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TDAGDDQPAGLVEHRGNVMVITINRPEARNAINGAVSVAVGDALESAQNDPEVRAVVITGAGDKSFCAGA DLLAISRRENIYHPDHNEWGFAGYVHHFIDKPTIAAVNGTALGGGTELALASDLVVADERAKFGLPEVKR GLIAAAGGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVLDAALALAARVTVNAPLSV RASKRIAYGVDDGVVADEERGWERTMREMRSLIRSEDAKEGPLAFAQKREPVWKAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4317 | echA1_1 | - | 100% (267) | enoyl-CoA hydratase, EchA1_1 |
| M. marinum M | MMAR_0465 | echA1 | 5e-58 | 45.11% (266) | enoyl-CoA hydratase EchA1 |
| M. marinum M | MMAR_5002 | echA19 | 2e-45 | 38.89% (270) | enoyl-CoA hydratase EchA19 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1168 | - | 1e-46 | 80.18% (111) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2117 | - | 1e-115 | 75.68% (259) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0222 | echA1 | 6e-58 | 44.24% (269) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 8e-33 | 34.75% (259) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_4588c | - | 3e-57 | 48.44% (256) | enoyl-CoA hydratase/isomerase |
| M. avium 104 | MAV_1277 | - | 1e-123 | 81.99% (261) | carnitinyl-CoA dehydratase |
| M. smegmatis MC2 155 | MSMEG_5198 | - | 1e-112 | 75.29% (259) | carnitinyl-CoA dehydratase |
| M. thermoresistible (build 8) | TH_4237 | - | 9e-93 | 76.78% (211) | PUTATIVE carnitinyl-CoA dehydratase |
| M. ulcerans Agy99 | MUL_0972 | echA1_1 | 1e-146 | 97.38% (267) | enoyl-CoA hydratase, EchA1_1 |
| M. vanbaalenii PYR-1 | Mvan_4588 | - | 1e-114 | 73.51% (268) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0222|M.tuberculosis_H37Rv MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGLADAMDQ
MAB_4588c|M.abscessus_ATCC_199 ---------MADEVLIEQRDRVLLITINRPDARNAVNRAVSQGLAAAADQ
MMAR_4317|M.marinum_M ---MTDAGDDQPAGLVEHRGNVMVITINRPEARNAINGAVSVAVGDALES
MUL_0972|M.ulcerans_Agy99 ---MTDAGDDQPAGLVEHRGNVMVITINRPEARNAINGAVSVAVGGALES
Mb1168|M.bovis_AF2122/97 ----------------------MVITINRPEARNAVNGAVSIVVGDALEE
MAV_1277|M.avium_104 -------MTDAPGALAERRGNVMVITINRPEARNAVNAAVSIGVGDALEE
Mflv_2117|M.gilvum_PYR-GCK ---------MAPGALTERRGNVLIITINRPEARNAINASVSIAVGDALQA
Mvan_4588|M.vanbaalenii_PYR-1 --MTDTVTDTAPGALTERRGNVLIITINRPEARNAVNASVSIGVGNALQA
MSMEG_5198|M.smegmatis_MC2_155 ------MTETAPGALTERRGNVLLITINRPEARNAINSSVSQAVGDALAE
TH_4237|M.thermoresistible__bu --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKE
Rv0222|M.tuberculosis_H37Rv LDGDAGLSVAILTGGGG-SFCAGMDLKAFARGEN----VVVEGRGLGFTE
MAB_4588c|M.abscessus_ATCC_199 LDSSADLSVAIITGAGG-NFCAGMDLKAFVSGEA----VLSE-RGLGFTN
MMAR_4317|M.marinum_M AQNDPEVRAVVITGAGDKSFCAGADLLAISRRENIYHPDHNEWGFAGYVH
MUL_0972|M.ulcerans_Agy99 AQNDAEVRAVVITGAGDKSFCAGADLLAISRRENIYHPDHNEWGFAGYVH
Mb1168|M.bovis_AF2122/97 AHDNPDVRAVVITGAGDKSLCAGADLKAIARRENPYHPHHGEWGIAGYRH
MAV_1277|M.avium_104 AQHDPEVRAVVLTGAGDKSFCAGADLKAIARRENLYHPDHPEWGFAGYVR
Mflv_2117|M.gilvum_PYR-GCK AQEDPDVRAVILTGAGDKSFCAGADLKAISRGENLFHPEHSEWGFAGYVR
Mvan_4588|M.vanbaalenii_PYR-1 AQDDPEIRAVILTGAGDKSFCAGADLKAISRGENLFHPEHTEWGFAGYVR
MSMEG_5198|M.smegmatis_MC2_155 AQNDPEVRAVVLTGAGDKSFCAGADLKAISRGENLFHPEHPEYGFAGYVS
TH_4237|M.thermoresistible__bu ---------VVLTGSGDKSFCAGADLKAIARGENLFHPDHPEWGFAGYVR
MLBr_02402|M.leprae_Br4923 LDIDPDVGAILITGSPK-VFAAGADIKEMASLTFTDAFDADFFSAWG-KL
::**. :.** *: : *
Rv0222|M.tuberculosis_H37Rv RPPTKPLIAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRGLVAGG
MAB_4588c|M.abscessus_ATCC_199 VPPRKPIIAAVEGFALAGGTELVLSCDLVVAGRSAKFGIPEVKRGLVAGA
MMAR_4317|M.marinum_M HFIDKPTIAAVNGTALGGGTELALASDLVVADERAKFGLPEVKRGLIAAA
MUL_0972|M.ulcerans_Agy99 HFIDKPTIAAVNGTALCGGTELALASDLVVADERAKFGLPEAKRGFIAAA
Mb1168|M.bovis_AF2122/97 HFIDKPTSAAVSGTALDDGAEPALASDLVVADEHT---------------
MAV_1277|M.avium_104 HFIDKPTIAAVNGTALGGGTELALASDLVVADERAQFGLPEVKRGLIAAA
Mflv_2117|M.gilvum_PYR-GCK HFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGLIAGA
Mvan_4588|M.vanbaalenii_PYR-1 HFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGLIAGA
MSMEG_5198|M.smegmatis_MC2_155 HFIDKPTIAAVNGTALGGGTELALASDLVVAEERAMFGLPEVKRGLIAGA
TH_4237|M.thermoresistible__bu HFMDKPTIAAVNGTALGGGTELALASDLVVARESAVFGLPEVKRGLIAGA
MLBr_02402|M.leprae_Br4923 AAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGM
.* *** * ** .* * .: .**::* :
Rv0222|M.tuberculosis_H37Rv GGLLRLPERIPYAIAMELALTGDNLPAERAHELGLVNVLAEPGTALDAAI
MAB_4588c|M.abscessus_ATCC_199 GGLLRLPNRIPYQVAMELALTGESFTAEDAAKYGFINRLVDDGQALDTAL
MMAR_4317|M.marinum_M GGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVLDAAL
MUL_0972|M.ulcerans_Agy99 GGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVLDAAL
Mb1168|M.bovis_AF2122/97 --------------------------------------------------
MAV_1277|M.avium_104 GGVFRIAEQLPRKVAMRLLLTGEPLSAAAARDWGLINEVVEAGSVLDAAL
Mflv_2117|M.gilvum_PYR-GCK GGVFRIVEQLPRKVALELIYTGEPISSADALRWGLINQVVPDGTVVDAAL
Mvan_4588|M.vanbaalenii_PYR-1 GGVFRIVEQLPRKVALELIYTGEPISSADALRWGLINQVVPDGTVVDAAL
MSMEG_5198|M.smegmatis_MC2_155 GGVFRIIEQLPRKVALELVYTGDPISAADALKWGLINQVVPDGTVVDAAL
TH_4237|M.thermoresistible__bu GGVFRIVEQLPRKVALELLFTGEPITAAEALRWGLINEVVPDGAELDAAL
MLBr_02402|M.leprae_Br4923 GGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAK
Rv0222|M.tuberculosis_H37Rv ALAEKITANGPLAVVATKRIITESRG---WSPDTMFAEQMKILVPVFTSN
MAB_4588c|M.abscessus_ATCC_199 ELAAKITANGPLAVAATKRIIIESAS---WAPEEAFAKQGEILMPIFVSE
MMAR_4317|M.marinum_M ALAARVTVNAPLSVRASKRIAYGVDDGVVADEERGWERTMREMRSLIRSE
MUL_0972|M.ulcerans_Agy99 ALAARVTVNAPLSVRASKRIAYGVDDGVVADEERGWERTMREMRSLIRSE
Mb1168|M.bovis_AF2122/97 --------------------------------------------------
MAV_1277|M.avium_104 ALASAITVNAPLSVQASKRIAYGVDDGVVVGDEPGWDRTMREMRALLKSE
Mflv_2117|M.gilvum_PYR-GCK ALAERITCNAPLAVRASKRVSYGAIDGVVGSDEPFWKQTFSEFSTLLKTE
Mvan_4588|M.vanbaalenii_PYR-1 ALAERITCNAPLAVQASKRVSYGAVDGVVGSEEPFWKQTFGEFSTLLKTE
MSMEG_5198|M.smegmatis_MC2_155 ALAERITCNAPLAVQASKRVAYGAEEGTVPAEQPSWKRTNREFVTLLKTE
TH_4237|M.thermoresistible__bu ALAERITVNAPLAVQASKRVAYGAENGTVPGDENGWKLTNREFSTLLKTE
MLBr_02402|M.leprae_Br4923 AVATTISQMSRSATRMAKEAVNRSFES---TLAEGLLHERRLFHSTFVTD
Rv0222|M.tuberculosis_H37Rv DAKEGAIAFAERRRPRWTGT
MAB_4588c|M.abscessus_ATCC_199 DAKEGAKAFAEKRAPVWQGK
MMAR_4317|M.marinum_M DAKEGPLAFAQKREPVWKAR
MUL_0972|M.ulcerans_Agy99 DAKEGPLAFAEKREPVWKTR
Mb1168|M.bovis_AF2122/97 --------------------
MAV_1277|M.avium_104 DAKEGPRAFAEKREPVWQAR
Mflv_2117|M.gilvum_PYR-GCK DAMEGPLAFAQKREPVWKAK
Mvan_4588|M.vanbaalenii_PYR-1 DAMEGPLAFAQKREPVWKAK
MSMEG_5198|M.smegmatis_MC2_155 DAMEGPLAFAQKRQPVWKAK
TH_4237|M.thermoresistible__bu DAKEGPLAFAEKREPVWKAR
MLBr_02402|M.leprae_Br4923 DQSEGMAAFIEKRAPQFTHR