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RTWTLPLGDATLQGQSVYDVEDPCTGDVLTQVPDCSSEDVDRVVATAHAAQRDWALRTPRQRGTALRALA TLMRDHSEELALLDAIDGGFPLPAMRDDVTWAADVLELMADDALDLGGRTIPLSANLHYTLQQPYGVVAR IVPFNHPVLFAGSKIAAPLMAGNAVVLKAPDQTPLSAIRLAELAREVLPEGLFGVVTGHGATAGAALVAH PLVRRIGFIGSPGTGRHIQRLAAEHGVKYVTLELGGKNPMIVMPDADLEAAAKSAVVGMNFTTTAGQSCG STSRLLLHEAIADEVIDLVVDQVAAIKVGDPLVDGTDMGPVIDQAQYSKSLRAIESGRAGGASVLTGGGR AQGVGSKGWYVAPTVLAGVAPQADVARDEIFGPVLSVLTVRDEAEAVEVANSVEFGLTAAVWTNDVSQAH RMAAGLDAGYVWINGSARHYWGLPFGGWKSSGVGSEESTEELLSYTQVKAVTVTLD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0643 | - | - | 100% (477) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4063 | - | 3e-81 | 39.43% (454) | betaine-aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4860 | - | 5e-74 | 37.01% (462) | gamma-aminobutyraldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 1e-77 | 38.68% (455) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv2858c | aldC | 1e-77 | 38.68% (455) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-57 | 31.88% (458) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0972 | - | 5e-74 | 37.53% (469) | putative aldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-73 | 36.92% (493) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-89 | 42.26% (478) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | 4e-86 | 38.58% (464) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2957 | - | 4e-82 | 38.26% (460) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 5e-72 | 36.71% (493) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0522 | - | 0.0 | 99.79% (477) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2883c|M.bovis_AF2122/97 -----------------------------MS----------TTQLINPAT
Rv2858c|M.tuberculosis_H37Rv -----------------------------MS----------TTQLINPAT
Mflv_0643|M.gilvum_PYR-GCK ----------------------MRTWTLPLGDATLQGQS--VYDVEDPCT
Mvan_0522|M.vanbaalenii_PYR-1 ----------------------MRTWTLPLGDATLQGQS--VYDVEDPCT
MAB_0972|M.abscessus_ATCC_1997 ------MAKYAAPGTEGSAVTFAPRYDNFIGGEWVAPADGQYFENASPID
MSMEG_6297|M.smegmatis_MC2_155 MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSYEPRS
MAV_1897|M.avium_104 ---------MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYT
TH_2957|M.thermoresistible__bu ----------------MTSTLERPEVTLRIGGEKRRTASGGTFDHINPCT
MMAR_2875|M.marinum_M -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
MUL_2877|M.ulcerans_Agy99 -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
MLBr_02573|M.leprae_Br4923 ----------------------------------------MSIATINPAT
.*
Mb2883c|M.bovis_AF2122/97 EEVLASVDHTDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAV
Rv2858c|M.tuberculosis_H37Rv EEVLASVDHTDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAV
Mflv_0643|M.gilvum_PYR-GCK GDVLTQVPDCSSEDVDRVVATAHAAQRD--WALRTPRQRGTALRALATLM
Mvan_0522|M.vanbaalenii_PYR-1 GDVLTQVPDCSSEDVDRVVATAHAAQRD--WALRTPRQRGTALRALATLM
MAB_0972|M.abscessus_ATCC_1997 GKVFTRVARGTAPDIEKALDAAHAAAEA--WGNTSAAERSNALLRIADRM
MSMEG_6297|M.smegmatis_MC2_155 GRVWARLPRANSTDIDRAVRAARAAFEGP-WGAVSPADRGRFLMKIAAVV
MAV_1897|M.avium_104 ALPWARVPDCGPADVDRAVAAARAALRGP-WGQLTGTARGKLLWRLGELI
TH_2957|M.thermoresistible__bu GAPDAAIPLAGPAEIDDAVKAAHDAFHS--WRQTNPAERRRLLFRLAELI
MMAR_2875|M.marinum_M ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
MUL_2877|M.ulcerans_Agy99 ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
MLBr_02573|M.leprae_Br4923 GETVKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLL
. :: .: * : *
Mb2883c|M.bovis_AF2122/97 QAHLDELAALEVANSGHPIVSAE-WEAGHVRDVLAFYAASPERLSGRQIP
Rv2858c|M.tuberculosis_H37Rv QAHLDELAALEVANSGHPIVSAE-WEAGHVRDVLAFYAASPERLSGRQIP
Mflv_0643|M.gilvum_PYR-GCK RDHSEELALLDAIDGGFPLPAMR-DDVTWAADVLELMADDALDLGGRTIP
Mvan_0522|M.vanbaalenii_PYR-1 RDHSEELALLDAIDGGFPLPAMR-DDVTWAADVLELMADDALDLGGRTIP
MAB_0972|M.abscessus_ATCC_1997 EQHIERLAVAETWDNGKPIRESLNADIPLAIDHFRYFAGVLRAQEGSIS-
MSMEG_6297|M.smegmatis_MC2_155 DRHRDQLTVIESRDNGKPVREVR-AEIDAVVRYFEYFAGVCQTTVGETH-
MAV_1897|M.avium_104 AREAESLAELEVRDGGKLVREMI-GQMKALPDYYIYYAGLADKLQGEVV-
TH_2957|M.thermoresistible__bu EQHTDDFVRLGTFDNGTPVGLVA-GLVAMSAEWTRYYAGWADKITSEVSG
MMAR_2875|M.marinum_M DQVTDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPA
MUL_2877|M.ulcerans_Agy99 DQVTDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPA
MLBr_02573|M.leprae_Br4923 EAEANQSAALMTLEMGKTLQSAK-DEAMKCAKGFRYYAEKAETLLADEPA
: * : *
Mb2883c|M.bovis_AF2122/97 VAGG---VDVTF--NEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLV
Rv2858c|M.tuberculosis_H37Rv VAGG---VDVTF--NEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLV
Mflv_0643|M.gilvum_PYR-GCK LSAN---LHYTL--QQPYGVVARIVPFNHPVLFAGSKIAAPLMAGNAVVL
Mvan_0522|M.vanbaalenii_PYR-1 LSAN---LHYTL--QQPYGVVARIVPFNHPVLFAGSKIAAPLMAGNAVVL
MAB_0972|M.abscessus_ATCC_1997 EIDH-DTVAYHF--HEPLGVVGQIIPWNFPLLMAVWKLAPALAAGNCVVL
MSMEG_6297|M.smegmatis_MC2_155 PQAA-TAFSYTR--REPVGVVGAIVPWNSPLLMLAWKLSPALAGGNTIIL
MAV_1897|M.avium_104 PVDKPNFFVYTR--HEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVV
TH_2957|M.thermoresistible__bu TYGTTGEFSYTL--SQPYGVIGVIITWNGPLISLAMKVPAALAAGNTVVV
MMAR_2875|M.marinum_M PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
MUL_2877|M.ulcerans_Agy99 PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
MLBr_02573|M.leprae_Br4923 EAAAVG-ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLL
:* **: : .:* *: . : .* ::
Mb2883c|M.bovis_AF2122/97 KPAELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKI
Rv2858c|M.tuberculosis_H37Rv KPAELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKI
Mflv_0643|M.gilvum_PYR-GCK KAPDQTPLSAIRLAELAREV-LPEGLFGVVTGHGATAGAALVAHPLVRRI
Mvan_0522|M.vanbaalenii_PYR-1 KAPDQTPLSAIRLAELAREV-LPEGLFGVVTGHGATAGAALVAHPLVRRI
MAB_0972|M.abscessus_ATCC_1997 KPAEQTPASILVLMELIADL-LPSGTVNVVNGFGVEAGKPLASSPRIAKI
MSMEG_6297|M.smegmatis_MC2_155 KPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAALVAHPDVDKI
MAV_1897|M.avium_104 KPSDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKI
TH_2957|M.thermoresistible__bu KPSELTPFSATLFADLAAEAGIPDGVINVVPGTG-DAGAALVAHPLVKKV
MMAR_2875|M.marinum_M KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
MUL_2877|M.ulcerans_Agy99 KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
MLBr_02573|M.leprae_Br4923 KHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAA
* . .. : : : . . .: . . : * :
Mb2883c|M.bovis_AF2122/97 VFTGSTEVGKRVMAGAAAQ-VKRVTLELGGKSANIVFH------DCDLER
Rv2858c|M.tuberculosis_H37Rv VFTGSTEVGKRVMAGAAAQ-VKRVTLELGGKSANIVFH------DCDLER
Mflv_0643|M.gilvum_PYR-GCK GFIGSPGTGRHIQRLAAEHGVKYVTLELGGKNPMIVMP------DADLEA
Mvan_0522|M.vanbaalenii_PYR-1 GFIGSPGTGRHIQRLAAEHGVKYVTLELGGKNPMIVMP------DADLEA
MAB_0972|M.abscessus_ATCC_1997 AFTGETTTGRLIMQYATEN-IIPVTLELGGKSPNIFMPDVMAADDAFLDK
MSMEG_6297|M.smegmatis_MC2_155 AFTGSTEVGKQIAATAASD-LKLVTFELGGKSPTVIF------DDADLDA
MAV_1897|M.avium_104 AFTGSTATGISVGKAAIDN-MTRFTLELGGKSAQVVF------DDADLDA
TH_2957|M.thermoresistible__bu TFTGGPDTARKILQSCAEH-IKPSVMELGGKSGNIIF------EDANLDT
MMAR_2875|M.marinum_M AFTGSTAVGREIMRLASGT-VKQVTLELGGKGPTIVLD------DADLEM
MUL_2877|M.ulcerans_Agy99 AFTGSTAVGREIMRLASGT-VKQVTLELGGKGPTIVLD------DADLEM
MLBr_02573|M.leprae_Br4923 TLTGSEPAGQAVGAIAGNE-IKPTVLELGGSDPFIVMP------SADLDA
: * .. : . : .:****.. :.: .. *:
Mb2883c|M.bovis_AF2122/97 AATTAPAGVFDN--AGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGD
Rv2858c|M.tuberculosis_H37Rv AATTAPAGVFDN--AGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGD
Mflv_0643|M.gilvum_PYR-GCK AAKSAVVGMNFTTTAGQSCGSTSRLLLHEAIADEVIDLVVDQVAAIKVGD
Mvan_0522|M.vanbaalenii_PYR-1 AAKSAVVGMNFTTTAGQSCGSTSRLLLHEAIADEVIDLVVDQVAAIKVGD
MAB_0972|M.abscessus_ATCC_1997 ALEG--FTMFALN-QGEVCTCPSRALVHASIYDEFIARAITRVEAIVGGD
MSMEG_6297|M.smegmatis_MC2_155 AVHRTAYGIFSA--AGQTCQAASRIFVQDTIHDEFLDRFAALARRIRVGD
MAV_1897|M.avium_104 AANGVIAGVFAA--TGQTCLAGSRLLVHESVADALVERIVARASTIKLGD
TH_2957|M.thermoresistible__bu ACSVGTLMSVGMM-SGQGCAFPTRMIVARPLYDEVLTRVSALAPMVKVGD
MMAR_2875|M.marinum_M AVEGVLYGCFAYS--GQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGP
MUL_2877|M.ulcerans_Agy99 AVEGVLYGCFAYS--GQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGP
MLBr_02573|M.leprae_Br4923 AVATAVTGRVQNN--GQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGD
* *: * .* : : : .: : *
Mb2883c|M.bovis_AF2122/97 PGSRATEMGPLVSRAHRDKVAGYVP----DDAPVAFRGTAP----AGRGF
Rv2858c|M.tuberculosis_H37Rv PGSRATEMGPLVSRAHRDKVAGYVP----DDAPVAFRGTAP----AGRGF
Mflv_0643|M.gilvum_PYR-GCK PLVDGTDMGPVIDQAQYSKSLRAIESGRAGGASVLTGGGRAQ-GVGSKGW
Mvan_0522|M.vanbaalenii_PYR-1 PLVDGTDMGPVIDQAQYSKSLRAIESGRAGGASVLTGGGRAQ-GVGSKGW
MAB_0972|M.abscessus_ATCC_1997 PLDEDTMIGAQASNDQYEKILSYIDIGRQEGAQVLTGGDARKVSEYPDGA
MSMEG_6297|M.smegmatis_MC2_155 PLSERTQMGAQISAQHRERIAGYVASGIQEGANLVCGGTQPTEAPLAQGY
MAV_1897|M.avium_104 PKDPATEMGPVSNQPQYEKVLSHFASAREQGATVAYGGEP---AGELGGF
TH_2957|M.thermoresistible__bu PLEPDTVAGPVVNEAALQRILGMIERAKQDGARLLTGGERLG-GDLADEY
MMAR_2875|M.marinum_M TRDWDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGF
MUL_2877|M.ulcerans_Agy99 TRDWDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGF
MLBr_02573|M.leprae_Br4923 PTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPD----RPGW
. * *. : . .* : *
Mb2883c|M.bovis_AF2122/97 WFPPTVLTPKRGDRTVT-DEIFGPVVVVLTFDDEADAISLANDTAYGLSG
Rv2858c|M.tuberculosis_H37Rv WFPPTVLTPKRGDRTVT-DEIFGPVVVVLTFDDEADAISLANDTAYGLSG
Mflv_0643|M.gilvum_PYR-GCK YVAPTVLAGVAPQADVARDEIFGPVLSVLTVRDEAEAVEVANSVEFGLTA
Mvan_0522|M.vanbaalenii_PYR-1 YVAPTVLAGVAPQADVARDEIFGPVLSVLTVRDEAEAVEVANSVEFGLTA
MAB_0972|M.abscessus_ATCC_1997 YIQPTVFAGTN-NMRIFQEEIFGPVLSVAKFDSLDEALKIANDTLYGLGA
MSMEG_6297|M.smegmatis_MC2_155 YYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDTEYGLAG
MAV_1897|M.avium_104 FVKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAA
TH_2957|M.thermoresistible__bu FVAPTVFADVDPYSELAQKEVFGPVLSIIPFDTEEQAVEIANSTPYGLSG
MMAR_2875|M.marinum_M WVAPTILTGVHNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAA
MUL_2877|M.ulcerans_Agy99 WVAPTILTGVHNDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAA
MLBr_02573|M.leprae_Br4923 FYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGS
: **:: .*:**** : :*: ** :** .
Mb2883c|M.bovis_AF2122/97 SIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGP
Rv2858c|M.tuberculosis_H37Rv SIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGP
Mflv_0643|M.gilvum_PYR-GCK AVWTNDVSQAHRMAAGLDAGYVWINGSARHYWGLPFGGWKSSGVGSEEST
Mvan_0522|M.vanbaalenii_PYR-1 AVWTNDVSQAHRMAAGLDAGYVWINGSSRHYWGLPFGGWKSSGVGSEEST
MAB_0972|M.abscessus_ATCC_1997 GVWSRDMTNAYRLGRGIKAGRVWTNCYHQYPAHAAFGGYKKSGIGRENHK
MSMEG_6297|M.smegmatis_MC2_155 SVWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGREGGQ
MAV_1897|M.avium_104 GVWTKDVHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGI
TH_2957|M.thermoresistible__bu YVFTNDLKRAHRVAEQLETGEVLINGAAPLTVHRPFGGFGISGIGKEGGR
MMAR_2875|M.marinum_M SIWTSDNARGLAMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGRELGP
MUL_2877|M.ulcerans_Agy99 SIWTSDNARGLAMAERIRSGSVWINDAHQINCRLLFGGYKQSGVGRELGP
MLBr_02573|M.leprae_Br4923 NAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELST
:: : . . : :* : * *** ** * *
Mb2883c|M.bovis_AF2122/97 DAPLQFTETKNVFIAVGEEM---------------
Rv2858c|M.tuberculosis_H37Rv DAPLQFTETKNVFIAVGEEM---------------
Mflv_0643|M.gilvum_PYR-GCK EELLSYTQVKAVTVTLD------------------
Mvan_0522|M.vanbaalenii_PYR-1 EELLSYTQVKAVTVTLD------------------
MAB_0972|M.abscessus_ATCC_1997 MMLDHYQQTKNILVSYSPDAAGFF-----------
MSMEG_6297|M.smegmatis_MC2_155 AVMEHYTRIKSVWVDMQDDLPNWYAD---------
MAV_1897|M.avium_104 DAVKDFTETKAVWVELSGATRDPFTLG--------
TH_2957|M.thermoresistible__bu EGLAEFLRTKSVSIA--------------------
MMAR_2875|M.marinum_M DALDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 DTLDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MLBr_02573|M.leprae_Br4923 HGIREFCNIKTVWIA--------------------
: . * : :