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MRETVIVGAVRTPVGKRNGGLSEQHAADLSAVVLNEVVERTGVDPDLVDDVVWGCVSQVGDQSSNIGRYA VLAAGWPEHIPGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGSARSTGMPYGPKVLA RYDDFSFNQGISAEMISAQWGLSRTRLDEYSAQSHERAAAAQDAGAFKDQIVPVFTEAADARSNSGGSVV TDDEGIRRGTTAEKLSGLKPAFTEDGVIHAGNSSQISDGAAALLVMTAENAVNLGLTPLVRYRAGAVTGA DPKLMLTGPIPATAKVLHKAGVTLDEVGVYEVNEAFAPVPLAWLADTGADEAKLNPLGGAIALGHPLGAS GAVLMTRMIHHMRDNGIRYGLQTMCEGGGTANATLVELVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2445 | - | - | 100% (390) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2116 | - | e-141 | 64.36% (390) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_3782 | - | e-105 | 51.49% (404) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3586c | fadA6 | 2e-98 | 47.85% (395) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv3556c | fadA6 | 2e-98 | 47.85% (395) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 3e-74 | 41.46% (410) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3455c | - | 1e-108 | 53.13% (399) | putative acyl-CoA thiolase |
| M. marinum M | MMAR_4740 | fadA6_2 | 0.0 | 83.76% (388) | acetyl-CoA acetyltransferase FadA6_2 |
| M. avium 104 | MAV_0909 | - | 0.0 | 84.58% (389) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_4833 | - | 0.0 | 81.23% (389) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0255 | - | 0.0 | 83.80% (389) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0971 | fadA6_3 | 1e-140 | 62.56% (390) | acetyl-CoA acetyltransferase FadA6_3 |
| M. vanbaalenii PYR-1 | Mvan_4206 | - | 0.0 | 91.28% (390) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3586c|M.bovis_AF2122/97 ----MTEAYVIDAVRTAVGKR--GGALAGIHPVDLGALAWRGLLDR-TDI
Rv3556c|M.tuberculosis_H37Rv ----MTEAYVIDAVRTAVGKR--GGALAGIHPVDLGALAWRGLLDR-TDI
Mflv_2445|M.gilvum_PYR-GCK ----MRETVIVGAVRTPVGKR--NGGLSEQHAADLSAVVLNEVVER-TGV
Mvan_4206|M.vanbaalenii_PYR-1 ----MRETVIVGAVRTPVGKR--NGGLSEQHAADLSAVVLNELVER-TGV
MMAR_4740|M.marinum_M MGGTGRETVIVEAVRTAVGKR--NGGLSGMHAADLSAVVLNELLER-AGV
MAV_0909|M.avium_104 ----MRETVIVEAVRTPVGKR--NGALSGMHAADLSAIVLNELVER-TGI
MSMEG_4833|M.smegmatis_MC2_155 ----MRETVIVEAVRTPVGKR--NGGLSGMHAADLSGLVLNALVEK-AGI
TH_0255|M.thermoresistible__bu ----MRETVIVEAVRTAVGKR--NGALADVHAADLSAVVLSELVER-AGI
MUL_0971|M.ulcerans_Agy99 ----MAEAVIVEAVRSPVGKR--NGALSGVHPADLSAQVLNGLADK-AGI
MAB_3455c|M.abscessus_ATCC_199 ----MRDAVIIDAVRTPVGKGKPGGSLSGVHPVDLHAHAIRELVER-AGI
MLBr_02162|M.leprae_Br4923 ---MSEEAFIYEAIRTPRGKQK-NGSLHEVKPVSLVVGLVEELRKRNPDL
:: : *:*:. ** .*.* :...* : .: ..:
Mb3586c|M.bovis_AF2122/97 DPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQ
Rv3556c|M.tuberculosis_H37Rv DPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQ
Mflv_2445|M.gilvum_PYR-GCK DPDLVDDVVWGCVSQVGDQSSNIGRYAVLAAGWPEHIPGTTVNRACGSSQ
Mvan_4206|M.vanbaalenii_PYR-1 DTDVIDDVIWGCVSQVGDQSSNIGRYSVLAAGWPEHIPGTTVNRACGSSQ
MMAR_4740|M.marinum_M GPEIVDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQ
MAV_0909|M.avium_104 GPELIDDVVWGCVSQVGDQSSNIGRYAVLAAGWPESIPGTTVNRACGSSQ
MSMEG_4833|M.smegmatis_MC2_155 GPDIIDDVIWGCVSQVGDQSSNIGRFAVLAAGWPEHIPGTTVNRACGSSQ
TH_0255|M.thermoresistible__bu DPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQ
MUL_0971|M.ulcerans_Agy99 DPEIVDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSSQ
MAB_3455c|M.abscessus_ATCC_199 DPALIDDVISGAVGQVGEQSSNTARWAALAAGLPETVPAVTVDRQCGSSQ
MLBr_02162|M.leprae_Br4923 DENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGL
. :.**: *.* * *. : .* : *:** * .. ::* *.*.
Mb3586c|M.bovis_AF2122/97 QAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNES
Rv3556c|M.tuberculosis_H37Rv QAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNES
Mflv_2445|M.gilvum_PYR-GCK QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGSARSTG--------MPYG
Mvan_4206|M.vanbaalenii_PYR-1 QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
MMAR_4740|M.marinum_M QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
MAV_0909|M.avium_104 QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------TPYG
MSMEG_4833|M.smegmatis_MC2_155 QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
TH_0255|M.thermoresistible__bu QALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
MUL_0971|M.ulcerans_Agy99 QSVHFAAAGVVAGHYDVVVAGGVESMSRTPMGSSLANGG-------RPYS
MAB_3455c|M.abscessus_ATCC_199 QAIHFAAQGVIAGAYDVVIASGIESMSRVPMGSQ-SLG-------KDFFG
MLBr_02162|M.leprae_Br4923 EAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDG-----------GAMG
::: .. : :* *:::*.*:: **: *:.: .
Mb3586c|M.bovis_AF2122/97 KQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAG
Rv3556c|M.tuberculosis_H37Rv KQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAG
Mflv_2445|M.gilvum_PYR-GCK PKVLARYDDFSFNQGISAEMISAQWGLSRTRLDEYSAQSHERAAAAQDAG
Mvan_4206|M.vanbaalenii_PYR-1 PKVFARYDDFSFNQGISAEMISQKWGFSRTQLDEYSALSHERAAAAQDAG
MMAR_4740|M.marinum_M PKVLARYDNFSFNQGLSAELIAKKWGFSRDRLDEYSALSHQRAAAAQDRG
MAV_0909|M.avium_104 PKVLARYDDFSFNQGLSAEMIAKKWGFSRTQLDEYSVRSHERAAAAQDAG
MSMEG_4833|M.smegmatis_MC2_155 PKVIDRYRDFSFNQGISAEMIAQKWGFTRTQLDEYSVASHERAAAAQDSG
TH_0255|M.thermoresistible__bu PKVLERYDNFGFNQGISAELIAERWNLSRTRLDEYSAQSHERAAAAQSSG
MUL_0971|M.ulcerans_Agy99 QTFLERYDGRIPNQGLGAEMIAEQWGLSRTMLDEFSLMSHEKAAAAQDSG
MAB_3455c|M.abscessus_ATCC_199 SEVARRYPEGLVPQGISAELIAAKWNLSREQLDTFAAESHRRAAQAWSEG
MLBr_02162|M.leprae_Br4923 LDPATNYDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGG
.* * .:::*: .::* :: :: *:.:* * *
Mb3586c|M.bovis_AF2122/97 HFENEIITVETESGP---------FRVDEGPRE-SSLEKMAGLQP-LVEG
Rv3556c|M.tuberculosis_H37Rv HFENEIITVETESGP---------FRVDEGPRE-SSLEKMAGLQP-LVEG
Mflv_2445|M.gilvum_PYR-GCK AFKDQIVPVFTEAADARSNSGGSVVTDDEGIRRGTTAEKLSGLKPAFTED
Mvan_4206|M.vanbaalenii_PYR-1 AFKDQIVPVFTD---------GGIVTDDEGIRRGTTVEKLAGLKPAFTED
MMAR_4740|M.marinum_M AFTDQIVPVFPAAAT--------VVDTDEGVRRGTTVEKLAGLKPAFVED
MAV_0909|M.avium_104 AFTDQIVPVFVEDAEN------KVVAADEGVRRGSSVEKLAALKPAFAED
MSMEG_4833|M.smegmatis_MC2_155 AFETQMITVFPDDGDP--------VVADEGVRRGTTVDKLANLKPAFKDD
TH_0255|M.thermoresistible__bu AFKDQIVPVFTDDA---------VVTEDEGIRRGTTVEKLATLKPAFTEN
MUL_0971|M.ulcerans_Agy99 AFDDQIVGIKDQDGNP--------VLKDEGIRRGTPMEKMAALKPAFKED
MAB_3455c|M.abscessus_ATCC_199 RFARDVVPIKAPDVNG----DLVEVSTDESVRPSTTVEVLAGLKPAFRNE
MLBr_02162|M.leprae_Br4923 YFAKSVVPVRDQNGLL-------ILDHDEHMRPDTSKEGLAKLKPAFEGL
* .:: : . ** * :. : :: *:* :
Mb3586c|M.bovis_AF2122/97 G---------------------RLTAAMASQISDGASAVLLASERAVKDH
Rv3556c|M.tuberculosis_H37Rv G---------------------RLTAAMASQISDGASAVLLASERAVKDH
Mflv_2445|M.gilvum_PYR-GCK G---------------------VIHAGNSSQISDGAAALLVMTAENAVNL
Mvan_4206|M.vanbaalenii_PYR-1 G---------------------VIHAGNSSQISDGAAALLVTTMENAVNL
MMAR_4740|M.marinum_M G---------------------LIHAGNSSQISDGSAALLVTTSEMALEL
MAV_0909|M.avium_104 G---------------------VIHAGNSSQISDGAAALLVTTAEMAVEL
MSMEG_4833|M.smegmatis_MC2_155 G---------------------VIHAGNSSQISDGAAALLVMTAENAVAM
TH_0255|M.thermoresistible__bu G---------------------VIHAGNSSQISDGAAALLVMTAETAVTL
MUL_0971|M.ulcerans_Agy99 G---------------------VIHAGNSSQISDGSAALLFMSAEKAKSL
MAB_3455c|M.abscessus_ATCC_199 LWQ-----------QRFPGLDWKVTAGNSSPINDGASAVLITSSETAHRL
MLBr_02162|M.leprae_Br4923 AAMGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQ
.. :* * **:: ::. :
Mb3586c|M.bovis_AF2122/97 GLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINE
Rv3556c|M.tuberculosis_H37Rv GLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINE
Mflv_2445|M.gilvum_PYR-GCK GLTPLVRYRAGAVTGADPKLMLTGPIPATAKVLHKAGVTLDEVGVYEVNE
Mvan_4206|M.vanbaalenii_PYR-1 GLTPLVRYRAGAVTGADPRLMLTGPIPATEKVLHKAGVTLDEVGVYEVNE
MMAR_4740|M.marinum_M GLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLGKSGVSLDEVGVFEVNE
MAV_0909|M.avium_104 GLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSDVGVFEVNE
MSMEG_4833|M.smegmatis_MC2_155 GLSPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVRLDEIGVFEVNE
TH_0255|M.thermoresistible__bu GLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEVNE
MUL_0971|M.ulcerans_Agy99 GMKPIAKVHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEVNE
MAB_3455c|M.abscessus_ATCC_199 GLTPRARVHSVAVVGDDPLYMLTGIIPATAKVLDRAGLSLADIDAFEVNE
MLBr_02162|M.leprae_Br4923 GLTPRARMVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNE
*: * .: . ** ***. *** .* ::*: : ::. *:**
Mb3586c|M.bovis_AF2122/97 AFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELER
Rv3556c|M.tuberculosis_H37Rv AFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELER
Mflv_2445|M.gilvum_PYR-GCK AFAPVPLAWLADTGADEAKLNPLGGAIALGHPLGASGAVLMTRMIHHMRD
Mvan_4206|M.vanbaalenii_PYR-1 AFAPVPLAWLADTGADAAKLNPLGGAIALGHPLGASGAVLMTRMIHHMRD
MMAR_4740|M.marinum_M AFAPVPLAWLAETGADPGRLNPLGGAIALGHPLGASGAVLMTRMVHHMRD
MAV_0909|M.avium_104 AFAPVPLAWLAETGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRD
MSMEG_4833|M.smegmatis_MC2_155 AFAPVPLAWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTRMINHMRD
TH_0255|M.thermoresistible__bu AFAPVPLAWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTRMVHHMRA
MUL_0971|M.ulcerans_Agy99 AFAPVPLAWLCDIGADENRLNPNGGAIALGHPLGGSGARVMTTLLYHMRD
MAB_3455c|M.abscessus_ATCC_199 AFASVVLAWQAETGADLSKVNVNGGATAIGHPLGASGGRLMTTLVSVLEQ
MLBr_02162|M.leprae_Br4923 AFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELER
***.* : : : : * *** *:*****.:*. :: : :.
Mb3586c|M.bovis_AF2122/97 IGGRYGLQTMCEGGGTANVTIIERL-
Rv3556c|M.tuberculosis_H37Rv IGGRYGLQTMCEGGGTANVTIIERL-
Mflv_2445|M.gilvum_PYR-GCK NGIRYGLQTMCEGGGTANATLVELVK
Mvan_4206|M.vanbaalenii_PYR-1 NGIRYGLQTMCEGGGTANATLIELVK
MMAR_4740|M.marinum_M NGIRYGLQTMCEGGGTANATLVELLS
MAV_0909|M.avium_104 NGIRYGLQTMCEGGGTANATLVELVS
MSMEG_4833|M.smegmatis_MC2_155 NGIQYGLQTMCEGGGTANATIVELLG
TH_0255|M.thermoresistible__bu NGIRYGLQTMCEGGGTANATVVELLA
MUL_0971|M.ulcerans_Agy99 NGIRYGLQTMCEGGGQANATVLELL-
MAB_3455c|M.abscessus_ATCC_199 GGGRYGLQTMCEAGGLANATILERL-
MLBr_02162|M.leprae_Br4923 CNARRALVTLCIGAGMGVATIIERV-
. : .* *:* ..* . .*::* :