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STPVIVGAARTAIGRSFKGTLVNTPPETLITTVLPEVIRRSGVDPADIDDIIFAESHYGGGDLARYAADA IGLQHVPGQSVNRHCAGSLTAIGNAAAQIGSGMERVMIAGGVQSLSMTPLVNWRIPGPELKFEERWMPPT HVETPDAPTKDMSITVGWNTAQAAGITREDMDAWAARSHQRAVAAQDDGKFLDEIVPLKVEQFDGSVIDF SVDEQPRRDTSVEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVEADYAAANGLTVMAKVRSWGAV GVAPRDTGLGGVKVIGRVLDKAGLKPSDVTLWEINEAFASVPIAAVREYGIDEELVNFSGSGCSLGHPIA ASGARMITTLIYELQRRGGGIGVAAMCAGGGQGGGVVIEV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4356 | - | - | 100% (391) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1347 | - | 4e-58 | 37.56% (402) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2445 | - | 5e-58 | 37.22% (403) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 2e-55 | 35.84% (413) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 3e-55 | 35.84% (413) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 9e-52 | 35.18% (398) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0902 | - | 1e-66 | 39.56% (407) | beta-ketoadipyl-CoA thiolase |
| M. marinum M | MMAR_4788 | - | 1e-109 | 53.49% (387) | beta-ketoacyl CoA thiolase |
| M. avium 104 | MAV_2127 | - | 0.0 | 84.91% (391) | acetyl-CoA C-acyltransferase |
| M. smegmatis MC2 155 | MSMEG_2224 | - | 0.0 | 91.30% (391) | acetyl-CoA C-acyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 1e-53 | 36.27% (397) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0357 | - | 1e-109 | 53.49% (387) | beta-ketoacyl CoA thiolase |
| M. vanbaalenii PYR-1 | Mvan_1988 | - | 0.0 | 94.12% (391) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01158|M.leprae_Br4923 ----------------MTTSVIVTGARTPIGKLM-GSLKDFSASDLGAIT
MAB_0902|M.abscessus_ATCC_1997 ---------------MVEQVFVVDGVRTAQGRYG-GALASVRPDDLAARV
TH_0255|M.thermoresistible__bu ----------------MRETVIVEAVRTAVGKRN-GALADVHAADLSAVV
Mb1103c|M.bovis_AF2122/97 ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Rv1074c|M.tuberculosis_H37Rv ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Mflv_4356|M.gilvum_PYR-GCK ----------------MSTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
Mvan_1988|M.vanbaalenii_PYR-1 ----------------MPTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MSMEG_2224|M.smegmatis_MC2_155 -------------MKIMPKPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MAV_2127|M.avium_104 ----------------MGTPVIVGAVRTAIGRSFKGTLVNTPPETLITAV
MMAR_4788|M.marinum_M ----------------MPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
MUL_0357|M.ulcerans_Agy99 MCGRLLASAPPKWRKPVPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
: .:* *:. * *:* . . *
MLBr_01158|M.leprae_Br4923 IAAALKKA-NVAPSIVQYVIIGQVLTAGAG-QMPARQAAVAAGIGWDVPA
MAB_0902|M.abscessus_ATCC_1997 IAEVVARA-GVPADAIGEVILGAANQAGEDNRNVARMAALLAGLPNTVPG
TH_0255|M.thermoresistible__bu LSELVERA-GIDPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPG
Mb1103c|M.bovis_AF2122/97 VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPG
Rv1074c|M.tuberculosis_H37Rv VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPG
Mflv_4356|M.gilvum_PYR-GCK LPEVIRRS-GVDPADIDDIIFAESHYGGGD---LARYAADAIGL-QHVPG
Mvan_1988|M.vanbaalenii_PYR-1 LPEVVRRS-GVDPADIDDIIFAESHYGGGD---LARYAADAVGL-QHVPG
MSMEG_2224|M.smegmatis_MC2_155 LPEIVRRS-GVDPADIDDIIFAESHYGGGD---LARYAADATGL-QHVPG
MAV_2127|M.avium_104 LPEVIRRS-GVDPAAIDDIIFAESHYGGGD---LARYAAAATGL-EDIPG
MMAR_4788|M.marinum_M VSEAT--A-DLDPGQIDDVILGEGLYGGGV---IARHAAITAGL-GHVPG
MUL_0357|M.ulcerans_Agy99 VSEAT--A-DLDPGQIDDVILGEGLYGGGV---IARHAAITAGL-GHVPG
: : . : :: . * .* .. * :*.
MLBr_01158|M.leprae_Br4923 LTINKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRS-
MAB_0902|M.abscessus_ATCC_1997 YTVNRLCASGLTAISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAP
TH_0255|M.thermoresistible__bu TTVNRACGSSQQALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARATG-
Mb1103c|M.bovis_AF2122/97 TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPD
Rv1074c|M.tuberculosis_H37Rv TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPD
Mflv_4356|M.gilvum_PYR-GCK QSVNRHCAGSLTAIGNAAAQIGSGMERVMIAGGVQSLSMTPLVNWRIPGP
Mvan_1988|M.vanbaalenii_PYR-1 QSVNRHCAGSLTAIGNASAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGP
MSMEG_2224|M.smegmatis_MC2_155 QSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGP
MAV_2127|M.avium_104 QSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGP
MMAR_4788|M.marinum_M LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQIDG-
MUL_0357|M.ulcerans_Agy99 LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQIDG-
: *: * .. : * : :* .::.* : : .
MLBr_01158|M.leprae_Br4923 ------------GYKYGDVTIVDH----LAYDGLHDVFTNQPMGALTEQR
MAB_0902|M.abscessus_ATCC_1997 WARPGEVVDTSLGWRFTNPRFAQMDAGIAADAGPETVKVTLAMGETAEEV
TH_0255|M.thermoresistible__bu -------------MPYG-PKVLER------YDNFG-----FNQGISAELI
Mb1103c|M.bovis_AF2122/97 TKNPLFDG----AQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENV
Rv1074c|M.tuberculosis_H37Rv TKNPLFDG----AQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENV
Mflv_4356|M.gilvum_PYR-GCK ------------ELKFEERWMPPT---HVETPDAPTKDMSITVGWNT---
Mvan_1988|M.vanbaalenii_PYR-1 ------------ELKFEERWMPPT---HVETPDAPTKDMSITVGWNT---
MSMEG_2224|M.smegmatis_MC2_155 ------------ELKFEERWMPPT---HVETPDAPTKDMSITVGWNT---
MAV_2127|M.avium_104 ------------ELKFEERWMPPT---HVEAPDAPTRDMSITVGWNT---
MMAR_4788|M.marinum_M --------------EWVD-WFPPT---HPDRPDAPNMDMSITVGWNA---
MUL_0357|M.ulcerans_Agy99 --------------EWVD-WFPPT---HPDRPDAPNMDMSITVGWNA---
. * :
MLBr_01158|M.leprae_Br4923 NDVEKFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQF
MAB_0902|M.abscessus_ATCC_1997 AVAEGISREDSDAFALRSHVRALAAQDAGRFVKEIVPIETVDGVVD----
TH_0255|M.thermoresistible__bu AERWNLSRTRLDEYSAQSHERAAAAQSSGAFKDQIVPVFTDDAVVT----
Mb1103c|M.bovis_AF2122/97 AIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVS---
Rv1074c|M.tuberculosis_H37Rv AIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVS---
Mflv_4356|M.gilvum_PYR-GCK AQAAGITREDMDAWAARSHQRAVAAQDDGKFLDEIVPLKVEQFDGSVIDF
Mvan_1988|M.vanbaalenii_PYR-1 AQAAGITREEMDVWAVRSHQRAVAAIDAGKFVDEIVPLKVTQFDGSVIDF
MSMEG_2224|M.smegmatis_MC2_155 AQAAGISREEMDAWAARSHQRAIAAIDAGKFLDEIVPLKVTQFDGSVIDF
MAV_2127|M.avium_104 AKTVGITREEMDAWAARSHQRAIAAIDAGKFVDEILPLKITQADGSVTEF
MMAR_4788|M.marinum_M AVAAGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTPHG-----LF
MUL_0357|M.ulcerans_Agy99 AVAAGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTPHG-----LF
.:* * :. :*: .* * . * * :: *: .
MLBr_01158|M.leprae_Br4923 TEDEGIRANTSAESLAGLKPAFRCGG--TITPGSASQISDGAATVVVMNK
MAB_0902|M.abscessus_ATCC_1997 -TDEGPRRQTTLAKLAALRPVFRAGG--IVTAGSSSPLSDGAAAVVLAGE
TH_0255|M.thermoresistible__bu -EDEGIRRGTTVEKLATLKPAFTENG--VIHAGNSSQISDGAAALLVMTA
Mb1103c|M.bovis_AF2122/97 -TDDGPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDGAAAVVITSD
Rv1074c|M.tuberculosis_H37Rv -TDDGPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDGAAAVVITSD
Mflv_4356|M.gilvum_PYR-GCK SVDEQPRRDTSVEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVEA
Mvan_1988|M.vanbaalenii_PYR-1 SVDESPRRDTTLEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVDA
MSMEG_2224|M.smegmatis_MC2_155 SVDEHPRRDTTVEKLAGLKVLHPEIEGFSITAGNSSGTNDAAAGVAVVDS
MAV_2127|M.avium_104 AVDEHPRRDTTVEKLAGLKVLHPEIEGFSITAGNSSGTNDAAAAVALVDR
MMAR_4788|M.marinum_M CVDEHPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDGAAVLTIASD
MUL_0357|M.ulcerans_Agy99 CVDEHPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDGAAVLTIASD
*: * *: .:: *: . : .*.:. .*.** : :
MLBr_01158|M.leprae_Br4923 EKAQQLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLD
MAB_0902|M.abscessus_ATCC_1997 RAVRQHGLTVRARVVAAASAGVAPNLMGLGPVPAVRKVVDRVGWRVDAID
TH_0255|M.thermoresistible__bu ETAVTLGLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIG
Mb1103c|M.bovis_AF2122/97 TKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDID
Rv1074c|M.tuberculosis_H37Rv TKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDID
Mflv_4356|M.gilvum_PYR-GCK DYAAANGLTVMAKVRSWGAVGVAPRDTGLGGVKVIGRVLDKAGLKPSDVT
Mvan_1988|M.vanbaalenii_PYR-1 DYAAANGLNVMAKVKAWGAVGVAPRDTGLGGVKVIGRVLDRAGLKPSDVA
MSMEG_2224|M.smegmatis_MC2_155 EYAAANGLNVMATVRAWGAVGVPPRDTGLGGVRVIGKVLDRAGLKPSDVA
MAV_2127|M.avium_104 EYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVLQRAGLSPDDVA
MMAR_4788|M.marinum_M RMAQGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALARGHLSISDVD
MUL_0357|M.ulcerans_Agy99 RMAQGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALARGHLSISDVD
. : : . . . :.: : :
MLBr_01158|M.leprae_Br4923 VVEINEAFAAVALASARELGIAPELVNVNGGAIAVGHPLGMSGARITLHV
MAB_0902|M.abscessus_ATCC_1997 ATEINEAFAAQTLAVLRRLGLDEDTVNADGGAIALGHPLGCSGARLIVTL
TH_0255|M.thermoresistible__bu VFEVNEAFAPVPLAWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTRM
Mb1103c|M.bovis_AF2122/97 LVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTL
Rv1074c|M.tuberculosis_H37Rv LVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTL
Mflv_4356|M.gilvum_PYR-GCK LWEINEAFASVPIAAVREYGIDEELVNFSGSGCSLGHPIAASGARMITTL
Mvan_1988|M.vanbaalenii_PYR-1 LWEINEAFASVPIAACKEYGIDEELVNFSGSGCSLGHPIAASGARMITTL
MSMEG_2224|M.smegmatis_MC2_155 LWEINEAFASVPIAACKEYGLDEELVNFNGSGCSLGHPIAASGARMVTTL
MAV_2127|M.avium_104 LWEINEAFASVPIAACREYGLDEEKVNFSGSGCSLGHPIAASGARMVTTL
MMAR_4788|M.marinum_M LFEINEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAATGARMLVTL
MUL_0357|M.ulcerans_Agy99 LFEINEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAATGARMLVTL
*:***** :. :* *.. ::***.. :** : :
MLBr_01158|M.leprae_Br4923 ALELARRGSGYGVAALCGAGGQGDALILRAV--
MAB_0902|M.abscessus_ATCC_1997 LNRLEREGASRGLATLCVGVGQGVAILIEAP--
TH_0255|M.thermoresistible__bu VHHMRANGIRYGLQTMCEGGGTANATVVELLA-
Mb1103c|M.bovis_AF2122/97 LNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv LNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Mflv_4356|M.gilvum_PYR-GCK IYELQRRGGGIGVAAMCAGGGQGGGVVIEV---
Mvan_1988|M.vanbaalenii_PYR-1 IYELQRRGGGIGVAAMCAGGGQGGGVVIEV---
MSMEG_2224|M.smegmatis_MC2_155 VYELQRRGGGIGVAAMCAGGGQGGAVVIEV---
MAV_2127|M.avium_104 TYELARRGGGIGVAAMCAGGGQGGAVVIEV---
MMAR_4788|M.marinum_M VHELRRRGGGIGLAAMCAGGGMGSATVIEVAAP
MUL_0357|M.ulcerans_Agy99 VHELRRRGGGIGLAAMCAGGGMGSATVIEVAAP
.: . *: ::* . * . . ::.