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GRKGWRGAPPADDREARQRILDAALASIERRGPRLTTLTEVAADLGITRPTIYRHFTSSEDLLAAAAEIA LDHWTARIGEMSGHFTDATDLLVEAVAYLIERLPDEPLLGLLLETDRMRVMSRKMVMPAAVARSRTMLEH TGIDWSAMGFTGRRMDDLVEFLLRMIQSMVIAPSNPARSAAALRGYLRQWIGPVMSAGAGDLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2232 | - | - | 100% (204) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4911 | - | 1e-37 | 37.76% (196) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5152 | - | 6e-33 | 41.27% (189) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3185c | - | 6e-08 | 36.78% (87) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4113 | - | 3e-86 | 77.94% (204) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3160c | - | 6e-08 | 36.78% (87) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 1e-07 | 33.33% (93) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 9e-30 | 33.67% (196) | putative regulatory protein TetR |
| M. marinum M | MMAR_0226 | - | 7e-30 | 34.52% (197) | hypothetical protein MMAR_0226 |
| M. avium 104 | MAV_1115 | - | 3e-36 | 37.50% (200) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5854 | - | 7e-35 | 39.90% (193) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1262 | - | 5e-35 | 38.07% (197) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4888 | - | 3e-21 | 32.10% (162) | hypothetical protein MUL_4888 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2232|M.vanbaalenii_PYR-1 -MGRK--------GWRGAP-------------------------------
Mflv_4113|M.gilvum_PYR-GCK -MGRK--------GWGGVP-------------------------------
MSMEG_5854|M.smegmatis_MC2_155 -MRTH--------GWSGSA-------------------------------
TH_1262|M.thermoresistible__bu -MRTH--------GWGGSA-------------------------------
MAV_1115|M.avium_104 -MRRH--------GWSGDI-------------------------------
MMAR_0226|M.marinum_M MARRR--------GWNGAP-------------------------------
MUL_4888|M.ulcerans_Agy99 MVSRP--------KRRGVS-------------------------------
MAB_4765|M.abscessus_ATCC_1997 MARRR--------GWDGQP-------------------------------
Mb3185c|M.bovis_AF2122/97 -MPRQ--------AGRWSP-------------------------------
Rv3160c|M.tuberculosis_H37Rv -MPRQ--------AGRWSP-------------------------------
MLBr_01733|M.leprae_Br4923 -MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDAR
Mvan_2232|M.vanbaalenii_PYR-1 ----PADDREARQRILDAALASIERRGPRLTTLTEVAADLGITRPTIYRH
Mflv_4113|M.gilvum_PYR-GCK ----PTDDAEARDRILRAALASIERRGPRLTTLTEVAADLGITRPTIYRH
MSMEG_5854|M.smegmatis_MC2_155 ----PATDEEAIARILAAAGKAIDERGA-DFSIADVARTLGVTRQTVYRY
TH_1262|M.thermoresistible__bu ----PASDEEAIARILEAAKRTIEERGA-EFSIADVARAVGVTRQTVYRY
MAV_1115|M.avium_104 ----PADDEEAVARILTATRRAIDERG--TVSVSQVASTLGVTRQTIYRY
MMAR_0226|M.marinum_M ----PASDEEASRRIVDTAVRLIAETGS-DVSLAQVAASLGVIRQTVYRY
MUL_4888|M.ulcerans_Agy99 ----RIG------RGVRRHRRGIAETGS-DVSLAQVAASLGVIRQTVYRY
MAB_4765|M.abscessus_ATCC_1997 ----PSSDEEAAERIVAAAVKLIGETGS-AVSLADVAAELGVIRQTVYRY
Mb3185c|M.bovis_AF2122/97 ----TAL------RILGAAAELIALRGYSSTSTRDIAAAVGVEQPAIYKH
Rv3160c|M.tuberculosis_H37Rv ----TAL------RILGAAAELIALRGYSSTSTRDIAAAVGVEQPAIYKH
MLBr_01733|M.leprae_Br4923 SERWREHRKKVRGEIVDAAFRALDRLGP-EVSVREIAEEAGTAKPKIYRH
. : : * : ::* * : :*::
Mvan_2232|M.vanbaalenii_PYR-1 FTSSEDLLAAAAEIALDHWTARIGEMSGHFTD-ATDLLVEAVAYLIERLP
Mflv_4113|M.gilvum_PYR-GCK FGSTDELLAAAAEIALDHWTARIGRMAVRLED-ATDFLVEAVAYLIEKLP
MSMEG_5854|M.smegmatis_MC2_155 FPSTDALLVAAAVHAASGFLDRLAAHLSGITD-PVEAVTEAIATALEWVP
TH_1262|M.thermoresistible__bu FPSTDALLVAAAMHAAGDFLDRLAVHLQGITD-PVEAVAEAIATTLEWLP
MAV_1115|M.avium_104 FPTHEALLGATALSAVEGFLDRLAAHLGSITD-PTEAVVEGIAYTFEQLA
MMAR_0226|M.marinum_M YPTADALMRAAAIASVDGFLDRLTEAVRGMRD-PAEAMAEAVMFTLRDVV
MUL_4888|M.ulcerans_Agy99 YPTADALMRAAAIASVDGFLDRLTEAVRGMRD-PAEAMAEAVMFTLRDVV
MAB_4765|M.abscessus_ATCC_1997 FPTADALMHAASLASVDGFLDRLTHVVRGITD-PAEALTEGVLYTLEEVT
Mb3185c|M.bovis_AF2122/97 FSAKRDILAALVRLAVEWPLELFGHITAMPVP-AVVKLHRWLTESLDHLH
Rv3160c|M.tuberculosis_H37Rv FSAKRDILAALVRLAVEWPLELFGHITAMPVP-AVVKLHRWLTESLDHLH
MLBr_01733|M.leprae_Br4923 FTDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVD
: :: * : . : . : . :
Mvan_2232|M.vanbaalenii_PYR-1 DEPLLGLLLETDRMRVMSRKMVMPAAVARSRTMLEHTGIDWSAMGFTGRR
Mflv_4113|M.gilvum_PYR-GCK HEPLLATMLETDRTRVMSRQMVMPAAVRRSREMLENTRIDWASAGFGGSR
MSMEG_5854|M.smegmatis_MC2_155 QDKHLGLLISPGRADAHTESVTSDVAVDFARAMLRKFDVDWAGLGFGDDD
TH_1262|M.thermoresistible__bu EDTHIGLLVAPGRPTAHTESVTSDVAIDFANRMLRRFDVDWAAVGYSDAD
MAV_1115|M.avium_104 HDRYLSLVFQPGKASAFTAGVTSDIAISFGRSILQRFEVDWGAAGFADAG
MMAR_0226|M.marinum_M RTPHLGILIAQPYAHTHPENLTSEEAQVFGVRMLERFDVDWAEYGFADES
MUL_4888|M.ulcerans_Agy99 RTPHLGILIAQPYAHTHPENLTSEEAQVFGVRMLERFDVDWAEYGFADES
MAB_4765|M.abscessus_ATCC_1997 RTPHLGIMMSEPYAHSHTSDMTSDEAQAFGLRMLDRFDVDWVQYGY-DDA
Mb3185c|M.bovis_AF2122/97 ASPYVLVSILIT-PDLHQESFVAERELVAEMERALVGLIETGQGEGDVRA
Rv3160c|M.tuberculosis_H37Rv ASPYVLVSILIT-PDLHQESFVAERELVAEMERALVGLIETGQGEGDVRA
MLBr_01733|M.leprae_Br4923 KHPNVLRVFIQGRFSAQSEATVRTLDEGREITLTMAEMFNNELREMELNR
: . . .:
Mvan_2232|M.vanbaalenii_PYR-1 MD-DLVEFLLRMIQSMVIAPSNPARSAAALRGYLRQWIG-------PVMS
Mflv_4113|M.gilvum_PYR-GCK MD-DLVEFLLRMIQSMVIAPPDPPRDPVALREYLRLWIG-------PAMA
MSMEG_5854|M.smegmatis_MC2_155 LD-ELAEHLLRIIQSFIIDPGRPPRTGATLRSYLRRWVG-------AAVK
TH_1262|M.thermoresistible__bu LD-ELAEHLLRVIQSFVIDPGRPPRDGQSLRAYLRRWVG-------AAVT
MAV_1115|M.avium_104 LD-ELVEVMLRTLQSLIVDPGRPPRTGAELRRFLQDWVA-------PAVR
MMAR_0226|M.marinum_M ARHDLVEFLLRVLLSFFVAPNVPSRSDDELKSFIKRWVG-------GAIL
MUL_4888|M.ulcerans_Agy99 ARHDLVEFLLRVLLSFFVAPNVPSRSDDELKSFIRRWVG-------GAIV
MAB_4765|M.abscessus_ATCC_1997 AKRELVEFALRIMLSFFVSPNEATRSRDELRGFLKRWLG-------GAVL
Mb3185c|M.bovis_AF2122/97 MHPLSAARLVQALFDALALPEFAVSPDEIVEFAMTALLSDP--DRLAEIR
Rv3160c|M.tuberculosis_H37Rv MHPLSAARLVQALFDALALPEFAVSPDEIVEFAMTALLSDP--DRLAEIR
MLBr_01733|M.leprae_Br4923 AASELAAFAAFGSVASATEWWLGPEPDSPRRMPREQFVAHLTIIMMAVIV
. . :. :
Mvan_2232|M.vanbaalenii_PYR-1 AGAGDLS--------------------
Mflv_4113|M.gilvum_PYR-GCK AGAGPVS--------------------
MSMEG_5854|M.smegmatis_MC2_155 PAQASVQSPRV----------------
TH_1262|M.thermoresistible__bu GAR------------------------
MAV_1115|M.avium_104 AHAISR---------------------
MMAR_0226|M.marinum_M AQKR-----------------------
MUL_4888|M.ulcerans_Agy99 AQKR-----------------------
MAB_4765|M.abscessus_ATCC_1997 AQGR-----------------------
Mb3185c|M.bovis_AF2122/97 AAADALEIQTAPPDRGL----------
Rv3160c|M.tuberculosis_H37Rv AAADALEIQTAPPDRGL----------
MLBr_01733|M.leprae_Br4923 GTAETLGISMNPDRPIHDAVPLDRSAS