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LIGDIATNNSRRYPDKRALVDADRALTWSQVDDRARRLAAFLIGRGLVPGDRVMVIARNCIEWPEISFGL AKAGLITVPVNIRLAPDEVAHVRDDSGARAVIIHADHLDKFLGELTELALILGVGAHSMLGTSELVTDYE TALAQAQPGAERRDITPDDVAFILYTSGTTGRAKGVMHTHRALLYQAADTNLVTEANRSDVMLATTPFFT AGGMVRTVSWLYLGQTMVIHQRFDPQAVIDEIERSAITFTTFIPTMLHRTLAILEDGPPRDMSSLRRISY GSAPVPPGLARKAMDLLGCELQQRYGLTECGGQATILTPQDHRDIVAGKTSIATSCGQETPMCVIRVIDV DGNDAPPGDVGEIVITSPANAIGYWNRPEQTAETFRPDGLRSGDLGYLDEEGYLHITGRKTDLIISGGFN VYPAEIERVIAQHSDVDMVAVVGVPDPEWGETPVAAVIAKSHVGDQDALTAELAALCRAELAGYKQPRRF VFWREFPLGPAGKILKREIANQVNHVSQSGGKMPVSTGSTEERR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2610 | - | - | 100% (535) | acyl-CoA synthase |
| M. avium 104 | MAV_1899 | - | 0.0 | 85.30% (517) | feruloyl-CoA synthetase |
| M. avium 104 | MAV_3523 | - | 8e-75 | 35.81% (511) | acyl-CoA synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 7e-70 | 35.00% (500) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 9e-88 | 37.30% (512) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 7e-70 | 35.20% (500) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 4e-58 | 31.41% (503) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 8e-70 | 32.81% (506) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 4e-68 | 34.53% (501) | fatty-acid-CoA ligase FadD5 |
| M. smegmatis MC2 155 | MSMEG_0131 | - | 2e-70 | 34.62% (520) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2854 | - | 3e-81 | 38.13% (514) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 4e-58 | 30.20% (510) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 1e-81 | 36.50% (515) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2610|M.avium_104 --------------------------------------------------
TH_2854|M.thermoresistible__bu -------------------------------------------------V
Mb0172|M.bovis_AF2122/97 -----------------------------MTAQLASHLTRALTLAQQQPY
Rv0166|M.tuberculosis_H37Rv -----------------------------MTAQLASHLTRALTLAQQQPY
MMAR_0409|M.marinum_M -----------------------------MTAELASHLPQAA-HALEQPY
MSMEG_0131|M.smegmatis_MC2_155 -----------------------------MTAEPS---------QIEQPY
MAB_4559|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0027|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0943|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
MAV_2610|M.avium_104 ----MLIGDIATNNSRRYPDKRALVDADRALTWSQVDDRARRLAAFLIGR
TH_2854|M.thermoresistible__bu SRSHLLIGDLITRAARTYGAAPALVHGDRVMSFREFDDATNRLGNALLAR
Mb0172|M.bovis_AF2122/97 LARRQNWVNQLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGR
Rv0166|M.tuberculosis_H37Rv LARRQNWVNQLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGR
MMAR_0409|M.marinum_M LARRQNWVNQLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRR
MSMEG_0131|M.smegmatis_MC2_155 LARRQNWVNQLTRHAMMQPDKTALRFLGRTTTWRELDDRVTRLAGALNRR
MAB_4559|M.abscessus_ATCC_1997 ----MQFTQWLHRALQQYPDRLITIDQGREHTVEQFADRVARLSAGLRAN
Mflv_0027|M.gilvum_PYR-GCK --MFHNLADIVRSHGRNRPDAPALIVGDRTVSYRELDERSNRTAQAFSRT
Mvan_0943|M.vanbaalenii_PYR-1 --MIHNLADIIRVHGRERPGAPALVVGDRTVTYGELDDRSSRAAQAFAQA
MLBr_02546|M.leprae_Br4923 MRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAK
MUL_1191|M.ulcerans_Agy99 IAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAGHAVANALLAK
: :. . :
MAV_2610|M.avium_104 GLVPGDRVMVIARNCIEWPEISFGLAKAGLITVPVNIRLAPDEVAHVRDD
TH_2854|M.thermoresistible__bu GLRPGDHVAVLAPNGIDGVVTYYALAKAGLVRVPLNSRETDFELAYKIDD
Mb0172|M.bovis_AF2122/97 GVGFGDRVMILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVED
Rv0166|M.tuberculosis_H37Rv GVGFGDRVMILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVED
MMAR_0409|M.marinum_M GVGFGDRVMILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVED
MSMEG_0131|M.smegmatis_MC2_155 GVGFGDRVLILMLNRTEFVEAMLAANRLGAIAVPVNFRMTPPEIAYLVSD
MAB_4559|M.abscessus_ATCC_1997 GVRPGDRVGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRE
Mflv_0027|M.gilvum_PYR-GCK GVGPGDRVAFVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIAD
Mvan_0943|M.vanbaalenii_PYR-1 GVGVGDRVAFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIAD
MLBr_02546|M.leprae_Br4923 GVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSER
MUL_1191|M.ulcerans_Agy99 GVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFSGPQIKEVSER
*: ** : .: * . * :* . : ::
MAV_2610|M.avium_104 SGARAVIIHADHLDKFLGELTELALILGVGAHSMLGTSELVTDYETALAQ
TH_2854|M.thermoresistible__bu SQARALVTDGR---------------IPAETELVIHTEELAG----MIAG
Mb0172|M.bovis_AF2122/97 CAAHVMLTEAALAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFGYEDLLNE
Rv0166|M.tuberculosis_H37Rv CVAHVMLTEAALAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFGYEDLLNE
MMAR_0409|M.marinum_M CAPRLVITEEVLAQVAVGVREIAPALSTIVVAG-GASDPTVVGYDELISE
MSMEG_0131|M.smegmatis_MC2_155 CEAHVVVTEPVLAGVATAVRDLDATLQTVIVAG-GATEDGVLGYDDLIAE
MAB_4559|M.abscessus_ATCC_1997 SGTRVLLVDDTFKAAAAPLRAACACLETVIYCGAGPAPQDMIGYEDLLAS
Mflv_0027|M.gilvum_PYR-GCK CGASVVVVGQEFTGRIEAIADD--LDVEVVVIG---KHRHWPTFDDLLAA
Mvan_0943|M.vanbaalenii_PYR-1 SGAKIVVVGQDFAGHLEAIEDG--LDADIVVIG---DHPRWPAFDDWVAS
MLBr_02546|M.leprae_Br4923 EGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELI
MUL_1191|M.ulcerans_Agy99 EGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEEDSGSTDETLAELI
. ::
MAV_2610|M.avium_104 AQPGAERRDITPDDVAFILYTSGTTGRAKGVMHTHRALLYQAAD--TNLV
TH_2854|M.thermoresistible__bu ADPGPCRIERDPEDPLRLAYTGGTTGKPKAVVLTTRSELAEIANFLVDLL
Mb0172|M.bovis_AF2122/97 AGDVHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSG
Rv0166|M.tuberculosis_H37Rv AGDVHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSG
MMAR_0409|M.marinum_M TGDPPEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGG
MSMEG_0131|M.smegmatis_MC2_155 EGEPPAPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLSAQAMMHLFTTG
MAB_4559|M.abscessus_ATCC_1997 -HEPIDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGN
Mflv_0027|M.gilvum_PYR-GCK APAVDPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGPWK
Mvan_0943|M.vanbaalenii_PYR-1 HPPVDPGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQ
MLBr_02546|M.leprae_Br4923 ARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVP
MUL_1191|M.ulcerans_Agy99 ARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTPPTLAPVGGILSHVP
. : *.**** .*.. .
MAV_2610|M.avium_104 TEANRSDVMLATTPFFTAGGMVRTVSWLYLGQTMVIHQR--FDPQAVIDE
TH_2854|M.thermoresistible__bu PDLTPDSVMLHAAP-ITHGSGAFFLPHLVKGARNVILPR--FTPQGFVDA
Mb0172|M.bovis_AF2122/97 ANINSDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDV
Rv0166|M.tuberculosis_H37Rv ANINSDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDV
MMAR_0409|M.marinum_M ANINSDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDV
MSMEG_0131|M.smegmatis_MC2_155 ADLNSDVGFVGVPLFHIAGVAGSVLSGVTLGVPTVLYPLGAFDPDGLLDV
MAB_4559|M.abscessus_ATCC_1997 FLTRGGRLLHSAPMFHMADFS-AVLAGNLSGSTHVIVPS--FSPQGVLDA
Mflv_0027|M.gilvum_PYR-GCK FDADS-VSLAVMPLFHMAGFG-WALAGLWEGAVTVVLRD--VDPGAILDA
Mvan_0943|M.vanbaalenii_PYR-1 FDADA-VSLAVMPLFHMAGSG-WALAGLWQGATTVVLRD--VEPAAILDA
MLBr_02546|M.leprae_Br4923 FRAHEVTLLP-APMFHALGYLHATLA-MFLGSTLVLRRR--FKPATVLED
MUL_1191|M.ulcerans_Agy99 FKANEVTSLP-APMFHALGYLHATIA-MFLGSTLVLRRK--FKPQLVLED
: . . :. * *: . * .::
MAV_2610|M.avium_104 IERSAITFTTFIPTMLHRTLAILEDGPP-RDMSSLRRISYGSAPVPPGLA
TH_2854|M.thermoresistible__bu AVEHGATATFMVPTMIAMMLEDAEID---RDRLKLRRLCYGGAPIAPTLL
Mb0172|M.bovis_AF2122/97 LEAEKVTGIFLVPAQWQAVCTEQQARP--RDLR-LRVLSWGAAPAPDALL
Rv0166|M.tuberculosis_H37Rv LEAEKVTGIFLVPAQWQAVCTEQQARP--RDLR-LRVLSWGAAPAPDALL
MMAR_0409|M.marinum_M LEAERVSGIFLVPAQWQAVCAEQQARP--RELS-LRVMSWGAAPAPDALL
MSMEG_0131|M.smegmatis_MC2_155 LESEQVTGIFLVPAQWQAVCAAQRARP--RNLK-LRALSWGAAPASDTLL
MAB_4559|M.abscessus_ATCC_1997 IVAHDVQDMLLVPTMIQMLVDHPGAAQ--LDLSGIRSITYGASVISEAVL
Mflv_0027|M.gilvum_PYR-GCK VARHRVTNMLLVPAVIQFLLDTTGLDD--TDLSRLRIVVYGASPITDDVL
Mvan_0943|M.vanbaalenii_PYR-1 IARHRITNMLLVPAVIQFLLDTDGVAE--VDLSTLRVIVYGASPISDDVL
MLBr_02546|M.leprae_Br4923 IEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELA
MUL_1191|M.ulcerans_Agy99 IEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFVSGSQLGAELA
.:*. : :: : ..: :
MAV_2610|M.avium_104 RKAMDLLG-CELQQRYGLTECGGQATILTPQDHRDIVAGKTSIATSCGQE
TH_2854|M.thermoresistible__bu ARGLETLG-PVFVQLYGQAEAPLAITCLQPWEH------TPERLTSAGKP
Mb0172|M.bovis_AF2122/97 RQMSATFPETQILAAFGQTEMSPVTCMLLGEDAIA-------KRGSVGRV
Rv0166|M.tuberculosis_H37Rv RQMSATFPETQILAAFGQTEMSPVTCMLLGEDAIA-------KRGSVGRV
MMAR_0409|M.marinum_M RQMSEVFPGTQIMAAFGQTEMSPVTCMLLGEDAIR-------KRGSVGKV
MSMEG_0131|M.smegmatis_MC2_155 REMNEVFPDAQIFAAFGQTEMSPVTCMLLGDDAIR-------KLGSVGRV
MAB_4559|M.abscessus_ATCC_1997 QRATRVFPNARFTQAYGMTEVSPVATLLLPDDHDDP-----ALLRSAGRA
Mflv_0027|M.gilvum_PYR-GCK MRGIDRFG-GIFAQVYGMTESTGSVTQLDGDEHLP------QLLRSCGRP
Mvan_0943|M.vanbaalenii_PYR-1 VRGIERFG-PIFAQVYGMTETTGSITQLDGPDHVP------ALLRSCGRP
MLBr_02546|M.leprae_Br4923 TRALEELG-PVIYNMYGSTEIAFATIAGPKDLQIN--------SATVGPV
MUL_1191|M.ulcerans_Agy99 SRALKDLG-PVIYNMYGSTEIAFATIAGPEDLQRN--------AATVGPV
. : : :* :* : *
MAV_2610|M.avium_104 TPMCVIRVIDVDGNDAPPGDVGEIVITSPANAIGYWNRPEQTAETFRPDG
TH_2854|M.thermoresistible__bu YTFVEMDIRDEEDNSVPPGTPGEVVTRGPHTMSGYWRRPEATAETLGEDG
Mb0172|M.bovis_AF2122/97 IPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFA-GG
Rv0166|M.tuberculosis_H37Rv IPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFA-GG
MMAR_0409|M.marinum_M IPTVSARVVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFA-GG
MSMEG_0131|M.smegmatis_MC2_155 IPTVSARVVDDNMNDVPVGEVGEIVYRGPNLMVGYWNNPKATAEAFA-GG
MAB_4559|M.abscessus_ATCC_1997 APHCEVRIVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIR-DG
Mflv_0027|M.gilvum_PYR-GCK YPWVQIRVVDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDG
Mvan_0943|M.vanbaalenii_PYR-1 YPWVQIRIVDETGADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADG
MLBr_02546|M.leprae_Br4923 VKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDG
MUL_1191|M.ulcerans_Agy99 VKGVKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGG----GHKQIIDG
: * .. * *.: * . .*
MAV_2610|M.avium_104 -LRSGDLGYLDEEGYLHITGRKTDLIISGGFNVYPAEIERVIAQHSDVDM
TH_2854|M.thermoresistible__bu WLRTGDIGQVDEEGYLYLLDRRNDVIISGGFNVYPREVEDALLTHPAVRE
Mb0172|M.bovis_AF2122/97 WFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAE
Rv0166|M.tuberculosis_H37Rv WFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAE
MMAR_0409|M.marinum_M WFHSGDLVRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVE
MSMEG_0131|M.smegmatis_MC2_155 WFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLAAHPAIME
MAB_4559|M.abscessus_ATCC_1997 WMHTGDAGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAA
Mflv_0027|M.gilvum_PYR-GCK WLRTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTD
Mvan_0943|M.vanbaalenii_PYR-1 WLKTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVAD
MLBr_02546|M.leprae_Br4923 LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVE
MUL_1191|M.ulcerans_Agy99 LMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHPDVVE
: :** * . : : .* :::::*. *:: *:* : *. :
MAV_2610|M.avium_104 VAVVGVPDPEWGETPVAAVIAKSHVGDQDALTAELAALCRAELAGYKQPR
TH_2854|M.thermoresistible__bu AVVVGVDDERWGQRVSAAVVLREEVD-----TQALIDHCAERLAGFKRPR
Mb0172|M.bovis_AF2122/97 VAVIGRADEKWGEVPIAVAAV---TN-DDLRIEDLGEFLTDRLARYKHPK
Rv0166|M.tuberculosis_H37Rv VAVIGRADEKWGEVPIAVAAV---TN-DDLRIEDLGEFLTDRLARYKHPK
MMAR_0409|M.marinum_M VAVIGRADEKWGEVPIAVAAV---TK-DHLRIEDLDEYLTERLARYKHPK
MSMEG_0131|M.smegmatis_MC2_155 VAVIGRPHEKWGEVPVAVVALNSATA-ESISLGELDSFLTERLARYKHPK
MAB_4559|M.abscessus_ATCC_1997 CAVIGIPDEQWGERVHAVVVK--QAQ-SECCDGDLQEHCREHIANYKVPR
Mflv_0027|M.gilvum_PYR-GCK VAVIGIPDTRWGEAVKAVVVAG-----APVTEAELIAFAREQLAGFKLPK
Mvan_0943|M.vanbaalenii_PYR-1 AAVIGVPDRRWGEAVKAVVVAAR--G-AQLTEAELIAFARDRIGGFKLPK
MLBr_02546|M.leprae_Br4923 ATAIGVDDKEWGARLRAFVVKK---QDATIDEDAIKAYVRDHLARYKVPR
MUL_1191|M.ulcerans_Agy99 ATALGVDDKEWGARLRAFVVKK---PDTDLDEETVKHYVRDHLARYKVPR
..:* . .** * . : .:. :* *:
MAV_2610|M.avium_104 RFVFWREFPLGPAGKILKREIANQVNHVSQSGGKMPVSTGSTEERR----
TH_2854|M.thermoresistible__bu HIEVWDELPKSPVGKSLRRTVR----------ETMRANEEVTAHA-----
Mb0172|M.bovis_AF2122/97 ALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv ALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M ALEIVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MSMEG_0131|M.smegmatis_MC2_155 ALEVVDALPRNPSGKVLKTELRERFGRATSLDGGESNSATTVSAG-----
MAB_4559|M.abscessus_ATCC_1997 SFEFVDELPLSGAGKILKRVLRQKY-----WESRDAGVS-----------
Mflv_0027|M.gilvum_PYR-GCK SVDFVDALPRNPSGKLLKRQLREPY-----WTDEDRHIG-----------
Mvan_0943|M.vanbaalenii_PYR-1 SVDFVDVLPRNPSGKLLKRALREPY-----WDGADRHIG-----------
MLBr_02546|M.leprae_Br4923 EVIFLEELPRNPTGKVLKRELRDFEVH-----------------------
MUL_1191|M.ulcerans_Agy99 EVIFLEELPRNPTGKILKRELREMEIE-----------------------
. . :* . ** *: :