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DILRWDRPPRLSRRANAVVTGAGSGIGRAFAVELARRGGRVVCADIDPVRAKETVGLVVQAGGEGLDIAC DVTDEEQVRELADSAEKWFGAAASLVINNAGIGIGGNVIGATPKRDWEATLSVNLWGVIYGCEIFVPRLR AKGSGGIINVASAASFGAAPRMGAYNVSKAGVLSLSETLAAELSGTGVAVTVLCPTFVKTNIVDNPGIEE SAAKLATNLMKWTGVSAESVARKTLDANDRGQLHVLPQVDAKILWLFKRAVPATYTRALGLVERIAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4610 | - | - | 100% (278) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2937 | - | 7e-32 | 40.20% (199) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2216 | - | 1e-30 | 35.04% (254) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0874c | - | 1e-36 | 37.55% (245) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0851c | - | 5e-37 | 37.55% (245) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-36 | 42.13% (197) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2071 | - | 1e-116 | 74.73% (277) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3141 | - | 1e-118 | 75.81% (277) | short-chain membrane-associated dehydrogenase |
| M. avium 104 | MAV_1797 | - | 3e-85 | 59.26% (270) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 2e-35 | 38.08% (260) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 1e-35 | 42.47% (186) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3643 | - | 6e-87 | 60.59% (269) | short-chain membrane-associated dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1521 | - | 1e-82 | 58.11% (265) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWD
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWD
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
TH_4323|M.thermoresistible__bu SVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAP
MSMEG_4280|M.smegmatis_MC2_155 GVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSP
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
TH_4323|M.thermoresistible__bu GQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDG
MSMEG_4280|M.smegmatis_MC2_155 DAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRG
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTM
TH_4323|M.thermoresistible__bu LAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRL
MSMEG_4280|M.smegmatis_MC2_155 LARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR----RGAARRLQA
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPV
TH_4323|M.thermoresistible__bu RDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH---FVRVPV
MSMEG_4280|M.smegmatis_MC2_155 ID--TPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH---YVQVPV
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 QLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
TH_4323|M.thermoresistible__bu QLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVT
MSMEG_4280|M.smegmatis_MC2_155 QLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVG
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELA
MMAR_3141|M.marinum_M --------------MRFLPFGSSPGRTHRAHAVVTGAGSGIGRAFAVELA
Mflv_4610|M.gilvum_PYR-GCK --------------MDILRWDRPPRLSRRANAVVTGAGSGIGRAFAVELA
MAV_1797|M.avium_104 --------------MLDRLLHRS-KTSRGALAVVTGAGSGIGAAFALELG
MUL_3643|M.ulcerans_Agy99 -----------MLGPLDKLLGKSRKTSHDALAVVTGAGSGIGAAFALELG
Mvan_1521|M.vanbaalenii_PYR-1 ------------------MGLFGAKRTHRADAVITGAGSGIGAAFAVELA
MLBr_00862|M.leprae_Br4923 DLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALA
TH_4323|M.thermoresistible__bu ELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFA
MSMEG_4280|M.smegmatis_MC2_155 EFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFA
Mb0874c|M.bovis_AF2122/97 -----------------------MDGFPGRGAVITGGASGIGLATGTEFA
Rv0851c|M.tuberculosis_H37Rv -----------------------MDGFPGRGAVITGGASGIGLATGTEFA
. :**...*** . :.
MAB_2071|M.abscessus_ATCC_1997 RRGGRVVCADRDPVTAKESAELVRQAGGEGFDIACDVTDLEQIRNLADVS
MMAR_3141|M.marinum_M RRGGRVVCADKDPITAKESAELVRQAGGEGFDVVCDVTDLEQVRNLADAS
Mflv_4610|M.gilvum_PYR-GCK RRGGRVVCADIDPVRAKETVGLVVQAGGEGLDIACDVTDEEQVRELADSA
MAV_1797|M.avium_104 KRGGTVVCSDIDQAAAQRTADAITEHGAKALATRCDVSQFGVVQALAEQS
MUL_3643|M.ulcerans_Agy99 RRGSAVVCSDIDEVAAQNTVAALTEAGARAISIGCDVSRIEDVTALAERS
Mvan_1521|M.vanbaalenii_PYR-1 RRGGRVVCSDVSVEAARGTADAIIADGGRALPAQCDVTDIDAMYRLAGEA
MLBr_00862|M.leprae_Br4923 RRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
TH_4323|M.thermoresistible__bu REGAEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEV
MSMEG_4280|M.smegmatis_MC2_155 RLGAEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDV
Mb0874c|M.bovis_AF2122/97 RRGARVVLGDVDKPGLRQAVNHLRAEGFDVHGVMCDVRHREEVTHLADEA
Rv0851c|M.tuberculosis_H37Rv RRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEA
: *. :: .* . : :. : * ** : :.
MAB_2071|M.abscessus_ATCC_1997 EDWFGKAASLVINNAGIGAGGNRIGATSIEDWKAAISVNLWGVIYGCETF
MMAR_3141|M.marinum_M EDWFGKAASLVINNAGIGAGGNRIGATSVEDWNAAISVNLWGVIYGCETF
Mflv_4610|M.gilvum_PYR-GCK EKWFGAAASLVINNAGIGIGGNVIGATPKRDWEATLSVNLWGVIYGCEIF
MAV_1797|M.avium_104 QSWFGAPPTLVINNAGVGAGGAAIGDAPLDDWQWTLGINLWGPIHGCHVF
MUL_3643|M.ulcerans_Agy99 QAWFDGPPTLVINNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVF
Mvan_1521|M.vanbaalenii_PYR-1 QTWFDGPPTLVINNAGVGAGGAFIGETELADWKWVLDINLWGPIHGCHVF
MLBr_00862|M.leprae_Br4923 SAKHG-VPDIVVNNAGIGQAG-RFLDTPPEEFDRVLAVNLGGVVNCCRAF
TH_4323|M.thermoresistible__bu CARHG-VPDIVVNNAGIGHAG-RFLDTPRDQWDRVLEVNLGGVVNGCRAF
MSMEG_4280|M.smegmatis_MC2_155 CATHG-VPDIVVNNAGIGHAG-NFLDTPADQYERVLEVNFGGVVNCCRAF
Mb0874c|M.bovis_AF2122/97 FRLLG-HFDVVFSNAGIVVGG-PIVEMTHDDWRWVIDVDLWGSIHTVEAF
Rv0851c|M.tuberculosis_H37Rv FRLLG-HVDVVFSNAGIVVGG-PIVEMTHDDWRWVIDVDLWGSIHTVEAF
. :*..***: .* : :: .: ::: * : . *
MAB_2071|M.abscessus_ATCC_1997 VPRLRSSGH----GGVINVASAASFGSAPRMAAYNVSKAGVLALSETLAA
MMAR_3141|M.marinum_M VPRLRSNGR----GGVINVASAASFGSAPRMGAYNVSKAGVLALSETLAA
Mflv_4610|M.gilvum_PYR-GCK VPRLRAKGS----GGIINVASAASFGAAPRMGAYNVSKAGVLSLSETLAA
MAV_1797|M.avium_104 TPILRDAAPSAAPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
MUL_3643|M.ulcerans_Agy99 TPILREAGRAVGPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
Mvan_1521|M.vanbaalenii_PYR-1 APILREAGR---PAGIINVASAAAFGAAPGMAAYNVSKAGTLSLSETLAA
MLBr_00862|M.leprae_Br4923 GQRLVERGTG---GHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
TH_4323|M.thermoresistible__bu APRLVERGTG---GHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRA
MSMEG_4280|M.smegmatis_MC2_155 GRRLVEQGTG---GHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRA
Mb0874c|M.bovis_AF2122/97 LPRLLEQGTG---GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAR
Rv0851c|M.tuberculosis_H37Rv LPRLLEQGTG---GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAR
* . :: :* *. . : ** .:* .. ::: *
MAB_2071|M.abscessus_ATCC_1997 ELSGTDVKVTVLCPTFVKTNIVKNPQIDEAAAR---------LAANLMKW
MMAR_3141|M.marinum_M ELSGTNVNVTVLCPTFVKTNIAKNPQIEESAAK---------LATNLMRW
Mflv_4610|M.gilvum_PYR-GCK ELSGTGVAVTVLCPTFVKTNIVDNPGIEESAAK---------LATNLMKW
MAV_1797|M.avium_104 ELSGTPVRVTVLCPTFVKTTILESGRISEESGE---------LAAKLMRW
MUL_3643|M.ulcerans_Agy99 ELSGTGINVTVLCPTFVKTNIVESGRISEQSSE---------VVTKLIRW
Mvan_1521|M.vanbaalenii_PYR-1 ELAGTGINVTVLCPTFVKTNIVESGRISTGTSQ---------LAERLMRW
MLBr_00862|M.leprae_Br4923 ELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRL
TH_4323|M.thermoresistible__bu ELDSAGIMLTTICPSTVNTNIIGSTRFNAPDGLDDVVDTRREQLQKLFAL
MSMEG_4280|M.smegmatis_MC2_155 ELAHAGIGVTTLCPGMIDTGIVDTTRFDVPAHKAGQVEARRAQVKKTFQA
Mb0874c|M.bovis_AF2122/97 EVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTG-SPGPLPLQD
Rv0851c|M.tuberculosis_H37Rv EVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTG-SPGPLPLQD
*: : ::.:** :.* : . :
MAB_2071|M.abscessus_ATCC_1997 TGISPQHVARTTLNAHDRGQIYVVPQLD--AKVLWQLKRALPGPFTRTLG
MMAR_3141|M.marinum_M TGISPDQVARTTLNAHDRGQIYVVPQLD--AKILWQLKRALPGQFTRALG
Mflv_4610|M.gilvum_PYR-GCK TGVSAESVARKTLDANDRGQLHVLPQVD--AKILWLFKRAVPATYTRALG
MAV_1797|M.avium_104 TGFSADKVARICLDAHDRGDLYCMPQLD--AQIGWHIKRLAPQAYTRAAG
MUL_3643|M.ulcerans_Agy99 TGFSPDKVARICLDANDRGDLYCMPQLD--AKIGWNIKRMAPGTYTRAAG
Mvan_1521|M.vanbaalenii_PYR-1 TGFPAARVARSALDTLDRGGLYCMPQPE--ARIGWGVKRFTPTVFTRAAG
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPE--AYALYGISRVLPQVLRSTAR
TH_4323|M.thermoresistible__bu RRFGPDKAAKAIVSAVKQNKPIRPVMPE--AYFVYGVSRVLPQALRSTAR
MSMEG_4280|M.smegmatis_MC2_155 RRYGPEKVAKAVTSAVSRNQALRPVTPE--AYVAYGVSRLFPAALRRAAR
Mb0874c|M.bovis_AF2122/97 DNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAE
Rv0851c|M.tuberculosis_H37Rv DNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAE
* .: . * ..* :
MAB_2071|M.abscessus_ATCC_1997 LVERMASWNDSAE----
MMAR_3141|M.marinum_M LVERVASWNDPAEQREQ
Mflv_4610|M.gilvum_PYR-GCK LVERIAR----------
MAV_1797|M.avium_104 LVSRINLP---------
MUL_3643|M.ulcerans_Agy99 LILRATMR---------
Mvan_1521|M.vanbaalenii_PYR-1 IATRITT----------
MLBr_00862|M.leprae_Br4923 IRVI-------------
TH_4323|M.thermoresistible__bu GRVL-------------
MSMEG_4280|M.smegmatis_MC2_155 SQVL-------------
Mb0874c|M.bovis_AF2122/97 GWRH-------------
Rv0851c|M.tuberculosis_H37Rv GWRH-------------