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TGKLEGKVAFITGAARGQGRAHAIAMAREGADIIAVDICRDIPSNPYPLATPDDLAETERSVKETGRRVV ARVADVRERHELREAVEAGVVDFGKIDIVVANAGILPMAMGNPDPMGFVDASDVDLVGVMNTVAVAIPHL PDGASVIVTGSTAGMIRGTTTSPDMGPGGAGYGWSKRIVIEYIEEMSLQLAPRMIRVNGIHPTNCNTHLL QNEGMYGVFRPDLKMEGKTPTREDAEPLFSLFQAMPIPYIEPEDMANLGVFLASDDSRYITGQQIRVDAG SLLKWPNGLGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4148 | - | - | 100% (292) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2500 | - | 8e-85 | 54.74% (285) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2430 | - | 2e-61 | 45.52% (290) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 2e-57 | 45.42% (284) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 2e-57 | 45.42% (284) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01094 | - | 6e-13 | 29.44% (214) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3081 | - | 6e-55 | 46.10% (282) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 1e-61 | 44.98% (289) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2946 | - | 1e-85 | 55.44% (294) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4801 | - | 4e-84 | 54.04% (285) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_4131 | - | 3e-83 | 53.33% (285) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3392 | fabG | 3e-54 | 41.67% (288) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_2006 | - | 1e-84 | 55.48% (283) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2771|M.bovis_AF2122/97 ---MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIAS-
Rv2750|M.tuberculosis_H37Rv ---MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIAS-
MUL_3392|M.ulcerans_Agy99 MSRPLDGPLSGRVAFITGAARGQGRAHALRLARDGADVIAVDLCDQIAS-
MAB_3081|M.abscessus_ATCC_1997 -----MGKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPS-
MMAR_4754|M.marinum_M MTEQLGGRVAGKVAFITGAARGQGRSHAVRLAQEGADIIAVDVCKPIVEN
MSMEG_4801|M.smegmatis_MC2_155 -MGSAEGRVAGKVAFITGAARGQGRSHAVRLAEEGADIIAVDLCQDIDS-
TH_4131|M.thermoresistible__bu -----VGRVEGKVAFITGAARGQGRSHAVRLAEEGADIIAVDICADIET-
MAV_2946|M.avium_104 -----MGRVTGKVAVISGAARGQGRSHARMLAAEGADIIAVDLCADIET-
Mvan_2006|M.vanbaalenii_PYR-1 -----MGKLDNKVAVVSGAARGQGRSHAVSLAAEGAHIIALDICADLEG-
Mflv_4148|M.gilvum_PYR-GCK ----MTGKLEGKVAFITGAARGQGRAHAIAMAREGADIIAVDICRDIPS-
MLBr_01094|M.leprae_Br4923 -----MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDG-----
. .:**.::**. * *:: * :* .** : *:
Mb2771|M.bovis_AF2122/97 VPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFG
Rv2750|M.tuberculosis_H37Rv VPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFG
MUL_3392|M.ulcerans_Agy99 VPYPLGTAEELATTVKLVEDTGARIVASQADVRDREALAAALQAGIDELG
MAB_3081|M.abscessus_ATCC_1997 VEYPMATTEDLDLTVKEVDALGRAISAHETDVRDREALQAAFDAGVHDLG
MMAR_4754|M.marinum_M TTIPASTPEDLAETADLVKGHNRRIFTAEADVRDYDALKAAVDAGVDELG
MSMEG_4801|M.smegmatis_MC2_155 IGYSLATPEDLEETARYVEKAGRRIVTAQADVRDAAQLKEALERGVSELG
TH_4131|M.thermoresistible__bu IGYSMAKPEDLEETAKLVEKTGRGVYTAQADVRNADQLRTALEGGLKEFG
MAV_2946|M.avium_104 NEYPLARPEDLDETARLVEKEGQRAITAVADVRDRVVLSAAIDAGVAEFG
Mvan_2006|M.vanbaalenii_PYR-1 NTYPLSRPEDLDETARLAEKEGVRVHTAIVDVRERAAVWKAVADGVDALG
Mflv_4148|M.gilvum_PYR-GCK NPYPLATPDDLAETERSVKETGRRVVARVADVRERHELREAVEAGVVDFG
MLBr_01094|M.leprae_Br4923 --------EGLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFG
: * * . . : ** : . :*
Mb2771|M.bovis_AF2122/97 RLDIVVANAGI----AMMQ--AGDDGWRDVIDVNLTGVFHTVQVAIPTLI
Rv2750|M.tuberculosis_H37Rv RLDIVVANAGI----AMMQ--AGDDGWRDVIDVNLTGVFHTVQVAIPTLI
MUL_3392|M.ulcerans_Agy99 QVDIVVANAGI----APMQ--SGDDGWRDVIDVNLSGAYYTVEVAIPTMI
MAB_3081|M.abscessus_ATCC_1997 PVDIVVANAGI----ATLTPECGDDGWRDVLDVNLTGVYHTIEVARPSMV
MMAR_4754|M.marinum_M RLDIIVANAGIGNGGATLD-KTSEHDWQEMIDVNLSGVWKSVKAAVPHLI
MSMEG_4801|M.smegmatis_MC2_155 KLDIVVAQAGIA---AMKGNPP-LQAWTDGINTNLVGTINAIQVALPHLS
TH_4131|M.thermoresistible__bu KVDIVVAQAGVA---GMKGQPP-LQAWTDVMNTNLVGTMNAIQVALPHLK
MAV_2946|M.avium_104 HLDIVVANAGIC---PLTAGLP-PQAFADAVDVDLGGVLNLVHASLKHLR
Mvan_2006|M.vanbaalenii_PYR-1 RLDIVVANAGIC---PMGRGQT-IQSWSDAIDTDLVGVFNVIQASLPHVN
Mflv_4148|M.gilvum_PYR-GCK KIDIVVANAGIL---PMAMGNPDPMGFVDASDVDLVGVMNTVAVAIPHLP
MLBr_01094|M.leprae_Br4923 KVNQIYNNAGIA--FTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLI
:: : :**: :.: *. . :
Mb2771|M.bovis_AF2122/97 EQGTGGSIVLISSAAGLVGIGSSDP--------GSLGYAAAKHGVVGLMR
Rv2750|M.tuberculosis_H37Rv EQGTGGSIVLISSAAGLVGIGSSDP--------GSLGYAAAKHGVVGLMR
MUL_3392|M.ulcerans_Agy99 EQGRGGSIVLISSAAGLVGISSADA--------GAIGYVASKHALVGLMR
MAB_3081|M.abscessus_ATCC_1997 QRGAGGSIVLTSSVAGLTGMVMDNP--------GGLAYTAAKHGLVGLMR
MMAR_4754|M.marinum_M AGGNGGSIVLTSSVGGMKAYPHCG------------NYVAAKHGVVGLMR
MSMEG_4801|M.smegmatis_MC2_155 ---EGASIVATASAAALMDAHNKPNPG---ADPGGMGYMVSKRMISEYVH
TH_4131|M.thermoresistible__bu ---EGASIIATASAAALMDAHQKPNPG---ADPGGMAYMSSKRLLAQYVH
MAV_2946|M.avium_104 ---AGASIIVIGSNAAFMSSLNTSGAGSGIGGPGGAGYAFAKLAAAHYVN
Mvan_2006|M.vanbaalenii_PYR-1 ---DGASIIATGSLAAQLGSATNQ-------GPGGSAYSLAKQVVAHYVN
Mflv_4148|M.gilvum_PYR-GCK ---DGASVIVTGSTAGMIRGTTTSPDM----GPGGAGYGWSKRIVIEYIE
MLBr_01094|M.leprae_Br4923 SSGDGHVINIS-SVFGLFSVP------------GQAAYNSAKFAVRGFTE
* : * . * :* .
Mb2771|M.bovis_AF2122/97 AY--ANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLT--T----ADMDA
Rv2750|M.tuberculosis_H37Rv AY--ANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLT--T----ADMDA
MUL_3392|M.ulcerans_Agy99 VY--ANLLAPHSIRVNSLHPSGVDPPMINNEFIRHWLADLV----AETGS
MAB_3081|M.abscessus_ATCC_1997 SY--ANMLAPHNIRVNTIHPSGVATPMLINPVTEKLFAD------GSPEG
MMAR_4754|M.marinum_M SF--AVELGQHMIRVNSVHPTHVRTPMLHNEGTFKMFRP-D----LENPG
MSMEG_4801|M.smegmatis_MC2_155 YL--ATELTPLGIRANVIHPTNCNTDMLQSEPMYRSFRPDL-----EHPT
TH_4131|M.thermoresistible__bu DL--ATELAVRGIRANVIHPTNCNTDMLQSEPMYRSFRPDL-----ENPT
MAV_2946|M.avium_104 DF--ALALAPFSIRMNAVHPTNVNTDMLHSPPMYRAFRPDL-----PAPT
Mvan_2006|M.vanbaalenii_PYR-1 DL--SIQLAKRMIRVNAIHPTNVNTDMLHNEGLYRVFRPDL-----KEPT
Mflv_4148|M.gilvum_PYR-GCK EM--SLQLAPRMIRVNGIHPTNCNTHLLQNEGMYGVFRPDLKME-GKTPT
MLBr_01094|M.leprae_Br4923 ALREEMALAGRPVNVTTVYPGGIKTAIARNATAAEGLDVSKIASRFDTWV
* :. . ::* . : . :
Mb2771|M.bovis_AF2122/97 PHNLG------NALPVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGF
Rv2750|M.tuberculosis_H37Rv PHNLG------NALPVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGF
MUL_3392|M.ulcerans_Agy99 GPGAG------NALPVQILQADDIAGALAWLVSDEARYITGVALPVDAGC
MAB_3081|M.abscessus_ATCC_1997 MSDTG------NALPVVLMEPEDMANTVAWLVSEDARYITGVALPVDAGF
MMAR_4754|M.marinum_M PDDMAPICQLFHTLPIPWVEAEDISNAVLFLASDESRYITGVTLPVDAGG
MSMEG_4801|M.smegmatis_MC2_155 RADAEPVFYVQQAMKVPWVEPSDISNAVLWLASDESRFVTGMQLRVDAGG
TH_4131|M.thermoresistible__bu RADAEPVFGVQQAMRVPYVEPEDISNAVLWLASEEARYVTGMQLRVDAGG
MAV_2946|M.avium_104 REDAEPVFPLVQAMPVPYVEPEDISEAVLFLASDAARYITGQQLRVDAGG
Mvan_2006|M.vanbaalenii_PYR-1 REEAEEAFPAMQAMPIPYIEPRDVSNAVVFLAGDDSRYITGTQLRIDAGG
Mflv_4148|M.gilvum_PYR-GCK REDAEPLFSLFQAMPIPYIEPEDMANLGVFLASDDSRYITGQQIRVDAGS
MLBr_01094|M.leprae_Br4923 AHTSPQHAARIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQ
: :. : :.. *: * .
Mb2771|M.bovis_AF2122/97 VNKR------
Rv2750|M.tuberculosis_H37Rv VNKR------
MUL_3392|M.ulcerans_Agy99 VNKR------
MAB_3081|M.abscessus_ATCC_1997 TNRR------
MMAR_4754|M.marinum_M CLK-------
MSMEG_4801|M.smegmatis_MC2_155 YLKWYDYHV-
TH_4131|M.thermoresistible__bu YLKWYDYHV-
MAV_2946|M.avium_104 FLKVKPWSGG
Mvan_2006|M.vanbaalenii_PYR-1 YVKAVPWKG-
Mflv_4148|M.gilvum_PYR-GCK LLKWPNGLGG
MLBr_01094|M.leprae_Br4923 VASRLILNQR