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MGRKGWGGVPPTDDAEARDRILRAALASIERRGPRLTTLTEVAADLGITRPTIYRHFGSTDELLAAAAEI ALDHWTARIGRMAVRLEDATDFLVEAVAYLIEKLPHEPLLATMLETDRTRVMSRQMVMPAAVRRSREMLE NTRIDWASAGFGGSRMDDLVEFLLRMIQSMVIAPPDPPRDPVALREYLRLWIGPAMAAGAGPVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4113 | - | - | 100% (204) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4096 | - | 4e-59 | 54.00% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1606 | - | 9e-33 | 40.93% (193) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2274c | - | 4e-07 | 28.44% (109) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv2250c | - | 5e-07 | 28.44% (109) | transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 5e-05 | 27.37% (95) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 8e-28 | 32.65% (196) | putative regulatory protein TetR |
| M. marinum M | MMAR_0226 | - | 2e-26 | 32.99% (197) | hypothetical protein MMAR_0226 |
| M. avium 104 | MAV_1115 | - | 2e-34 | 36.00% (200) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5854 | - | 1e-33 | 39.29% (196) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1262 | - | 3e-34 | 40.20% (199) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4888 | - | 2e-20 | 32.10% (162) | hypothetical protein MUL_4888 |
| M. vanbaalenii PYR-1 | Mvan_2232 | - | 4e-86 | 77.94% (204) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2274c|M.bovis_AF2122/97 --------------MLSM--------------------------------
Rv2250c|M.tuberculosis_H37Rv --------------MLSM--------------------------------
Mflv_4113|M.gilvum_PYR-GCK --------MGRKGWGGVP--------------------------------
Mvan_2232|M.vanbaalenii_PYR-1 --------MGRKGWRGAP--------------------------------
MSMEG_5854|M.smegmatis_MC2_155 --------MRTHGWSGSA--------------------------------
TH_1262|M.thermoresistible__bu --------MRTHGWGGSA--------------------------------
MAV_1115|M.avium_104 --------MRRHGWSGDI--------------------------------
MMAR_0226|M.marinum_M -------MARRRGWNGAP--------------------------------
MUL_4888|M.ulcerans_Agy99 -------MVSRPKRRGVS--------------------------------
MAB_4765|M.abscessus_ATCC_1997 -------MARRRGWDGQP--------------------------------
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
Mb2274c|M.bovis_AF2122/97 ---SNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRW
Rv2250c|M.tuberculosis_H37Rv ---SNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRW
Mflv_4113|M.gilvum_PYR-GCK ---PTDDAEARDRILRAALASIERRGPRLTTLTEVAADLGITRPTIYRHF
Mvan_2232|M.vanbaalenii_PYR-1 ---PADDREARQRILDAALASIERRGPRLTTLTEVAADLGITRPTIYRHF
MSMEG_5854|M.smegmatis_MC2_155 ---PATDEEAIARILAAAGKAIDERGA-DFSIADVARTLGVTRQTVYRYF
TH_1262|M.thermoresistible__bu ---PASDEEAIARILEAAKRTIEERGA-EFSIADVARAVGVTRQTVYRYF
MAV_1115|M.avium_104 ---PADDEEAVARILTATRRAIDERG--TVSVSQVASTLGVTRQTIYRYF
MMAR_0226|M.marinum_M ---PASDEEASRRIVDTAVRLIAETGS-DVSLAQVAASLGVIRQTVYRYY
MUL_4888|M.ulcerans_Agy99 ---RIG------RGVRRHRRGIAETGS-DVSLAQVAASLGVIRQTVYRYY
MAB_4765|M.abscessus_ATCC_1997 ---PSSDEEAAERIVAAAVKLIGETGS-AVSLADVAAELGVIRQTVYRYF
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLGP-EVSVREIAEEAGTAKPKIYRHF
. : : * :: ::* * : .:** :
Mb2274c|M.bovis_AF2122/97 PDTRSIMASMLTSHIAAVLREVPLDG----DDREALVKQIVAVADRLRGD
Rv2250c|M.tuberculosis_H37Rv PDTRSIMASMLTSHIADVLREVPLDG----DDREALVKQIVAVADRLRGD
Mflv_4113|M.gilvum_PYR-GCK GSTDELLAAAAEIALDHWTARIGRMAVRLEDATDFLVEAVAYLIEKLPHE
Mvan_2232|M.vanbaalenii_PYR-1 TSSEDLLAAAAEIALDHWTARIGEMSGHFTDATDLLVEAVAYLIERLPDE
MSMEG_5854|M.smegmatis_MC2_155 PSTDALLVAAAVHAASGFLDRLAAHLSGITDPVEAVTEAIATALEWVPQD
TH_1262|M.thermoresistible__bu PSTDALLVAAAMHAAGDFLDRLAVHLQGITDPVEAVAEAIATTLEWLPED
MAV_1115|M.avium_104 PTHEALLGATALSAVEGFLDRLAAHLGSITDPTEAVVEGIAYTFEQLAHD
MMAR_0226|M.marinum_M PTADALMRAAAIASVDGFLDRLTEAVRGMRDPAEAMAEAVMFTLRDVVRT
MUL_4888|M.ulcerans_Agy99 PTADALMRAAAIASVDGFLDRLTEAVRGMRDPAEAMAEAVMFTLRDVVRT
MAB_4765|M.abscessus_ATCC_1997 PTADALMHAASLASVDGFLDRLTHVVRGITDPAEALTEGVLYTLEEVTRT
MLBr_01733|M.leprae_Br4923 TDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVDK
:: : : * : . :
Mb2274c|M.bovis_AF2122/97 D--LIMSVMHSEL-ARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSG
Rv2250c|M.tuberculosis_H37Rv D--LIMSVMHSEL-ARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSG
Mflv_4113|M.gilvum_PYR-GCK P--LLATMLETDR-TRVMSRQMVMPAAVRRSREMLENTRIDWASAGFGGS
Mvan_2232|M.vanbaalenii_PYR-1 P--LLGLLLETDR-MRVMSRKMVMPAAVARSRTMLEHTGIDWSAMGFTGR
MSMEG_5854|M.smegmatis_MC2_155 K--HLGLLISPGR-ADAHTESVTSDVAVDFARAMLRKFDVDWAGLGFGDD
TH_1262|M.thermoresistible__bu T--HIGLLVAPGR-PTAHTESVTSDVAIDFANRMLRRFDVDWAAVGYSDA
MAV_1115|M.avium_104 R--YLSLVFQPGK-ASAFTAGVTSDIAISFGRSILQRFEVDWGAAGFADA
MMAR_0226|M.marinum_M P--HLGILIAQPY-AHTHPENLTSEEAQVFGVRMLERFDVDWAEYGFADE
MUL_4888|M.ulcerans_Agy99 P--HLGILIAQPY-AHTHPENLTSEEAQVFGVRMLERFDVDWAEYGFADE
MAB_4765|M.abscessus_ATCC_1997 P--HLGIMMSEPY-AHSHTSDMTSDEAQAFGLRMLDRFDVDWVQYGY-DD
MLBr_01733|M.leprae_Br4923 HPNVLRVFIQGRFSAQSEATVRTLDEGREITLTMAEMFNNELREMELNRA
: .. :
Mb2274c|M.bovis_AF2122/97 DAR-RLATMVLLIAQS---TIQSADIVDSILDSAALATELTHALNGYLC-
Rv2250c|M.tuberculosis_H37Rv DAR-RLATMVLLIAQS---TIQSADIVDSILDSAALATELTHALNGYLC-
Mflv_4113|M.gilvum_PYR-GCK RMD-DLVEFLLRMIQS---MVIAPPDPP--RDPVALREYLRLWIGPAMAA
Mvan_2232|M.vanbaalenii_PYR-1 RMD-DLVEFLLRMIQS---MVIAPSNPA--RSAAALRGYLRQWIGPVMSA
MSMEG_5854|M.smegmatis_MC2_155 DLD-ELAEHLLRIIQS---FIIDPGRPP--RTGATLRSYLRRWVGAAVKP
TH_1262|M.thermoresistible__bu DLD-ELAEHLLRVIQS---FVIDPGRPP--RDGQSLRAYLRRWVGAAVTG
MAV_1115|M.avium_104 GLD-ELVEVMLRTLQS---LIVDPGRPP--RTGAELRRFLQDWVAPAVRA
MMAR_0226|M.marinum_M SARHDLVEFLLRVLLS---FFVAPNVPS--RSDDELKSFIKRWVGGAILA
MUL_4888|M.ulcerans_Agy99 SARHDLVEFLLRVLLS---FFVAPNVPS--RSDDELKSFIRRWVGGAIVA
MAB_4765|M.abscessus_ATCC_1997 AAKRELVEFALRIMLS---FFVSPNEAT--RSRDELRGFLKRWLGGAVLA
MLBr_01733|M.leprae_Br4923 ASELAAFAAFGSVASATEWWLGPEPDSPRRMPREQFVAHLTIIMMAVIVG
: . : : : :
Mb2274c|M.bovis_AF2122/97 --------------------------
Rv2250c|M.tuberculosis_H37Rv --------------------------
Mflv_4113|M.gilvum_PYR-GCK GAGPVS--------------------
Mvan_2232|M.vanbaalenii_PYR-1 GAGDLS--------------------
MSMEG_5854|M.smegmatis_MC2_155 AQASVQSPRV----------------
TH_1262|M.thermoresistible__bu AR------------------------
MAV_1115|M.avium_104 HAISR---------------------
MMAR_0226|M.marinum_M QKR-----------------------
MUL_4888|M.ulcerans_Agy99 QKR-----------------------
MAB_4765|M.abscessus_ATCC_1997 QGR-----------------------
MLBr_01733|M.leprae_Br4923 TAETLGISMNPDRPIHDAVPLDRSAS