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VASADDSESTGSGSVTTSKTEARVSAKPAPARSDAPDGVGDENSTSDESADVSSSPLTRIRGRDGDDTQR EPREAVADRDAPEDVEEVVEEVVPDPSPAPPAAAPMADAPRHRYDAAAQNAVVFTDEPTLFDQVVVGSLY VMRAVSTALGIDLYGVIGKILENDDPPWFVRAGLDVRRTEYPSSGEKPWDVWEFRPPNPTGKTVIAVHGG GFIVEPLVTHWLDYAQMARQTGATVLVPMYPLATTPAGTAVTAVPVMAQFIADQIASRGAHNVSIYADSA GPSLAMAAVRELILTGRPVPASLVLLSFAPDASLSNPAICDVRDPIIDVRTLDFYTRENHWSDGLDPQDP LLSPLFFEDAVFAALPPSTIYVGELEYALPDTLLLHEKWSAAGGVVSTVVGVGQFHDWALGGLPVNSQAP KVRPAVYRQLGLNDVASGPDTITTGPPTYSDRLVADILRTLRWLNETTGITILSGLAGASIITDPPPLLM HGLTVTEREFNGWTVWEIAAPRRSGEYVVALHGGGFESEANILHWSDYAQMARDTAATVLVPIYPLAPPK NTGTAATLVPPMADYVSQLIAEHGVDNVSLYGDSSGGSYAVLVVRELLRRCAIEVACVPSQAGPSRMVLI SPALHLTLRGPEVDAIDDPILPRHAPGEGPRFNGDWSLDDPRVNPIAGDNLSGLPPTTVYIGTQEKLYPG AIAFRDKVLAQDPAADLTVVIGDGQLHGWALGGIVVNSQAQIWRPNVYRQLGLLPTNSARYVTLTVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4715 | - | - | 100% (767) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4426 | - | 1e-51 | 34.91% (444) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4606 | - | 2e-08 | 26.80% (250) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3124c | PE_PGRS63 | 9e-39 | 34.41% (311) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv3097c | lipY | 9e-39 | 34.41% (311) | triacylglycerol lipase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2584 | - | 7e-17 | 29.12% (261) | putative esterase |
| M. marinum M | MMAR_1547 | - | 1e-44 | 34.23% (333) | PE-PGRS family protein |
| M. avium 104 | MAV_3032 | - | 6e-08 | 27.23% (224) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 6e-14 | 31.20% (234) | acetyl-hydrolase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 7e-07 | 25.51% (247) | lipase LipU_1 |
| M. vanbaalenii PYR-1 | Mvan_1749 | - | 0.0 | 77.20% (614) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4715|M.gilvum_PYR-GCK MASADDSESTGSGSVTTSKTEARVSAKPAPARSDAPDGVGDENSTSDESA
Mvan_1749|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3124c|M.bovis_AF2122/97 --------------------------------------------------
Rv3097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1547|M.marinum_M --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK DVSSSPLTRIRGRDGDDTQREPREAVADRDAPEDVEEVVEEVVPDPSPAP
Mvan_1749|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3124c|M.bovis_AF2122/97 --------------------------------------------------
Rv3097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1547|M.marinum_M --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK PAAAPMADAPRHRYDAAAQNAVVFTDEPTLFDQVVVGSLYVMRAVSTALG
Mvan_1749|M.vanbaalenii_PYR-1 ----------------------------------------MLRGFSSLIG
Mb3124c|M.bovis_AF2122/97 --------------------------------------------------
Rv3097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1547|M.marinum_M --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK IDLYGVIGKILENDDPPWFVRAGLDVRRTEYPSSGEKPWDVWEFRPPNPT
Mvan_1749|M.vanbaalenii_PYR-1 IDIYGLIGQALESPNPPWFVKYGLDVRRTEYEVSEDDFWRVWEFHPPNPT
Mb3124c|M.bovis_AF2122/97 --------------MVSYVVALP------------------EVMSAAATD
Rv3097c|M.tuberculosis_H37Rv --------------MVSYVVALP------------------EVMSAAATD
MMAR_1547|M.marinum_M ------MSFWMWPPEVNSVLLLDGPGPGPMLEAAAAWDGIGTELSAAASA
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK GKTVIAVHGGGFIVEPLVTHWLDYAQMARQTGATVLVPMYPLATTPAGTA
Mvan_1749|M.vanbaalenii_PYR-1 GNTVIAVHGGGFILEPLVTHWLDYAAMARDTGATVIVPMYPLATTAAGTA
Mb3124c|M.bovis_AF2122/97 VASIGSVVA-------------------------TASQGVAGATTTVLAA
Rv3097c|M.tuberculosis_H37Rv VASIGSVVA-------------------------TASQGVAGATTTVLAA
MMAR_1547|M.marinum_M FGSVTSELAGQAWQGPASASMRAAAVRYLDWLGGTAAQAEQSATQARAAA
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK VTAVPVMAQFIADQIASRG--AHNVSIYADSAGPSLAMAAVRELILTGRP
Mvan_1749|M.vanbaalenii_PYR-1 VKVVPAMARFISGQIAIHG--AGNVGVYADSAGSALAMAAVRELVLDGRP
Mb3124c|M.bovis_AF2122/97 AEDEVSAA---------------IAALFS-AHGQDYQALSAQLAVFHERF
Rv3097c|M.tuberculosis_H37Rv AEDEVSAA---------------IAALFS-GHGQDYQALSAQLAVFHERF
MMAR_1547|M.marinum_M VAYEAALATIVDPGLIVANRGQLVSLAFSNLFGQNAPAIAAAEAAYEQMW
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 ---------------------MSGVTTFDKLFGPPYDAIRPRRNRRVGRR
MAV_3032|M.avium_104 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 ---------------------MIQACVILRHHGNGLVTAHTLAPMS----
Mflv_4715|M.gilvum_PYR-GCK VPASLVLLSFAPDASLSNPAICDVRDPIIDVRTLDFYTRENHWSDGLDPQ
Mvan_1749|M.vanbaalenii_PYR-1 VPASMVLLSLAPDSSLSNPDIDDVDDPIIDVRNLDFYTDVNHWSDGLDPQ
Mb3124c|M.bovis_AF2122/97 VQALTGAAKGYAAAELANASL-----------------LQSEFASGIGNG
Rv3097c|M.tuberculosis_H37Rv VQALTGAAKGYAAAELANASL-----------------LQSEFASGIGNG
MMAR_1547|M.marinum_M AQDVAAMGGYYSSASATVAALGPWAR--------ALENLPGEFARALDNG
MAB_2584|M.abscessus_ATCC_1997 -------------------------------------------MVSVRAR
MUL_2832|M.ulcerans_Agy99 AAS----------------------------------------GHGAHVE
MAV_3032|M.avium_104 -----------------------------------------MTSPPLDPD
MSMEG_3010|M.smegmatis_MC2_155 ------------------------------------------INQPNDPL
Mflv_4715|M.gilvum_PYR-GCK DPLLSPLFFEDAVFAALPPSTIYVG---ELEYALPDTLLLHEKWSAAGGV
Mvan_1749|M.vanbaalenii_PYR-1 DPMVSPLFFEDAVLAALPPTTLYVG---ELEWALPDTLLLHDKWSAAGGA
Mb3124c|M.bovis_AF2122/97 FATIHQEIQRAPTALAAGFTQV--------------PPFAAAQAGIFTGT
Rv3097c|M.tuberculosis_H37Rv FATIHQEIQRAPTALAAGFTQV--------------PPFAAAQAGIFTGT
MMAR_1547|M.marinum_M LVLVEQEIEQAATTLATEFTQVSNTLFTTIFGAPADPPFAASQTGTFTGT
MAB_2584|M.abscessus_ATCC_1997 AFIAAARLQRKKSFYATAAGMR--------------RRLSAHQSAARCEP
MUL_2832|M.ulcerans_Agy99 VVESGPSIAARVVSLASRLTVR--------------PVIAVASHFPHLPW
MAV_3032|M.avium_104 AAARIASFGETAPMRQRGLPAVR-------------AGLESAPRPATMPE
MSMEG_3010|M.smegmatis_MC2_155 GVIYAEWTEEFVANPDMSLRLMR---------------WVFEDWQRVTSE
Mflv_4715|M.gilvum_PYR-GCK VSTVVGVGQFHDWALGGLPVNSQAPKVRPAVYRQLGLNDVASGPDTITTG
Mvan_1749|M.vanbaalenii_PYR-1 VSTVIGHGQVHDWALGGIAANSQGPKVRPDIYRRLGLDDVASGPRTITTG
Mb3124c|M.bovis_AF2122/97 PSGAAGFDIASLWPVKPLLS--------------------LSALETHFAI
Rv3097c|M.tuberculosis_H37Rv PSGAAGFDIASLWPVKPLLS--------------------LSALETHFAI
MMAR_1547|M.marinum_M PSLITRFENTALLPLKPLLS--------------------VSGLDSQIAV
MAB_2584|M.abscessus_ATCC_1997 PRSVR---------------------------------------------
MUL_2832|M.ulcerans_Agy99 PWSLVDFALLPITWASG---------------------------------
MAV_3032|M.avium_104 MASVT---------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 PEDVT---------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK PPTYSDRLVADILRTLRWLNETTGITILSGLAGASIITDPPPLLMHGLTV
Mvan_1749|M.vanbaalenii_PYR-1 PPSFGDTFVVGLLRTLRWINEETGIKILSGIAGGSTSIAPPPQLVRGLAV
Mb3124c|M.bovis_AF2122/97 PNNPLLALIASDIPPLSWFLGNSPPPLLN--------------SLLGQTV
Rv3097c|M.tuberculosis_H37Rv PNNPLLALIASDIPPLSWFLGNSPPPLLN--------------SLLGQTV
MMAR_1547|M.marinum_M PGNPLLALVASDIPPLSWFIGNSPPPLLN--------------LLLGETV
MAB_2584|M.abscessus_ATCC_1997 ---------------------------------------------RHRRI
MUL_2832|M.ulcerans_Agy99 --------------------------------------------IIGERV
MAV_3032|M.avium_104 -----------------------------------------------EAL
MSMEG_3010|M.smegmatis_MC2_155 ----------------------------------------------YAST
Mflv_4715|M.gilvum_PYR-GCK TEREFNGWTVWEIAA--PRRSGEYVVALHGGGFESEANILHWSDYAQMAR
Mvan_1749|M.vanbaalenii_PYR-1 TERTYNGWTVWELAS--PDPSGEFVVALHGGGFEAEATVLHWSDYAQMAR
Mb3124c|M.bovis_AF2122/97 QYTTYDGMSVVQITP--AHPTGEYVVAIHGGAFILPPSIFHWLNYSVTAY
Rv3097c|M.tuberculosis_H37Rv QYTTYDGMSVVQITP--AHPTGEYVVAIHGGAFILPPSIFHWLNYSVTAY
MMAR_1547|M.marinum_M QYSTYDGMSVVQITP--AHPTGDYVVAIHGGAFIFPPSFLHWINYSVMAH
MAB_2584|M.abscessus_ATCC_1997 TRHEVQGHSCYTLHPD-GRWDGLHVFHLHGGGFVEQPEKHHWRFADNLVG
MUL_2832|M.ulcerans_Agy99 SLPNASGHLVRASGVPPPDGSRRVVLYMHGGAFLKGGIHSHARLAGTLSK
MAV_3032|M.avium_104 VPSAAGGIPVRIYRPT-TDSGVAVLVYLHGGGLVMGSNRSFEPLARELAS
MSMEG_3010|M.smegmatis_MC2_155 RIGGVPGILVKPLDAD----PGQMLVVLHGGGFALGSSASHRKLAGHLAR
* :. :***.: .
Mflv_4715|M.gilvum_PYR-GCK DTAATVLVPIYPLAPPKNTGTAATLVPPMADYVSQLIAEHGV--DNVSLY
Mvan_1749|M.vanbaalenii_PYR-1 ETGATVLVPIYPMAPPKSTGTAATLVPPMADYLKMLIDAHGV--DNVSLY
Mb3124c|M.bovis_AF2122/97 QTGATVQVPIYPLVQ--EGGTAGTVVPAMAGLISTQIAQHGV--SNVSVV
Rv3097c|M.tuberculosis_H37Rv QTGATVQVPIYPLVQ--EGGTAGTVVPAMAGLISTQIAQHGV--SNVSVV
MMAR_1547|M.marinum_M QTGATVQVPIYPLLQ--EGGTAGTVVPAMAGLISNQIMQHGA--ANVSVI
MAB_2584|M.abscessus_ATCC_1997 ALGCRYSMFMYPLAP---EHDHREITAVSRRAYREMMADTPQ--SGRVLF
MUL_2832|M.ulcerans_Agy99 FADSPLLVVNYRLVP--KHTVGMALEDCHDAYLWLRLRGHAP--EQIVLA
MAV_3032|M.avium_104 ASAATVVAVDYRLAPESPPPAQFDDAYAATEWVSRKAGELGVDADRLAVI
MSMEG_3010|M.smegmatis_MC2_155 AFGAHAFVADFRLAP--EHPYPAQIDDATAVFTSLLDNGIDA--SSITFV
. : : .
Mflv_4715|M.gilvum_PYR-GCK GDSSGGSYAVLVVRELLRRCAIEVACVPSQAGPSRMVLISPALHLTLRGP
Mvan_1749|M.vanbaalenii_PYR-1 GDSSGGSYAVLAVQEMLRRCRIDVHCVVSEAQPSRMVLVSPALHLTLRGP
Mb3124c|M.bovis_AF2122/97 GDSAGGNLALAAAQYMVS---------QGNPVPSSMVLLSPWLDVGT---
Rv3097c|M.tuberculosis_H37Rv GDSAGGNLALAAAQYMVS---------QGNPVPSSMVLLSPWLDVGT---
MMAR_1547|M.marinum_M GDSAGGNLALGAVEYMAS---------QGSQVPSSMVLLSPWLDLGMTNP
MAB_2584|M.abscessus_ATCC_1997 GDSAGGSLSLGITQELRD---------RGEAQPACIALFSPWLNMAVDHE
MUL_2832|M.ulcerans_Agy99 GDSAGGYLAFALAQRLRAR----------GEEPAALVAISPLLQLAMRSK
MAV_3032|M.avium_104 GDSAGGSLAAAVALAARD---------RRGPPICAQVLLYPGLDRDMSVA
MSMEG_3010|M.smegmatis_MC2_155 GDSAGASIAVATTLRLLR---------DGAPVPGRVITISPWLDMENSGS
***:*. : . . * *.
Mflv_4715|M.gilvum_PYR-GCK EVDAID--DPILPRHAP-GEGPRFNGDWSLDDPR-----VNPIAGDNLSG
Mvan_1749|M.vanbaalenii_PYR-1 QIDAID--DPILPRPAPPGEGPRWNGDWDMDDPR-----VNPIAGADLTG
Mb3124c|M.bovis_AF2122/97 -----------------WQISQAWAGNLAVNDPL-----VSPLYGS-LNG
Rv3097c|M.tuberculosis_H37Rv -----------------WQISQAWAGNLAVNDPL-----VSPLYGS-LNG
MMAR_1547|M.marinum_M NIAFVQ--DPLLPFGPAQQIGKAWAGNLAVTDPM-----VSPLYGS-LSG
MAB_2584|M.abscessus_ATCC_1997 LSQVIEPHDPELGLAGLQQAGRWYAADRPLDDPE-----LSPEHAN-LAG
MUL_2832|M.ulcerans_Agy99 KAHPNIKSDAMFPARAFDALVAIVAGAAARNETAGRREEIYEPLEHIAPG
MAV_3032|M.avium_104 SIAAMP-DAPLLIRDDIDYMHALVDGDAGPPTDP----YLVPAYAADLSG
MSMEG_3010|M.smegmatis_MC2_155 TIESNDATDFLITREGLQGNIDRYLSGGASPTDP-----LVNPLYADFTG
. : *
Mflv_4715|M.gilvum_PYR-GCK LPPTTVYIGTQEKLYPGAIAFRDKVLAQDPAADLTVVIGDGQLHGWALGG
Mvan_1749|M.vanbaalenii_PYR-1 LPPTTVYIGTVEKLLPGVIAFRDKVLSQDPQADLTVVIGDGQLHGWALGG
Mb3124c|M.bovis_AF2122/97 LPPTYVYSGSLDPLAQQAVVLEHTAVVQG--APFSFVLAPWQIHDWIL--
Rv3097c|M.tuberculosis_H37Rv LPPTYVYSGSLDPLAQQAVVLEHTAVVQG--APFSFVLAPWQIHDWIL--
MMAR_1547|M.marinum_M LPPTYVYAGSQEILAPDVLVLQQEAAAIG--APFNFVLAHGQIHDWVL--
MAB_2584|M.abscessus_ATCC_1997 IAALSIFIGTRDILLPDALLLHFNACTVG--TTSRLQIYDGMFHNWAMKP
MUL_2832|M.ulcerans_Agy99 LPPTLIHVSGAEALLHDARLAAGKLAAAG--VRAEVRVWPGQLHDFQVAA
MAV_3032|M.avium_104 LPPAIVVTAGCDPIRDWGERYADRLRDAG--VQTTVTRYPGMYHGFLMRS
MSMEG_3010|M.smegmatis_MC2_155 FPRLYITVSDTESLYADATRLAEKARAAG--VDVTFEVASGQQHVFPLQA
:. : . : : . . . * : :
Mflv_4715|M.gilvum_PYR-GCK IVVNSQAQIWRPNVYRQLGLLPTNSARYVTLTVA----------------
Mvan_1749|M.vanbaalenii_PYR-1 IVVNSQAPIWRANVYRQLGLSAIPA-------------------------
Mb3124c|M.bovis_AF2122/97 --LTPWGLLSWPQINQQLGIAA----------------------------
Rv3097c|M.tuberculosis_H37Rv --LTPWGLLSWPQINQQLGIAA----------------------------
MMAR_1547|M.marinum_M --LTLDGPRYLAQINQELGIAA----------------------------
MAB_2584|M.abscessus_ATCC_1997 IPEAHRARRQLIEFLAESTRAAALSEKEQTHHDRSDNRRDHRNRPTARHR
MUL_2832|M.ulcerans_Agy99 P-MLPEATYSLRQIGEYIRQATG---------------------------
MAV_3032|M.avium_104 -DATARGRLAIAEIGGLLRAKFTHPLRFDVPITGRHSTPTR---------
MSMEG_3010|M.smegmatis_MC2_155 G-VLPEADAAIESMAAWYRSAKPLAV------------------------
. ..
Mflv_4715|M.gilvum_PYR-GCK -----------
Mvan_1749|M.vanbaalenii_PYR-1 -----------
Mb3124c|M.bovis_AF2122/97 -----------
Rv3097c|M.tuberculosis_H37Rv -----------
MMAR_1547|M.marinum_M -----------
MAB_2584|M.abscessus_ATCC_1997 ELDVEADRSRG
MUL_2832|M.ulcerans_Agy99 -----------
MAV_3032|M.avium_104 -----------
MSMEG_3010|M.smegmatis_MC2_155 -----------