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MPTPVIVGAARTAIGRSFKGTLVNTPPETLITTVLPEVVRRSGVDPADIDDIIFAESHYGGGDLARYAAD AVGLQHVPGQSVNRHCAGSLTAIGNASAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGPELKFEERWMPP THVETPDAPTKDMSITVGWNTAQAAGITREEMDVWAVRSHQRAVAAIDAGKFVDEIVPLKVTQFDGSVID FSVDESPRRDTTLEKLAGLKVLHPEIEGFSITAGNASGTNDAAAGVALVDADYAAANGLNVMAKVKAWGA VGVAPRDTGLGGVKVIGRVLDRAGLKPSDVALWEINEAFASVPIAACKEYGIDEELVNFSGSGCSLGHPI AASGARMITTLIYELQRRGGGIGVAAMCAGGGQGGGVVIEV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1988 | - | - | 100% (391) | acetyl-CoA acetyltransferases |
| M. vanbaalenii PYR-1 | Mvan_4677 | - | 3e-56 | 35.21% (409) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 2e-54 | 35.82% (402) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 3e-57 | 37.05% (413) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4356 | - | 0.0 | 94.12% (391) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 3e-57 | 37.05% (413) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 4e-50 | 34.67% (398) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0902 | - | 2e-66 | 39.56% (407) | beta-ketoadipyl-CoA thiolase |
| M. marinum M | MMAR_4788 | - | 1e-110 | 53.45% (391) | beta-ketoacyl CoA thiolase |
| M. avium 104 | MAV_2127 | - | 0.0 | 86.45% (391) | acetyl-CoA C-acyltransferase |
| M. smegmatis MC2 155 | MSMEG_2224 | - | 0.0 | 93.61% (391) | acetyl-CoA C-acyltransferase |
| M. thermoresistible (build 8) | TH_0166 | fadA6 | 3e-53 | 36.27% (397) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_0357 | - | 1e-110 | 53.45% (391) | beta-ketoacyl CoA thiolase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01158|M.leprae_Br4923 ----------------MTTSVIVTGARTPIGKLM-GSLKDFSASDLGAIT
MAB_0902|M.abscessus_ATCC_1997 ---------------MVEQVFVVDGVRTAQGRYG-GALASVRPDDLAARV
TH_0166|M.thermoresistible__bu --------------MAMTEAYIVDAVRTPVGKRN-GGLSGAHPADMAAHV
Mb1103c|M.bovis_AF2122/97 ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Rv1074c|M.tuberculosis_H37Rv ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Mvan_1988|M.vanbaalenii_PYR-1 ----------------MPTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
Mflv_4356|M.gilvum_PYR-GCK ----------------MSTPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MSMEG_2224|M.smegmatis_MC2_155 -------------MKIMPKPVIVGAARTAIGRSFKGTLVNTPPETLITTV
MAV_2127|M.avium_104 ----------------MGTPVIVGAVRTAIGRSFKGTLVNTPPETLITAV
MMAR_4788|M.marinum_M ----------------MPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
MUL_0357|M.ulcerans_Agy99 MCGRLLASAPPKWRKPVPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
: :* *:. * * * . . :
MLBr_01158|M.leprae_Br4923 IAAALKKA-NVAPSIVQYVIIGQVLTAGAG-QMPARQAAVAAGIGWDVPA
MAB_0902|M.abscessus_ATCC_1997 IAEVVARA-GVPADAIGEVILGAANQAGEDNRNVARMAALLAGLPNTVPG
TH_0166|M.thermoresistible__bu IKTLVGRH-DFDPAAIDDVIFGCLDNIGSQAGDIARTAALAAGLPESVPG
Mb1103c|M.bovis_AF2122/97 VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPG
Rv1074c|M.tuberculosis_H37Rv VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPG
Mvan_1988|M.vanbaalenii_PYR-1 LPEVVRRS-GVDPADIDDIIFAESHYGGGD---LARYAADAVGL-QHVPG
Mflv_4356|M.gilvum_PYR-GCK LPEVIRRS-GVDPADIDDIIFAESHYGGGD---LARYAADAIGL-QHVPG
MSMEG_2224|M.smegmatis_MC2_155 LPEIVRRS-GVDPADIDDIIFAESHYGGGD---LARYAADATGL-QHVPG
MAV_2127|M.avium_104 LPEVIRRS-GVDPAAIDDIIFAESHYGGGD---LARYAAAATGL-EDIPG
MMAR_4788|M.marinum_M VSEAT--A-DLDPGQIDDVILGEGLYGGGV---IARHAAITAGL-GHVPG
MUL_0357|M.ulcerans_Agy99 VSEAT--A-DLDPGQIDDVILGEGLYGGGV---IARHAAITAGL-GHVPG
: . . : :::. * ** .* * :*.
MLBr_01158|M.leprae_Br4923 LTINKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRS-
MAB_0902|M.abscessus_ATCC_1997 YTVNRLCASGLTAISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAP
TH_0166|M.thermoresistible__bu VTIDRQCGSAQQAVHFAAQGVMSGTVDLIVAGGVQKMSQFPILSAFAAG-
Mb1103c|M.bovis_AF2122/97 TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWP-
Rv1074c|M.tuberculosis_H37Rv TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWP-
Mvan_1988|M.vanbaalenii_PYR-1 QSVNRHCAGSLTAIGNASAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGP
Mflv_4356|M.gilvum_PYR-GCK QSVNRHCAGSLTAIGNAAAQIGSGMERVMIAGGVQSLSMTPLVNWRIPGP
MSMEG_2224|M.smegmatis_MC2_155 QSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGP
MAV_2127|M.avium_104 QSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGP
MMAR_4788|M.marinum_M LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQIDG-
MUL_0357|M.ulcerans_Agy99 LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSASTSPRPRMQIDG-
: :: * .. : * : :* .::.* :. : .
MLBr_01158|M.leprae_Br4923 ------------GYKYGDVTIVDH----LAYDGLHDVFTNQ-------PM
MAB_0902|M.abscessus_ATCC_1997 WARPGEVVDTSLGWRFTNPRFAQMDAGIAADAGPETVKVTL-------AM
TH_0166|M.thermoresistible__bu -----------EPYGATDP--------WTGCEGWQARYGDQ-------EI
Mb1103c|M.bovis_AF2122/97 ----------DTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAM
Rv1074c|M.tuberculosis_H37Rv ----------DTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAM
Mvan_1988|M.vanbaalenii_PYR-1 -----------------ELKFEERWMPPTHVETPDAPTKDMS-----ITV
Mflv_4356|M.gilvum_PYR-GCK -----------------ELKFEERWMPPTHVETPDAPTKDMS-----ITV
MSMEG_2224|M.smegmatis_MC2_155 -----------------ELKFEERWMPPTHVETPDAPTKDMS-----ITV
MAV_2127|M.avium_104 -----------------ELKFEERWMPPTHVEAPDAPTRDMS-----ITV
MMAR_4788|M.marinum_M -------------------EWVD-WFPPTHPDRPDAPNMDMS-----ITV
MUL_0357|M.ulcerans_Agy99 -------------------EWVD-WFPPTHPDRPDAPNMDMS-----ITV
. :
MLBr_01158|M.leprae_Br4923 GAL--TEQRNDVEKFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIP
MAB_0902|M.abscessus_ATCC_1997 GET--AEEVAVAEGISREDSDAFALRSHVRALAAQDAGRFVKEIVPIETV
TH_0166|M.thermoresistible__bu SQFRGAEMIAEHWKLSREDNEKFALESHRRAVAAIEAGYFDKEITPYADA
Mb1103c|M.bovis_AF2122/97 GQT--AENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLP
Rv1074c|M.tuberculosis_H37Rv GQT--AENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLP
Mvan_1988|M.vanbaalenii_PYR-1 GWN-----TAQAAGITREEMDVWAVRSHQRAVAAIDAGKFVDEIVPLKVT
Mflv_4356|M.gilvum_PYR-GCK GWN-----TAQAAGITREDMDAWAARSHQRAVAAQDDGKFLDEIVPLKVE
MSMEG_2224|M.smegmatis_MC2_155 GWN-----TAQAAGISREEMDAWAARSHQRAIAAIDAGKFLDEIVPLKVT
MAV_2127|M.avium_104 GWN-----TAKTVGITREEMDAWAARSHQRAIAAIDAGKFVDEILPLKIT
MMAR_4788|M.marinum_M GWN-----AAVAAGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTP
MUL_0357|M.ulcerans_Agy99 GWN-----AAVAAGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTP
. .:* : : :. .*: .* * . * * *: *
MLBr_01158|M.leprae_Br4923 QSKGDSLQFTEDEGIRANTSAESLAGLKPAFRCGG--TITPGSASQISDG
MAB_0902|M.abscessus_ATCC_1997 DGVVD-----TDEGPRRQTTLAKLAALRPVFRAGG--IVTAGSSSPLSDG
TH_0166|M.thermoresistible__bu T---------VDEGPRPDTSLEKMASL-PTLIEGG--VLTAAVASQISDG
Mb1103c|M.bovis_AF2122/97 DGTTVS----TDDGPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDG
Rv1074c|M.tuberculosis_H37Rv DGTTVS----TDDGPRPGTTYEKVSELKPAFRPNG--TVTAGNACPLNDG
Mvan_1988|M.vanbaalenii_PYR-1 QFDGSVIDFSVDESPRRDTTLEKLAGLKVLHPEIEGFSITAGNASGTNDA
Mflv_4356|M.gilvum_PYR-GCK QFDGSVIDFSVDEQPRRDTSVEKLAGLKVLHPEIEGFSITAGNASGTNDA
MSMEG_2224|M.smegmatis_MC2_155 QFDGSVIDFSVDEHPRRDTTVEKLAGLKVLHPEIEGFSITAGNSSGTNDA
MAV_2127|M.avium_104 QADGSVTEFAVDEHPRRDTTVEKLAGLKVLHPEIEGFSITAGNSSGTNDA
MMAR_4788|M.marinum_M HG-----LFCVDEHPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDG
MUL_0357|M.ulcerans_Agy99 HG-----LFCVDEHPRRDTTMEKLAALKPLHPEIDGFSITAGNACGANDG
*: * *: .:: * :*.. :. .*.
MLBr_01158|M.leprae_Br4923 AATVVVMNKEKAQQLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDR
MAB_0902|M.abscessus_ATCC_1997 AAAVVLAGERAVRQHGLTVRARVVAAASAGVAPNLMGLGPVPAVRKVVDR
TH_0166|M.thermoresistible__bu AAALLVASKDAVDRFNLTPRARIHHMSVRGADPVMMLTAPIPATQHALKR
Mb1103c|M.bovis_AF2122/97 AAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALER
Rv1074c|M.tuberculosis_H37Rv AAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALER
Mvan_1988|M.vanbaalenii_PYR-1 AAGVALVDADYAAANGLNVMAKVKAWGAVGVAPRDTGLGGVKVIGRVLDR
Mflv_4356|M.gilvum_PYR-GCK AAGVALVEADYAAANGLTVMAKVRSWGAVGVAPRDTGLGGVKVIGRVLDK
MSMEG_2224|M.smegmatis_MC2_155 AAGVAVVDSEYAAANGLNVMATVRAWGAVGVPPRDTGLGGVRVIGKVLDR
MAV_2127|M.avium_104 AAAVALVDREYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVLQR
MMAR_4788|M.marinum_M AAVLTIASDRMAQGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALAR
MUL_0357|M.ulcerans_Agy99 AAVLTIASDRMAQGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALAR
** : : . : : . . . :.: :
MLBr_01158|M.leprae_Br4923 EGISVEQLDVVEINEAFAAVALASARELGIAPELVNVNGGAIAVGHPLGM
MAB_0902|M.abscessus_ATCC_1997 VGWRVDAIDATEINEAFAAQTLAVLRRLGLDEDTVNADGGAIALGHPLGC
TH_0166|M.thermoresistible__bu AGMSIDDIDAVEINEAFAPVVLAWLAELGADPARVNPNGGAIALGHPIGC
Mb1103c|M.bovis_AF2122/97 AGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGM
Rv1074c|M.tuberculosis_H37Rv AGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGM
Mvan_1988|M.vanbaalenii_PYR-1 AGLKPSDVALWEINEAFASVPIAACKEYGIDEELVNFSGSGCSLGHPIAA
Mflv_4356|M.gilvum_PYR-GCK AGLKPSDVTLWEINEAFASVPIAAVREYGIDEELVNFSGSGCSLGHPIAA
MSMEG_2224|M.smegmatis_MC2_155 AGLKPSDVALWEINEAFASVPIAACKEYGLDEELVNFNGSGCSLGHPIAA
MAV_2127|M.avium_104 AGLSPDDVALWEINEAFASVPIAACREYGLDEEKVNFSGSGCSLGHPIAA
MMAR_4788|M.marinum_M GHLSISDVDLFEINEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAA
MUL_0357|M.ulcerans_Agy99 GHLSISDVDLFEINEAFASMCVATVKLLELDADRVNVSGSGCSLGHPVAA
: ******* :. :* .*.. ::***..
MLBr_01158|M.leprae_Br4923 SGARITLHVALELARRGSGYGVAALCGAGGQGDALILRAV--
MAB_0902|M.abscessus_ATCC_1997 SGARLIVTLLNRLEREGASRGLATLCVGVGQGVAILIEAP--
TH_0166|M.thermoresistible__bu TGARLMTSLLHHLERTGGRYGLQTMCEGGGQANVTIIERL--
Mb1103c|M.bovis_AF2122/97 TGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv TGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Mvan_1988|M.vanbaalenii_PYR-1 SGARMITTLIYELQRRGGGIGVAAMCAGGGQGGGVVIEV---
Mflv_4356|M.gilvum_PYR-GCK SGARMITTLIYELQRRGGGIGVAAMCAGGGQGGGVVIEV---
MSMEG_2224|M.smegmatis_MC2_155 SGARMVTTLVYELQRRGGGIGVAAMCAGGGQGGAVVIEV---
MAV_2127|M.avium_104 SGARMVTTLTYELARRGGGIGVAAMCAGGGQGGAVVIEV---
MMAR_4788|M.marinum_M TGARMLVTLVHELRRRGGGIGLAAMCAGGGMGSATVIEVAAP
MUL_0357|M.ulcerans_Agy99 TGARMLVTLVHELRRRGGGIGLAAMCAGGGMGSATVIEVAAP
:***: : .* . *: ::* . * . ::.