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MVSVRARAFIAAARLQRKKSFYATAAGMRRRLSAHQSAARCEPPRSVRRHRRITRHEVQGHSCYTLHPDG RWDGLHVFHLHGGGFVEQPEKHHWRFADNLVGALGCRYSMFMYPLAPEHDHREITAVSRRAYREMMADTP QSGRVLFGDSAGGSLSLGITQELRDRGEAQPACIALFSPWLNMAVDHELSQVIEPHDPELGLAGLQQAGR WYAADRPLDDPELSPEHANLAGIAALSIFIGTRDILLPDALLLHFNACTVGTTSRLQIYDGMFHNWAMKP IPEAHRARRQLIEFLAESTRAAALSEKEQTHHDRSDNRRDHRNRPTARHRELDVEADRSRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2584 | - | - | 100% (341) | putative esterase |
| M. abscessus ATCC 19977 | MAB_4052c | - | 9e-21 | 28.67% (286) | putative lipase/esterase |
| M. abscessus ATCC 19977 | MAB_2076 | - | 5e-13 | 25.44% (228) | putative esterase/acetyl hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1105 | lipU | 1e-14 | 28.33% (233) | putative lipase LIPU |
| M. gilvum PYR-GCK | Mflv_4426 | - | 5e-20 | 29.20% (250) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1076 | lipU | 1e-14 | 28.33% (233) | lipase LipU |
| M. leprae Br4923 | MLBr_00314 | - | 8e-15 | 28.05% (246) | putative esterase |
| M. marinum M | MMAR_1547 | - | 3e-22 | 28.04% (214) | PE-PGRS family protein |
| M. avium 104 | MAV_1200 | - | 9e-13 | 25.43% (232) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 4e-14 | 26.87% (227) | acetyl-hydrolase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 2e-09 | 25.93% (243) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_0204 | lipU | 5e-14 | 28.33% (233) | lipase LipU |
| M. vanbaalenii PYR-1 | Mvan_1822 | - | 2e-18 | 27.07% (266) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4426|M.gilvum_PYR-GCK ---------------MTERRIRPSIGRASAWAGA---WTVAVGAGAVIAC
Mvan_1822|M.vanbaalenii_PYR-1 ---------------MADRNK-----LVVARVGG---LAIAAGAGAVIAC
MMAR_1547|M.marinum_M MSFWMWPPEVNSVLLLDGPGPGPMLEAAAAWDGIGTELSAAASAFGSVTS
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4426|M.gilvum_PYR-GCK SATAPAWASEDDTSAEPRTAAAAPSKP-SQDRPSR-------ASAERRAD
Mvan_1822|M.vanbaalenii_PYR-1 SAPAPAFASAEDVGSSANVSTSEPSRPQSTKAPSRQDNADESAASGTSDD
MMAR_1547|M.marinum_M ELAGQAWQGPASASMRAAAVRYLDWLGGTAAQAEQSATQARAAAVAYEAA
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4426|M.gilvum_PYR-GCK TDTGADPSETRVSLR--PS---------RTRATDGDGGDPDTTTVELAVA
Mvan_1822|M.vanbaalenii_PYR-1 NDLGDDRSDESAASG--TSDDNDLGDDRSDEAEEPRHSDETVTDEEEAVA
MMAR_1547|M.marinum_M LATIVDPGLIVANRGQLVSLAFSNLFGQNAPAIAAAEAAYEQMWAQDVAA
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 -----------------------------------MTAPSEVSGSQSPVR
TH_1370|M.thermoresistible__bu -----------------------------------MTAPSKVPRTSPLAT
Mflv_4426|M.gilvum_PYR-GCK D---EPSDPGDVEEPA----------------------PESPVAAPALWS
Mvan_1822|M.vanbaalenii_PYR-1 DQEVATPDLGPVDKPAGVPSVHTIDDGFAPAGGDHATPPAGPNLSPAAWT
MMAR_1547|M.marinum_M MGGYYSSASATVAALGPWARALENLPGEFARALDNGLVLVEQEIEQAATT
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1105|M.bovis_AF2122/97 ------------------------------------------MAVRPVLA
Rv1076|M.tuberculosis_H37Rv ------------------------------------------MAVRPVLA
MUL_0204|M.ulcerans_Agy99 -----------------------------------------------MLA
MLBr_00314|M.leprae_Br4923 --------------MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILA
MAV_1200|M.avium_104 VHDVLKARRARIRKFAISDGAPVEVLESGPSVAARLANLTSRLTIRPILA
TH_1370|M.thermoresistible__bu R----AARGHYSRTFPVSDGTPSEYVEDGPSLAGRLTALAAYLTVRPTLA
Mflv_4426|M.gilvum_PYR-GCK LVGSARPQDSGDTATAAVPGTATEAPPTADTTDTDTVPAAA---DAPVVD
Mvan_1822|M.vanbaalenii_PYR-1 LLGSARRDTEAAAVPPSQPDTTSETVNTDAAAATDPATAVASLKDPLGED
MMAR_1547|M.marinum_M LATEFTQVSNTLFTTIFGAPADPPFAASQTGTFTGTPSLITRFENTALLP
MSMEG_3010|M.smegmatis_MC2_155 ----------MIQACVILRHHGNGLVTAHTLAPMSINQPNDPLGVIYAEW
MAB_2584|M.abscessus_ATCC_1997 --------------------------------MVSVRARAFIAAARLQRK
Mb1105|M.bovis_AF2122/97 VGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLP--------NASAQL
Rv1076|M.tuberculosis_H37Rv VGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLP--------NASAQL
MUL_0204|M.ulcerans_Agy99 VGSHVPHLPWPWGLIDHAAKALVPASATVRAAVSLP--------NAAAQL
MLBr_00314|M.leprae_Br4923 VGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVNLS--------NTSAQL
MAV_1200|M.avium_104 VGSHAPNLPWPWGLIDLTARVLLPVSATVRETVALP--------HASAQL
TH_1370|M.thermoresistible__bu IGSFAPRLPWPWGLLDFAARAVRPVPGTVRATIRLP--------HCTAQL
Mflv_4426|M.gilvum_PYR-GCK QPVYTGRPSFVQQVVIAGLNVLKVVLKPFGGLLAFTSLKIPFFTDGVPPF
Mvan_1822|M.vanbaalenii_PYR-1 ESRYTGKPSFVHDVVTFGLYVLKAVLKPFGGLLAFTGLKVPFFTDGIPPF
MMAR_1547|M.marinum_M LKPLLSVSGLDSQIAVPGNPLLALVASDIPPLSWFIG-------NSPPPL
MSMEG_3010|M.smegmatis_MC2_155 TEEFVANPDMSLRLMRWVFEDWQRVTSEPEDVTYAS-----------TRI
MAB_2584|M.abscessus_ATCC_1997 KSFYATAAGMRRRLSAHQSAARCEPPRSVRRHRRIT--RHEVQGHSCYTL
: :
Mb1105|M.bovis_AF2122/97 VRASGVLP----------------ADGTRRAVLYLHGGAFLTCGANSHGR
Rv1076|M.tuberculosis_H37Rv VRASGVLP----------------ADGTRRAVLYLHGGAFLTCGANSHGR
MUL_0204|M.ulcerans_Agy99 VRAPGVLP----------------ADGTRRVVLYLHGGAFLTCGANSHGR
MLBr_00314|M.leprae_Br4923 VRAAGVRP----------------ADGSGRIVLYLHGGAFLGCGANSHRR
MAV_1200|M.avium_104 VRAPGVLP----------------ADGTRRVVVYLHGGAFLTCGANSHGR
TH_1370|M.thermoresistible__bu VRAPGVLP----------------ADGRRSVVLYLHGGAFLTCGAHTHGR
Mflv_4426|M.gilvum_PYR-GCK FLTPGLDVERTEFDGMKVWSLAPRRDQTDKVVVALHGGAYVATASIFHWW
Mvan_1822|M.vanbaalenii_PYR-1 FLTPGLDVERSEFEGMKVWTLTPRKNATEKTVVALHGGAYVATASIFHWW
MMAR_1547|M.marinum_M LNLLLGETVQYSTYDGMSVVQITPAHPTGDYVVAIHGGAFIFPPSFLHWI
MSMEG_3010|M.smegmatis_MC2_155 GGVPGILVKP-------------LDADPGQMLVVLHGGGFALGSSASHRK
MAB_2584|M.abscessus_ATCC_1997 HPD---------------------GRWDGLHVFHLHGGGFVEQPEKHHWR
:. :***.: *
Mb1105|M.bovis_AF2122/97 LVELLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQI
Rv1076|M.tuberculosis_H37Rv LVELLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQI
MUL_0204|M.ulcerans_Agy99 FFELLSKFADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQI
MLBr_00314|M.leprae_Br4923 LVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQI
MAV_1200|M.avium_104 LVEALSTFADAPVLVVNYRLLPKNSVGMALQDCHDAYQWLRLRGYQPDQI
TH_1370|M.thermoresistible__bu LVTALSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQI
Mflv_4426|M.gilvum_PYR-GCK TYADMARDTGATVVVPLQTLVPRGGTAATEVPRTADFLTEMIDAHGAHNV
Mvan_1822|M.vanbaalenii_PYR-1 TYADMARDTGATVIVPLQTLVPAGGTAASEVPRTANFISKVIEDHGADNV
MMAR_1547|M.marinum_M NYSVMAHQTGATVQVPIYPLLQEGGTAGTVVPAMAGLISNQIMQHGAANV
MSMEG_3010|M.smegmatis_MC2_155 LAGHLARAFGAHAFVADFRLAPEHPYPAQIDDATAVFTSLLDNGIDASSI
MAB_2584|M.abscessus_ATCC_1997 FADNLVGALGCRYSMFMYPLAPEHDHREITAVSRRAYREMMADTPQS-GR
: .. : : .
Mb1105|M.bovis_AF2122/97 VLAGDSAGGYLALALAQRLQE-VGEEPAALVAISPLLQLAKEHKQAHPNI
Rv1076|M.tuberculosis_H37Rv VLAGDSAGGYLALALAQRLQE-VGEEPAALVAISPLLQLAKEHKQAHPNI
MUL_0204|M.ulcerans_Agy99 VLAGDSAGGYLALTLAQRLQE-EGEEPAALVAISPLLQLAKEQKKAHPNI
MLBr_00314|M.leprae_Br4923 VLAGDSAGGYLALALAQRLQD-VGEEPAALVAISPLLQLAKKGKQAHPNA
MAV_1200|M.avium_104 VLAGDSAGGYLALTLAQRLQR-DGEEPAALVMISPLLQLAKEPKQAHPNI
TH_1370|M.thermoresistible__bu VLAGDSAGGYLALSLAQRLLD-EGEEPAALVALSPLFEIDNESRAQHPNI
Mflv_4426|M.gilvum_PYR-GCK SVFGDSAGGGLALAAVQELNRRSAATPSRLVLLAPWLDVSMS------DP
Mvan_1822|M.vanbaalenii_PYR-1 SVIGDSAGGGLALAAIQELARRNSRNPSRLVLISPWLDVSMS------DP
MMAR_1547|M.marinum_M SVIGDSAGGNLALGAVEYMASQGSQVPSSMVLLSPWLDLGMT------NP
MSMEG_3010|M.smegmatis_MC2_155 TFVGDSAGASIAVATTLRLLRDGAPVPGRVITISPWLDMENSGSTIESND
MAB_2584|M.abscessus_ATCC_1997 VLFGDSAGGSLSLGITQELRDRGEAQPACIALFSPWLNMAVD------HE
. *****. ::: : *. : ::* ::: .
Mb1105|M.bovis_AF2122/97 KTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLI
Rv1076|M.tuberculosis_H37Rv KTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLI
MUL_0204|M.ulcerans_Agy99 KRDAMFPPKAFDALGELVASAAAKNRVDGKPEELYEPLEHIRPGLPRTLI
MLBr_00314|M.leprae_Br4923 KTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLI
MAV_1200|M.avium_104 DTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLI
TH_1370|M.thermoresistible__bu RTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTLI
Mflv_4426|M.gilvum_PYR-GCK RSAEIRDP--LLDIPNLVRSGAKWAGSAGVTDPLASPLFGSLEGLPPTYV
Mvan_1822|M.vanbaalenii_PYR-1 RSAEIRDP--LLDLANPTKSGAKWAGEAGTADPQASPLFGSLKGLPPTYV
MMAR_1547|M.marinum_M NIAFVQDP--LLPFGPAQQIGKAWAGNLAVTDPMVSPLYGSLSGLPPTYV
MSMEG_3010|M.smegmatis_MC2_155 ATDFLITREGLQGNIDRYLSGGAS-----PTDPLVNPLYADFTGFPRLYI
MAB_2584|M.abscessus_ATCC_1997 LSQVIEPHDPELGLAGLQQAGRWYAADRPLDDPELSPEHANLAGIAALSI
: . : .* *:. :
Mb1105|M.bovis_AF2122/97 HVSGSEVLLHDAQLAAAKLAAAGVP-AEVRVWPGQVHDFQVAASMLPEAI
Rv1076|M.tuberculosis_H37Rv HVSGSEVLLHDAQLAAAKLAAAGVP-AEVRVWPGQVHDFQVAASMLPEAI
MUL_0204|M.ulcerans_Agy99 HVSGSEVLLHDAQLAARKLAAVGVP-AEVRVWPGQVHDFQVAGPLLPEAT
MLBr_00314|M.leprae_Br4923 HVSGSEVLLHDAQLAATKLAAVGVP-AEIRVWPGQVHVFQAAAPMVPEAT
MAV_1200|M.avium_104 HVSGSEVLLHDARLAASRLAAAGVP-AEVRVWPGQIHDFQLAAPMVPEAR
TH_1370|M.thermoresistible__bu HVSGSEALISDARKAARRLAAAGVP-VEIRVWPGQMHVFQIAAPFVPEAK
Mflv_4426|M.gilvum_PYR-GCK YSSSRDLLSVDTLRLRERVGAEGIPNVEFRLRAGLIHDWFTFP-FLPDAH
Mvan_1822|M.vanbaalenii_PYR-1 YSSSLDLLTVDTLRLRDRVLAEQVPDVEFRLRKNLIHDWFTFP-FLPEAH
MMAR_1547|M.marinum_M YAGSQEILAPDVLVLQQEAAAIGAP-FNFVLAHGQIHDWVLLT---LDGP
MSMEG_3010|M.smegmatis_MC2_155 TVSDTESLYADATRLAEKARAAGVD-VTFEVASGQQHVFPLQAGVLPEAD
MAB_2584|M.abscessus_ATCC_1997 FIGTRDILLPDALLLHFNACTVGTT-SRLQIYDGMFHNWAMKP--IPEAH
. : * *. . : . : . * : :.
Mb1105|M.bovis_AF2122/97 RSLRQIGEYIREATG-----------------------------------
Rv1076|M.tuberculosis_H37Rv RSLRQIGEYIREATG-----------------------------------
MUL_0204|M.ulcerans_Agy99 RSLRQIGDYIREATG-----------------------------------
MLBr_00314|M.leprae_Br4923 LSLRQISQYIREATASKASRDRQSL-------------------------
MAV_1200|M.avium_104 RSLRQIGDYIREATG-----------------------------------
TH_1370|M.thermoresistible__bu RSLRQIGEYIREATW-----------------------------------
Mflv_4426|M.gilvum_PYR-GCK EDRAGVYSDLLGAASPVS--------------------------------
Mvan_1822|M.vanbaalenii_PYR-1 EDRPGVYRDLLGSAGSRAVGLAR---------------------------
MMAR_1547|M.marinum_M RYLAQINQELGIAA------------------------------------
MSMEG_3010|M.smegmatis_MC2_155 AAIESMAAWYRSAKPLAV--------------------------------
MAB_2584|M.abscessus_ATCC_1997 RARRQLIEFLAESTRAAALSEKEQTHHDRSDNRRDHRNRPTARHRELDVE
: :
Mb1105|M.bovis_AF2122/97 ------
Rv1076|M.tuberculosis_H37Rv ------
MUL_0204|M.ulcerans_Agy99 ------
MLBr_00314|M.leprae_Br4923 ------
MAV_1200|M.avium_104 ------
TH_1370|M.thermoresistible__bu ------
Mflv_4426|M.gilvum_PYR-GCK ------
Mvan_1822|M.vanbaalenii_PYR-1 ------
MMAR_1547|M.marinum_M ------
MSMEG_3010|M.smegmatis_MC2_155 ------
MAB_2584|M.abscessus_ATCC_1997 ADRSRG