVRHLSEV NHLAAESARLLGQIDVVFSNAGIVVAGPIADMTHDDWRWVIDIDLWGSIHTVEAFLPKLLEHGGHIAFTA SFAGLVPNAGLGAYGVAKYGVVGLAETLSREMKDRGVGVTVLCPMVVETRLVSNSERIRGADYGLSSAPQ VTGDMGSLPAQDDSLSVDELARLTADAILANRLYVLPHEGARTSIQRRFARIDRTFDEQAAEGWRH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4755 | - | - | 100% (276) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_3141 | - | 4e-34 | 37.25% (247) | short-chain membrane-associated dehydrogenase |
| M. marinum M | MMAR_3700 | - | 8e-33 | 36.25% (251) | short-chain membrane-associated dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0874c | - | 1e-122 | 77.34% (278) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3370 | - | 2e-33 | 40.00% (190) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0851c | - | 1e-122 | 76.98% (278) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 7e-29 | 35.61% (205) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4053c | - | 8e-35 | 40.64% (251) | putative short chain dehydrogenase/reductase |
| M. avium 104 | MAV_0895 | - | 1e-123 | 76.98% (278) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1760 | - | 2e-31 | 30.92% (262) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_2445 | - | 4e-29 | 35.00% (240) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0326 | - | 1e-155 | 98.55% (276) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0852 | - | 3e-33 | 38.24% (238) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3370|M.gilvum_PYR-GCK --------MASTDTAQLSGKVAFVTGGASGIGAALVAKLATAGTEVWIAD
TH_2445|M.thermoresistible__bu --------------MTFAGKHALVTGAGSGIGAALCRALAAAGAEVMCTD
Mvan_0852|M.vanbaalenii_PYR-1 -----------MVSNHFRGKVCVVTGAASGIGLAVGAALLDHGATVVLAD
MMAR_4755|M.marinum_M ---------MDGFA----GRGAVITGGASGIGLATATEFARRGAKVVLAD
MUL_0326|M.ulcerans_Agy99 ---------MDGFA----GSGAVITGGASGIGLATATEFARRGAKVVLAD
Mb0874c|M.bovis_AF2122/97 ---------MDGFP----GRGAVITGGASGIGLATGTEFARRGARVVLGD
Rv0851c|M.tuberculosis_H37Rv ---------MDGFP----GRGAVITGGASGIGLATGTEFARRGARVVLGD
MAV_0895|M.avium_104 ---------MDGFLSGFDGRAAVVTGGASGIGLATATEFARRGARLVLSD
MAB_4053c|M.abscessus_ATCC_199 MTAPDVGIYPRRRPKVSYGASAVVTGAGSGIGRAFAQTLAARGGRVVCAD
MSMEG_1760|M.smegmatis_MC2_155 --------------MDIDGTTAVVTGGGSGIGAALAEAFAAAGARVVVAD
MLBr_01094|M.leprae_Br4923 -------------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISD
* ..:**..**** * : * : *
Mflv_3370|M.gilvum_PYR-GCK RQIAPAEELAAQLRATGAVAHAVELDVRDPAAFAHAVHTAVDTSGR-LDY
TH_2445|M.thermoresistible__bu IDGAAAERTAQSIGGR-----WAALDVTDAAAVQAAVDGVVDRAGR-LDL
Mvan_0852|M.vanbaalenii_PYR-1 FDADRLTTVAEGLCMHDGRVHSAVVDVTVQEAVQALVEGAARAHGS-LDF
MMAR_4755|M.marinum_M IDKPGLERSVEHLRGKGFDAHGVMCDVRHLSEVNHLAAESARLLGQ-IDV
MUL_0326|M.ulcerans_Agy99 IDKPGLERSVEHLRGKGFDAHGVMCDVRHLSEVNHLAAESARLLGQ-IDV
Mb0874c|M.bovis_AF2122/97 VDKPGLRQAVNHLRAEGFDVHGVMCDVRHREEVTHLADEAFRLLGH-FDV
Rv0851c|M.tuberculosis_H37Rv VDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEAFRLLGH-VDV
MAV_0895|M.avium_104 VDQPALEQAVNGLRGQGFDAHGVVCDVRHLDEMVRLADEAFRLLGG-VDV
MAB_4053c|M.abscessus_ATCC_199 IDVGRAQETVDIIGGG--KAHAVPCDVTSYEQVAELARVATSWLRQPADL
MSMEG_1760|M.smegmatis_MC2_155 LDEPGAAATAARIESAGGNAVAVRADASATADIEALTRTEFG----PVDI
MLBr_01094|M.leprae_Br4923 VDGEGLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGK-VNQ
: : *. . . :
Mflv_3370|M.gilvum_PYR-GCK LFNNAGIGIGG-EVDTLTLDDWTDIIDVNLKGVIHGVHAAYPQMIRQG-S
TH_2445|M.thermoresistible__bu LFNNAGIVWGG-DTELLTLDQWNAIIDVNIRGVVHGVAAAYPLMVRQG-H
Mvan_0852|M.vanbaalenii_PYR-1 LFNNAGVGGTM-PIGVATLEQWRRIVDLNLWGVIYGVHAAVPIMVRQG-S
MMAR_4755|M.marinum_M VFSNAGIVVAG-PIADMTHDDWRWVIDIDLWGSIHTVEAFLPKLLEHG--
MUL_0326|M.ulcerans_Agy99 VFSNAGIVVAG-PIADMTHDVWRWVIDIDLWGSIHTVEAFLPKLLEHG--
Mb0874c|M.bovis_AF2122/97 VFSNAGIVVGG-PIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTG
Rv0851c|M.tuberculosis_H37Rv VFSNAGIVVGG-PIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTG
MAV_0895|M.avium_104 VFSNAGIVVAG-PLAQMNHDDWRWVIDIDLWGSIHAVEAFLPRLLEQGTG
MAB_4053c|M.abscessus_ATCC_199 VINNAGIGTGGLPVGAMSMSDWEGTLAINLWGVIHGCQVFTPLLREQR-F
MSMEG_1760|M.smegmatis_MC2_155 YVANAGIIGAS---GLGTDEEWDRILAVNLRAHIRAADVLVPQWISRG-R
MLBr_01094|M.leprae_Br4923 IYNNAGIAFTG-DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSG-D
***: . : :: . : . *
Mflv_3370|M.gilvum_PYR-GCK GHIVNTASMAGLITTSAQGGYSATKHAVVALSKTMRVEAATHG--VRVSV
TH_2445|M.thermoresistible__bu GHIVNTASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEAAAHG--VGVLA
Mvan_0852|M.vanbaalenii_PYR-1 GHIVNTASLAGLVPFPYQSLYCTTKYGVVGLSESLRYELAADG--VRVSV
MMAR_4755|M.marinum_M GHIAFTASFAGLVPNAGLGAYGVAKYGVVGLAETLSREMKDRG--VGVTV
MUL_0326|M.ulcerans_Agy99 GHIAFTASFAGLVPNAGLGAYGVAKYGVVGLAETLSREMKDRG--VGVTV
Mb0874c|M.bovis_AF2122/97 GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADG--IGVSV
Rv0851c|M.tuberculosis_H37Rv GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADG--IGVSV
MAV_0895|M.avium_104 GHIAFTASFAGLVPNAGLGTYGVAKYGVVGLAETLAREVKPNG--IGVSV
MAB_4053c|M.abscessus_ATCC_199 GGIINVASAASFAAAPLMAAYNVSKAGVLTLSETLSAELSGSG--VKVTV
MSMEG_1760|M.smegmatis_MC2_155 GYFVSVASAAGLLSQIGAAGYAVTKHAAVGFAEWLAITYGDDG--VGVSC
MLBr_01094|M.leprae_Br4923 GHVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTT
* . :* .: . * :* .. :: : * : *
Mflv_3370|M.gilvum_PYR-GCK LCPGVVRTPILTGGAFGRNKSVSREDQLKLGEALR-PMDAGVFAQKALRG
TH_2445|M.thermoresistible__bu VCPAAVETPLLDKGAVG---GFLGRDYFIRGQGVRSAYDPDRLASDTLRA
Mvan_0852|M.vanbaalenii_PYR-1 VCPGNVVSRIFGTPILGRPVDAAPPEDSIPAEEAARLILAGVAAGEGIIA
MMAR_4755|M.marinum_M LCPMVVETRLVSNSERIRGADYGLSSAPQVTGDMGSLPAQDDSLSVDELA
MUL_0326|M.ulcerans_Agy99 LCPMVVETQLVSNSERIRGADYGLSSAPQVTGDMGSLPAQDDSLSVDELA
Mb0874c|M.bovis_AF2122/97 LCPMVVETNLVANSERIRGAACAQSST---TGSPGPLPLQDDNLGVDDIA
Rv0851c|M.tuberculosis_H37Rv LCPMVVETNLVANSERIRGAACAQSST---TGSPGPLPLQDDNLGVDDIA
MAV_0895|M.avium_104 LCPMVVETKLVSNSERIRGADYGMSATP--EGAFGPLPTQDESVSADDVA
MAB_4053c|M.abscessus_ATCC_199 LCPTFVKTNIVNDG-RISGSASGLAASMMKYTGVSPERIARGTLDAHDRG
MSMEG_1760|M.smegmatis_MC2_155 VCPLGVDTPLLHAVRNSAETDALVGAES--------IVQSGDVITPQDVA
MLBr_01094|M.leprae_Br4923 VYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVR
: * : : :
Mflv_3370|M.gilvum_PYR-GCK VLRNEAIIVVPRWWKALWYLERLSPALSMRTAAVALKRTREVQSAVPLQ-
TH_2445|M.thermoresistible__bu VQRNKALLVKPRVAHAGWLFARLAPGLMQRASIRFVERQRAGQRAAQVGR
Mvan_0852|M.vanbaalenii_PYR-1 FPEKPRELWRSYAESPDSVEGYLKEVARQRRAAFATGDAQALFRATQSAG
MMAR_4755|M.marinum_M RLTADAILANRLYVLPHEGARTSIQRRFARIDRTFDEQAAEGWRH-----
MUL_0326|M.ulcerans_Agy99 RLTADAILANGLYVLPHEGARTSIQRRFARIDRTFDEQAAEGWRH-----
Mb0874c|M.bovis_AF2122/97 QLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH-----
Rv0851c|M.tuberculosis_H37Rv QLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH-----
MAV_0895|M.avium_104 RLTADAILANRLYILPHAAARESIRRRFERIDRTFDEQAAEGWTH-----
MAB_4053c|M.abscessus_ATCC_199 RFYVVPQLDAKLVWHLKRHIPNPYRWGAGLIGRLMPTAVEAKELLGADVR
MSMEG_1760|M.smegmatis_MC2_155 TVTVEAVQAGRFLVLPHPHVLDLYRRKGSDYDRWIAGMRRYQRSLRGTAV
MLBr_01094|M.leprae_Br4923 K-KKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR------
Mflv_3370|M.gilvum_PYR-GCK ---
TH_2445|M.thermoresistible__bu ---
Mvan_0852|M.vanbaalenii_PYR-1 GT-
MMAR_4755|M.marinum_M ---
MUL_0326|M.ulcerans_Agy99 ---
Mb0874c|M.bovis_AF2122/97 ---
Rv0851c|M.tuberculosis_H37Rv ---
MAV_0895|M.avium_104 ---
MAB_4053c|M.abscessus_ATCC_199 ---
MSMEG_1760|M.smegmatis_MC2_155 PGT
MLBr_01094|M.leprae_Br4923 ---