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MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGLADAMDQLDGDAGLSVAILTGGGGSFC AGMDLKAFARGENVVVEGRGLGFTERPPTKPLIAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRG LVAGGGGLLRLPERIPYAIAMELALTGDNLPAERAHELGLVNVLAEPGTALDAAIALAEKITANGPLAVV ATKRIITESRGWSPDTMFAEQMKILVPVFTSNDAKEGAIAFAERRRPRWTGT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0222 | echA1 | - | 100% (262) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv3516 | echA19 | 3e-50 | 43.73% (263) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0675 | echA5 | 6e-36 | 38.84% (242) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3545 | echA19 | 2e-50 | 43.73% (263) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4354 | - | 3e-96 | 69.60% (250) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 5e-32 | 33.85% (260) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_4588c | - | 3e-93 | 69.08% (249) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_0465 | echA1 | 1e-129 | 91.73% (254) | enoyl-CoA hydratase EchA1 |
| M. avium 104 | MAV_4951 | - | 1e-119 | 84.92% (252) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2227 | - | 3e-90 | 65.61% (253) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3963 | - | 1e-113 | 79.07% (258) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_1114 | echA1 | 1e-128 | 91.34% (254) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_1990 | - | 1e-94 | 67.60% (250) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0465|M.marinum_M MSELN----GDTEPEVLVEQRDRILIITINRPKAKNSVNAAVSRALADAM
MUL_1114|M.ulcerans_Agy99 MSELN----GDTEPEVLVEQRDRILIITINRPKAKNSVNAAVSRALADAM
Rv0222|M.tuberculosis_H37Rv MSSESDA--ANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGLADAM
MAV_4951|M.avium_104 MRHVSTGNEEAGEPEVLVEQRDRILIITINRPKAKNAVNAAVANGLAAAV
TH_3963|M.thermoresistible__bu VTEQG-----SSDNPVLVEQRGRILIITINRPEAKNAVNLAVAQGLAAAM
Mflv_4354|M.gilvum_PYR-GCK ----------MSDEVLL-ERRDRVLIITINRPEARNAFNLAVAQGLADAM
Mvan_1990|M.vanbaalenii_PYR-1 ----------MADEVLL-ERRDRVLIITINRPEARNAFNLAVAQGLADAM
MSMEG_2227|M.smegmatis_MC2_155 ----------MSEEVVLRERRDRTLIITINRPEARNAFNLAVAKGLAEAV
MAB_4588c|M.abscessus_ATCC_199 -----------MADEVLIEQRDRVLLITINRPDARNAVNRAVSQGLAAAA
Mb3545|M.bovis_AF2122/97 ---------MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAW
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAA
* : : ::*:*** * *:.. : . :. *
MMAR_0465|M.marinum_M DRLDADAGLSVGILTGAGGSFCAGMDLKAFAR---GENVVVEGRGLG---
MUL_1114|M.ulcerans_Agy99 DRLDADAGLSVGILTGAGGSFCAGMDLKAFAR---GENVVVEGRGLG---
Rv0222|M.tuberculosis_H37Rv DQLDGDAGLSVAILTGGGGSFCAGMDLKAFAR---GENVVVEGRGLG---
MAV_4951|M.avium_104 DRLDSEPGLSVGVLTGAGGSFCAGMDLKAFAR---GELPIVEGRGMG---
TH_3963|M.thermoresistible__bu DRLDDDKGLSVGIVTGAGGSFSAGMDLKAFAR---GEFPVVEGRGLG---
Mflv_4354|M.gilvum_PYR-GCK DELDDTPELSVAIITGAGGNFCAGMDLKAFMA---GEVPAIEGRGIG---
Mvan_1990|M.vanbaalenii_PYR-1 DELDSSAELSVAIITGAGGNFCAGMDLKAFMA---GEVPAIEGRGIG---
MSMEG_2227|M.smegmatis_MC2_155 DELDDTQELSVGIITGAGGTFCAGMDLKGFAS---GELPHVPGRGIG---
MAB_4588c|M.abscessus_ATCC_199 DQLDSSADLSVAIITGAGGNFCAGMDLKAFVS---GEAVLSE-RGLG---
Mb3545|M.bovis_AF2122/97 DRVDNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYDPSRID
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDADFFSAWG--
..:* : ::**. *.** *:* : .
MMAR_0465|M.marinum_M --FTERPPAKPLIAAVEGYALAGGTELALATDLIVAARDSAFGIPEVKRG
MUL_1114|M.ulcerans_Agy99 --FTERPPAKPLIAAVEGYALAGGTELALATDLIVAARDSAFGIPEVKRG
Rv0222|M.tuberculosis_H37Rv --FTERPPTKPLIAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRG
MAV_4951|M.avium_104 --FTERPPAKPLIAAVEGYALAGGTELALATDLIVASKDAAFGIPEVKRG
TH_3963|M.thermoresistible__bu --YTEKPPAKPLIAAVEGYALAGGTELALAADMIVASRESAFGIPEVKRG
Mflv_4354|M.gilvum_PYR-GCK --FTERPPRKPLIAAVEGYALAGGTEIVLATDLIVAAKNAKFGIPEVKRG
Mvan_1990|M.vanbaalenii_PYR-1 --FTERPPRKPVIAAVEGYALAGGTEIVLATDLIVAAKNAKFGIPEVKRG
MSMEG_2227|M.smegmatis_MC2_155 --FTEKPPRKPLIAAVEGYALAGGTEIVLATDLVVASRTAKFGIPEVKRG
MAB_4588c|M.abscessus_ATCC_199 --FTNVPPRKPIIAAVEGFALAGGTELVLSCDLVVAGRSAKFGIPEVKRG
Mb3545|M.bovis_AF2122/97 ALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWS
MLBr_02402|M.leprae_Br4923 ---KLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLG
. .*:**** * *:.** *: *: :*. : ** .* * .
MMAR_0465|M.marinum_M LVAGGGGLLRLPERIPYAIAMELALTGDNLSAERAHALGMVNVLAEPGAA
MUL_1114|M.ulcerans_Agy99 LAAGGGGLLRLPERIPYAIAMELALTGDNLSAERAHALGMVNVLAEPGAA
Rv0222|M.tuberculosis_H37Rv LVAGGGGLLRLPERIPYAIAMELALTGDNLPAERAHELGLVNVLAEPGTA
MAV_4951|M.avium_104 LVAGGGGLLRLPQRIPSAIAMELALTGDNLSAERAHALGMVNVLAEPGSA
TH_3963|M.thermoresistible__bu LVAGGGGLLRLPERIPYSIAMELALTGDILPAERAHDLGLVNALTEPGAA
Mflv_4354|M.gilvum_PYR-GCK LVAAGGGLLRLQKRIPYQKALELALTGDSFTAEEASAWGFVNVLTEPGGA
Mvan_1990|M.vanbaalenii_PYR-1 LVAAGGGLLRLQKRIPYQKALELALTGDSFTAEEASQWGFVNVLTEPGEA
MSMEG_2227|M.smegmatis_MC2_155 LVAAGGGLLRLPKRIPYQKALELALTGDNFTAEEAAAWGFVNKLTEPGEA
MAB_4588c|M.abscessus_ATCC_199 LVAGAGGLLRLPNRIPYQVAMELALTGESFTAEDAAKYGFINRLVDDGQA
Mb3545|M.bovis_AF2122/97 LYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVPDGQA
MLBr_02402|M.leprae_Br4923 VLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDL
: . *. ** . * * :* *** : * * *::. :. .
MMAR_0465|M.marinum_M LDAAIALAEKITANGPLAVAATKRIITESRGWSLDTRFAQQMKILFPIFT
MUL_1114|M.ulcerans_Agy99 LDAAIALAEKITANGPLAVAATKRIITESRGWSLDTRFAQQMKILFPIFT
Rv0222|M.tuberculosis_H37Rv LDAAIALAEKITANGPLAVVATKRIITESRGWSPDTMFAEQMKILVPVFT
MAV_4951|M.avium_104 LDEAIALAEKIAANGPLAVAATKRIIVESRGWSPETMFAEQNKLLAPVFS
TH_3963|M.thermoresistible__bu LDGAIELAERIAANGPLAVATTKRIIIESKKWTPDTMFAEQGKLMAPVFS
Mflv_4354|M.gilvum_PYR-GCK LDGALALAERITANGPLAVAATKEVIAKSADWTEAEMWKKQGEIVFPVFS
Mvan_1990|M.vanbaalenii_PYR-1 LNGALALAERITANGPLAVAVTKEVIVKSADWTEAEMWKKQGELVMSVFS
MSMEG_2227|M.smegmatis_MC2_155 LAGALELAERITANGPLAVAVTKEVIVKSAEWSEAEMWKKQGELIGPVFS
MAB_4588c|M.abscessus_ATCC_199 LDTALELAAKITANGPLAVAATKRIIIESASWAPEEAFAKQGEILMPIFV
Mb3545|M.bovis_AF2122/97 LTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVFL
MLBr_02402|M.leprae_Br4923 LPEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFV
* * :* *: . *. . : .: . : .: *
MMAR_0465|M.marinum_M SNDAKEGAIAFAEKRPPRWTGT
MUL_1114|M.ulcerans_Agy99 SNDAKEGAIAFAEKRPPRWTGT
Rv0222|M.tuberculosis_H37Rv SNDAKEGAIAFAERRRPRWTGT
MAV_4951|M.avium_104 SNDAKEGAIAFAEKRPPKWTGT
TH_3963|M.thermoresistible__bu SNDAKEGAIAFAEKRAPNWTGT
Mflv_4354|M.gilvum_PYR-GCK SKDAMEGATAFAEKRKPNWTGT
Mvan_1990|M.vanbaalenii_PYR-1 SKDAMEGATAFAEKRKPNWTGS
MSMEG_2227|M.smegmatis_MC2_155 SKDAIEGATAFAEKRKPNWTGS
MAB_4588c|M.abscessus_ATCC_199 SEDAKEGAKAFAEKRAPVWQGK
Mb3545|M.bovis_AF2122/97 SDDAKEGPRAFAEKRAPNFQNR
MLBr_02402|M.leprae_Br4923 TDDQSEGMAAFIEKRAPQFTHR
:.* ** ** *:* * :