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VHGQEVGAVTMDFSEVELSDDDRAFQAELRGFLARVVTDDVIERDRRTGDNFDETVHLALGAAGYLERDW RAGQDGGFTAVQRRIFELEIGRAHTPWFHWGTTSMVARALDQFGSDELKDEVLDRVLSGEFRLCLGYTEP DGGSDVATCKTRAVRDGDGWIVNGSKMFTSNAHHAQYVFLITNTDPAAPKHQSLTMFLVPLDATGVEIQP IRTVDGDRTNITFYSDVRIDDRYRVGAVNGGWAVLREALNAEHGTVEHDDSGLNKIAVMTEHATLLADEV DRIAGEMYRSGRLDDDSIGYRLGRSIARLEAALSTPEMFGRVAIAQTLRDITPDLMDVLGTTSVVPEGLN AEYLFRLALPTGIYGGTLDVFRNMIAQHALGLGRPNYSPPVQRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2246 | - | - | 100% (394) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1998 | - | e-149 | 65.98% (391) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5256 | - | 3e-37 | 36.78% (242) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3573c | fadE29 | 3e-36 | 30.18% (391) | acyl-CoA dehydrogenase FADE29 |
| M. gilvum PYR-GCK | Mflv_4100 | - | 0.0 | 81.51% (384) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3543c | fadE29 | 3e-36 | 30.18% (391) | acyl-CoA dehydrogenase FADE29 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-12 | 21.39% (388) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0615 | - | 1e-41 | 31.98% (394) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4010 | - | 1e-142 | 63.75% (389) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_5127 | - | 1e-146 | 63.75% (389) | acyl-CoA dehydrogenase middle domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0578 | - | 1e-158 | 69.97% (383) | acyl-CoA dehydrogenase middle domain-containing protein |
| M. thermoresistible (build 8) | TH_2587 | - | 1e-160 | 69.52% (397) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3874 | - | 1e-141 | 63.50% (389) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3573c|M.bovis_AF2122/97 -------------MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRH
Rv3543c|M.tuberculosis_H37Rv -------------MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRH
MAB_0615|M.abscessus_ATCC_1997 -------------MLIDLTPEQAKLQNDLRHYFSNLVTAEETREMMIDRH
Mvan_2246|M.vanbaalenii_PYR-1 MHGQEVGAVTMDFSEVELSDDDRAFQAELRGFLARVVT-DDVIERDRRTG
Mflv_4100|M.gilvum_PYR-GCK MG------VAVDFSEVELCDADKAFRDEVREFLAAVVT-DDVIRRDLESG
MSMEG_0578|M.smegmatis_MC2_155 ----------MDFSRVELSDEDTRFRDELRAFLAEIVT-DEVIRRDRETG
TH_2587|M.thermoresistible__bu ----------MDFSTVELSPEDQRFRAELRDFLTRHVT-AEVIRRDRETG
MAV_5127|M.avium_104 ----------MDFSRVELSTQDAAFQESTRAFLAEHVT-DEVRRRDRETG
MMAR_4010|M.marinum_M ----------MDFSRVQISDADREFRETARSFLATHVT-EEVRRHDRETG
MUL_3874|M.ulcerans_Agy99 ----------MDFSRVQISDADREFRETARSFLATHVT-EEVRRHDRETG
MLBr_00737|M.leprae_Br4923 ---MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA---PHAADVDQR
..: . :: * ::
Mb3573c|M.bovis_AF2122/97 GPAYRAVIRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVP-L
Rv3543c|M.tuberculosis_H37Rv GPAYRAVIRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVP-L
MAB_0615|M.abscessus_ATCC_1997 GSSYEAVVRRMGQDGWLGVGWPKEYGGHGFGPLEQQIFMNEVMRADVP-M
Mvan_2246|M.vanbaalenii_PYR-1 DNFDETVHLALGAAGYLERDWRAGQDG-GFTAVQRRIFELEIGRAHTPWF
Mflv_4100|M.gilvum_PYR-GCK DNFDEQVHLALGSAGYLERDWRAEADG-GFTAVQRRIFELEIGRAHTPWF
MSMEG_0578|M.smegmatis_MC2_155 ENFDESVHLALGGAGYLAADYRCADDG-GFSAVRRRIWELEIGRAHTPWF
TH_2587|M.thermoresistible__bu DNFDEGVHTALGAAGYLEKDFRSEAEG-GWNALRRRIWELEIGRAHTPWF
MAV_5127|M.avium_104 ENFSEPVHVALGEAGYLESDWKLESEG-GFDPVRRRIFQLEIGRAHTPWF
MMAR_4010|M.marinum_M DNFHEGLHLALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAHVPWV
MUL_3874|M.ulcerans_Agy99 DNFHEGLHLALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAHVPWV
MLBr_00737|M.leprae_Br4923 ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS
. :. * * * : * * *....
Mb3573c|M.bovis_AF2122/97 PAVTLQTVGPT-LQAHGSELQKKKFLPAILAGEAHFAIGYTEPEAGTDLA
Rv3543c|M.tuberculosis_H37Rv PAVTLQTVGPT-LQAHGSELQKKKFLPAILAGEAHFAIGYTEPEAGTDLA
MAB_0615|M.abscessus_ATCC_1997 PLVTLQTVGPT-LQKYGTEEQKKKFLPGILAGEIHFAIGYTEPEAGTDLA
Mvan_2246|M.vanbaalenii_PYR-1 HWGTTSMVARA-LDQFGSDELKDEVLDRVLSGEFRLCLGYTEPDGGSDVA
Mflv_4100|M.gilvum_PYR-GCK HWPTTAMVANA-VDHFGSDELKDEVLPQVLAGRYRLCLGYTEPEGGSDIA
MSMEG_0578|M.smegmatis_MC2_155 HWGTTAMAAHT-VEKFGTPELVEEVLPGVLSGRVRICLGYTEPEGGSDVA
TH_2587|M.thermoresistible__bu HWGTTAMVAQS-VEKFGTPELRDEVIPGVLTGEIRLCLGYTEPEGGSDVA
MAV_5127|M.avium_104 HWGTTAVVARL-VKQFGAPELADAILPGVLSGKIRLCLGYTEPEGGSDVA
MMAR_4010|M.marinum_M TWGTTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGGSDVA
MUL_3874|M.ulcerans_Agy99 TWGTTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGGSDVA
MLBr_00737|M.leprae_Br4923 LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAA
: . : *: . .: : : . . :* :.*:* *
Mb3573c|M.bovis_AF2122/97 SLRTTAVRDGDH--YIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGIS
Rv3543c|M.tuberculosis_H37Rv SLRTTAVRDGDH--YIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGIS
MAB_0615|M.abscessus_ATCC_1997 SLRTTAVRDGDH--YVVNGQKIFTTGAHQAQYIWLACRTDPSAPKHKGIS
Mvan_2246|M.vanbaalenii_PYR-1 TCKTRAVRDGDG--WIVNGSKMFTSNAHHAQYVFLITNTDPAAPKHQSLT
Mflv_4100|M.gilvum_PYR-GCK TCKTRAVREADGSTWIINGSKMFTSNAHHAQYVYLITNTDPQAPKHQSLT
MSMEG_0578|M.smegmatis_MC2_155 TCKTRAVRDGDA--WIINGSKMFTSNAHNAQYVFLVTNTDPEAPKHNSLT
TH_2587|M.thermoresistible__bu TCRTRAVREADGSSWIINGAKMFTSNAHHAQYVFLLTNTDPAAPKHQSLT
MAV_5127|M.avium_104 TCKTRAVRDGSG--WIINGSKMFTSNAQNAEYVFLLTNTDPRRPKHKNLT
MMAR_4010|M.marinum_M TCKTRALRDGDS--WLINGSKMFTTGAHNCQYVFLITNTDPQARKHKSLT
MUL_3874|M.ulcerans_Agy99 TCKTRALRDGDS--WLINGSKMFTTGAHNCQYVFLITNTDPQARKHKSLT
MLBr_00737|M.leprae_Br4923 SMRTRAKADGDD--WILNGFKCWITNGGKSTWYTVMAVTDPDKG-ANGIS
: :* * :.. :::** * : :.. .. : : *** :.::
Mb3573c|M.bovis_AF2122/97 ILIVDTKDPGYSWTP--IILADGAHHTNATYYNDVRVPVDMLVGKENDGW
Rv3543c|M.tuberculosis_H37Rv ILIVDTKDPGYSWTP--IILADGAHHTNATYYNDVRVPVDMLVGKENDGW
MAB_0615|M.abscessus_ATCC_1997 ILIVDTKDPGYSWTP--IITNDGAHHTNATYYTDVRVPVEMLVGEENAGW
Mvan_2246|M.vanbaalenii_PYR-1 MFLVPLDATGVEIQP--IRTVD-GDRTNITFYSDVRIDDRYRVGAVNGGW
Mflv_4100|M.gilvum_PYR-GCK MFLVPLDSPGVEIQP--IRTVD-GDRTNITFYSDVRVDDRYRIGPVNGGW
MSMEG_0578|M.smegmatis_MC2_155 MFLVPLGTPGVEIQG--IRTVD-GDRTNITYYSDVRVSDRYRVGDVNGGW
TH_2587|M.thermoresistible__bu MFLVPLDTPGIEIGP--IRTVD-GDRTNIVYYSDVRVDDHYRIGEVNGGW
MAV_5127|M.avium_104 MFLVPLDSPGIEIQG--IRTVD-GDRTNIVYYSDVRVDDLYRIGEVNGGW
MMAR_4010|M.marinum_M MFLVPLDSAGIEIQG--IRTVD-GDRTNIVYYSDVRIDDKYRLGAVNGGW
MUL_3874|M.ulcerans_Agy99 MFLVPLDSAGIEIQG--IRTVD-GDRTNIVYYSDVRIDDKYRLGAVNGGW
MLBr_00737|M.leprae_Br4923 AFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGF
::* * . . *. :: . *: :* . *:
Mb3573c|M.bovis_AF2122/97 RLITTQLNNERVMLGPAGR-----FASIYDRVHAWASVPGGNGVTPIDHD
Rv3543c|M.tuberculosis_H37Rv RLITTQLNNERVMLGPAGR-----FASIYDRVHAWASVPGGNGVTPIDHD
MAB_0615|M.abscessus_ATCC_1997 KLITTQLNHERVSLGPSGR-----IAGMYDRVYEWASKPGPDGVAPLSHE
Mvan_2246|M.vanbaalenii_PYR-1 AVLREALNAEHGTVEHDDS-----GLNKIAVMTEHATLLADEVDRIAGEM
Mflv_4100|M.gilvum_PYR-GCK GVLREALNAEHGTVERDAS-----GLQKIAVMTEHALLLAEEVDRVASVV
MSMEG_0578|M.smegmatis_MC2_155 GVLRGALDVEHGTFERDTH-----GLQKIATMTEHITLMAEALDLVAAQA
TH_2587|M.thermoresistible__bu TVLREALNVEHGTVERDSQ-----GLQKLATMTEHALLTAEGLDWAVAVA
MAV_5127|M.avium_104 TVMRFALDAEHGITDPQDH-----GLQNISMLSEHGHLMAEAADGVAAIL
MMAR_4010|M.marinum_M TVLREPLNVEHGAVAAAPD-----GLQDTSIMMHQAGSMAEAVDRAASCV
MUL_3874|M.ulcerans_Agy99 TVLREPLNVEHGAVAAAPD-----GLQDTSIMMHQAGSMAEAVDRAASCV
MLBr_00737|M.leprae_Br4923 KTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQ
*: : .
Mb3573c|M.bovis_AF2122/97 DVKRALG-EIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRA
Rv3543c|M.tuberculosis_H37Rv DVKRALG-EIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRA
MAB_0615|M.abscessus_ATCC_1997 DVRRVLG-EMKAVWRLNELLNWQVASSGDDISMADAAATKILATEWIQKL
Mvan_2246|M.vanbaalenii_PYR-1 YRS-----GRLDDDSIGYRLGRSIARLEAALSTPEMFGRVAIAQTLRDIT
Mflv_4100|M.gilvum_PYR-GCK G-------DRLGDGEVAYRLGRSVARLEAALSTPEMFGRVAIAQTLRDIT
MSMEG_0578|M.smegmatis_MC2_155 P----------GDGASRFRLGRGIACTEAAMSTPDMYGRVAIAQTMRDVT
TH_2587|M.thermoresistible__bu ASPGPDGRRLLDDESVQYRLGRSVARLEAALSTPAEYGRVAIAQMMRDIT
MAV_5127|M.avium_104 ARPDAAGRRPIDDESVKYRLGRGMARIEAAMSTPGMYGRVALIQTMREVS
MMAR_4010|M.marinum_M MRPDPDGRRPIDDTSVAYRLGRSVARMEAALSAPSIFGRVAIAQTMRDIS
MUL_3874|M.ulcerans_Agy99 MRPDPDGRRPIDDTSVAYRLGRSVARMEAALSAPSIFGRVAIAQTMRDIS
MLBr_00737|M.leprae_Br4923 FMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVT
:. . :
Mb3573c|M.bovis_AF2122/97 GRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMI
Rv3543c|M.tuberculosis_H37Rv GRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMI
MAB_0615|M.abscessus_ATCC_1997 GRLSEGVVGRYGDPADANTAETLEWLDAQTKRHLVITFGGGVNEVMREMV
Mvan_2246|M.vanbaalenii_PYR-1 PDLMDVLGTTSVVPEGLN-------AEYLFRLALPTGIYGGTLDVFRNMI
Mflv_4100|M.gilvum_PYR-GCK PDLMDILGPASVLPSGRS-------AEYLFRLALPMGIYGGTLDVFRNMI
MSMEG_0578|M.smegmatis_MC2_155 PDLMDILGPAGALTDG---------VEYIFRLAGPTGIYGGTLEVFRNMI
TH_2587|M.thermoresistible__bu PELMDVLGAASALPVDTTGAAADGAVEYLFRLASPVAIYGGTVEVFRNMI
MAV_5127|M.avium_104 QELMDLLGTASALPTDTPGSPDDGAIEFIFRHAVPAGIYGGTMEVFRNMI
MMAR_4010|M.marinum_M PDLMDILGSAAALPFGTDGAVDDGGAEYVYRFAPLVGIYGGTLEVFRNMI
MUL_3874|M.ulcerans_Agy99 PDLMDILGSAAALPFGTDGAVDDGGAEYVYRFAPLVGIYGGTHEVFRNMI
MLBr_00737|M.leprae_Br4923 TDAVQLFGGAGYTSDFP--------VERFMRDAKITQIYEGTNQIQRVVM
: . . : : : *. :: * ::
Mb3573c|M.bovis_AF2122/97 AASGLKVPRVPR--------
Rv3543c|M.tuberculosis_H37Rv AASGLKVPRVPR--------
MAB_0615|M.abscessus_ATCC_1997 STAGLGTPRVPR--------
Mvan_2246|M.vanbaalenii_PYR-1 AQHALGLGRPNYSPPVQRP-
Mflv_4100|M.gilvum_PYR-GCK AQHALGLGKPNYSPPR----
MSMEG_0578|M.smegmatis_MC2_155 AQHGLGLGKPNYAQPVKKVS
TH_2587|M.thermoresistible__bu AQHALGLGKPSYGTPVKR--
MAV_5127|M.avium_104 AQHELGLGRPSYGR------
MMAR_4010|M.marinum_M AQHVLGLGKPSYPHRT----
MUL_3874|M.ulcerans_Agy99 AQHVLGLGKPSYPHRT----
MLBr_00737|M.leprae_Br4923 SRALLR--------------
: *