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DFSRVQLSDDEQKFQDEVRTFLSEIVTDEVIRRDRETGDNFDEGVHLALGAAGYLDRDWNPATERPFSRV ERRIWELEKRRAHVPWVTSGTTAMITKSVEKFGSPELKDEVLPRVYSGHVRLCLGYTEPEGGSDVATCKT RAVRDGSSWVINGSKMFTTGAHNCQYVFLITNTDPSAPKHKSLTMFLVPLDTPGVEIQGIRTVDGDRTNI VYYSDVRVDDRYRLGEVNGGWTVVREPLNAEHGDVAAADDGLADVSIMMHQAMFMAKAVDTAAQKSTIPD PNGRRLIDDGAVAYRLGRSVARLEASLSAPSIFGRVALAQTMRDISPDLMDILGTASALPVGTDGAADDG AAEYVYRFAPLVGIYGGTLEVFRNMIAQYVLGLGKPNYSPPRKAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4346 | - | - | 100% (396) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4100 | - | e-148 | 66.58% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1551 | - | 1e-40 | 30.34% (412) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3573c | fadE29 | 2e-37 | 31.07% (309) | acyl-CoA dehydrogenase FADE29 |
| M. tuberculosis H37Rv | Rv3543c | fadE29 | 2e-37 | 31.07% (309) | acyl-CoA dehydrogenase FADE29 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-13 | 22.67% (300) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0615 | - | 8e-43 | 32.01% (403) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4010 | - | 0.0 | 79.95% (389) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1595 | - | 0.0 | 83.12% (391) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2234 | - | 1e-178 | 76.84% (393) | acyl-CoA dehydrogenase middle domain-containing protein |
| M. thermoresistible (build 8) | TH_3716 | - | 0.0 | 82.07% (396) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_3874 | - | 0.0 | 79.69% (389) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1998 | - | 0.0 | 91.56% (391) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3573c|M.bovis_AF2122/97 ----------MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPA
Rv3543c|M.tuberculosis_H37Rv ----------MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPA
MAB_0615|M.abscessus_ATCC_1997 ----------MLIDLTPEQAKLQNDLRHYFSNLVTAEETREMMIDRHGSS
Mflv_4346|M.gilvum_PYR-GCK -------MDFSRVQLSDDEQKFQDEVRTFLSEIVT-DEVIRRDRETGDNF
Mvan_1998|M.vanbaalenii_PYR-1 -------MDFSRVELSDEDQKFLDEVRTFLGEIVT-EDVIRRDRETGDNF
MMAR_4010|M.marinum_M -------MDFSRVQISDADREFRETARSFLATHVT-EEVRRHDRETGDNF
MUL_3874|M.ulcerans_Agy99 -------MDFSRVQISDADREFRETARSFLATHVT-EEVRRHDRETGDNF
MAV_1595|M.avium_104 -------MDFSRVTLSDEDQRFLDEAREFLRTHVT-DEVRRRDRETGDNF
TH_3716|M.thermoresistible__bu -------MDFSRVELSDEDQAFYHEVRRFLREVVT-DEVIQRDRETGDNF
MSMEG_2234|M.smegmatis_MC2_155 -------MDFSHVELSSEDAAFREELRAFLAQIVT-EDVIRRDRETGDNF
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA---PHAADVDQRARF
. :. . : * :: :
Mb3573c|M.bovis_AF2122/97 YRAVIRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLP-AV
Rv3543c|M.tuberculosis_H37Rv YRAVIRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLP-AV
MAB_0615|M.abscessus_ATCC_1997 YEAVVRRMGQDGWLGVGWPKEYGGHGFGPLEQQIFMNEVMRADVPMP-LV
Mflv_4346|M.gilvum_PYR-GCK DEGVHLALGAAGYLDRDWNPATE-RPFSRVERRIWELEKRRAHVPWVTSG
Mvan_1998|M.vanbaalenii_PYR-1 DEGVHLALGAAGYLERDWNPDSD-RAFTRVQRRIWELEKRRAHVPWVTSG
MMAR_4010|M.marinum_M HEGLHLALGAAGYLAAEWKPEAD-GGFSRVRRRIWELEKRRAHVPWVTWG
MUL_3874|M.ulcerans_Agy99 HEGLHLALGAAGYLAAEWKPEAD-GGFSRVRRRIWELEKRRAHVPWVTWG
MAV_1595|M.avium_104 DEGVHLALGAAGYLEREWKPEAE-GGFSRVQRRIWELEKRRAHVPWVTWG
TH_3716|M.thermoresistible__bu DEGVHLALGAAGYLEKEWKPADE-GGFSRVRRRIWELEKRRAHVPWVTWG
MSMEG_2234|M.smegmatis_MC2_155 DEGVHLALGQAGYLEREFKSEQD-GGFTRVQRRIWALERRRAEVPWVTWG
MLBr_00737|M.leprae_Br4923 PEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
. :. * : * * *....
Mb3573c|M.bovis_AF2122/97 TLQTVGPT-LQAHGSELQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLR
Rv3543c|M.tuberculosis_H37Rv TLQTVGPT-LQAHGSELQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLR
MAB_0615|M.abscessus_ATCC_1997 TLQTVGPT-LQKYGTEEQKKKFLPGILAGEIHFAIGYTEPEAGTDLASLR
Mflv_4346|M.gilvum_PYR-GCK TTAMITKS-VEKFGSPELKDEVLPRVYSGHVRLCLGYTEPEGGSDVATCK
Mvan_1998|M.vanbaalenii_PYR-1 TTAMIAKS-VERFGSPELKDEVMPKVYSGHVRLCLGYTEPEGGSDVATCK
MMAR_4010|M.marinum_M TTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGGSDVATCK
MUL_3874|M.ulcerans_Agy99 TTAMVARS-VAKFGSPELVEEVLPGVFSGHVRMCLGYTEPEGGSDVATCK
MAV_1595|M.avium_104 TTAMVARS-VAKFGSEELQREVLPGVFSGHVRLCLGYTEPEGGSDVATCK
TH_3716|M.thermoresistible__bu TSALVARS-VVRFGSPELQEEVMPGFFSGHVRMCLGYTEPEGGSDIATCK
MSMEG_2234|M.smegmatis_MC2_155 TTIMIARS-VAKFASPEIRDDVLRGVFDGTVRMCLGYTEPEGGSDVATCK
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
: : : .: ..: . . . :* *.*:* *: :
Mb3573c|M.bovis_AF2122/97 TTAVRDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGISILIVD
Rv3543c|M.tuberculosis_H37Rv TTAVRDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGISILIVD
MAB_0615|M.abscessus_ATCC_1997 TTAVRDGDHYVVNGQKIFTTGAHQAQYIWLACRTDPSAPKHKGISILIVD
Mflv_4346|M.gilvum_PYR-GCK TRAVRDGSSWVINGSKMFTTGAHNCQYVFLITNTDPSAPKHKSLTMFLVP
Mvan_1998|M.vanbaalenii_PYR-1 TRAVRDGDSWVINGSKMFTTGAHNCQYVFLITNTDPSAPKHKSLTMFLVP
MMAR_4010|M.marinum_M TRALRDGDSWLINGSKMFTTGAHNCQYVFLITNTDPQARKHKSLTMFLVP
MUL_3874|M.ulcerans_Agy99 TRALRDGDSWLINGSKMFTTGAHNCQYVFLITNTDPQARKHKSLTMFLVP
MAV_1595|M.avium_104 TRAVRDGNGWIINGSKMFTTGAHNCQYVFLITNTDPDAPKHKSLTMFLVP
TH_3716|M.thermoresistible__bu TRAVRDGDHWVINGSKMFTTGAHNCQYVFLITNTDPDAPKHQSLTMFLVP
MSMEG_2234|M.smegmatis_MC2_155 TRAVRDGDQWVINGSKMFTTGAHNCQYVFLITNTDPDAPKHKSLTMFLVP
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN-GISAFIVH
* * **. :::** * : *.. .. : : ***. : .:: ::*
Mb3573c|M.bovis_AF2122/97 TKDPGYSWTP--IILADGAHHTNATYYNDVRVPVDMLVGKENDGWRLITT
Rv3543c|M.tuberculosis_H37Rv TKDPGYSWTP--IILADGAHHTNATYYNDVRVPVDMLVGKENDGWRLITT
MAB_0615|M.abscessus_ATCC_1997 TKDPGYSWTP--IITNDGAHHTNATYYTDVRVPVEMLVGEENAGWKLITT
Mflv_4346|M.gilvum_PYR-GCK LDTPGVEIQG--IRTVD-GDRTNIVYYSDVRVDDRYRLGEVNGGWTVVRE
Mvan_1998|M.vanbaalenii_PYR-1 LDSPGVEIQG--IRTVD-GDRTNIVYYSDVRVDDRYRLGEVNDGWTVVRE
MMAR_4010|M.marinum_M LDSAGIEIQG--IRTVD-GDRTNIVYYSDVRIDDKYRLGAVNGGWTVLRE
MUL_3874|M.ulcerans_Agy99 LDSAGIEIQG--IRTVD-GDRTNIVYYSDVRIDDKYRLGAVNGGWTVLRE
MAV_1595|M.avium_104 LDSPGIDIQG--IRTVD-GDRTNIVYYSDVRVDDKYRLGDVNAGWTVLRE
TH_3716|M.thermoresistible__bu LDTPGIEIQG--IRTVD-GDRTNIVYYSDVRVPDKYRLGEVNGGWQVLRE
MSMEG_2234|M.smegmatis_MC2_155 LDTPGIEIQG--IRTVD-GDRTNIVYYSDVRVDDKYRLGEVNGGWSVVRE
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
. * . . *. *: . *: :* . *:
Mb3573c|M.bovis_AF2122/97 QLNNERVMLGPAGR-----FASIYDRVHAWASVPGGNGVTPIDHDDVKRA
Rv3543c|M.tuberculosis_H37Rv QLNNERVMLGPAGR-----FASIYDRVHAWASVPGGNGVTPIDHDDVKRA
MAB_0615|M.abscessus_ATCC_1997 QLNHERVSLGPSGR-----IAGMYDRVYEWASKPGPDGVAPLSHEDVRRV
Mflv_4346|M.gilvum_PYR-GCK PLNAEHGDVAAADDGLADVSIMMHQAMFMAKAVDTAAQKSTIPDPNGRRL
Mvan_1998|M.vanbaalenii_PYR-1 PLNAEHGAVDAADDGLQDVSIMMHQAMFMAAAVDKAAQKSTIPDPNGRRL
MMAR_4010|M.marinum_M PLNVEHGAVAAAPDGLQDTSIMMHQAGSMAEAVDRAASCVMRPDPDGRRP
MUL_3874|M.ulcerans_Agy99 PLNVEHGAVAAAPDGLQDTSIMMHQAGSMAEAVDRAASCVMRPDPDGRRP
MAV_1595|M.avium_104 PLNVEHGAVAAAPDGLQDVSIMMHQAGFMADALDKVAAKVTLPDPHGRRL
TH_3716|M.thermoresistible__bu PLNAEHGAVAAAPDGLQDVSIMNHQAGFLATAVDRAAAAVNRADSSGRRL
MSMEG_2234|M.smegmatis_MC2_155 PLDAEHGAVAAAHDGLDDVAIMTHQATFMAHAADNVAALVGTRDAAGRAA
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVG---IAQGALDAAIVYTKDRKQFGESISTFQSIQFM
*: : : . : :
Mb3573c|M.bovis_AF2122/97 LGEIRAIWRIN-ELLNWQVASAGEDIN--MADAAATKVFGTERVQRAGRL
Rv3543c|M.tuberculosis_H37Rv LGEIRAIWRIN-ELLNWQVASAGEDIN--MADAAATKVFGTERVQRAGRL
MAB_0615|M.abscessus_ATCC_1997 LGEMKAVWRLN-ELLNWQVASSGDDIS--MADAAATKILATEWIQKLGRL
Mflv_4346|M.gilvum_PYR-GCK IDDGAVAYRLGRSVARLEASLSAPSIFGRVALAQTMRDISPDLMDILGTA
Mvan_1998|M.vanbaalenii_PYR-1 IDDGSVAYRLGRSVARLEASLSAPSIFGRVALAQTMRDISPDLMDVMGAA
MMAR_4010|M.marinum_M IDDTSVAYRLGRSVARMEAALSAPSIFGRVAIAQTMRDISPDLMDILGSA
MUL_3874|M.ulcerans_Agy99 IDDTSVAYRLGRSVARMEAALSAPSIFGRVAIAQTMRDISPDLMDILGSA
MAV_1595|M.avium_104 IDDSAIAYRLGRNAARMEAALSAPSIYGRVALAQTMRDISPDLMDILGTA
TH_3716|M.thermoresistible__bu IDDGSVAYRLGRSVARLEMALSTPSIFGRVAVAQTMRDISPDLMDILGAA
MSMEG_2234|M.smegmatis_MC2_155 VDDGSVAYRLGRSFARLEASLSTPSIFGRVAMAQTMRDISPDFMDIAGSV
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
: : . : : . : : : :..:
Mb3573c|M.bovis_AF2122/97 AEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAAS
Rv3543c|M.tuberculosis_H37Rv AEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAAS
MAB_0615|M.abscessus_ATCC_1997 SEGVVGRYGDPADANTAETLEWLDAQTKRHLVITFGGGVNEVMREMVSTA
Mflv_4346|M.gilvum_PYR-GCK SALPVGTDGAADDGAAEYVYRFAP-------LVGIYGGTLEVFRNMIAQY
Mvan_1998|M.vanbaalenii_PYR-1 SALPVGTDGAADDGASEYIYRFAP-------LVGIYGGTLEVFRNMIAQY
MMAR_4010|M.marinum_M AALPFGTDGAVDDGGAEYVYRFAP-------LVGIYGGTLEVFRNMIAQH
MUL_3874|M.ulcerans_Agy99 AALPFGTDGAVDDGGAEYVYRFAP-------LVGIYGGTHEVFRNMIAQH
MAV_1595|M.avium_104 SALPVGTDGAADDGASEYVFRFAP-------LVGIYGGTLEVFRNMIAQY
TH_3716|M.thermoresistible__bu SALPVGADGAADDGAAEYVYRFAP-------LVGIYGGTLEVFRNMIAQY
MSMEG_2234|M.smegmatis_MC2_155 SALPMGADGGADD-RSEYIYRFAP-------LVGIYGGTLEVFRNMIAQH
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAK-------ITQIYEGTNQIQRVVMSRA
: .* * : . : : *. :: * :::
Mb3573c|M.bovis_AF2122/97 GLKVPRVPR--------
Rv3543c|M.tuberculosis_H37Rv GLKVPRVPR--------
MAB_0615|M.abscessus_ATCC_1997 GLGTPRVPR--------
Mflv_4346|M.gilvum_PYR-GCK VLGLGKPNYSPPRKAS-
Mvan_1998|M.vanbaalenii_PYR-1 ALGLGKPNYSPVKT---
MMAR_4010|M.marinum_M VLGLGKPSYP---HRT-
MUL_3874|M.ulcerans_Agy99 VLGLGKPSYP---HRT-
MAV_1595|M.avium_104 MLGLGKPAYAPVAQRAS
TH_3716|M.thermoresistible__bu VLGLGKPSYGQPVKKSA
MSMEG_2234|M.smegmatis_MC2_155 VLGLGKPNYSPPKARAS
MLBr_00737|M.leprae_Br4923 LLR--------------
*