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LRGFSSLIGIDIYGLIGQALESPNPPWFVKYGLDVRRTEYEVSEDDFWRVWEFHPPNPTGNTVIAVHGGG FILEPLVTHWLDYAAMARDTGATVIVPMYPLATTAAGTAVKVVPAMARFISGQIAIHGAGNVGVYADSAG SALAMAAVRELVLDGRPVPASMVLLSLAPDSSLSNPDIDDVDDPIIDVRNLDFYTDVNHWSDGLDPQDPM VSPLFFEDAVLAALPPTTLYVGELEWALPDTLLLHDKWSAAGGAVSTVIGHGQVHDWALGGIAANSQGPK VRPDIYRRLGLDDVASGPRTITTGPPSFGDTFVVGLLRTLRWINEETGIKILSGIAGGSTSIAPPPQLVR GLAVTERTYNGWTVWELASPDPSGEFVVALHGGGFEAEATVLHWSDYAQMARETGATVLVPIYPMAPPKS TGTAATLVPPMADYLKMLIDAHGVDNVSLYGDSSGGSYAVLAVQEMLRRCRIDVHCVVSEAQPSRMVLVS PALHLTLRGPQIDAIDDPILPRPAPPGEGPRWNGDWDMDDPRVNPIAGADLTGLPPTTVYIGTVEKLLPG VIAFRDKVLSQDPQADLTVVIGDGQLHGWALGGIVVNSQAPIWRANVYRQLGLSAIPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1749 | - | - | 100% (619) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1822 | - | 5e-44 | 36.22% (312) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0225 | - | 1e-05 | 27.23% (235) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3124c | PE_PGRS63 | 1e-39 | 40.91% (264) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_4715 | - | 0.0 | 77.20% (614) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv3097c | lipY | 1e-39 | 40.91% (264) | triacylglycerol lipase |
| M. leprae Br4923 | MLBr_00314 | - | 1e-06 | 26.67% (225) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2584 | - | 3e-16 | 28.97% (252) | putative esterase |
| M. marinum M | MMAR_1547 | - | 2e-48 | 41.26% (286) | PE-PGRS family protein |
| M. avium 104 | MAV_1200 | - | 5e-07 | 23.98% (221) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 1e-14 | 30.66% (212) | acetyl-hydrolase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 1e-07 | 24.77% (222) | lipase LipU_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1749|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK MASADDSESTGSGSVTTSKTEARVSAKPAPARSDAPDGVGDENSTSDESA
Mb3124c|M.bovis_AF2122/97 --------------------------------------------------
Rv3097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1547|M.marinum_M --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1749|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4715|M.gilvum_PYR-GCK DVSSSPLTRIRGRDGDDTQREPREAVADRDAPEDVEEVVEEVVPDPSPAP
Mb3124c|M.bovis_AF2122/97 --------------------------------------------------
Rv3097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1547|M.marinum_M --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1749|M.vanbaalenii_PYR-1 ----------------------------------------MLRGFSSLIG
Mflv_4715|M.gilvum_PYR-GCK PAAAPMADAPRHRYDAAAQNAVVFTDEPTLFDQVVVGSLYVMRAVSTALG
Mb3124c|M.bovis_AF2122/97 --------------------------------------------------
Rv3097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1547|M.marinum_M --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1749|M.vanbaalenii_PYR-1 IDIYGLIGQALESPNPPWFVKYGLDVRRTEYEVSEDDFWRVWEFHPPNPT
Mflv_4715|M.gilvum_PYR-GCK IDLYGVIGKILENDDPPWFVRAGLDVRRTEYPSSGEKPWDVWEFRPPNPT
Mb3124c|M.bovis_AF2122/97 --------------MVSYVVALP------------------EVMSAAATD
Rv3097c|M.tuberculosis_H37Rv --------------MVSYVVALP------------------EVMSAAATD
MMAR_1547|M.marinum_M ------MSFWMWPPEVNSVLLLDGPGPGPMLEAAAAWDGIGTELSAAASA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1749|M.vanbaalenii_PYR-1 GNTVIAVHGGGFILEPLVTHWLDYAAMARDTGATVIVPMYPLATTAAGTA
Mflv_4715|M.gilvum_PYR-GCK GKTVIAVHGGGFIVEPLVTHWLDYAQMARQTGATVLVPMYPLATTPAGTA
Mb3124c|M.bovis_AF2122/97 VASIGSVVA-------------------------TASQGVAGATTTVLAA
Rv3097c|M.tuberculosis_H37Rv VASIGSVVA-------------------------TASQGVAGATTTVLAA
MMAR_1547|M.marinum_M FGSVTSELAGQAWQGPASASMRAAAVRYLDWLGGTAAQAEQSATQARAAA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1749|M.vanbaalenii_PYR-1 VKVVPAMARFISGQIAIHG--AGNVGVYADSAGSALAMAAVRELVLDGRP
Mflv_4715|M.gilvum_PYR-GCK VTAVPVMAQFIADQIASRG--AHNVSIYADSAGPSLAMAAVRELILTGRP
Mb3124c|M.bovis_AF2122/97 AEDEVSAA---------------IAALFS-AHGQDYQALSAQLAVFHERF
Rv3097c|M.tuberculosis_H37Rv AEDEVSAA---------------IAALFS-GHGQDYQALSAQLAVFHERF
MMAR_1547|M.marinum_M VAYEAALATIVDPGLIVANRGQLVSLAFSNLFGQNAPAIAAAEAAYEQMW
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------MTAPSEVSGSQSPVRVHDVLKARR
MUL_2832|M.ulcerans_Agy99 --------------------------MSGVTTFDKLFGPP--YDAIRPRR
MSMEG_3010|M.smegmatis_MC2_155 ------------------------------------------MIQACVIL
MAB_2584|M.abscessus_ATCC_1997 ---------------------------------------------MVSVR
Mvan_1749|M.vanbaalenii_PYR-1 VPASMVLLSLAPDSSLSNPDIDDVDDPIIDVRNLDFYTDVNHWSDGLDPQ
Mflv_4715|M.gilvum_PYR-GCK VPASLVLLSFAPDASLSNPAICDVRDPIIDVRTLDFYTRENHWSDGLDPQ
Mb3124c|M.bovis_AF2122/97 VQALTGAAKGYAAAELANASL-----------------LQSEFASGIGNG
Rv3097c|M.tuberculosis_H37Rv VQALTGAAKGYAAAELANASL-----------------LQSEFASGIGNG
MMAR_1547|M.marinum_M AQDVAAMGGYYSSASATVAALGPWAR--------ALENLPGEFARALDNG
MLBr_00314|M.leprae_Br4923 -------MAISAGAPVEIVES----------------------GPSIAAR
MAV_1200|M.avium_104 AR--IRKFAISDGAPVEVLES----------------------GPSVAAR
MUL_2832|M.ulcerans_Agy99 NRRVGRRAASGHGAHVEVVES----------------------GPSIAAR
MSMEG_3010|M.smegmatis_MC2_155 RHHGNGLVTAHTLAPMSINQP----------------------NDPLGVI
MAB_2584|M.abscessus_ATCC_1997 ARAFIAAARLQRKKSFYATAA------------------------GMRRR
:
Mvan_1749|M.vanbaalenii_PYR-1 DPMVSPLFFEDAVLAALPPTTLYVG---ELEWALPDTLLLHDKWSAAGGA
Mflv_4715|M.gilvum_PYR-GCK DPLLSPLFFEDAVFAALPPSTIYVG---ELEYALPDTLLLHEKWSAAGGV
Mb3124c|M.bovis_AF2122/97 FATIHQEIQRAPTALAAGFTQV--------------PPFAAAQAGIFTGT
Rv3097c|M.tuberculosis_H37Rv FATIHQEIQRAPTALAAGFTQV--------------PPFAAAQAGIFTGT
MMAR_1547|M.marinum_M LVLVEQEIEQAATTLATEFTQVSNTLFTTIFGAPADPPFAASQTGTFTGT
MLBr_00314|M.leprae_Br4923 LASLTSRLTIRPILAVG---------------------------------
MAV_1200|M.avium_104 LANLTSRLTIRPILAVG---------------------------------
MUL_2832|M.ulcerans_Agy99 VVSLASRLTVRPVIAVA---------------------------------
MSMEG_3010|M.smegmatis_MC2_155 YAEWTEEFVANPDMSLR---------------------------------
MAB_2584|M.abscessus_ATCC_1997 LSAHQSAARCEPPRSVR---------------------------------
.
Mvan_1749|M.vanbaalenii_PYR-1 VSTVIGHGQVHDWALGGIAANSQGPKVRPDIYRRLGLDDVASGPRTITTG
Mflv_4715|M.gilvum_PYR-GCK VSTVVGVGQFHDWALGGLPVNSQAPKVRPAVYRQLGLNDVASGPDTITTG
Mb3124c|M.bovis_AF2122/97 PSGAAGFDIASLWPVKPLLS--------------------LSALETHFAI
Rv3097c|M.tuberculosis_H37Rv PSGAAGFDIASLWPVKPLLS--------------------LSALETHFAI
MMAR_1547|M.marinum_M PSLITRFENTALLPLKPLLS--------------------VSGLDSQIAV
MLBr_00314|M.leprae_Br4923 -----SYVPQLPWPFG----------------------------------
MAV_1200|M.avium_104 -----SHAPNLPWPWG----------------------------------
MUL_2832|M.ulcerans_Agy99 -----SHFPHLPWPWS----------------------------------
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1749|M.vanbaalenii_PYR-1 PPSFGDTFVVGLLRTLRWINEETGIKILSGIAGGSTSIAPPPQLVRGLAV
Mflv_4715|M.gilvum_PYR-GCK PPTYSDRLVADILRTLRWLNETTGITILSGLAGASIITDPPPLLMHGLTV
Mb3124c|M.bovis_AF2122/97 PNNPLLALIASDIPPLSWFLGNSPPPLLN--------------SLLGQTV
Rv3097c|M.tuberculosis_H37Rv PNNPLLALIASDIPPLSWFLGNSPPPLLN--------------SLLGQTV
MMAR_1547|M.marinum_M PGNPLLALVASDIPPLSWFIGNSPPPLLN--------------LLLGETV
MLBr_00314|M.leprae_Br4923 -------LIDHAARVLLPVTNAAR---------------------AEVNL
MAV_1200|M.avium_104 -------LIDLTARVLLPVSATVR---------------------ETVAL
MUL_2832|M.ulcerans_Agy99 -------LVDFALLPITWASGIIG---------------------ERVSL
MSMEG_3010|M.smegmatis_MC2_155 -------LMRWVFEDWQRVTSEPE----------------------DVTY
MAB_2584|M.abscessus_ATCC_1997 ---------------------------------------------RHRRI
Mvan_1749|M.vanbaalenii_PYR-1 TERTYNGWTVWELASPDP-SGEFVVALHGGGFEAEATVLHWSDYAQMARE
Mflv_4715|M.gilvum_PYR-GCK TEREFNGWTVWEIAAPRR-SGEYVVALHGGGFESEANILHWSDYAQMARD
Mb3124c|M.bovis_AF2122/97 QYTTYDGMSVVQITPAHP-TGEYVVAIHGGAFILPPSIFHWLNYSVTAYQ
Rv3097c|M.tuberculosis_H37Rv QYTTYDGMSVVQITPAHP-TGEYVVAIHGGAFILPPSIFHWLNYSVTAYQ
MMAR_1547|M.marinum_M QYSTYDGMSVVQITPAHP-TGDYVVAIHGGAFIFPPSFLHWINYSVMAHQ
MLBr_00314|M.leprae_Br4923 SNTSAQLVRAAGVRPADG-SGRIVLYLHGGAFLGCGANSHRRLVETLSKL
MAV_1200|M.avium_104 PHASAQLVRAPGVLPADG-TRRVVVYLHGGAFLTCGANSHGRLVEALSTF
MUL_2832|M.ulcerans_Agy99 PNASGHLVRASGVPPPDG-SRRVVLYMHGGAFLKGGIHSHARLAGTLSKF
MSMEG_3010|M.smegmatis_MC2_155 ASTRIGGVPGILVKPLDADPGQMLVVLHGGGFALGSSASHRKLAGHLARA
MAB_2584|M.abscessus_ATCC_1997 TRHEVQGHSCYTLHPDGRWDGLHVFHLHGGGFVEQPEKHHWRFADNLVGA
: . :. :***.* *
Mvan_1749|M.vanbaalenii_PYR-1 TGATVLVPIYPMAPPKSTGTAATLVPPMADYLKMLIDAHGVDNVSLYGDS
Mflv_4715|M.gilvum_PYR-GCK TAATVLVPIYPLAPPKNTGTAATLVPPMADYVSQLIAEHGVDNVSLYGDS
Mb3124c|M.bovis_AF2122/97 TGATVQVPIYPLVQ--EGGTAGTVVPAMAGLISTQIAQHGVSNVSVVGDS
Rv3097c|M.tuberculosis_H37Rv TGATVQVPIYPLVQ--EGGTAGTVVPAMAGLISTQIAQHGVSNVSVVGDS
MMAR_1547|M.marinum_M TGATVQVPIYPLLQ--EGGTAGTVVPAMAGLISNQIMQHGAANVSVIGDS
MLBr_00314|M.leprae_Br4923 ADSPILVVNYRLLP--KHSIGMALDDCHDGYQWLRRLGYDPEQIVLAGDS
MAV_1200|M.avium_104 ADAPVLVVNYRLLP--KNSVGMALQDCHDAYQWLRLRGYQPDQIVLAGDS
MUL_2832|M.ulcerans_Agy99 ADSPLLVVNYRLVP--KHTVGMALEDCHDAYLWLRLRGHAPEQIVLAGDS
MSMEG_3010|M.smegmatis_MC2_155 FGAHAFVADFRLAP--EHPYPAQIDDATAVFTSLLDNGIDASSITFVGDS
MAB_2584|M.abscessus_ATCC_1997 LGCRYSMFMYPLAP---EHDHREITAVSRRAYREMMADTPQSGRVLFGDS
. : : : : . ***
Mvan_1749|M.vanbaalenii_PYR-1 SGGSYAVLAVQEMLRRCRIDVHCVVSEAQPSRMVLVSPALHLTLRGPQID
Mflv_4715|M.gilvum_PYR-GCK SGGSYAVLVVRELLRRCAIEVACVPSQAGPSRMVLISPALHLTLRGPEVD
Mb3124c|M.bovis_AF2122/97 AGGNLALAAAQYMVS---------QGNPVPSSMVLLSPWLDVGT------
Rv3097c|M.tuberculosis_H37Rv AGGNLALAAAQYMVS---------QGNPVPSSMVLLSPWLDVGT------
MMAR_1547|M.marinum_M AGGNLALGAVEYMAS---------QGSQVPSSMVLLSPWLDLGMTNPNIA
MLBr_00314|M.leprae_Br4923 AGGYLALALAQRLQD----------VGEEPAALVAISPLLQLAKKGKQAH
MAV_1200|M.avium_104 AGGYLALTLAQRLQR----------DGEEPAALVMISPLLQLAKEPKQAH
MUL_2832|M.ulcerans_Agy99 AGGYLAFALAQRLRA----------RGEEPAALVAISPLLQLAMRSKKAH
MSMEG_3010|M.smegmatis_MC2_155 AGASIAVATTLRLLR---------DGAPVPGRVITISPWLDMENSGSTIE
MAB_2584|M.abscessus_ATCC_1997 AGGSLSLGITQELRD---------RGEAQPACIALFSPWLNMAVDHELSQ
:*. :. . : *. : .** *.:
Mvan_1749|M.vanbaalenii_PYR-1 A--IDDPILPRPAPP-GEGPRWNGDWDMDDP-----RVNPIAGADLTGLP
Mflv_4715|M.gilvum_PYR-GCK A--IDDPILPRHAP--GEGPRFNGDWSLDDP-----RVNPIAGDNLSGLP
Mb3124c|M.bovis_AF2122/97 --------------W-QISQAWAGNLAVNDP-----LVSPLYGS-LNGLP
Rv3097c|M.tuberculosis_H37Rv --------------W-QISQAWAGNLAVNDP-----LVSPLYGS-LNGLP
MMAR_1547|M.marinum_M F--VQDPLLPFGPAQ-QIGKAWAGNLAVTDP-----MVSPLYGS-LSGLP
MLBr_00314|M.leprae_Br4923 PNAKTDAMFPPKAFD-ALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLP
MAV_1200|M.avium_104 PNIDTDAMFGAGAFD-ALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLP
MUL_2832|M.ulcerans_Agy99 PNIKSDAMFPARAFD-ALVAIVAGAAARNETAGRREEIYEPLEHIAPGLP
MSMEG_3010|M.smegmatis_MC2_155 SNDATDFLITREGLQGNIDRYLSGGASPTDP------LVNPLYADFTGFP
MAB_2584|M.abscessus_ATCC_1997 VIEPHDPELGLAGLQ-QAGRWYAADRPLDDP------ELSPEHANLAGIA
. *:.
Mvan_1749|M.vanbaalenii_PYR-1 PTTVYIGTVEKLLPGVIAFRDKVLSQDPQADLTVVIGDGQLHGWALGGIV
Mflv_4715|M.gilvum_PYR-GCK PTTVYIGTQEKLYPGAIAFRDKVLAQDPAADLTVVIGDGQLHGWALGGIV
Mb3124c|M.bovis_AF2122/97 PTYVYSGSLDPLAQQAVVLEHTAVVQG--APFSFVLAPWQIHDWIL----
Rv3097c|M.tuberculosis_H37Rv PTYVYSGSLDPLAQQAVVLEHTAVVQG--APFSFVLAPWQIHDWIL----
MMAR_1547|M.marinum_M PTYVYAGSQEILAPDVLVLQQEAAAIG--APFNFVLAHGQIHDWVL----
MLBr_00314|M.leprae_Br4923 RTLIHVSGSEVLLHDAQLAATKLAAVG--VPAEIRVWPGQVHVFQAAAP-
MAV_1200|M.avium_104 RTLIHVSGSEVLLHDARLAASRLAAAG--VPAEVRVWPGQIHDFQLAAP-
MUL_2832|M.ulcerans_Agy99 PTLIHVSGAEALLHDARLAAGKLAAAG--VRAEVRVWPGQLHDFQVAAP-
MSMEG_3010|M.smegmatis_MC2_155 RLYITVSDTESLYADATRLAEKARAAG--VDVTFEVASGQQHVFPLQAG-
MAB_2584|M.abscessus_ATCC_1997 ALSIFIGTRDILLPDALLLHFNACTVG--TTSRLQIYDGMFHNWAMKP--
: . : * . . . . : * :
Mvan_1749|M.vanbaalenii_PYR-1 VNSQAPIWRANVYRQLGLSAIPA---------------------------
Mflv_4715|M.gilvum_PYR-GCK VNSQAQIWRPNVYRQLGLLPTNSARYVTLTVA------------------
Mb3124c|M.bovis_AF2122/97 LTPWGLLSWPQINQQLGIAA------------------------------
Rv3097c|M.tuberculosis_H37Rv LTPWGLLSWPQINQQLGIAA------------------------------
MMAR_1547|M.marinum_M LTLDGPRYLAQINQELGIAA------------------------------
MLBr_00314|M.leprae_Br4923 MVPEATLSLRQISQYIREATASKASRDRQSL-------------------
MAV_1200|M.avium_104 MVPEARRSLRQIGDYIREATG-----------------------------
MUL_2832|M.ulcerans_Agy99 MLPEATYSLRQIGEYIRQATG-----------------------------
MSMEG_3010|M.smegmatis_MC2_155 VLPEADAAIESMAAWYRSAKPLAV--------------------------
MAB_2584|M.abscessus_ATCC_1997 -IPEAHRARRQLIEFLAESTRAAALSEKEQTHHDRSDNRRDHRNRPTARH
. .:
Mvan_1749|M.vanbaalenii_PYR-1 ------------
Mflv_4715|M.gilvum_PYR-GCK ------------
Mb3124c|M.bovis_AF2122/97 ------------
Rv3097c|M.tuberculosis_H37Rv ------------
MMAR_1547|M.marinum_M ------------
MLBr_00314|M.leprae_Br4923 ------------
MAV_1200|M.avium_104 ------------
MUL_2832|M.ulcerans_Agy99 ------------
MSMEG_3010|M.smegmatis_MC2_155 ------------
MAB_2584|M.abscessus_ATCC_1997 RELDVEADRSRG