For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. gilvum PYR-GCK Mflv_4100 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 4352187 - 4353344
length: 385

GVAVDFSEVELCDADKAFRDEVREFLAAVVTDDVIRRDLESGDNFDEQVHLALGSAGYLERDWRAEADGG
FTAVQRRIFELEIGRAHTPWFHWPTTAMVANAVDHFGSDELKDEVLPQVLAGRYRLCLGYTEPEGGSDIA
TCKTRAVREADGSTWIINGSKMFTSNAHHAQYVYLITNTDPQAPKHQSLTMFLVPLDSPGVEIQPIRTVD
GDRTNITFYSDVRVDDRYRIGPVNGGWGVLREALNAEHGTVERDASGLQKIAVMTEHALLLAEEVDRVAS
VVGDRLGDGEVAYRLGRSVARLEAALSTPEMFGRVAIAQTLRDITPDLMDILGPASVLPSGRSAEYLFRL
ALPMGIYGGTLDVFRNMIAQHALGLGKPNYSPPR*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_4100 - - 100% (385) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_4346 - e-148 66.58% (395) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1510 - 2e-35 34.02% (244) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3534 fadE26 2e-34 30.02% (403) acyl-CoA dehydrogenase FADE26
M. tuberculosis H37Rv Rv3504 fadE26 2e-34 30.02% (403) acyl-CoA dehydrogenase FADE26
M. leprae Br4923 MLBr_00737 fadE25 1e-13 23.86% (373) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0615 - 1e-38 30.95% (391) putative acyl-CoA dehydrogenase
M. marinum M MMAR_4010 - 1e-142 65.22% (391) acyl-CoA dehydrogenase
M. avium 104 MAV_1595 - 1e-146 66.16% (393) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_0578 - 1e-161 72.89% (380) acyl-CoA dehydrogenase middle domain-containing protein
M. thermoresistible (build 8) TH_2587 - 1e-163 72.59% (394) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_3874 - 1e-141 64.96% (391) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_2246 - 0.0 81.51% (384) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3534|M.bovis_AF2122/97            -------------MRISYTPQQEELRRELRSYFATLMTPERREALSSVQG
Rv3504|M.tuberculosis_H37Rv         -------------MRISYTPQQEELRRELRSYFATLMTPERREALSSVQG
MAB_0615|M.abscessus_ATCC_1997      -------------MLIDLTPEQAKLQNDLRHYFSNLVTAEETREMMIDR-
Mflv_4100|M.gilvum_PYR-GCK          MG------VAVDFSEVELCDADKAFRDEVREFLAAVVTDDVIRRDLESG-
Mvan_2246|M.vanbaalenii_PYR-1       MHGQEVGAVTMDFSEVELSDDDRAFQAELRGFLARVVTDDVIERDRRTG-
MSMEG_0578|M.smegmatis_MC2_155      ----------MDFSRVELSDEDTRFRDELRAFLAEIVTDEVIRRDRETG-
TH_2587|M.thermoresistible__bu      ----------MDFSTVELSPEDQRFRAELRDFLTRHVTAEVIRRDRETG-
MMAR_4010|M.marinum_M               ----------MDFSRVQISDADREFRETARSFLATHVTEEVRRHDRETG-
MUL_3874|M.ulcerans_Agy99           ----------MDFSRVQISDADREFRETARSFLATHVTEEVRRHDRETG-
MAV_1595|M.avium_104                ----------MDFSRVTLSDEDQRFLDEAREFLRTHVTDEVRRRDRETG-
MLBr_00737|M.leprae_Br4923          ---MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR-
                                                   .     .  :    *      :: .          

Mb3534|M.bovis_AF2122/97            EYGVGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAG
Rv3504|M.tuberculosis_H37Rv         EYGVGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAG
MAB_0615|M.abscessus_ATCC_1997      ---HGSSYEAVVRRMGQDGWLGVGWPKEYGGHGFGPLEQQIFMNEVMRAD
Mflv_4100|M.gilvum_PYR-GCK          ----DNFDEQVHLALGSAGYLERDWRAEADG-GFTAVQRRIFELEIGRAH
Mvan_2246|M.vanbaalenii_PYR-1       ----DNFDETVHLALGAAGYLERDWRAGQDG-GFTAVQRRIFELEIGRAH
MSMEG_0578|M.smegmatis_MC2_155      ----ENFDESVHLALGGAGYLAADYRCADDG-GFSAVRRRIWELEIGRAH
TH_2587|M.thermoresistible__bu      ----DNFDEGVHTALGAAGYLEKDFRSEAEG-GWNALRRRIWELEIGRAH
MMAR_4010|M.marinum_M               ----DNFHEGLHLALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAH
MUL_3874|M.ulcerans_Agy99           ----DNFHEGLHLALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAH
MAV_1595|M.avium_104                ----DNFDEGVHLALGAAGYLEREWKPEAEG-GFSRVQRRIWELEKRRAH
MLBr_00737|M.leprae_Br4923          ------FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
                                            .     :.  *:          * *   :   *   *   . 

Mb3534|M.bovis_AF2122/97            AP-VPFLTINSVAPT-IMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAG
Rv3504|M.tuberculosis_H37Rv         AP-VPFLTINSVAPT-IMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAG
MAB_0615|M.abscessus_ATCC_1997      VP-MPLVTLQTVGPT-LQKYGTEEQKKKFLPGILAGEIHFAIGYTEPEAG
Mflv_4100|M.gilvum_PYR-GCK          TPWFHWPTTAMVANA-VDHFGSDELKDEVLPQVLAGRYRLCLGYTEPEGG
Mvan_2246|M.vanbaalenii_PYR-1       TPWFHWGTTSMVARA-LDQFGSDELKDEVLDRVLSGEFRLCLGYTEPDGG
MSMEG_0578|M.smegmatis_MC2_155      TPWFHWGTTAMAAHT-VEKFGTPELVEEVLPGVLSGRVRICLGYTEPEGG
TH_2587|M.thermoresistible__bu      TPWFHWGTTAMVAQS-VEKFGTPELRDEVIPGVLTGEIRLCLGYTEPEGG
MMAR_4010|M.marinum_M               VPWVTWGTTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGG
MUL_3874|M.ulcerans_Agy99           VPWVTWGTTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGG
MAV_1595|M.avium_104                VPWVTWGTTAMVARS-VAKFGSEELQREVLPGVFSGHVRLCLGYTEPEGG
MLBr_00737|M.leprae_Br4923          ASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAG
                                    ..     :    .   :   *: *    .:  : :     . . :*  .*

Mb3534|M.bovis_AF2122/97            TDLANLRTTAVRDGDD--YVVNGQKMWTSLIQYADYVWLAVRTNPESSGA
Rv3504|M.tuberculosis_H37Rv         TDLANLRTTAVRDGDD--YVVNGQKMWTSLIQYADYVWLAVRTNPESSGA
MAB_0615|M.abscessus_ATCC_1997      TDLASLRTTAVRDGDH--YVVNGQKIFTTGAHQAQYIWLACRTDP---SA
Mflv_4100|M.gilvum_PYR-GCK          SDIATCKTRAVREADGSTWIINGSKMFTSNAHHAQYVYLITNTDP---QA
Mvan_2246|M.vanbaalenii_PYR-1       SDVATCKTRAVRDGDG--WIVNGSKMFTSNAHHAQYVFLITNTDP---AA
MSMEG_0578|M.smegmatis_MC2_155      SDVATCKTRAVRDGDA--WIINGSKMFTSNAHNAQYVFLVTNTDP---EA
TH_2587|M.thermoresistible__bu      SDVATCRTRAVREADGSSWIINGAKMFTSNAHHAQYVFLLTNTDP---AA
MMAR_4010|M.marinum_M               SDVATCKTRALRDGDS--WLINGSKMFTTGAHNCQYVFLITNTDP---QA
MUL_3874|M.ulcerans_Agy99           SDVATCKTRALRDGDS--WLINGSKMFTTGAHNCQYVFLITNTDP---QA
MAV_1595|M.avium_104                SDVATCKTRAVRDGNG--WIINGSKMFTTGAHNCQYVFLITNTDP---DA
MLBr_00737|M.leprae_Br4923          SDAASMRTRAKADGDD--WILNGFKCWITNGGKSTWYTVMAVTDP----D
                                    :* *. :* *  :.:   :::** * : :    . :  :   *:*     

Mb3534|M.bovis_AF2122/97            KKHRGISVLIVPTTAEGFSWTPVHTMAGP---DTSATYYSDVRVPVANRV
Rv3504|M.tuberculosis_H37Rv         KKHRGISVLIVPTTAEGFSWTPVHTMAGP---DTSATYYSDVRVPVANRV
MAB_0615|M.abscessus_ATCC_1997      PKHKGISILIVDTKDPGYSWTPIITNDGAH--HTNATYYTDVRVPVEMLV
Mflv_4100|M.gilvum_PYR-GCK          PKHQSLTMFLVPLDSPGVEIQPIRTVDGD---RTNITFYSDVRVDDRYRI
Mvan_2246|M.vanbaalenii_PYR-1       PKHQSLTMFLVPLDATGVEIQPIRTVDGD---RTNITFYSDVRIDDRYRV
MSMEG_0578|M.smegmatis_MC2_155      PKHNSLTMFLVPLGTPGVEIQGIRTVDGD---RTNITYYSDVRVSDRYRV
TH_2587|M.thermoresistible__bu      PKHQSLTMFLVPLDTPGIEIGPIRTVDGD---RTNIVYYSDVRVDDHYRI
MMAR_4010|M.marinum_M               RKHKSLTMFLVPLDSAGIEIQGIRTVDGD---RTNIVYYSDVRIDDKYRL
MUL_3874|M.ulcerans_Agy99           RKHKSLTMFLVPLDSAGIEIQGIRTVDGD---RTNIVYYSDVRIDDKYRL
MAV_1595|M.avium_104                PKHKSLTMFLVPLDSPGIDIQGIRTVDGD---RTNIVYYSDVRVDDKYRL
MLBr_00737|M.leprae_Br4923          KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRII
                                       ..:: ::*     * .     .  *     *.  :: . *:     :

Mb3534|M.bovis_AF2122/97            GEENAGWKLVTNQLNHERVALVSPAP--IFGCLREVREWAQNTKDAGGTR
Rv3504|M.tuberculosis_H37Rv         GEENAGWKLVTNQLNHERVALVSPAP--IFGCLREVREWAQNTKDAGGTR
MAB_0615|M.abscessus_ATCC_1997      GEENAGWKLITTQLNHERVSLGPSGR--IAGMYDRVYEWAS-KPGPDGVA
Mflv_4100|M.gilvum_PYR-GCK          GPVNGGWGVLREALNAEHGTVERDAS--GLQKIAVMTEHALLLAEEVDRV
Mvan_2246|M.vanbaalenii_PYR-1       GAVNGGWAVLREALNAEHGTVEHDDS--GLNKIAVMTEHATLLADEVDRI
MSMEG_0578|M.smegmatis_MC2_155      GDVNGGWGVLRGALDVEHGTFERDTH--GLQKIATMTEHITLMAEALDLV
TH_2587|M.thermoresistible__bu      GEVNGGWTVLREALNVEHGTVERDSQ--GLQKLATMTEHALLTAEGLDWA
MMAR_4010|M.marinum_M               GAVNGGWTVLREPLNVEHGAVAAAPD--GLQDTSIMMHQAGSMAEAVDRA
MUL_3874|M.ulcerans_Agy99           GAVNGGWTVLREPLNVEHGAVAAAPD--GLQDTSIMMHQAGSMAEAVDRA
MAV_1595|M.avium_104                GDVNAGWTVLREPLNVEHGAVAAAPD--GLQDVSIMMHQAGFMADALDKV
MLBr_00737|M.leprae_Br4923          GEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESI
                                    *  . *:      *:  : :.                             

Mb3534|M.bovis_AF2122/97            LIDSEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKV
Rv3504|M.tuberculosis_H37Rv         LIDSEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKV
MAB_0615|M.abscessus_ATCC_1997      PLSHEDVRRVLGEMKAVWRLNELLNWQVASS-----GDDISMADAAATKI
Mflv_4100|M.gilvum_PYR-GCK          ASVVG-------DRLGDGEVAYRLGRSVARL------EAALSTPEMFGRV
Mvan_2246|M.vanbaalenii_PYR-1       AGEMYRS-----GRLDDDSIGYRLGRSIARL------EAALSTPEMFGRV
MSMEG_0578|M.smegmatis_MC2_155      AAQAP----------GDGASRFRLGRGIACT------EAAMSTPDMYGRV
TH_2587|M.thermoresistible__bu      VAVAASPGPDGRRLLDDESVQYRLGRSVARL------EAALSTPAEYGRV
MMAR_4010|M.marinum_M               ASCVMRPDPDGRRPIDDTSVAYRLGRSVARM------EAALSAPSIFGRV
MUL_3874|M.ulcerans_Agy99           ASCVMRPDPDGRRPIDDTSVAYRLGRSVARM------EAALSAPSIFGRV
MAV_1595|M.avium_104                AAKVTLPDPHGRRLIDDSAIAYRLGRNAARM------EAALSAPSIYGRV
MLBr_00737|M.leprae_Br4923          STFQSIQFMLADMAMKVEAARLIVYAAAARAE---RGEPDLGFISAASKC
                                                           :    *                   : 

Mb3534|M.bovis_AF2122/97            FGTELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGG
Rv3504|M.tuberculosis_H37Rv         FGTELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGG
MAB_0615|M.abscessus_ATCC_1997      LATEWIQKLGRLSEGVVGRYGDPADANTAETLE-WLDAQTKRHLVITFGG
Mflv_4100|M.gilvum_PYR-GCK          AIAQTLRDITPDLMDILGPASVLPSGRS-------AEYLFRLALPMGIYG
Mvan_2246|M.vanbaalenii_PYR-1       AIAQTLRDITPDLMDVLGTTSVVPEGLN-------AEYLFRLALPTGIYG
MSMEG_0578|M.smegmatis_MC2_155      AIAQTMRDVTPDLMDILGPAGALTDG---------VEYIFRLAGPTGIYG
TH_2587|M.thermoresistible__bu      AIAQMMRDITPELMDVLGAASALPVDTTGAAADGAVEYLFRLASPVAIYG
MMAR_4010|M.marinum_M               AIAQTMRDISPDLMDILGSAAALPFGTDGAVDDGGAEYVYRFAPLVGIYG
MUL_3874|M.ulcerans_Agy99           AIAQTMRDISPDLMDILGSAAALPFGTDGAVDDGGAEYVYRFAPLVGIYG
MAV_1595|M.avium_104                ALAQTMRDISPDLMDILGTASALPVGTDGAADDGASEYVFRFAPLVGIYG
MLBr_00737|M.leprae_Br4923          FASDIAMEVTTDAVQLFGGAGYTSDFP--------VERFMRDAKITQIYE
                                      ::   .       :.*  .               :   :      :  

Mb3534|M.bovis_AF2122/97            GTNEVQRDIIGMVALGLPRANR--------
Rv3504|M.tuberculosis_H37Rv         GTNEVQRDIIGMVALGLPRANR--------
MAB_0615|M.abscessus_ATCC_1997      GVNEVMREMVSTAGLGTPRVPR--------
Mflv_4100|M.gilvum_PYR-GCK          GTLDVFRNMIAQHALGLGKPNYSPPR----
Mvan_2246|M.vanbaalenii_PYR-1       GTLDVFRNMIAQHALGLGRPNYSPPVQRP-
MSMEG_0578|M.smegmatis_MC2_155      GTLEVFRNMIAQHGLGLGKPNYAQPVKKVS
TH_2587|M.thermoresistible__bu      GTVEVFRNMIAQHALGLGKPSYGTPVKR--
MMAR_4010|M.marinum_M               GTLEVFRNMIAQHVLGLGKPSYP---HRT-
MUL_3874|M.ulcerans_Agy99           GTHEVFRNMIAQHVLGLGKPSYP---HRT-
MAV_1595|M.avium_104                GTLEVFRNMIAQYMLGLGKPAYAPVAQRAS
MLBr_00737|M.leprae_Br4923          GTNQIQRVVMSRALLR--------------
                                    *. :: * ::.   *

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_4100	-	-	100% (385)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_4346	-	e-148	66.58% (395)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1510	-	2e-35	34.02% (244)	acyl-CoA dehydrogenase domain-containing protein